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Evolution and future of laparoscopic colorectal surgery

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World Journal of Gastroenterology 2014年第41期20卷 15119-15124页

作者： andreas m.kaiser Department of Colorectal Surgery Keck School of MedicineUniversity of Southern California

The advances of laparoscopic surgery since the early 1990 s have caused one of the largest technical revolutions in medicine since the detection of antibiotics(1922,Flemming),the discovery of DNA structure(1953,Watson and Crick),and solid organ transplantation(1954,murray).Perseverance through a rocky start and increased familiarity with the chop-stick surgery in conjunction with technical refinements has resulted in a rapid expansion of the indications for minimally invasive ***-related factors initially contributed to this success and included the improved postoperative recovery and cosmesis,fewer wound complications,lower risk for incisional hernias and for subsequent adhesionrelated small bowel obstructions; the major breakthrough however came with favorable long-term outcomes data on oncological *** future will have to determine the specific role of various technical approaches,define prognostic factors of success and true progress,and consider directing further innovation while potentially limiting approaches that do not add to patient outcomes.

关键词： Laparoscopic Laparoscopy Open surgery Colorectal surgery Colectomy Robot

Fecal incontinence - Challenges and solutions

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World Journal of Gastroenterology 2017年第1期23卷 11-24页

作者： Nallely Saldana Ruiz andreas m.kaiser Department of Surgery Division of Colorectal SurgeryKeck School of MedicineUniversity of Southern California Department of Surgery Division of Colorectal SurgeryKeck School of MedicineUniversity of Southern California

Fecal incontinence is not a diagnosis but a frequent and debilitating common final pathway symptom resulting from numerous different causes. Incontinence not only impacts the patient’s self-esteem and quality of life but may result in significant secondary morbidity, disability, and cost. Treatment is difficult without any panacea and an individualized approach should be chosen that frequently combines different modalities. Several new technologies have been developed and their specific roles will have to be defined. The scope of this review is outline the evaluation and treatment of patients with fecal incontinence.

关键词： Fecal incontinence Sphincteroplasty Sacral nerve stimulation Endorectal ultrasound New technologies Quality of life

Update on the management of sigmoid diverticulitis

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World Journal of Gastroenterology 2021年第9期27卷 760-781页

作者： mark H Hanna andreas m.kaiser Division of Colorectal Surgery Department of SurgeryCity of Hope National Medical CenterDuarteCA 91010-3000United States

Diverticular disease and diverticulitis are the most common non-cancerous pathology of the *** has traditionally been considered a disease of the elderly and associated with cultural and dietary *** has been a growing evolution in our understanding and the treatment guidelines for this *** provide an updated review of the epidemiology,pathogenesis,classification and highlight changes in the medical and surgical management of *** is increasingly being seen in young patients(may be larger than previously *** similarities and overlap with inflammatory bowel disease and irritable bowel syndrome *** tomography imaging represents the standard to classify the severity of *** to the traditional Hinchey classification might serve to better delineate mild and intermediate forms as well as better classify chronic presentations of ***-operative management is primarily based on antibiotics and supportive measures,but antibiotics may be omitted in mild *** colonoscopy remains advisable after an acute attack,particularly after a complicated *** surgery is needed for the most severe as well as refractory cases,whereas elective resections are individualized and should be considered for chronic,smoldering,or recurrent forms and respective complications(stricture,fistula,etc.)and for patients with factors highly predictive of recurrent *** is no longer a disease of the *** evolving understanding of diverticulitis as a clinical entity has led into a more nuanced approach in both the medical and surgical management of this common ***-surgical management remains the appropriate treatment for greater than 70%of *** individuals with non-relenting,persistent,or recurrent symptoms and those with complicated disease and sequelae,a segmental colectomy remains the most effec

关键词： Diverticulitis Epidemiology Antibiotics Surgical resection Laparoscopic lavage Classification

Pulsed DC magnetron sputtering of transparent conductive oxide layers

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Chinese Optics Letters 2013年第13期11卷 21-25页

作者： Astrid Bingel Kevin Fiichsel Norbert kaiser andreas Tunnerman Institute of Applied Physics Abbe Center of Photonics Friedrich-Schiller-Universitgt Jena Max-Wien-Platz 1 07743 Jena Germany Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Str. 7 07745 3ena Germany

A comprehensive material study of different transparent conductive oxides （TCOs） is presented. The layers are deposited by pulsed direct current （DC） magnetron sputtering in an inline sputtering system. Indium tin oxide （ITO） films are studied in detail. The optimum pressure of 0.33 Pa （15Ar：202） produces a 300- nm thin film with a specific resistivity p of 2.2 × 10-6 Ωm and a visual transmittance of 81%. Alternatively, ZnO：A1 and ZnO：Ga layers with thicknesses of 200 and 250 nm are deposited with a minimum resistivity of 5.5× 10-6 and 6.8× 10-6Ωm, respectively. To compare the optical properties in the ultraviolet （UV） range, the optical spectra are modeled and the band gap is determined.

关键词： 310.0310 Thin films 220.0220 Optical design and fabrication 160.0160 materials

Coulomb-actuated microbeams revisited: experimental and numerical modal decomposition of the saddle-node bifurcation

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microsystems & Nanoengineering 2021年第3期7卷 111-123页

作者： Anton melnikov Hermann A.G.Schenk Jorge m.monsalve Franziska Wall michael Stolz andreas mrosk Sergiu Langa Bert kaiser Fraunhofer Institute for Photonic microsystems IPmS Dresden 01109Germany Arioso Systems GmbH Dresden 01109Germany Brandenburg University of Technology Cottbus-Senftenberg Cottbus 03046Germany

Electrostatic micromechanical actuators have numerous applicati ons in scie nee and *** many applications,they are operated in a narrow frequency range close to resonanee and at a drive voltage of low ***,new applications,such as microelectromechanical systems(mEmS)microspeakers(μSpeakers),have emerged that require operation over a wide frequency and dynamic *** the dynamic performance under such circumstances is still highly ***-of-the-art finite element analysis struggles with pull-in instability and does not deliver the necessary in formation about un stable equilibrium states *** lumped-parameter models amenable to direct physical interpretation are *** inhibits the in dispensable in-depth analysis of the dynamic stability of such *** this paper,we take a major step towards mending the *** combining the finite element method(FEm)with an arc-length solver,we obtain the full bifurcation diagram for electrostatic actuators based on prismatic Euler-Bernoulli beams.A subsequent modal analysis then shows that within very narrow error margins,it is exclusively the lowest Euler-Bernoulli eigenmode that dominates the beam physics over the entire relevant drive voltage *** experiment directly recording the deflection profile of a mEmS microbeam is performed and confirms the numerical findings with astonishing *** enables modeling the system using a single spatial degree of freedom.

关键词： bifurcation modal narrow

Impact of technology on indications and limitations for transanal surgical removal of rectal neoplasms

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World Journal of Surgical Procedures 2015年第1期5卷 1-13页

作者： Bikash Devaraj andreas m.kaiser Department of Colorectal Surgery Keck School of MedicineUniversity of Southern California

Transanal surgery has and continues to be well accepted for local excision of benign rectal disease not amenable to endoscopic resection. more recently, there has been increasing interest in applying transanal surgery to local resection of early malignant disease. In addition, some groups have started utilizing a transanal route in order to accomplish total mesorectal excision(TmE) for more advanced rectal malignancies. We aim to review the role of various transanal and endoscopic techniquesin the local resection of benign and malignant rectal disease based on published trial data. Preliminary data on the use of transanal platforms to accomplish TmE will also be highlighted. For endoscopically unresectable rectal adenomas, transanal surgery remains a widely accepted method with minimal morbidity that avoids the downsides of a major abdomino-pelvic operation. Transanal endoscopic microsurgery and transanal minimally invasive surgery offer improved visualization and magnification, allowing for finer and more precise dissection of more proximal and larger rectal lesions without compromising patient outcome. Some studies have demonstrated efficacy in utilizing transanal platforms in the surgical management of early rectal malignancies in selected patients. There is an overall higher recurrence rate with transanal surgery with the concern that neither chemoradiation nor salvage surgery may compensate for previous approach and correct the inferior outcome. Application of transanal platforms to accomplish transanal TmE in a natural orifice fashion are still in their infancy and currently should be considered experimental. The current data demonstrate that transanal surgery remains an excellent option in the surgical management of benign rectal disease. However, care should be used when selecting patients with malignant disease. The application of transanal platforms continues to evolve. While the new uses of transanal platforms in TmE for more advanced rectal malignancy ar

关键词： Transanal surgery Transanal endoscopic microsurgery Endoscopic mucosal resection Transanal total mesorectal excision Transanal minimally invasive surgery Robotic transanal surgery Local excision rectal neoplasms

Off-label-use of sulfur-hexafluoride in voiding urosonography for diagnosis of vesicoureteral reflux in children:A survey on adverse events

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World Journal of Clinical Pediatrics 2017年第1期6卷 52-59页

作者： Alexander Sauer Clemens Wirth Isabel Platzer Henning Neubauer Simon Veldhoen Alexander Dierks Reinhard kaiser andreas Kunz meinrad Beer Thorsten Bley Section of Pediatric Radiology Department of Diagnostic and Interventional RadiologyUniversity Hospital Wuerzburg Department of Diagnostic and Interventional Radiology University Hospital Wuerzburg Department of Pediatrics Hegau-Bodensee-Hospital Singen Department of Diagnostic and Interventional Radiology University Hospital Ulm

AIm To evaluate the risk profile of sulfur hexafluoride in voiding urosonography(VUS) based on a large cohort of *** Since 2011 sulfur hexafluoride(SH,SonoV ue?,Bracco,Italy) is the only ultrasound contrast available in the European Union and its use in children has not been *** a 4-year-period,531 children with suspected or proven vesicoureteral reflux(f/m = 478/53; mean age 4.9 years; 1 mo-25.2 years) following parental informed consent underwent VUS with administration of 2.6 ± 1.2 mL SH in a two-center study.A standardizedtelephone survey on adverse events was conducted three days *** No acute adverse reactions were *** survey revealed subacute,mostly self-limited adverse events in 4.1%(22/531).The majority of observed adverse events(17/22) was not suspected to be caused by an allergic reaction: Five were related to catheter placement,three to reactivated urinary tract infections,five were associated with perineal disinfection before voiding urosonography or perineal dermatitis and four with a common *** five patients(0.9%) hints to a potential allergic cause were noted: Perineal urticaria was reported in three interviews and isolated,mild fever in *** were minor self-limited adverse events with a subacute onset and no hospital admittance was ***-six point two percent of the parents would prefer future VUS examinations with use of *** No severe adverse events were observed and indications of self-limited minor allergic reactions related to intravesical administration of SH were reported in less than 1%.

关键词： Voiding urosonography Ultrasound contrast agent Vesicoureteral reflux SonoV ue Adverse events Sulfur hexafluoride

Effect of insulin stimulation in vivo on mitochondrial phosphoproteome in human skeletal muscle

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Effect of insulin stimulation in vivo on mitochondrial phosp...