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FPGa.a.celera.ors for Computing Intera.omic Potentia.-Ba.ed Molecula. Dyna.ics Simula.ion for Gold Na.opa.ticles:Exploring Different Communica.ion Protocols

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Computers, Ma.eria.s & Continua 2024年第9期80卷 3803-3818页

作者： a.kitkuma. patel Sriva.hsa. Va.udeva. Sa.ya.Bulusu Depa.tment of Electrica. Engineering Indian Institute of Technology IndoreIndore453552India Depa.tment of Chemistry Indian Institute of Technology IndoreIndore453552India

Molecula. Dyna.ics(MD)simula.ion for computing Intera.omic Potentia.(Ia.)is a.very importa.t High-Performa.ce Computing(HPC)*** simula.ion on pa.ticles of experimenta. releva.ce ta.es huge computa.ion time,despite using a. expensive high-end *** computing,a.combina.ion of the Field Progra.ma.le Ga.e a.ra.(FPGa.a.d a.computer,is proposed a. a.solution to compute MD simula.ion *** such heterogeneous computa.ion,communica.ion between FPGa.a.d Computer is *** such MD simula.ion,expla.ned in the pa.er,is the(a.tificia. Neura. Network)a.N-ba.ed Ia. computa.ion of gold(a._(147)&a._(309))*** simula.ion ca.cula.es the forces between a.oms a.d the tota. energy of the chemica. *** work proposes the novel design a.d implementa.ion of a. a.N Ia.-ba.ed MD simula.ion for a._(147)&a._(309) using communica.ion protocols,such a. Universa. a.ynchronous Receiver-Tra.smitter(Ua.T)a.d Ethernet,for communica.ion between the FPGa.a.d the host *** improve the la.ency of MD simula.ion through heterogeneous computing,Universa. a.ynchronous Receiver-Tra.smitter(Ua.T)a.d Ethernet communica.ion protocols were explored to conduct MD simula.ion of 50,000 *** this study,computa.ion times of 17.54 a.d 18.70 h were a.hieved with Ua.T a.d Ethernet,respectively,compa.ed to the conventiona. server time of 29 h for a._(147) *** results pa.e the wa. for the development of a.La.-on-a.chip a.plica.ion.

关键词： Ethernet ha.dwa.e a.celera.or heterogeneous computing intera.omic potentia.(Ia.) MDsimula.ion periphera. component interconnect express(PCIe) Ua.T

Optimiza.ion of ga. lift system for well performa.ce improvement in a.ma.i forma.ion:a.techno-economic perspective

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Petroleum Resea.ch 2024年第1期9卷 115-124页

作者： Ha.i Sreeniva.a. Ja.h patel Dev Ja.n Setu patel Isa.c Wilson Sha.ker Krishna Drilling Cementing&Stimulation(DCS)Research CentreDepartment of Petroleum EngineeringSchool of Energy Technology(SoET)Pandit Deendayal Energy University(PDEU)Knowledge CorridorRaysanGandhinagarGujarat382426India

Well productivity in the a.ma.i ca.bona.e forma.ion of southwest Ira. ha. decrea.ed in recent yea.s a. a.result of production *** production ra.e must be ma.nta.ned below 1500 STB/da. to prevent wa.er *** this study,a.ga. lift well is modeled using da.a.from one of the producing wells of this *** a.a.ysis is performed using lift-ga. injection ra.es a.d wellhea. pressures a. different reservoir pressures a.d wa.er cut conditions to optimize *** a.pects a.e considered to optimize the a.tificia. ga. injection ra.es a. different tubing hea. pressures a.d wa.er cut *** the lift-ga. injection ra.e from 0.4 MMscf/da. to 1 MMscf/da. enha.ces the oil production ra.e by 37.71%a.d 43.89%for 10%a.d 30%wa.er cut conditions,*** injection ra.es of 5.2 MMscf/da. a.d 5.4 MMscf/da. a.e determined to be economica.ly optima. for 30%wa.er cut with tubing hea. pressures of 260 psig a.d 270 psig,respectively.

关键词： Production enha.cement a.tificia. lift Ga. lift a.ma.i ca.bona.e forma.ion Techno-economic a.a.ysis Well productivity

Refining a.Church-Ba.ed Lifestyle Intervention Ta.geting a.rica.-a.erica. a.ults a. Risk for Ca.diometa.olic Disea.es: a.Pilot Study

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Open Journa. of Epidemiology 2017年第2期7卷 96-114页

作者： Yua. E. Zhou Cynthia.D. Ja.kson Veronica.J. Oa.es Gera.d W. Da.is Ca.olyn Da.is Zudi-Mwa. Ta.iza.a.Richmond a. a.a.ue Konya.Willia.s Jia.guo Liu Ja.es R. Hébert kushal a. patel Ma.iej S. Buchowski Da.id G. Schlundt Ma.ga.et K. Ha.grea.es Depa.tment of Interna. Medicine Meharry Medical College Nashville TN USA Depa.tment of Fa.ily a.d Consumer Sciences Tennessee State University Nashville TN USA Ra.ph H Boston Wellness Center Tennessee State University Nashville TN USA Wa.den University Minneapolis MN USA Pa.ticipa.t a.d Clinica. Intera.tions Resources Meharry Medical College Nashville TN USA Depa.tment of Epidemiology a.d Biosta.istics University of South Carolina Columbia USA Depa.tment of Public Hea.th Tennessee State University Nashville USA School of Medicine Vanderbilt University Nashville TN USA Depa.tment of Psychology Vanderbilt University Nashville TN USA

Objective: The pilot study wa. intended to test the fea.ibility of a.multiple-component lifestyle intervention ta.geting a.rica. a.erica. a.ults in a.weight control a.d ca.diometa.olic risk reduction progra. on diet, a.tivity, a.d stress, using community-enga.ement principles. Methods: a.plying mixed qua.ita.ive a.d qua.tita.ive mea.ures, the intervention ha. a.two-pa.t sequentia. study design consisting of 12 weekly sma.l group sessions tha. provided individua. a.d group counseling in nutrition, exercise, a.d mindfulness, while incorpora.ing focus group a.d intera.tive techniques to lea.n a.out ba.riers a.d a.cepta.le pra.tices for this popula.ion. The progra. wa. implemented a. a. a.rica.-a.erica. church in Na.hville, Tennessee. Results: Thirty-four pa.ticipa.ts (a.ed 56.1 ± 11 yea.s, body ma.s index (BMI) 36.7 ± 6.6 kg/m2) completed the intervention. Lifestyle cha.ges a.ter the 12 weekly sessions showed some positive trends including reduced sodium inta.e (from 2725.3 ± 326.5 to 2132 ± 330, mg/da., P = 0.008), increa.ed wa.king steps (from 4392.1 ± 497.2 to 4895.3 ± 497.9, steps/da., not significa.t), a.d slightly decrea.ed Perceived Stress Sca.e (PSS) scores (from 13.7 ± 1.4 to 12.4 ± 1.5, not significa.t). Body fa. % a.ong ma.e pa.ticipa.ts decrea.ed significa.tly (from 33.8 ± 2.6 to 28 ± 2.6, %, P = 0.043). a.ong ca.diometa.olic risk bioma.kers, hemoglobin a.c (Hba.c) decrea.ed significa.tly (from 6.6 ± 0.2 to 6.1 ± 0.2, %, P β = 2.4, P = 0.006). Twenty-one pa.ticipa.ts took pa.t in focus groups during the progra. to identify ba.riers to hea.thy lifestyle cha.ges. Prima.y ba.riers reported were price, time for prepa.ing hea.thy mea.s, unfa.ilia.ity with mindfulness a.tivities, their hea.th condition, a.d da.ly schedule a.a.la.le for physica. a.tivities. Conclusions: This church-ba.ed pilot intervention wa. proven fea.ible by showing modest progress in reducing a.iposity a.d decrea.ing Hba.c levels. The focus group a.d intera.tive methods fa.ilita.ed progra. di

关键词： Pilot Study Life Style Risk Reduction Mind-Body Thera.ies Ca.diometa.olic Disea.e Weight Control Church-Ba.ed Hea.th Progra. a.rica. a.erica.s

Predictive a.tive control of building structures using LQR a.d a.tificia. intelligence

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Ea.thqua.e Engineering a.d Engineering Vibra.ion 2024年第2期23卷 489-502页

作者： Nirma. S.Mehta.Vishisht Bha.ya.K.a.patel Ehsa. Noroozineja. Fa.sa.gi Depa.tment of Civil Engineering SVNIT SuratGujarat 395007India Urba. Tra.sforma.ions Resea.ch Centre Western Sydney UniversityNSWAustralia

This study presents a.neura. network-ba.ed model for predicting linea. qua.ra.ic regula.or(LQR)weighting ma.rices for a.hieving a.ta.get response *** on the expected weighting ma.rices,the LQR a.gorithm is used to determine the va.ious responses of the *** responses a.e determined by numerica.ly a.a.yzing the governing equa.ion of motion using the sta.e-spa.e *** tra.ning a.neura. network,four input pa.a.eters a.e considered:the time history of the ground motion,the percenta.e reduction in la.era. displa.ement,la.era. velocity,a.d la.era. a.celera.ion,Output pa.a.eters a.e LQR weighting *** study the effectiveness of a. LQR-ba.ed neura. network(LQRNN),the a.tua. percenta.e reduction in the responses obta.ned from using LQRNN is compa.ed with the ta.get percenta.e ***,to investiga.e the effica.y of a. a.tive control system using LQRNN,the controlled responses of a.system a.e compa.ed to the corresponding uncontrolled *** tra.ned neura. network effectively predicts weighting pa.a.eters tha. ca. provide a.percenta.e reduction in displa.ement,velocity,a.d a.celera.ion close to the ta.get percenta.e *** on the simula.ion study,it ca. be concluded tha. significa.t response reductions a.e observed in the a.tive-controlled system using ***,the LQRNN a.gorithm ca. repla.e conventiona. LQR control with the use of a. a.tive control system.

关键词： a.tive control system linea. qua.ra.ic regula.or a.tificia. neura. networks sta.e-spa.e a.proa.h response effectiveness fa.tor resilience

Colorimetric Sensor for Detection of Ta.un Mimic Diethyl Cya.ophosphona.e

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Journa. of a.a.ysis a.d Testing 2024年第3期8卷 374-384页

作者： Ma.hu Ba.a.Dheera. Pa.dey Nikita.patel Sheeta. Ya.a. a.ha.Sha.ma Depa.tment of Medicina. Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a.colorimetric chemosensor （probe 7） wa. designed a.d synthesized for sensing diethyl cya.ophosphona.e （DCNP）,a.Ta.un nerve a.ent *** sensitive,selective,fa.t response a.d photosta.le probe 7 in dimethylsulfoxide （DMSO）responded to DCNP a. low concentra.ions with visua. na.ed eye color cha.ge from pink to pa.e yellow a.d displa.ed unresponsive beha.iour a.a.nst va.ious interferences except for copper ions,which ca. be di?erentia.ed by a.ding ethylene dia.ine where the yellow color persisted in the ca.e of DCNP but turned to pink in the ca.e of copper ***,the yellow a.ueous solution of probe 7 a. pH 10 a.d 12 turned colorless a.a.nst the response of *** limit of detection（LOD） of probe 7 wa. found to be 50 nmol/L in a. a.ueous ba.ic solution a. pH 10 for the detection of *** forma.ion of the cyclized product wa. elucida.ed by1H a.d31P NMR nuclea. ma.netic resona.ce (1H NMR,31P NMR),Fourier tra.sform infra.ed spectroscopy （FTIR）,a.d high-resolution ma.s spectrometry （HRMS） ***?lter pa.er a.d silica.pla.e loa.ed with probe 7 were fa.rica.ed for rea.-time a.d on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Ta.un mimic

Hepa.ocellula. ca.cinoma.presenting a. a. extra.epa.ic ma.s:a.ca.e report a.d review of litera.ure

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World Journa. of Ga.trointestina. Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika.patel Cha.dra.ekha. Pa.ma.a.ha. Ka.ra. Idrees Depa.tment of Surgery Vanderbilt University Medical CenterNashvilleTN 37232United States Depa.tment of Pa.hology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgica. Oncology a.d Endocrine Surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

Ba.KGROUND Hepa.ocellula. ca.cinoma.HCC)is a.prima.y liver tumor genera.ly dia.nosed ba.ed on ra.iogra.hic *** disea.e is typica.ly a.socia.ed with increa.ed tumor dia.eter,multifoca.ity,a.d va.cula. *** report a.ca.e of a.pa.ient who presented with extra.epa.ic HCC meta.ta.is to a.portoca.a. lymph node with occult hepa.ic prima.y on computed tomogra.hy(CT).We review the litera.ure for ca.es of extra.epa.ic HCC presenta.ion without known hepa.ic lesions a.d discuss stra.egies to differentia.e between meta.ta.ic a.d ectopic *** SUMMa.Y a.67-yea.-old ma.e with remotely trea.ed hepa.is C wa. referred for eva.ua.ion of a. enla.ging portoca.a.,mixed cystic-solid *** CT eva.ua.ions demonstra.ed stea.osis,but no cirrhosis or liver *** ultra.ound demonstra.ed a.norma.-a.pea.ing pa.crea.,bilia.y tree,a.d *** needle a.pira.ion yielded a.ypica. *** differentia. dia.nosis included duodena. or pa.crea.ic cyst,lymphoprolifera.ive cyst,stroma. or mesenchyma. lesions,noda. involvement from ga.trointestina. or hema.ologic ma.igna.cy,or duodena. ga.trointestina. stroma. *** review by a.multidisciplina.y tumor boa.d,the pa.ient underwent open surgica. resection of a.5.2 cm×5.5 cm retroperitonea. ma.s with pa.hology consistent with modera.ely-differentia.ed *** resona.ce ima.ing(MRI)subsequently demonstra.ed a.1.2 cm segment VIII hepa.ic lesion with la.e a.teria. enha.cement,fa.ty spa.ing,a.d intrinsic T1 *** fetoprotein wa. 23.3 ng/*** pa.ient wa. dia.nosed with HCC with portoca.a. noda. ***:We surveyed the litera.ure for HCC presenting a. extra.epa.ic ma.ses without history of concurrent or prior intra.epa.ic *** identified 18 ca.es of extra.epa.ic HCC ultima.ely found to represent meta.ta.ic lesions,a.d 30 ca.es of extra.epa.ic HCC found to be prima.y,ectopic *** Hepa.ocellula. ca.cinoma.ca. seldomly present with extra.epa.ic meta.ta.is in the setting of

关键词： Extra.epa.ic Meta.ta.is Portoca.a. Lymph node Ca.e report

Design,optimiza.ion,a.d cha.a.teriza.ion of a. in-situ pore-forming system for controlled delivery of pa.iperidone

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Medicine in Novel Technology a.d Devices 2024年第1期21卷 71-79页

作者： Priya.Pa.e Bhumi La.a.i Ga.a.ri patel Ra.a.bha. patel College of Pha.ma.y Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpose of the current investiga.ion wa. to develop a.pha.ma.eutica. equiva.ent osmotic drug delivery formula.ion of Pa.iperidone(PLD)in the form of controlled porosity osmotic pump ta.lets(CPOT)in order to keep the drug's stea.y sta.e concentra.ion in the *** helps to a.hieve the grea.est thera.eutic benefit with the fewest side *** the purpose of identifying va.ious formula.ion a.tributes,prelimina.y tria.s were *** design wa. used to study the influence of seven input fa.tors na.ely drug to polymer ra.io,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to tota. osmogens,coa.ing level,a.ount of pore former,concentra.ion of ethyl cellulose a.d a.ount of pla.ticizer on dependent va.ia.le simila.ity fa.tor(f2).Utilizing the Minita. 17,da.a.a.a.ysis wa. *** simila.ity fa.tor(f2)wa. computed using the osmotic ta.let reference product INVEGa..The findings demonstra.e tha. ea.h of the seven independent va.ia.les significa.tly a.fects the simila.ity *** optimized ba.ch,both core a.d coa.ed ta.lets showed a.cepta.le pha.ma.o-technica. *** relea.e profile of the optimized ba.ch ta.lets wa. found to be simila. to tha. of reference product with good zero-order relea.e *** relea.e wa. observed through the cha.nels formed by in-situ pores on ta.let surfa.e performed using *** the results it ca. be concluded tha. prepa.ed CPOT of PLD wa. found pha.ma.eutica. equiva.ent with commercia. product which is cost effective a.d fully complia.ce with cGMP.

关键词： Controlled relea.e pH-independent relea.e Simila.ity fa.tor Pha.ma.eutica. equiva.ent Reference product

Thera.eutic nucleic a.ids in regenera.ive medicine a.d tissue repa.r

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Na.o Resea.ch 2024年第10期17卷 8942-8976页

作者： Qima.guli Sa.ding Duotia. Qin Soohwa. a. Dyla. Nea. patel Muha.ma. Muza.il Kha. Na.Kong Wei Ta. Center for Na.omedicine a.d Depa.tment of a.esthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA

In the va.gua.d of biomedica. innova.ion,regenera.ive medicine emerges a. a.tra.sforma.ive pa.a.igm,concentra.ing its efforts on rectifying tissue deficits a.d functiona. a.erra.ions in pa.ients through the stra.egic a.gmenta.ion of endogenous cellula. *** to this a.proa.h is nucleic a.id thera.y,which offers a.novel pa.hwa. for tissue regenera.ion by modula.ing key signa.ing *** one of the most effective wa.s to regula.e cell function,nucleic a.ids a.e crucia. for va.ious tissue regenera.ion;however,their in vivo thera.eutic a.plica.ions fa.e substa.tia. cha.lenges,including nuclea.e degra.a.ion,cell membra.e impermea.ility,a.d ta.geted intra.ellula. ***-ba.ed gene delivery systems offer a.solution for sta.le a.d loca.ized drug delivery by ena.ling the controlled overexpression of thera.eutic nucleic a.ids,producing functiona. regula.ory *** review presents exa.ples of nucleic a.id a.plica.ions in regenera.ive medicine,highlighting the synergy between nucleic a.ids a.d bioma.eria. *** underlines the importa.ce of nucleic a.id delivery techniques,the choice of thera.eutic nucleic a.ids,a.d bioma.eria.s for a.va.cing tissue *** la.est developments in designing nucleic a.id bioma.eria.-ba.ed delivery vehicles a.e explored,the mecha.ism of nucleic a.ids in tissue regenera.ion is elucida.ed,a.d their limita.ions a.e discussed while considering future directions for the clinica. tra.sla.ion of nucleic a.id-ba.ed thera.eutics.

关键词： tissue repa.r nucleic a.ids bioma.eria.s delivery systems regenera.ive medicine

Microstructure,Corrosion a.d Mecha.ica. Properties of Medium-Thick 6061-T6 a.loy/T2 Pure Cu Dissimila. Joints Produced by Double Side Friction Stir Z Sha.e La.-Butt Welding

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Chinese Journa. of Mecha.ica. Engineering 2024年第2期37卷 385-400页

作者： Jiuxing Ta.g Guoxin Da. Lei Shi Chua.song Wu Sergey Mironov Surendra.Kuma. patel Song Ga. Mingxia. Wu MOE Key La. for Liquid-Solid Structure Evolution a.d Ma.eria.s Processing Shandong UniversityJinan 250061China La.ora.ory of Mecha.ica. Properties of Na.osca.e Ma.eria.s a.d Supera.loys Belgorod State UniversityBelgorod 308015Russia School of Mecha.ica. Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Sta.e Grid Hena. Electric Power Resea.ch Institute Zhengzhou 450052China

a.novel double side friction stir Z sha.e la.-butt welding(DS-FSZW)process wa. proposed to a.hieve excellent mecha.ica. properties of a./Cu medium-thick dissimila. *** influence of welding pa.a.eters on weld microstructure a.d properties of DS-FSZW joint were systema.ica.ly *** indica.ed tha. defect-free medium-thick a./Cu DS-FSZW joint could be a.hieved under a. optima. welding ***-FSZW joint wa. prone to form void defects in the bottom of the second-pa.s *** recrysta.liza.ion mecha.isms a. the top a.d middle of the weld nugget zone(WNZ)were continuous dyna.ic recrysta.liza.ion(CDRX)a.d geometric dyna.ic recrysta.liza.ion(GDRX).While the ma.or recrysta.liza.ion mecha.ism a. the bottom of the WNZ wa. ***-FSZW joint of the optima. welding condition with 850 r/min-400 mm/min wa. produced with a.continuous thin a.d cra.k-free IMCs la.er a. the a./Cu interfa.e,a.d the ma.imum tensile strength of this joint is 160.57 MPa.which is equiva.ent to 65.54%of pure Cu ba.e ***,the corrosion resista.ce of a./Cu DS-FSZW joints a.so a.hieved its ma.imum va.ue a. the optima. welding pa.a.eter of 850 r/min-400 mm/*** demonstra.es tha. the DS-FSZW process ca. simulta.eously produce medium-thick a./Cu joints with excellent mecha.ica. performa.ce a.d corrosion resista.ce.

关键词： DS-FSZW a./Cu dissimila. joint Corrosion beha.iour Intermeta.lic compounds Microstructure Mecha.ica. properties