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The Significant and Profound Impacts of chou’s Distorted Key Theory for Developing Peptide Drugs

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Natural Science 2020年第9期12卷 638-639页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

In this short review paper, the significant and profound impacts of the distorted key theory for developing peptide drugs have been briefly recalled with crystal clear convincingness.

关键词： AIDS Peptide Drugs Distorted Key Theory Microenvironment

The Significant and Profound Impacts of chou’s Invariance Theorem

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Natural Science 2020年第9期12卷 659-660页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

In this short review paper, the significant and profound impacts of the chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.

关键词： Invariance Theorem Mahalanobis Distance Significant Impacts Profound Impacts

The Significant and Profound Impacts of chou’s 5-Steps Rule

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Natural Science 2020年第9期12卷 633-637页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

In this short review paper, the significant and profound impacts of the 5-steps rule have been briefly recalled with crystal clear convincingness.

关键词： 5-Step Rules Significant Impacts Profound Impacts Curie Temperature

Use chou’s 5-Steps Rule to Predict Remote Homology Proteins by Merging Grey Incidence Analysis and Domain Similarity Analysis

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Natural Science 2020年第3期12卷 181-198页

作者： Weizhong Lin Xuan Xiao Wangren Qiu kuo-chen chou Computer Department Jing-De-Zhen Ceramic Institute Jing-De-Zhen China Gordon Life Science Institute Boston MA 02478 USA

Detecting remote homology proteins is a challenging problem for both basic research and drug development. Although there are a couple of methods to deal with this problem, the benchmark datasets based on which the existing methods were trained and tested contain many high homologous samples as reflected by the fact that the cutoff threshold was set at 95%. In this study, we reconstructed the benchmark dataset by setting the threshold at 40%, meaning none of the proteins included in the benchmark dataset has more than 40% pairwise sequence identity with any other in the same subset. Using the new benchmark dataset, we proposed a new predictor called “dRHP-GreyFun” based on the grey modeling and functional domain approach. Rigorous cross-validations have indicated that the new predictor is superior to its counterparts in both enhancing success rates and reducing computational cost. The predictor can be downloaded from https://***/jcilwz/dRHP-GreyFun.

关键词： Remote Homology Proteins Grey Model Domain Similarity chou’s 5-Steps Rules

Showcase to Illustrate How the Web-Server iSulf_Wide-PseAAC Is Working

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Natural Science 2020年第8期12卷 620-631页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

Current coronavirus pandemic has endangered the entire mankind life. The reported cas-es are increasing exponentially. Information of protein post-translational modification (PTM) can provide useful clues to develop antiviral drugs. According to our recent works, the PTM prediction can be significantly improved by widening the samples of training da-taset. Based on such an idea, a new predictor called “iSulf_Wide-PseAAC” has been de-veloped. Its accuracy is overwhelmingly higher than its counterparts. To maximize the convenience for most experimental scientists, a user-friendly web-server for the new pre-dictor has been established at http://121.***.221.79/Isulf_Pse/, which will become a very useful tool for fighting pandemic coronavirus and save the mankind of this planet.

关键词： Pandemic Coronavirus 5-Step Rule PseAAC Learning at Wide Region Webserver

Showcase to Illustrate How the Web-Server pLoc_Deep-mHum Is Working

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Advances in Bioscience and Biotechnology 2020年第7期11卷 273-288页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

Recently, a very useful method called “pLoc_Deep-mHum” has been proposed for finding against the Pandemic COVID-19. Illustrated in this short report is a step-by-step guide for how to use its web-server.

关键词： Coronavirus Human Proteins Multi-Label System PseAAC Five-Steps Rules

Coronavirus and Gordon Life Science Institute

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Natural Science 2020年第7期12卷 429-440页

作者： kuo-chen chou Gordon Life Science Institute Boston Massachusetts 02478 United States of America

The impacts of coronavirus to our planet are unprecedented;i.e., they are going to eliminate the entire mankind. Driven by such horrible situation, some philosophical viewpoints have naturally happened. Whether the “World End” must come? If yes, when? During this waiting period, the best way to do science is via the Internet Institute, such as “Gordon Life Science Institute”, and the results thus achieved will be most rewarding.

关键词： Pandemic COVID-19 The End of World The Holy Bible Prophecy The Deducted Outcomes of Many Philosophers

Showcase to Illustrate How the Web-Server pLoc_Deep-mEuk Is Working

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Advances in Bioscience and Biotechnology 2020年第7期11卷 257-272页

作者： kuo-chen chou Gordon Life Science Institute Boston MA USA

Recently, a very useful method called “pLoc_Deep-mEuk” has been proposed for finding against the Pandemic COVID-19. Illustrated in this short report is a step-by-step guide for how to use its web-server.

关键词： Coronavirus Eukaryotic Proteins Multi-Label System PseAAC Five-Steps Rules

The Implication of “I Am the Alpha and the Omega” to Internet Institutes

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Natural Science 2020年第7期12卷 482-494页

作者： kuo-chen chou Gordon Life Science Institute Boston Massachusetts 02478 United States of America

It is extremely fearful for the pestilences covering our Earth. Does that mean the “World End” is around the corner? For the so-called “Atheists” originally proposed by Karl Max and Friedrich Engels, “there is a Beginning, there must be an End”, meaning our Earth will finally no longer exist in the entire Universe by colliding with the other planet. According to Holly Bible, however, Jesus, will send out his angels to separate the wicked from the righteous and throw the former into the fiery furnace. For such a special time-period, many useful ideas or outcomes can be acquired by the Internet Institutes.

关键词： Pandemic COVID-19 Coronavirus Atheists Fiery Furnace Evil and Righteous Internet Institutes