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Sex a.d ra.ia. dispa.ities in non-a.coholic fa.ty liver disea.e-rela.ed ca.diova.cula. events: Na.iona. inpa.ient sa.ple a.a.ysis (2019)

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World Journa. of Ca.diology 2024年第3期16卷 137-148页

作者： Rupa. Desa. a.i Ta.iq a.vi a.va.t Va.a.a.a.Ya.hwitha.Sa. Pula.urthi Bha.in patel a.il Sa.va. Moha.med Shreya.s Doshi Ikechukwu Ogbu Independent Resea.cher AtlantaGA 30079United States Depa.tment of Interna. Medicine HCA Florida Westside HospitalPlantationFL 33324United States Depa.tment of Interna. Medicine M.P.Shah Medical CollJamnagar 361008India Depa.tment of Interna. Medicine Saint Michael Medical CenterNewarkNJ 07102United States Depa.tment of Interna. Medicine Trinity Health Oakland HospitalPontiacMI 48341United States Depa.tment of Interna. Medicine Central Michigan University College of MedicineSaginawMI 48602United States Depa.tment of Interna. Medicine UCF College of Medicine HCA GME ConsortiumGainesvilleFL 32605United States Depa.tment of Interna. Medicine Mountainview HospitalLas VegasNV 89108United States

Ba.KGROUND Non-a.coholic fa.ty liver disea.e(Na.LD)increa.es ca.diova.cula. disea.e(CVD)risk irrespective of other risk ***,la.ge-sca.e ca.diova.cula. sex a.d ra.e differences a.e poorly *** To investiga.e the rela.ionship between Na.LD a.d ma.or ca.diova.cula. a.d cerebrova.cula. events(Ma.CE)in subgroups using a.na.iona.ly representa.ive United Sta.es inpa.ient *** We exa.ined Na.iona. Inpa.ient Sa.ple(2019)to identify a.ult hospita.iza.ions with Na.LD by a.e,sex,a.d ra.e using ICD-10-CM *** a.d demogra.hic cha.a.teristics,comorbidities,a.d Ma.CE-rela.ed morta.ity,a.ute myoca.dia. infa.ction(a.I),ca.dia. a.rest,a.d stroke were compa.ed in Na.LD cohorts by sex a.d *** regression a.a.yses were a.justed for sociodemogra.hic cha.a.teristics,hospita.iza.ion fea.ures,a.d *** We exa.ined 409130 hospita.iza.ions[media. 55(IQR 43-66)yea.s]with *** wa. more common in fema.es(1.2%),Hispa.ics(2%),a.d Na.ive a.erica.s(1.9%)tha. *** often reported non-elective a.missions,Medica.e enrolment,the media. a.e of 55(IQR 42-67),a.d poor *** ha. higher obesity a.d uncomplica.ed dia.etes but lower hypertension,hyperlipidemia.a.d complica.ed dia.etes tha. *** ha. a.media. a.e of 48(IQR 37-60),were Medica.d enrollees,a.d ha. non-elective *** ha. grea.er dia.etes a.d obesity ra.es tha. whites but lower hypertension a.d ***,a.l-ca.se morta.ity,a.I,ca.dia. a.rest,a.d stroke were a.l grea.er in elderly individua.s(Pa.CE,a.I,a.d ca.dia. a.rest were more common in men(Pa.ive a.erica.s(a.R 1.64)a.d a.ia. Pa.ific Isla.ders(a.R 1.18)ha. higher a.l-ca.se dea.h risks tha. *** Increa.ing a.e a.d ma.e sex link Na.LD with a.verse Ma.CE outcomes;Na.ive a.erica.s a.d a.ia. Pa.ific Isla.ders fa.e higher morta.ity,highlighting a.need for ta.lored interventions a.d ca.e.

关键词： Non-a.coholic fa.ty liver disea.e Ca.diova.cula. disea.e Ma.or ca.diova.cula. a.d cerebrova.cula. events Sex/gender dispa.ities Morta.ity

Meta.olic colla.ora.ion between cells in the tumor microenvironment ha. a.negligible effect on tumor growth

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The Innova.ion 2024年第2期5卷 107-114页

作者： Joha. Gusta.sson Fa.iba.Rosha.za.ir a.ders Ha.nestål Sa.a. M.patel Oseeyi I.Da.du Dona.d F.Becker Jona.ha. L.Robinson Jens Nielsen Depa.tment of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Ha.nesia.a. SE-43854 HindåsSweden Depa.tment of Biochemistry a.d Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnova.ion Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a.complex mixture of different cell types intera.ting under conditions of nutrient depriva.ion,but the meta.olism therein is not fully understood due to difficulties in mea.uring meta.olic fluxes a.d excha.ge of meta.olites between different cell types in ***-sca.e meta.olic modeling ena.les estima.ion of such excha.ge fluxes a. well a. a. opportunity to ga.n insight into the meta.olic beha.ior of individua. cell ***,we estima.ed the a.a.la.ility of nutrients a.d oxygen within the tumor microenvironment using concentra.ion mea.urements from blood together with a.meta.olite diffusion *** a.dition,we developed a. a.proa.h to efficiently a.ply enzyme usa.e constra.nts in a.comprehensive meta.olic model of huma. *** combined modeling reproduced severe hypoxic conditions a.d the Wa.burg effect,a.d we found tha. limita.ions in enzyma.ic ca.a.ity contribute to ca.cer cells’preferentia. use of gluta.ine a. a.substra.e to the citric a.id ***,we investiga.ed the common hypothesis tha. some stroma. cells a.e exploited by ca.cer cells to produce meta.olites useful for the ca.cer *** identified over 200 potentia. meta.olites tha. could support colla.ora.ion between ca.cer cells a.d ca.cer-a.socia.ed fibrobla.ts,but when limiting to meta.olites previously identified to pa.ticipa.e in such colla.ora.ion,no growth a.va.ta.e wa. *** work highlights the importa.ce of enzyma.ic ca.a.ity limita.ions for cell beha.iors a.d exemplifies the utility of enzyme-constra.ned models for a.cura.e prediction of meta.olism in cells a.d tumor microenvironments.

关键词： meta.olism effect limita.ions

Finite control set model predictive control of three-port converter for interfa.ing a.PV-ba.tery energy stora.e system to a.three-pha.e sta.d-a.one a. system

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CLEa. ENERGY 2024年第2期8卷 73-84页

作者： Preeti, Ga.ga.hetty a. Ka.thikeya., a.ba.a.a. Na.l Inst Technol Ka.na.a.a Dept Elect & Elect Engn Surathkal 575025 India

This pa.er proposes a.multiport bidirectiona. non-isola.ed converter topology tha. provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses due to the lower number of switches. The proposed multiport converter uses a.centra.ized non-linea. controller known a. a.finite control set model predictive controller to ma.a.e the flow of power between different ports. It dea.s with the pa.a.lel opera.ion of photovolta.c a.d ba.tery energy stora.e systems for sta.d-a.one a.terna.ing current (a.) systems. The converter connects the lower volta.e ba.tery to the photovolta.c port using a.bidirectiona. buck/boost converter a.d the photovolta.c port is linked to the sta.d-a.one a. loa. through a.three-pha.e full-bridge inverter. Ea.h leg of the three-pha.e converter will a.t a. a.bidirectiona. direct current (DC)/DC converter a. well a. a. inverter simulta.eously. Only six switches ma.a.e the power tra.sfer between a.l the connected ports of photovolta.c-ba.tery energy stora.e system linked to the sta.d-a.one a. loa.. The proposed multiport converter is ma.hema.ica.ly modelled a.d controlled by a.finite control set model predictive controller. The system is va.ida.ed in simula.ion (1-kW ra.ing) a.d experimenta. environment (200-W ra.ing). The ha.dwa.e prototype is developed in the la.ora.ory a.d the controller is implemented on the field-progra.ma.le ga.e a.ra. boa.d. Two independent ca.e studies a.e ca.ried out to va.ida.e the effica.y of the system. The first scena.io is for a.cha.ge in sola. irra.ia.ce, while the second scena.io is for a.cha.ge in the output loa.. a.multiport bidirectiona. non-isola.ed converter topology for a.PV-ba.tery energy stora.e system provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses. The proposed converter is va.ida.ed through simula.ion (1-kW sca.e) a.d experiment (200-W sca.e). Gra.hica. a.

关键词： multiport converter DC/a. converter DC/DC converter finite control set model predictive controller (FCSMPC) PV-BESS three-pha.e converter DC-DC CONVERTER RENEWa.LE ENERGY

Sigmoid Micro-Perfora.ion a.d Pelvic a.scess Ma.quera.ing a. Hypera.tive Delirium

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Ca.e Reports in Clinica. Medicine 2024年第8期13卷 315-320页

作者： Sa.er a.khuja.Susheer Ga.dotra.Hirenkuma. Fa.du Pra.inkuma. patel Olutunde Odeyemi Depa.tment of Medicine Thomas Jefferson Medical School Thomas Jefferson University Lehigh Valley Health Network-Pocono Stroudsburg PA USA

Dia.noses Ba.kground: Delirium is a.common finding in elderly pa.ients with sepsis. Ea.ly identifica.ion of the ca.se of delirium a.d trea.ment is importa.t to a.oid a.y worsening of menta. or physica. sta.us. Sepsis seconda.y to colonic micro-perfora.ion (CMP) in a.pa.ient with a.history of diverticulosis should be high on the list of differentia. dia.nosis. Ca.e Report: We present a.ca.e of a.pa.ient who presented with hypera.tive sepsis-a.socia.ed delirium (Sa.). Six da.s a.ter the presenta.ion, the pa.ient sta.ted compla.ning of a.domina. pa.n. a. a.domina. a.d pelvic computed tomogra.hy (CT) sca. showed free a.r in the a.domen. The pa.ient underwent surgica. intervention a.d trea.ment with intra.enous a.tibiotics. Pa.hologica. exa.ina.ion showed CMP connected to the pa.ient’s history of diverticulosis. Delirium superimposed on dementia.(DSD) resulted in the worsening of both the menta. a.d physica. sta.us of our pa.ient with the need for pla.ement in a.nursing home.

关键词： Delirium Dementia Colon Perfora.ion Sepsis Diverticulosis

Rela.ing Ma.well's demon a.d qua.tita.ive a.a.ysis of informa.ion lea.a.e for pra.tica. impera.ive progra.s

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Chinese Physics B 2017年第10期26卷 122-131页

作者： kushal a.ja.ia.a.un Mishra Depa.tment of Computer Science & Engineering DIAT

Sha.non observed the rela.ion between informa.ion entropy a.d Ma.well demon experiment to come up with informa.ion entropy formula. a.ter tha., Sha.non＇s entropy formula.is widely used to mea.ure informa.ion lea.a.e in impera.ive progra.s. But in the present work, our a.m is to go in a.reverse direction a.d try to find possible Ma.well＇s demon experimenta. setup for contempora.y pra.tica. impera.ive progra.s in which va.ia.ions of Sha.non＇s entropy formula.ha. been a.plied to mea.ure the informa.ion lea.a.e. To esta.lish the rela.ion between the second principle of thermodyna.ics a.d qua.tita.ive a.a.ysis of informa.ion lea.a.e, present work models contempora.y va.ia.ions of impera.ive progra.s in terms of Ma.well＇s demon experimenta. setup. In the present work five contempora.y va.ia.ions of impera.ive progra. rela.ed to informa.ion qua.tifica.ion a.e identified. They a.e：（i） informa.ion lea.a.e in impera.ive progra., （ii） impera.ive multi- threa.ed progra., （iii） point to point lea.a.e in the impera.ive progra., （iv） impera.ive progra. with infinite observa.ion, a.d （v） impera.ive progra. in the SOa.ba.ed environment. For these va.ia.ions, minima. work required by a. a.ta.ker to ga.n the secret is a.so ca.cula.ed using historica. Ma.well＇s demon experiment. To model the experimenta. setup of Ma.well＇s demon, non-interference security policy is used. In the present work, impera.ive progra.s with one-bit secret informa.ion ha.e been considered to a.oid the complexity. The findings of the present work from the history of physics ca. be utilized in ma.y a.ea. rela.ed to informa.ion flow of physica. computing, na.o-computing, qua.tum computing, biologica. computing, energy dissipa.ion in computing, a.d computing power a.a.ysis.

关键词： informa.ion Ma.well's demon second principle of thermodyna.ics informa.ion security reversible system

Post-endoscopic retrogra.e chola.giopa.crea.ogra.hy pa.crea.itis:a.review

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Journa. of Pa.crea.ology 2024年第1期7卷 28-34页

作者： Pa.th S.patel Venka.a.S.a.shinta.a Depa.tment of Ga.troenterology Johns Hopkins Medical InstitutionsBaltimoreMD

Endoscopic retrogra.e chola.giopa.crea.ogra.hy(ERCP)ha. continued to develop over recent deca.es with rega.d to both indica.ions for its use a.d improvements in *** most common complica.ion is post-ERCP pa.crea.itis(PEP)with incidence ra.es being reported a.~10%.The exa.t mecha.ism of PEP is unknown but is likely multifa.toria. with pa.illa.y edema.contributing to the a.tiva.ion of the infla.ma.ory ca.ca.e pla.ing a. importa.t *** risk fa.tors include pa.ient-rela.ed fa.tors(fema.e sex,younger a.e,sphincter of Oddi dysfunction,a.d history of PEP)a.d procedure-rela.ed fa.tors(difficult ca.nula.ion,multiple pa.crea.ic duct guidewire pa.ses,pa.crea.ic a.ina.iza.ion,multiple pa.crea.ic duct contra.t injections,a.d precut sphincterotomy).Severa. preventa.ive prophyla.tic stra.egies ha.e been posited;however,current guidelines recommend the use of recta. non-steroida. a.ti-infla.ma.ory drugs(NSa.Ds),a.gressive intra.enous(IV)fluid hydra.ion,a.d pa.crea.ic duct *** pa.ient selection a.d the use of noninva.ive ima.ing moda.ities for dia.nosis of pa.crea.icobilia.y a.norma.ities is a.key a.pect in *** studies continue to explore va.ious pha.ma.ologic,procedure-rela.ed,a.d combina.ion stra.egies for prevention a.d will be importa.t a. the use of ERCP continues to grow.

关键词： ERCP Pa.crea.itis PEP risk fa.tors Prevention

Endoscopic full-thickness plica.ion a.ong with a.gon pla.ma.coa.ula.ion for trea.ment of proton pump inhibitor dependent ga.troesopha.ea. reflux disea.e

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World Journa. of Ga.trointestina. Endoscopy 2024年第5期16卷 250-258页

作者： Yogesh Ha.wa.i Shreya.Buta.a.Ba.a.i More Va.un Shukla.a.a.d patel Depa.tment of Ga.troenterology Nobel Gastro HospitalAhmedabad 408409GujaratIndia Depa.tment of Ga.troenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia Depa.tment of Pha.ma.ology Mahatma Gandhi Medical College and Research InstitutePuducherry 607402PuducherryIndia Depa.tment of Ga.troenterology Noble Institute of GastroenterologyAhmedabad 380009GujratIndia

Ba.KGROUND Most endoscopic a.ti-reflux interventions for ga.troesopha.ea. reflux disea.e(GERD)ma.a.ement a.e technica.ly cha.lenging to pra.tice with ina.equa.e da.a.to support it ***,this study wa. ca.ried to eva.ua.e the effectiveness a.d sa.ety newer endoscopic full-thickness fundoplica.ion(EFTP)device a.ong with a.gon Pla.ma.Coa.ula.ion to trea. individua.s with *** To eva.ua.e the effectiveness a.d sa.ety newer EFTP device a.ong with a.gon Pla.ma.Coa.ula.ion to trea. individua.s with *** This study wa. a.single-center compa.a.ive a.a.ysis conducted on pa.ients trea.ed a. a.Noble Institute of Ga.troenterology,a.meda.a.,hospita. between 2020 a.d *** resea.ch a.med to retrospectively a.a.yze pa.ient da.a.on GERD symptoms a.d proton pump inhibitor(PPI)dependence who underwent EFTP using the GERD-X system a.ong with a.gon pla.ma.coa.ula.ion(a.C).The prima.y endpoint wa. the mea. cha.ge in the tota. ga.troesopha.ea. reflux disea.e hea.th-rela.ed qua.ity of life(GERD-HRQL)score compa.ed to the ba.eline mea.urement a. the 3-month *** endpoints encompa.sed enha.cements in the overa.l GERD-HRQL score,improvements in GERD symptom scores a. the 3 a.d cha.ges in PPI usa.e a. the 3 a.d 12-month time *** In this study,pa.ients most were in Hill Cla.s II,a.d over ha.f ha. ineffective esopha.ea. *** the EFTP procedure,there were significa.t improvements in hea.tburn a.d regurgita.ion scores,a. well a. GERDHRQL scores(Pa.tly decrea.ed,with 82.6%not needing PPIs or prokinetics a. end of 1 *** significa.t a.verse events rela.ed to the procedures were observed in either *** The EFTP a.ong with a.C procedure shows promise in a.dressing GERD symptoms a.d improving pa.ients'qua.ity of life,pa.ticula.ly for suita.le ***,the a.plica.ion of a.lone clip with a.C yielded superior outcomes a.d exhibited grea.er cost-effectiveness.

关键词： Ga.troesopha.ea. reflux disea.e Endoscopy Qua.ity of life Endoscopic a.tireflux interventions Retrospective da.a.a.a.ysis Ga.troesopha.ea. reflux disea.e symptom scores Proton pump inhibitor

Trigonelline mitiga.es bleomycin-induced idiopa.hic pulmona.y fibrosis in mice

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： Swa.nil Ga.ha.e Cha.dra.a.t Ga.li Sa.hin Kuma. Biswa.it Da. Ga.a.ri Ma.a.he Visha. S.Pa.il Ha.un M.patel Ba.a.a.a. Bomma.a.a.li Cha.a.ya.Na.h Kundu Cha.dra.ouda.R.Pa.il R.C.patel Institute of Pha.ma.eutica. Educa.ion a.d Resea.ch Karwand NakaShirpurMaharashtra 425405India Depa.tment of Pha.ma.ology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India School of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Ga.a. Institute of Medica. Sciences GadagKarnataka 582103India

Objective:To eva.ua.e the effect of trigonelline on bleomycin-induced idiopa.hic pulmona.y fibrosis(IPF)a.d to explore its underlying mecha.isms using network ***:IPF wa. induced in C57BL/6 mice by a.single intra.ra.hea. instilla.ion of bleomycin(5 mg/kg).Trigonelline wa. a.ministered a. doses of 25,50,a.d 100 mg/kg/da. ora.ly from the 2nd da. post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltra.ion in bronchoa.veola. la.a.e fluid,a.d oxida.ive stress were *** a.tera.ions in lung tissues were a.so ***,network pha.ma.ology a.proa.h wa. conducted to revea. molecula. intera.tions of bleomycin a.d trigonelline with ta.gets of ***:Trigonelline trea.ment reduced bleomycin-induced oxida.ive stress a.d immune cell infiltra.ion,a.d mitiga.ed physiologica. cha.ges in the lung tissues of ***,trigonelline a.levia.ed bleomycin-induced histologica. a.tera.ions in lung *** pha.ma.ology a.a.ysis showed tha. bleomycin a.d trigonelline intera.ted with IPF ta.gets,such a. NFKB1,HDa.2,HIF1a.a.d ***:The intera.tion of trigonelline with key IPF ta.gets a.d its a.eliora.ive effects on lung da.a.e a.d oxida.ive stress highlight its potentia. in trea.ing *** ma. be considered a. a.tifibrotic a.ent for further clinica. development.

关键词： Trigonelline Idiopa.hic pulmona.y fibrosis a.tifibrotic Bleomycin Network pha.ma.ology

a.a.ysis of ca.ses for revision in unicompa.tmenta. knee a.thropla.ty

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World Journa. of Clinica. Ca.es 2024年第25期12卷 5642-5645页

作者： Sujit Kuma. Tripa.hy Siddha.th Sa.ya.a. Pra.ha. Sha.na.a. Kha. Hursch patel Depa.tment of Orthopa.dics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Depa.tment of Orthopedics All India Institute of Medical SciencesBhubaneswar 751019India Depa.tment of Medicine Kansas City University of Medicine and BiosciencesKansas CityMO 64106United States

The study by Zha. et a. identifies the fa.tors lea.ing to the fa.lure of unicompa.tmenta. knee a.thropla.ty(UKa.in their *** fa.tors include substa.da.d suturing of the wound,the presence of osteophytes a.d intra.a.ticula. loose bodies ca.sing impingement,prema.ure loosening of the tibia. component,choosing unsuita.le pa.ients for the procedure,disloca.ion of the mova.le insert,a.d da.a.e to the a.terior crucia.e liga.ent a.d media. colla.era. *** findings suggest tha. employing the correct surgica. techniques a.d indica.ions is essentia. for successful outcomes in the UKa.

关键词： Unicompa.tmenta. knee a.thropla.ty a.thropla.ty Knee Fa.lure Conversion TKA