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Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

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Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An huang Ching-Heng Lin Ming-Ju Wu Yi-Hsing Chen kuo-Cheng Chang Chung-wei Hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of Medical Research Taichung Veterans General HospitalTaichungTaiwan Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research Database.Patients with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December 2013.Adjusted HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival analysis.Results In total,8310 patients with SLE and 16620 patients without SLE were included.In general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in controls.In multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with SLE.Patients with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,p<0.001).Antiplatelet use increased the risk of haemorrhagic stroke in SLE group(aHR=1.74,95%CI:1.18 to 2.57).Conclusions Patients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 years.Antiplatelets should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

Adaptive learning-based optimal tracking control system design and analysis of a disturbed nonlinear hypersonic vehicle model

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Science China Technological Sciences 2024年第6期67卷 1893-1906页

作者： AN Kai WANG ZhenGuo huang wei National University of Defense Technology Hypersonic Technology Laboratory

We propose an adaptive learning-based optimal control scheme for height-velocity control models considering model uncertainties and external disturbances of hypersonic winged-cone vehicles. The longitudinal nonlinear model is first established and transformed into the control-oriented error equations, and the control scheme is organized by a steady-compensation combination. To overcome and eliminate the impact of model uncertainties and external disturbances, an adaptive radial basis function neural network(RBFNN) is designed by a q-gradient approach. Taking the height-velocity error system with estimated uncertainties into account, the adaptive learning-based optimal tracking control(ALOTC) scheme is proposed by combining the critic-only adaptive dynamic programming(ADP) framework and parameter optimization of system settling time. Furthermore,a novel weight update law is proposed to satisfy the online iteration requirements, and the algorithm convergence and closedloop stability are discussed by the Lyapunov theory. Finally, four simulation cases are provided to prove the effectiveness,accuracy, and robustness of the proposed scheme for the hypersonic longitudinal control system.

关键词： optimal tracking control adaptive dynamic programming RBFNN hypersonic vehicle

A Dual Discriminator Method for Generalized Zero-Shot Learning

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Computers, Materials & Continua 2024年第4期79卷 1599-1612页

作者： Tianshu wei Jinjie huang School of Computer Science and Technology Harbin University of Science and TechnologyHarbin150006China School of Automation Harbin University of Science and TechnologyHarbin150006China

Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof different types of features and domain shift problems are two of the critical issues in zero-shot learning. Toaddress both of these issues, this paper proposes a new modeling structure. The traditional approach mappedsemantic features and visual features into the same feature space;based on this, a dual discriminator approachis used in the proposed model. This dual discriminator approach can further enhance the consistency betweensemantic and visual features. At the same time, this approach can also align unseen class semantic features andtraining set samples, providing a portion of information about the unseen classes. In addition, a new feature fusionmethod is proposed in the model. This method is equivalent to adding perturbation to the seen class features,which can reduce the degree to which the classification results in the model are biased towards the seen classes.At the same time, this feature fusion method can provide part of the information of the unseen classes, improvingits classification accuracy in generalized zero-shot learning and reducing domain bias. The proposed method isvalidated and compared with othermethods on four datasets, and fromthe experimental results, it can be seen thatthe method proposed in this paper achieves promising results.

关键词： Generalized zero-shot learning modality consistent discriminator domain shift problem feature fusion

Asymmetric Electrolytes Design for Aqueous Multivalent Metal Ion Batteries

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Nano-Micro Letters 2024年第3期16卷 227-253页

作者： Xiaochen Yang Xinyu Wang Yue Xiang Longtao Ma wei huang Frontiers Science Center for Flexible Electronics Institute of Flexible ElectronicsNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641People’s Republic of China

With the rapid development of portable electronics and electric road vehicles,high-energy-density batteries have been becoming front-burner issues.Traditionally,homogeneous electrolyte cannot simultaneously meet diametrically opposed demands of high-potential cathode and low-potential anode,which are essential for high-voltage batteries.Meanwhile,homogeneous electrolyte is difficult to achieve bi-or multi-functions to meet different requirements of electrodes.In comparison,the asymmetric electrolyte with bi-or multi-layer disparate components can satisfy distinct requirements by playing different roles of each electrolyte layer and meanwhile compensates weakness of individual electrolyte.Consequently,the asymmetric electrolyte can not only suppress by-product sedimentation and continuous electrolyte decomposition at the anode while preserving active substances at the cathode for high-voltage batteries with long cyclic lifespan.In this review,we comprehensively divide asymmetric electrolytes into three categories:decoupled liquid-state electrolytes,bi-phase solid/liquid electrolytes and decoupled asymmetric solid-state electrolytes.The design principles,reaction mechanism and mutual compatibility are also studied,respectively.Finally,we provide a comprehensive vision for the simplification of structure to reduce costs and increase device energy density,and the optimization of solvation structure at anolyte/catholyte interface to realize fast ion transport kinetics.

关键词： Asymmetric electrolyte Aqueous multivalent metal ion batteries Electrochemical stability windows Electrolyte interface

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Sutured scleral fixation of existing subluxated/dislocated acrylic one-piece intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 665-669页

作者： wei-Yu huang Yung-Jen Chen Department of Ophthalmology Chi Mei Medical CenterTainan City 710TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalKaohsiung City 833TaiwanChina

AIM:To evaluate the visual and refractive outcomes in cases after sutured scleral fixation of existing subluxated or dislocated acrylic one-piece intraocular lenses(IOLs).METHODS:This study retrospectively enrolled a consecutive series of patients who underwent a surgery of sutured existing subluxated or dislocated IOLs from October 2018 to June 2020.All patients underwent comprehensive preoperative and postoperative ophthalmologic examination,and data were collected including age,sex,surgical indications,best-corrected visual acuity,refractive error,intraocular pressure.Presence of intraoperative and postoperative surgical complications was documented.RESULTS:A total of 20 consecutive cases were enrolled for analysis with mean final follow-up period 9.8±5.3mo.Visual acuity improved from a mean of 0.35(0.46±0.32 logMAR)preoperatively to 0.61(0.21±0.18 logMAR)at the 3-month follow-up(P=0.002).The mean amount of preoperative keratometric astigmatism and total postoperative refractive astigmatism was-1.24±0.80 diopters(D)and-1.42±0.97 D,respectively.There was no statistically significant difference between preoperative and postoperative astigmatism(P=0.156).The mean IOL-induced astigmatism was-0.23±0.53 D.The mean spherical equivalent at the 3-month follow-up was-0.1±0.94 D.No major complications were noted during the follow-up period.CONCLUSION:Surgical techniques using sutured scleral fixation of existing subluxated or dislocated acrylic one-piece IOLs result in favorable visual and refractive outcomes without major complications.

关键词： intraocular lens dislocation intraocular lens subluxation lens dislocation lens subluxation scleral fixation

Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia:a case report

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Journal of Geriatric Cardiology 2024年第2期21卷 242-245页

作者： wei CHEN Kun huang wei-wei GUO Fan ZHOU De-Ning LIAO Department of Cardiology Shanghai Jingan District Zhabei Central HospitalShanghaiChina Department of Cardiology Shanghai Changzheng HospitalShanghaiChina Department of Hematology Shanghai Jingan District Zhabei Central HospitalShanghaiChina

Cardiac tumors are rare.However,cardiac metastases can occur in up to 10%of patients with cancer.Among cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most... 详细信息

关键词： neoplasms sustained cardiac

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IMAGE SUPER-RESOLUTION RECONSTRUCTION BY HUBER REGULARIZATION AND TAILORED FINITE POINT METHOD

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Journal of Computational Mathematics 2024年第2期42卷 313-336页

作者： Wenli Yang Zhongyi huang wei Zhu School of Mathematics China University of Mining and TechnologyXuzhou 221116China Department of Mathematics Tsinghua UniversityBeijing 100084China Department of Mathematics University of AlabamaTuscaloosaAL 35487USA

In this paper,we propose using the tailored finite point method(TFPM)to solve the resulting parabolic or elliptic equations when minimizing the Huber regularization based image super-resolution model using the augmented Lagrangian method(ALM).The Hu-ber regularization based image super-resolution model can ameliorate the staircase for restored images.TFPM employs the method of weighted residuals with collocation tech-nique,which helps get more accurate approximate solutions to the equations and reserve more details in restored images.We compare the new schemes with the Marquina-Osher model,the image super-resolution convolutional neural network(SRCNN)and the classical interpolation methods:bilinear interpolation,nearest-neighbor interpolation and bicubic interpolation.Numerical experiments are presented to demonstrate that with the new schemes the quality of the super-resolution images has been improved.Besides these,the existence of the minimizer of the Huber regularization based image super-resolution model and the convergence of the proposed algorithm are also established in this paper.

关键词： Image super-resolution Variational model Augmented Lagrangian methods Tailored finite point method

Adaptive Sparse Grid Discontinuous Galerkin Method:Review and Software Implementation

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Communications on Applied Mathematics and Computation 2024年第1期6卷 501-532页

作者： Juntao huang wei Guo Yingda Cheng Department of Mathematics and Statistics Texas Tech UniversityLubbockTX79409USA Department of Computational Mathematics Science and EngineeringMichigan State UniversityEast LansingMI48824USA Department of Mathematics Michigan State UniversityEast LansingMI48824USA

This paper reviews the adaptive sparse grid discontinuous Galerkin(aSG-DG)method for computing high dimensional partial differential equations(PDEs)and its software implementation.The C++software package called AdaM-DG,implementing the aSG-DG method,is available on GitHub at https://***/Juntaohuang/adaptive-multiresolution-DG.The package is capable of treating a large class of high dimensional linear and nonlinear PDEs.We review the essential components of the algorithm and the functionality of the software,including the multiwavelets used,assembling of bilinear operators,fast matrix-vector product for data with hierarchical structures.We further demonstrate the performance of the package by reporting the numerical error and the CPU cost for several benchmark tests,including linear transport equations,wave equations,and Hamilton-Jacobi(HJ)equations.

关键词： Adaptive sparse grid Discontinuous Galerkin High dimensional partial differential equation Software development

Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan wei Xue Jun huang Xiao Zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much attention.Conventional classification algorithms are susceptible to data skew to favor majority samples and ignore minority samples.Majority weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority data.To this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these problems.Firstly,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority sample.Note that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate samples.Finally,data cleaning is performed on the processed data to further eliminate class overlap.Experiments on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering