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Ablation strategies for arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis

Journal of Geriatric Cardiology 2020年第11期17卷 694-703页

作者： Li-Shui SHEN Li-Min LIU Li-Hui ZHENG Feng HU Zhi-Cheng HU Shang-Yu LIU Jin-Rui GUO kush kumar bhagat Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Arrhythmia Center Yunnan Fuwai Cardiovascular HospitalKunmingChina Eternal hospital JaipurRajasthanIndia

Background Catheter ablation for ventricular tachycardia(VT) in patients with arrhythmogenic right ventricular cardiomyopathy(ARVC) has significantly evolved over the past decade. However, different ablation strategies showed inconsistency in acute and long-term outcomes. Methods We searched the databases of Medline, Embase and Cochrane Library through October 17, 2019 for studies describing the clinical outcomes of VT ablation in ARVC. Data including VT recurrence, all-cause mortality, acute procedural efficacy and major procedural complications were extracted. A meta-analysis with trial sequential analysis was further performed in comparative studies of endo-epicardial versus endocardial-only ablation. Results A total of 24 studies with 717 participants were enrolled. The literatures of epicardial ablation were mainly published after 2010 with total ICD implantation of 73.7%, acute efficacy of 89.8%, major complication of 5.2%, follow-up of 28.9 months, VT freedom of 75.3%, all-cause mortality of 1.1% and heart transplantation of 0.6%. Meta-analysis of 10 comparative studies revealed that compared with endocardial-only approach, epicardial ablation significantly decreased VT recurrence(OR: 0.50;95% CI: 0.30–0.85;P = 0.010), but somehow increased major procedural complications(OR: 4.64;95% CI: 1.28–16.92;P = 0.02), with not evident improvement of acute efficacy(OR: 2.74;95% CI: 0.98–7.65;P = 0.051) or all-cause mortality(OR: 0.87;95% CI: 0.09–8.31;P = 0.90). Conclusion Catheter ablation for VT in ARVC is feasible and effective. Epicardial ablation is associated with better long-term VT freedom, but with more major complications and unremarkable survival or acute efficacy benefit.

关键词： Arrhythmogenic right ventricular cardiomyopathy Catheter ablation Ventricular tachycardia

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Sentiment Analysis on Social Media Using Genetic Algorithm with CNN

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Computers, Materials & Continua 2022年第3期70卷 5399-5419页

作者： Dharmendra Dangi Amit bhagat Dheeraj kumar Dixit Department of Mathematics and Computer Applications Maulana Azad National Institute of Technology(MANIT)BhopalMadhya PradeshIndia

There are various intense forces causing customers to use evaluated data when using social media platforms and microblogging ***,customers throughout the world share their points of view on all kinds of topics through these *** massive volume of data created by these customers makes it impossible to analyze such data ***,an efficient and intelligent method for evaluating social media data and their divergence needs to be ***,various types of equipment and techniques are available for automatically estimating the classification of *** analysis involves determining people’s emotions using facial *** analysis can be performed for any individual based on specific *** present study describes the analysis of an image dataset using CNNswithPCA intended to detect people’s sentiments(specifically,whether a person is happy or sad).This process is optimized using a genetic algorithm to get better ***,a comparative analysis has been conducted between the different models generated by changing the mutation factor,performing batch normalization,and applying feature reduction using *** steps are carried out across five experiments using *** maximum accuracy obtained is 96.984%,which is associated with the Happy and Sad sentiments.

关键词： Sentiment analysis convolutional neural networks facial expression genetic algorithm

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Fake News Classification Using a Fuzzy Convolutional Recurrent Neural Network

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Computers, Materials & Continua 2022年第6期71卷 5733-5750页

作者： Dheeraj kumar Dixit Amit bhagat Dharmendra Dangi Department of Mathematics and Computer Applications Maulana Azad National Institute of Technology(MANIT)BhopalMadhya PradeshIndia

In recent years,social media platforms have gained immense *** a result,there has been a tremendous increase in content on social media *** content can be related to an individual’s sentiments,thoughts,stories,advertisements,and news,among many other content *** the recent increase in online content,the importance of identifying fake and real news has ***,there is a lot of work present to detect fake news,a study on Fuzzy CRNN was not explored into this *** this work,a system is designed to classify fake and real news using fuzzy *** initial feature extraction process is done using a convolutional recurrent neural network(CRNN).After the extraction of features,word indexing is done with high ***,based on the indexing measures,the ranking process identifies whether news is fake or *** fuzzy CRNN model is trained to yield outstanding resultswith 99.99±0.01%*** work utilizes three different datasets(LIAR,LIAR-PLUS,and ISOT)to find the most accurate model.

关键词： Fake news detection text classification convolution recurrent neural network fuzzy convolutional recurrent neural networks

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Angiotensin-converting enzyme 2 as a potential therapeutic target for COVID-19:A review

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Journal of Pharmaceutical Analysis 2022年第2期12卷 215-220页

作者： bhagat Singh Dheer Singh Vinod Verma Ramakant Yadav Raj kumar Department of Medical Laboratory Technology Faculty of Paramedical SciencesUttar Pradesh University of Medical SciencesEtawah206130India Department of Anaesthesiology and Critical Care Uttar Pradesh University of Medical SciencesEtawah206130India Stem Cell Research Centre Department of HematologySanjay Gandhi Post Graduate Institute of Medical SciencesLucknow226014India Department of Neurology Uttar Pradesh University of Medical SciencesEtawah206130India Department of Neurosurgery Uttar Pradesh University of Medical SciencesEtawah206130India

As of August 16,2021,there have been 207,173,086 confirmed cases and 4,361,996 deaths due to the coronavirus disease(COVID-19),and the pandemic remains a global *** date,no effective and approved drugs are available for the treatment of ***-converting enzyme 2(ACE2)plays a crucial role in the invasion into host cells by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of ***,ACE2 density is influenced by medical conditions,such as hypertension,or by drugs,including angiotensin-converting enzyme inhibitors(ACEIs)and angiotensin receptor blockers(ARBs),which can change the fate of SARS-CoV-2 ***2 is a target for these drugs and can be manipulated to limit the viral entry and replication within the *** strategies aimed at blocking ACE2 with small molecules,peptides,and antibodies,or by neutralizing the virus through its competitive binding with human recombinant soluble ACE2(hrsACE2)are currently under *** this article,we review the current state of knowledge that emphasizes the need to find effective therapeutic agents against COVID-19 by exploiting ACE2 as a potential *** increased soluble ACE2 levels and the application of hrsACE2 in patients with COVID-19 can be implemented to control the *** has not yet been established whether hypertension and other comorbidities,independent of age,have a direct role in ***,the use of renin-angiotensin system inhibitors,ACEIs and ARBs,should not be discontinued during COVID-19 treatment.

关键词： COVID-19 ACE2 receptors hrsACE2 ACE inhibitors RAS AT1R blocker

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A novel,green 1-glycyl-3-methyl imidazolium chloride-copper(Ⅱ) complex catalyzed C-H oxidation of alkyl benzene and cyclohexane

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Chinese Chemical Letters 2012年第6期23卷 681-684页

作者： Parasuraman Karthikeyan Pundlik Rambhau bhagat S.Senthil kumar Organic Chemistry Division School of Advanced SciencesVIT UniversityVellore 632 014India

A variety of alkyl-arenes and cyclohexane were converted to the corresponding ketones with NaC10 as the oxidant in the presence of 1-glycyl-3-methyl imidazolium chloride--copper（II） complex. This method contains simplified product isolation and catalyst recycling, affording benzylic C-H oxidation of alkyl-arenes imparting high yield of ketones. Furthermore, complex could be reused seven times without a significant loss of its catalytic activity.

关键词： Copper Alkane Ionic liquid Room temperature

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Hybrid Whale Optimization Algorithm for Resource Optimization in Cloud E-Healthcare Applications

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Computers, Materials & Continua 2022年第6期71卷 5659-5676页

作者： Punit Gupta Sanjit bhagat Dinesh kumar Saini Ashish kumar Mohammad Alahmadi Prakash Chandra Sharma School of Computing&Information Technology Manipal University JaipurJaipur303007India School of Basic Sciences Manipal University JaipurJaipur303007India Department of Software Engineering College of Computer Science and EngineeringUniversity of JeddahJeddah23218Saudi Arabia

In the next generation of computing environment e-health care services depend on cloud *** Cloud computing environment provides a real-time computing environment for e-health care *** these services generate a huge number of computational tasks,real-time computing and comes with a deadline,so conventional cloud optimizationmodels cannot fulfil the task in the least time and within the *** overcome this issue many resource optimization meta-heuristic models are been proposed but these models cannot find a global best solution to complete the task in the least time and manage utilization with the least simulation *** order to overcome existing issues,an artificial neural-inspired whale optimization is proposed to provide a reliable solution for healthcare *** this work,two models are proposed one for reliability estimation and the other is based on whale optimization technique and neural network-based binary *** predictive model enhances the quality of service using performance metrics,makespan,least average task completion time,resource usages cost and utilization of the *** as compared to existing algorithms the proposedANN-WHOalgorithms prove to improve the average start time by 29.3%,average finish time by 29.5%and utilization by 11%.

关键词： Cloud computing whale optimization health care resource optimization

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Seismic response evaluation of base-isolated reinforced concrete buildings under bidirectional excitation

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Earthquake Engineering and Engineering Vibration 2017年第2期16卷 365-382页

作者： Satish bhagat Anil C Wijeyewickrema Department of Civil and Environmental Engineering Tokyo Institute of Technology Tokyo 152-8552 Japan

This paper reports on an investigation of the seismic response of base-isolated reinforced concrete buildings, which considers various isolation system parameters under bidirectional near-fault and far-fault motions. Three-dimensional models of 4-, 8-, and 12-story base-isolated buildings with nonlinear effects in the isolation system and the superstructure are investigated, and nonlinear response history analysis is carried out. The bounding values of isolation system properties that incorporate the aging effect of isolators are also taken into account, as is the current state of practice in the design and analysis of base-isolated buildings. The response indicators of the buildings are studied for near-fault and far-fault motions weight-scaled to represent the design earthquake （DE） level and the risk-targeted maximum considered earthquake （MCER） level. Results of the nonlinear response history analyses indicate no structural damage under DE-level motions for near-fault and far-fault motions and for MCER-level far-fault motions, whereas minor structural damage is observed under MCER- level near-fault motions. Results of the base-isolated buildings are compared with their fixed-base counterparts. Significant reduction of the superstructure response of the 12-story base-isolated building compared to the fixed-base condition indicates that base isolation can be effectively used in taller buildings to enhance performance. Additionally, the applicability of a rigid superstructure to predict the isolator displacement demand is also investigated. It is found that the isolator displacements can be estimated accurately using a rigid body model for the superstructure for the buildings considered.

关键词： Keywords: base isolation bidirectional excitation bounding analysis far-fault ground motion near-fault groundmotion nonlinear analysis

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N-policy for M^(x)/G/1 Unreliable Retrial G-Queue with Preemptive Resume and Multi-services

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Journal of the Operations Research Society of China 2016年第4期4卷 437-459页

作者： Amita bhagat Madhu Jain Department of Applied Sciences The Northcap UniversityGurgaon 122017India Department of Mathematics Indian Institute of Technology RoorkeeRoorkee 247667India

Bulk arrival retrial G-queue with impatient customers and multi-servicessubject to server breakdowns has been analyzed. The system allows the arrival oftwo types of customers: positive customers and negative customers in the *** negative customers make the server fail if they find the server in busy state,whereas positive customers are served if the server is idle otherwise they join thevirtual pool of customers called orbit. The customers from the retrial orbit try theirchance again for the service. The customers have the option of obtaining more than oneservice. Moreover, the customers are impatient and may renege from the system withprobability (1−r ). The server is sent for repair as soon as it breakdowns;after repair,the service process starts again. Also, the server has the provision to initiate the servicewhen there areN customers accumulated in the system. Using supplementary variablestechnique and generating functions, various performance measures like reliabilityindices and long run probabilities have been obtained.

关键词： Retrial queue N-policy vacation Negative customers Reneging Bulk arrival Breakdowns Preemptive resume Multi-services

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Contraceptive effect of Curcuma longa (L.) in male albino rat

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Asian Journal of Andrology 2004年第1期6卷 71-74页

作者： Purohit Ashok bhagat Meenakshi Reproductive Physiology Section Department of Zoology JNV University Jodhpur (Raj.) 342005 IndiaReproductive Physiology Section Department of Zoology JNV University Jodhpur (Raj.) 342005 India

Aim: To study the contraceptive effect of the crude extracts of Curcuma longa in male albino rats. Methods: Rats were fed orally with Curcuma longa aqueous and 70 % alcoholic extract for 60 days (500 mg·kg-1· day-1). Results: A reduction in sperm motility and density was observed in both the treated groups. Conclusion: Curcuma longa may have affected the androgen synthesis either by inhibiting the Leydig cell function or the hypo-thalamus pituitary axis and as a result, spermatogenesis is arrested.

关键词： Leydig cells Curcuma longa seminiferous tubules antiandrogens spermatozoa male contraception

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Geometric grid network and third-order compact scheme for solving nonlinear variable coefficients 3D elliptic PDEs

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第6期9卷 72-99页

作者： Navnit Jha Venu Gopal bhagat Singh Department of Mathematics South Asian University ChanakyapuriNew Delhi 110070India The School of Mathematical Sciences University of Science and Technology of China Hefei Anhui 230026P.R.China

By using nonuniform(geometric)grid network,a new high-order finite-difference compact scheme has been obtained for the numerical solution of three-space dimensions partial differential equations of elliptic *** cell discretization to the elliptic equation makes it easier to compute and exhibit stability of the numerical *** monotone and irreducible property of the Jacobian matrix to the system of difference equations analyses the converging behavior of the numerical solution *** an experiment,applications of the compact scheme to Schr¨odinger equations,sine-Gordon equations,elliptic Allen–Cahn equation and Poisson’s equation have been presented with root mean squared errors of exact and approximate solution *** results corroborate the reliability and efficiency of the scheme.

关键词： Finite-difference method nonuniform grid compact operator monotone matrix sine-Gordon equation elliptic Allen-Cahn equation.

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