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Bone metastasis is a late-onset and unfavorable event in survivors of gastric cancer after radical gastrectomy:Results from a clinical observational cohort

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Cancer Pathogenesis and Therapy 2024年第1期2卷 50-57页

作者： cheng Zhang Xiaopeng Zhang Chong Feng Yahui Yang Minmin Xie Ying Feng Zhijun Wu Hui Xu Changhao Wu tai Ma Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Anhui Provincial Cancer Institute/Anhui Provincial Office for Cancer Prevention and Control HefeiAnhui 230022China Department of Noncommunicable Diseases and Health Education Hefei Center for Disease Control and PreventionHefeiAnhui 230091China Department of Oncology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China Department of Oncology Ma’anshan Municipal People’s HospitalMa’anshanAnhui 243099China Department of Biochemistry and Physiology Faculty of Health and Medical SciencesUniversity of SurreyGuildford GU27HXUnited Kingdom

Background The timing and incidence of recurrent bone metastasis(BM)after radical gastrectomy in patients with gastric cancer(GC)as well as the survival of these patients were not fully *** aim of this study was to analyze the data of an observational GC cohort and identify patients who underwent curative gastrectomy and had recurrent BM to describe and clarify the pattern and profile of BM evolution after *** Data were retrieved from a hospital-based GC cohort,and patients who underwent upfront radical gastrectomy were *** time points of specific organ metastatic events were recorded,and the person-year incidence rate of metastatic events was *** latency period of BM events after gastrectomy was measured and compared with that of the other two most common metastatic events,liver metastasis(LM)and distant lymph node metastasis(LNM),using analysis of *** score matching and subgroup analysis were used for sensitivity *** A total of 1324 GC cases underwent radical gastrectomy between January 2011 and December *** these,67 BM,218 LM,and 248 LNM occurred before the last *** incidence of BM events was 1.7/100 person-years,which was approximately 3-fold lower than that of LM and distant LNM events(5.5 and 6.3 per 100 person-years,respectively).BM events had a significantly longer latency(median time,16.5 months)than LM and LNM events(11.1 and 12.0 months,respectively).Recurrent BM led to a worse prognosis(median survival,4.5 months)than those of LM and LNM events(median survival,7.7 and 7.1 months,respectively).However,no difference in overall survival after gastrectomy was observed among the *** Compared with other common metastatic events,BM in GC after gastrectomy is a late-onset event indicating poor survival.

关键词： Stomach neoplasms Neoplasm metastasis Incidence Survival analysis Propensity score

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Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen Lin Ling-Jie Lin Feng Lu tai-Chen Lai Jing Zou Lin-Ling Guo Zhi-Ming Lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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层理煤的冲击破坏行为及其倾向性评价

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岩石力学与工程学报 2024年第9期43卷 2178-2188页

作者：李红儒何满潮乔亚飞程泰同济大学土木工程学院地下建筑与工程系上海200092 中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100083

冲击地压严重制约了深部煤炭资源的安全开采。从材料固有属性的角度,建立合理的冲击倾向性指标对评估冲击地压风险十分重要。鉴于层理结构对煤的力学行为存在显著影响,对不同层理角度煤样开展了单轴压缩实验和离散元数值模拟,分析层理... 详细信息

冲击地压严重制约了深部煤炭资源的安全开采。从材料固有属性的角度,建立合理的冲击倾向性指标对评估冲击地压风险十分重要。鉴于层理结构对煤的力学行为存在显著影响,对不同层理角度煤样开展了单轴压缩实验和离散元数值模拟,分析层理角度对煤力学特性及其冲击破坏行为的影响。实验及数值模拟结果表明:随着层理角度增加,煤的强度、变形以及冲击破坏程度均先降低后升高;细观破裂模式逐渐由剪切主导演变为张拉主导。指出冲击地压是一个动态断裂问题,能量释放速率高于动态断裂的能量需求是动能产生的原因。据此,基于实验结果提出真实能量释放速率RERR这一新指标作为冲击倾向性判据。RERR考虑了峰后能量对冲击地压的贡献以及破坏的时间效应,反映了动态断裂阶段能量释放的剧烈程度。结合实际破坏情况(声响、弹射)和传统指标(单轴抗压强度USC、弹性能量指数WET、冲击能量指数KE和动态破坏时间DT)的评估结果,全面分析了不同层理角度煤的冲击倾向性,发现真实能量释放速率RERR与传统指标呈高度线性关系,验证了真实能量释放速率RERR的合理性和有效性。最后,建立了基于真实能量释放速率RERR的冲击倾向性等级划分标准。

关键词：采矿工程冲击倾向性层理煤离散元真实能量释放速率动能

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E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 25-35页

作者： Cuicui Xiao Jiao Gong Yusheng Jie Weicheng Liang Yan tai Wei Qin Tongyu Lu Yutian Chong Ziqing Hei Bo Hu Qi Zhang Biotherapy Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Anesthesiology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Liver Disease of Guangdong Province Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cell-Gene Therapy Translational Medicine Research Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains ***:The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression *** curves were plotted to compare the predictive ability of NCAPG and *** luciferase reporter system,and ChIP were used to investigate transcriptional potential of E2F1 to *** was observed by scanning electron *** expression of NCAPG,E2F1,and major proteins constituting NLRP3 inflammasome was determined by western blotting and *** in vivo tumor formation assay was conducted to verify the in vitro ***:Up-regulated NCAPG was identified in HCC tissues compared with adjacent tissue and high NCAPG was positively correlated with poor *** NCAPG mRNA level was a prognostic factor in HCC patients and also a diagnostic factor with higher predictive ability compared with AFP[AUROC 0.766(95%CI:0.650–0.881)vs.0.649(95%CI 0.506–0.793)].HBx transfection resulted in concomitant up-regulation of E2F1 and NCAPG.E2F1 significantly increased the activity of luciferase reporter fused with NCAPG reporter,and the interaction of E2F1 and NCAPG gene was confirmed by *** of E2F1 resulted in significant down-regulation of *** of NCAPG promote pyroptosis mediated by NLRP3 inflammasome activation in multiple HCC cell lines and also suppressed tumorigenesis in ***:We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis,which was regulated by its upstream transactivator,*** role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

关键词： NCAPG Hepatocellular carcinoma Pyroptosis NLRP3 inflammasome Serum marker circulating RNA.

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中国共产党领导中国式现代化的理论基点与推进机制

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山东大学学报（哲学社会科学版） 2024年第2期 12-20页

作者：张泰山东大学马克思主义学院济南250100

政党领导现代化国家建设是政党政治时代人类文明发展的基本特征。现代化的全球推进及其历史性变革催生了马克思主义政党,并引起了世界现代化类型的拓展,进而从根本上决定了政党领导作为马克思主义政党的价值目标,贯穿于以人的彻底解放... 详细信息

政党领导现代化国家建设是政党政治时代人类文明发展的基本特征。现代化的全球推进及其历史性变革催生了马克思主义政党,并引起了世界现代化类型的拓展,进而从根本上决定了政党领导作为马克思主义政党的价值目标,贯穿于以人的彻底解放与全面自由发展为根本指向的人类文明新形态的创造过程。中国共产党的领导是以中国式现代化全面推进中华民族伟大复兴的核心驱动、显著标识和前提保障。坚持和加强党对中国式现代化的领导,既关涉党的马克思主义政党属性、政党职能、政党权威以及政党文化等理论范畴,也需要构建由发展党内民主、实现党的领导法治化、完善中国特色新型政党制度、开发运用党的核心政治资源以及提升党的综合能力等价值要素构成的实践机制。

关键词：中国式现代化党的领导理论基点实践机制

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Experimental observation of Fermi-level flat band in novel kagome metal CeNi_(5)

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Chinese Physics B 2024年第8期33卷 467-472页

作者：陈学智王乐张帅张任杰程以伟胡裕栋孟承诺刘正太吕佰晴黄耀波 Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Zhangjiang Institute for Advanced Study Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Kagome materials are a class of material with a lattice structure composed of corner-sharing triangles that produce various exotic electronic phenomena,such as Dirac fermions,van Hove singularities,and flat ***,most of the known kagome materials have a flat band detached from the Fermi energy,which limits the investigation of the emergent flat band *** this work,by combining soft x-ray angle-resolved photoemission spectroscopy(ARPES)and the first-principles calculations,the electronic structure is investigated of a novel kagome metal CeNi_(5) with a clear dispersion along the kz direction and a Fermi level flat band in theΓ–K–M–Γ***,resonant ARPES experimental results indicate that the valence state of Ce ions is close to 4^(+),which is consistent with the transport measurement *** results demonstrate the unique electronic properties of CeNi_(5) as a new kagome metal and provide an ideal platform for exploring the flat band physics and the interactions between different types of flat bands by tuning the valence state of Ce ions.

关键词： ARPES kagome lattice band structure flat band

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Efficient photocatalytic reduction of COto formate by a molecular noble metal-free system

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Science China Chemistry 2024年

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/AgCl） in the presence of 12 mM Et3NHBF4also produced HCOO-with Faradaic efficiency of39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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基于复变函数理论的无中导连拱隧道应力与位移解析解

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岩土力学 2024年第3期45卷 777-787页

作者：毕钛俊邓琴汤华姜成业秦雨樵中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 中国科学院大学北京100049

无中导连拱隧道由于后行洞衬砌搭接于先行洞衬砌拱腰之上,围岩与衬砌受力情况复杂,开展相应的围岩与衬砌应力和位移分析具有重要的工程意义。基于复变函数理论和Schwarz交替法,提出了深埋条件下考虑衬砌的无中导连拱隧道围岩与衬砌应力... 详细信息

无中导连拱隧道由于后行洞衬砌搭接于先行洞衬砌拱腰之上,围岩与衬砌受力情况复杂,开展相应的围岩与衬砌应力和位移分析具有重要的工程意义。基于复变函数理论和Schwarz交替法,提出了深埋条件下考虑衬砌的无中导连拱隧道围岩与衬砌应力和变形的计算方法。针对无中导连拱隧道两洞具有共用边界的特点,在利用柯西积分法进行求解时,将单洞衬砌与围岩接触的边界积分条件转化为仅存在单洞时的完整边界积分与共用边界积分之差,对于Schwarz交替法中求解“附加面力”的过程亦进行类似处理。给出共用边界应力与位移的计算方法。通过算例,将上述解析结果和数值仿真结果进行对比,证明了方法的可行性和准确性。

关键词：无中导连拱隧道复变函数 Schwarz交替法应力场位移场

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浅埋无中导洞连拱隧道先行洞衬砌承担围岩荷载确定方法

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岩土力学 2024年第4期45卷 1170-1180页

作者：汤华姜成业邓琴毕钛俊秦雨樵中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 中国科学院大学北京100049

不同于常规隧道衬砌结构,无中导洞连拱隧道先行洞衬砌施作稳定后还要受到邻近后行洞开挖的二次扰动,后行洞开挖对先行洞衬砌受力的影响不可忽视。依托杨家寨公路隧道工程,基于考虑了后行洞开挖影响的隧道围岩压力计算方法,结合现场监测... 详细信息

不同于常规隧道衬砌结构,无中导洞连拱隧道先行洞衬砌施作稳定后还要受到邻近后行洞开挖的二次扰动,后行洞开挖对先行洞衬砌受力的影响不可忽视。依托杨家寨公路隧道工程,基于考虑了后行洞开挖影响的隧道围岩压力计算方法,结合现场监测位移数据采用荷载-结构法进行位移反分析,提出了一种确定浅埋无中导洞连拱隧道先行洞衬砌承担围岩荷载的方法,最后和衬砌背后围岩荷载现场监测值进行对比验证。研究结果表明:后行洞开挖对先行洞衬砌承担围岩荷载的影响较为显著,监测点增长幅度均值高达142%;先行洞衬砌受力呈现“拱腰较小,拱顶及拱肩较大”的分布规律,且靠近后行洞一侧拱肩位置受力最大;通过现场监测位移反分析得到的先行洞衬砌受力结果和现场监测结果较为一致,论证了该方法的合理性和实用性,研究成果可为无中导洞连拱隧道结构设计提供参考。

关键词：荷载结构法无中导洞连拱隧道位移反分析衬砌受力

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马克思拜物教思想演化的内生驱动研究

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政治经济学评论 2024年第4期15卷 128-141页

作者：邰丽华中国政法大学

在批判与继承前人相关研究成果的基础上,马克思拜物教思想的创新具有内生性的特点,包含了抽象分析与具体研究紧密结合、形式探讨与本源揭示彼此呼应、提出和分析问题直至达成解决方案的有机统一。马克思突破了法学、历史、哲学和宗教等... 详细信息

在批判与继承前人相关研究成果的基础上,马克思拜物教思想的创新具有内生性的特点,包含了抽象分析与具体研究紧密结合、形式探讨与本源揭示彼此呼应、提出和分析问题直至达成解决方案的有机统一。马克思突破了法学、历史、哲学和宗教等研究范式的束缚,运用政治经济学的立场、观点和方法,对拜物教的思考由不成熟渐渐走向成熟,由表象层面逐步深入到问题的本质与核心,由零散化碎片式研讨直至形成系统性理论构建的全过程,彰显了马克思主义理论勇于创新不断超越自我的独特品质。马克思拜物教思想发展和演化的内生驱动,根源于他的政治经济学研究转向,反映了马克思主义理论的科学性与实践性的辩证统一,体现了未来社会主义模式的动态性、多样式与差异化,对深入推进中国特色社会主义改革与建设事业具有十分重要的启示与借鉴。

关键词：拜物教思想发展演化自我创新内生驱动现实意义

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