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Uncertainty Reduction Through Data Management in the Development, Validation, Calibration, and Operation of a Hurricane Vulnerability Model

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International Journal of Disaster Risk Science 2020年第6期11卷 790-806页

作者： Jean-Paul Pinelli Josemar Da Cruz kurtis gurley Andres Santiago Paleo-Torres Mohammad Baradaranshoraka Steven Cocke Dongwook Shin College of Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Civil and Coastal Engineering University of FloridaGainesvilleFL 32611USA Center for Ocean-Atmospheric Prediction Studies(COAPS) Florida State UniversityTallahasseeFL 32306USA

Catastrophe models estimate risk at the intersection of hazard,exposure,and *** of these areas requires diverse sources of data,which are very often incomplete,inconsistent,or missing *** poor quality of the data is a source of epistemic uncertainty,which affects the vulnerability models as well as the output of the catastrophe *** article identifies the different sources of epistemic uncertainty in the data,and elaborates on strategies to reduce this uncertainty,in particular through identification,augmentation,and integration of the different types of *** challenges are illustrated through the Florida Public Hurricane Loss Model(FPHLM),which estimates insured losses on residential buildings caused by hurricane events in *** define the input exposure,and for model development,calibration,and validation purposes,the FPHLM teams accessed three main sources of data:county tax appraiser databases,National Flood Insurance Protection(NFIP)portfolios,and wind insurance *** data from these different sources were reformatted and processed,and the insurance databases were separately cross-referenced at the county level with tax appraiser *** FPHLM hazard teams assigned estimates of natural hazard intensity measure to each insurance *** efforts produced an integrated and more complete set of building descriptors for each policy in the NFIP and wind *** article describes the impact of these uncertainty reductions on the development and validation of the vulnerability models,and suggests avenues for data *** learned should be of interest to professionals involved in disaster risk assessment and management.

关键词： Catastrophe modeling Data augmentation and integration Florida Public Hurricane Loss Model(FPHLM) Uncertainty reduction Vulnerability model

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Identification and characterization of GIP1, an Arabidopsis thaliana protein that enhances the DNA binding affinity and reduces the oligomeric state of G-box binding factors

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Cell Research 2005年第8期15卷 567-575页

作者： Paul C. SEHNKE,Beth J. LAUGHNER,Carla R. LYERLY LINEBARGER,William B. gurley,Robert J. FERL Program in Plant Cellular and Molecular Biology Department of Horticultural Sciences University of Florida Gainesville FL USA 32611 Program in Plant Cellular and Molecular Biology Department of Horticultural Sciences University of Florida Gainesville FL USA 32611 Program in Plant Cellular and Molecular Biology Department of Horticultural Sciences University of Florida Gainesville FL USA 32611 Department of Microbiology and Cell Science University of Florida Gainesville FL USA 32611 Program in Plant Cellular and Molecular Biology Department of Horticultural Sciences University of Florida Gainesville FL USA 32611

Environmental control of the alcohol dehydrogenase (Adh) and other stress response genes in plants is in part brought about by transcriptional regulation involving the G-box cis-acting DNA element and bZIP G-box Binding Factors (GBFs). The mechanisms of GBF regulation and requirements for additional factors in this control process are not well understood. In an effort to identify potential GBF binding and control partners, maize GBF1 was used as bait in a yeast two-hybrid screen of an A. thaliana cDNA library. GBF Interacting Protein 1 (GIP1) arose from the screen as a 496 amino acid protein with a predicted molecular weight of 53,748 kDa that strongly interacts with GBFs. Northern analysis of A. thaliana tissue suggests a 1.8-1.9 kb GIP1 transcript, predominantly in roots. Immunolocalization studies indicate that GIP1 protein is mainly localized to the nucleus. In vitro electrophoretic mobility shift assays using an Adh G-box DNA probe and recombinant A. thaliana GBF3 or maize GBF1, showed that the presence of GIP1 resulted in a tenfold increase in GBF DNA binding activity without altering the migration, suggesting a transient association between GIP1 and GBF. Addition of GIP1 to intentionally aggregated GBF converted GBF to lower molecular weight macromolecular complexes and GIP1 also refolded denatured rhodanese in the absence of ATP. These data suggest GIP1 functions to enhance GBF DNA binding activity by acting as a potent nuclear chaperone or crowbar, and potentially regulates the multimeric state of GBFs, thereby contributing to bZIP-mediated gene regulation.

关键词： G-box binding factor interacting protein nuclear chaperone DNA binding affinity.

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HIV protease inhibitor,the unfolded protein response,and atherosclerosis

HIV protease inhibitor,the unfolded protein response,and ath...

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第六届海峡两岸心血管科学研讨会

作者： Emily C.gurley Elaine Studer William M．Pandak Phillip B．Hylemon Department of Microbiology ＆ Immunology Department of Microbiology ＆ Immunology Department of Internal Medicine and McGuire Veterans Affairs Medical Center Virginia Commonwealth University RichmondVirginia 23298 Department of Microbiology ＆ Immunology

＜正＞HIV protease inhibitors（PIs）have been associated with the serious Metabolic Syndrome,which is the major risk factor of atherosclerotic cardiovascular ***,the cellular/molecular mechanisms of the HIV pro- tease inhibitor-induced lipid dysregulation and atherosclerosis remain *** is widely considered to be a chronic inflammatory *** are the most prominent cell type present in atherosclerotic le-

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金融理论中的货币

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作者： J.G.·格利(J.G. gurley) E.S.·肖(E.S. Shaw)

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水处理对CSP钢厂产品质量和产能的影响

水处理对CSP钢厂产品质量和产能的影响

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第十七届（2013年）全国炼钢学术会议

作者： George gurley Joseph S.Strasser James L.Hatcher 矫云祥谢韦尔钢铁公司哥伦布公司纳尔科公司

结晶器均匀传热对于保证高速薄板坯连铸机的最佳性能至关重要。铜板传热速率的差异导致固化坯壳内出现温度梯度,造成表面缺陷。本文讨论采用紧凑型热带钢生产工艺（CSP）的钢厂在提高产量和产品质量时遇到的传热问题。对该CSP钢厂的产... 详细信息

结晶器均匀传热对于保证高速薄板坯连铸机的最佳性能至关重要。铜板传热速率的差异导致固化坯壳内出现温度梯度,造成表面缺陷。本文讨论采用紧凑型热带钢生产工艺（CSP）的钢厂在提高产量和产品质量时遇到的传热问题。对该CSP钢厂的产品质量问题进行分析后发现,在结晶器的水质参数与产品表面缺陷频率增加之间存在一定联系。在实施了工程学解决方案后,即在采用独特的水处理技术、改进机械设备和实施创新的自动控制后,减少了水侧沉积,改进产品质量并增加产能。

关键词：水侧沉积传热紧凑式热带钢工艺水质水化学

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