检索结果-南通市图书馆

Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第20期11卷 3040-3045页

作者： kuo-ching yang Yih-Huei Uen Fat-Moon Suk Yu-Chih Liang Ying-Jan Wang Yuan-Soon Ho I-Hsuan Li Shyr-Yi Lin Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei Taiwan Department of Internal Medicine Taipei Medical University Taipei Taiwan China Department of Surgery Chi-Mei Foundational Medical Center Yung-Kane City Tainan Taiwan China Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan China School of Medical Technology Taipei Medical University Taipei Taiwan China Department of Environmental and Occupational Health National Cheng Kung University Medical College TainanTaiwan China Department of Internal Medicine School of Medicine Taipei Medical University Taipei Taiwan China Department of Internal Medicine School of Medicine and Department of Internal Medicine Taipei Medical University Hospital Taipei Medical University Taipei Taiwan China

AIM: To explore both the in vitro and in vivo effects of denbinobin against colon cancer cells and clarify its underlying signal pathways. METHODS: We used COLO 205 cancer cell lines and nude mice xenograft model to study the in vitro and in vivo anti-cancer effects of denbinobin. RESULTS: Denbinobin at concentration of 10-20 μmol/L dose-dependently suppressed COLO 205 cell proliferation by MTT test. Flow cytometry analysis and DNA fragmentation assay revealed that 10-20 μmol/L denbinobin treatment induced COLO 205 cells apoptosis. Western blot analysis showed that caspases 3,8,9 and Bid protein were activated by denbinobin treatment to COLO 205 cells accompanied with cytochrome c and apoptosis-inducing factor (AIF) translocation. Pretreatment of MEK 1 inhibitor (U10126), but not p38 inhibitor (SB203580) and JNK inhibitor (SP600125), reversed denbinobin-induced caspase 8, 9 and Bid activation in COLO 205 cells suggesting that extracellular signal-regulated kinase were involved in the denbinobin-induced apoptosis in COLO 205 cells. Significant regression of tumor up to 68% was further demonstrated in vivo by treating nude mice bearing COLO 205 tumor xenografts with denbinobin 50 mg/kg intraperitoneally. CONCLUSION: Our findings suggest that denbinobin could inhibit colon cancer growth both in vitro and in vivo. Activation of extrinsic and intrinsic apoptotic pathways and AIF were involved in the denbinobin-induced COLO 205 cell apoptosis.

关键词： Denbinobin Colon cancer Nude mice Apoptosis ERK pathway

SG-NeRF:Sparse-Input Generalized Neural Radiance Fields for Novel View Synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2024年第4期39卷 785-797页

作者： kuo Xu Jie Li Zhen-Qiang Li yang-Jie Cao School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou 450002China Intelligent Big Data System(iBDSys)Lab Shanghai Jiao Tong UniversityShanghai 200240China School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou 450001China

Traditional neural radiance fields for rendering novel views require intensive input images and pre-scene optimization,which limits their practical *** propose a generalization method to infer scenes from input images and perform high-quality rendering without pre-scene optimization named SG-NeRF(Sparse-Input Generalized Neural Radiance Fields).Firstly,we construct an improved multi-view stereo structure based on the convolutional attention and multi-level fusion mechanism to obtain the geometric features and appearance features of the scene from the sparse input images,and then these features are aggregated by multi-head attention as the input of the neural radiance *** strategy of utilizing neural radiance fields to decode scene features instead of mapping positions and orientations enables our method to perform cross-scene training as well as inference,thus enabling neural radiance fields to generalize for novel view synthesis on unseen *** tested the generalization ability on DTU dataset,and our PSNR(peak signal-to-noise ratio)improved by 3.14 compared with the baseline method under the same input *** addition,if the scene has dense input views available,the average PSNR can be improved by 1.04 through further refinement training in a short time,and a higher quality rendering effect can be obtained.

关键词： Neural Radiance Fields(NeRF) multi-view stereo(MVS) new view synthesis(NVS)

Combinations of electron and proton donors in transition-metal complex mediated nitrogen reduction reactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2136-2154页

作者： Delong Han Li yang Hao Huang Priyanka Chakraborty Shashikant U.Dighe kuo-Wei Huang KAUST Catalysis Center and Division of Physical Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Agency for Science Technologyand ResearchInstitute of Materials Research and Engineering and Institute of Sustainability for ChemicalsEnergy and EnvironmentSingapore 138634Singapore

Nitrogen fixation is a complex process involving the transfer of six electrons and *** from the conventional Haber-Bosch process,which relies on hydrogen(H_(2))to provide both electrons and protons to reduce nitrogen(N_(2)),homogeneous transition metal complex-catalyzed N_(2)reduction reactions(NRR)employ an array of electron and proton donors or even electron donors combined with *** the synthesis of diverse catalytic progress,the categories of donors have seen rapid ***,existing literature only provides summaries regarding the metal,ligands,and *** the significance of electron and proton donor combinations in nitrogen reduction reactions,no literature has thoroughly reviewed this ***,we hereby compiled a comprehensive list of commonly used reagents in N_(2)reduction and classified them according to their specific donor *** review presents clear and organized information about these combinations,along with a summary of their general performance trend in NRR with related ***,we conclude the discussion by highlighting key points for researchers to consider when selecting catalysts and donor combinations,with the ultimate goal of advancing the field of nitrogen fixation.

关键词： dinitrogen reduction reaction reducing donor combination transition metal complexes homogeneous catalysis

Diffusion and reaction mechanism of limestone and quartz in fluxed iron ore pellet roasting process

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 485-497页

作者： Yufeng Guo Jinlai Zhang Shuai Wang Jianjun Fan Haokun Li Feng Chen kuo Liu Lingzhi yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Technology Center Taiyuan Iron Steel(Group)Co.Ltd.(TISCO)Taiyuan 030003China

The increase to the proportion of fluxed pellets in the blast furnace burden is a useful way to reduce the carbon emissions in the ironmaking *** this study,the interaction between calcium carbonate and iron ore powder and the mineralization mechanism of fluxed iron ore pellet in the roasting process were investigated through diffusion couple *** electron microscopy with energy dispersive spectroscopy was used to study the elements’diffusion and phase transformation during the roasting *** results indicated that limestone decomposed into calcium oxide,and magnetite was oxidized to hematite at the early stage of *** the increase in roasting temperature,the diffusion rate of Fe and Ca was obviously accelerated,while the diffusion rate of Si was relatively *** order of magnitude of interdiffusion coefficient of Fe_(2)O_(3)-CaO diffusion couple was 10^(−10) m^(2)·s^(−1) at a roasting temperature of 1200℃for 9 ***_(2)Fe_(2)O_(5) was the initial product in the Fe_(2)O_(3)-CaO-SiO_(2) diffusion interface,and then Ca_(2)Fe_(2)O_(5) continued to react with Fe_(2)O_(3) to form CaFe_(2)O_(4).With the expansion of the diffusion region,the sillico-ferrite of calcium liquid phase was produced due to the melting of SiO_(2) into CaFe_(2)O_(4),which can strengthen the consolidation of fluxed ***,andradite would be formed around a small part of quartz particles,which is also conducive to the consolidation of fluxed *** addition,the principle diagram of limestone and quartz diffusion reaction in the process of fluxed pellet roasting was discussed.

关键词： fluxed iron ore pellet limestone hematite quartz diffusion reaction

One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban Xi-yang Yu Hai-kuo Tian Zheng-Qing Huang Chun-Ran Chang Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e *** is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 *** work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired C_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang ching-Heng Lin Ming-Ju Wu Yi-Hsing Chen kuo-Cheng Chang Chung-Wei Hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of Medical Research Taichung Veterans General HospitalTaichungTaiwan Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research *** with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December *** HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival *** In total,8310 patients with SLE and 16620 patients without SLE were *** general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in *** multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with *** with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,p<0.001).Antiplatelet use increased the risk of haemorrhagic stroke in SLE group(aHR=1.74,95%CI:1.18 to 2.57).Conclusions Patients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 *** should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

Enhancing the Tribological Performance of Conductive Grease Through the Modification of Polypyrrole with Ionic Liquids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 158-172页

作者： Xia Yanqiu Chen Wenhao Jiang Zhirong yang kuo School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

This study prepared four types of ionic liquid-modified polypyrrole(IL-modified PPy)as conductive additives and investigated their tribological performance and conductivity in polytetrafluoroethylene lubricating *** results indicated that IL-modified PPy effectively enhanced the anti-wear performance and conductivity of the base *** the additives,1-octyl-3-methylimidazolium tetrafluoroborate([OMIm][BF4])modified PPy showed superior performance compared to the other three additives,with the best effect observed at a mass fraction of 0.5%.X-ray photoelectron spectroscopy analysis revealed that IL-modified PPy forms a stable friction chemical film during the friction process,effectively enhancing the lubrication performance and conductivity of the base *** indicates broad potential applications in the field of conductive lubrication.

关键词： conductive lubricating grease ILs modified PPy anti-friction and anti-wear additive

PVDF/6H-SiC composite fiber films with enhanced piezoelectric performance by interfacial engineering for diversified applications

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第3期170卷 238-245页

作者： Linlin Zhou Tao yang Chunyu Guo Kang Wang Enhui Wang Laipan Zhu Hailong Wang Sheng Cao kuo-Chih Chou Xinmei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

Piezoelectric silicon carbide(SiC)has been quite attractive due to its superior chemical and physical properties as well as wide potential ***,the inherent brittleness and unsatisfactory piezoelectric response of piezoelectric semiconductors remain the major obstacles to their diversified ***,flexible multifunctional PVDF/6H-SiC composite fiber films are fabricated and utilized to assemble both piezoelectric nanogenerators(PENGs)and stress/temperature/light *** open cir-cuit voltage(V_(oc))and the density of short circuit current(I_(sc))of the PENG based on the PVDF/5 wt%6H-SiC composite fiber films reach 28.94 V and 0.24μA cm^(-2),showing a significant improvement of 240%and 300%compared with that based on the pure PVDF *** effect of 6H-SiC nanoparticles(NPs)on inducing interfacial polarization and stress concentration in composite fiber films is proved by first-principles calculation and finite element *** stress/temperature/light sensors based on the composite fiber film also show high sensitivity to the corresponding *** study shows that the PVDF/6H-SiC composite fiber film is a promising candidate for assembling high-performance energy harvesters and diverse sensors.

关键词： 6H-SiC PVDF Multifunctional composite fiber film Energy harvester Stress/temperature/light sensor

Recent advances in memristors based on two-dimensional ferroelectric materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第1期19卷 195-218页

作者： Wenbiao Niu Guanglong Ding Ziqi Jia Xin-Qi Ma JiYu Zhao Kui Zhou Su-Ting Han Chi-ching kuo Ye Zhou Institute for Advanced Study Shenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Institute of Organic and Polymeric Materials Research and Development Center of Smart Textile TechnologyTaipei University of TechnologyTaipei 10608TaiwanChina

In this big data era, the explosive growth of information puts ultra-high demands on the data storage/computing, such as high computing power, low energy consumption, and excellent stability. However, facing this challenge, the traditional von Neumann architecture-based computing system is out of its depth owing to the separated memory and data processing unit architecture. One of the most effective ways to solve this challenge is building brain inspired computing system with in-memory computing and parallel processing ability based on neuromorphic devices. Therefore, there is a research trend toward the memristors, that can be applied to build neuromorphic computing systems due to their large switching ratio, high storage density, low power consumption, and high stability. Two-dimensional (2D) ferroelectric materials, as novel types of functional materials, show great potential in the preparations of memristors because of the atomic scale thickness, high carrier mobility, mechanical flexibility, and thermal stability. 2D ferroelectric materials can realize resistive switching (RS) because of the presence of natural dipoles whose direction can be flipped with the change of the applied electric field thus producing different polarizations, therefore, making them powerful candidates for future data storage and computing. In this review article, we introduce the physical mechanisms, characterizations, and synthetic methods of 2D ferroelectric materials, and then summarize the applications of 2D ferroelectric materials in memristors for memory and synaptic devices. At last, we deliberate the advantages and future challenges of 2D ferroelectric materials in the application of memristors devices.

关键词： two-dimensional ferroelectric materials synthesis strategies memristors artificial synapses