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Improvement of lenvatinib-induced nephrotic syndrome after adaptation to sorafenib in thyroid cancer:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4883-4894页

作者： Che Hseuh Yang kuo tung Chen Yi Sheng Lin Chao Yu Hsu Yen Chuan Ou Min Che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung City 435403Taiwan Division of General Surgery Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung City 435403Taiwan

BACKGROUND Target therapy is licensed by United States Food and Drug Administration on certain *** sorafenib and lenvatinib are tyrosine kinase inhibitor and indicated on radioactive iodine(RAI)-refractory differentiated thyroid cancer(DTC).Lenvatinib is more effective in cancers'control than sorafenib,but causes more nephrotoxicity than sorafenib *** case is the second published case about the serial adaptions from lenvatinib to sorafenib for improving the proteinuria and,meanwhile,achieving the therapeutic *** SUMMARY A 56-year-old man suffered from bilateral edematous lower extremities after 1-mo prescription of lenvatinib of 20 mg/d for RAI-refractory *** from this symptom,he also developed *** laboratory showed grade-3 proteinuria(estimated 24-h urine protein:9993 mg),hypoalbuminemia and ***-vascular endothelial growth factor(VEGF)therapyinduced nephrotic syndrome was *** reduced dosage of lenvatinib of 10 mg/d and related symptomatic drugs,limited improvement was observed in both adverse effects and caner *** this condition,we substituted sorafenib of 400 mg/d for lenvatinib of 10 mg/*** a 5-mo prescription,not only hypertension and peripheral edema were greatly improved,but also proteinuria was improved from grade three to grade one(estimated 24-h urine protein:962 mg).At the same time the cancer control was achieved,judged from computed tomography and laboratory evidence[thyroglobulin(Tg)before prescription of sorafenib:354.7 ng/m L;Tg after prescription of sorafenib:108.9 ng/m L].CONCLUSION Adaption from lenvatinib to sorafenib is a feasible method to improve the antiVEGF therapy-induced nephrotic syndrome and achieve the therapeutic goal at the same time.

关键词： Molecular targeted therapy/methods Receptors Vascular endothelial growth factor/drug effects Vascular endothelial growth factor/therapeutic use Vascular endothelial growth factor A/drug effects Nephrotic syndrome/drug therapy Case report

Overt hypothyroidism with rhabdomyolysis and myopathy： a case report

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Chinese Medical Journal 2010年第5期123卷 633-637页

作者： kuo Hsu-tung JENG Chii-yuan Department of Family Medicine Lin-Shin Medical Corporation Lin-Shin Hospital Taichung Taiwan China Division of Metabolism and Endocrinology Department of Medicine Lin-Shin Medical Corporation Lin-Shin Hospital Taichung Taiwan China Graduate Institute of Medical Sciences National Defense University Internal Medicine National Defense Medical Center Taipei Taiwan China

Muscle involvement in adults with hypothyroidism is common. At least 79% of patients with hypothyroidism have muscle weakness, cramps, and myalgia complaints.1 The patients with hypothyroidism do have myopathy rather than functional muscle diseases.2 Nonspecific muscle stiffness related to myalgia may be associated with serum muscle enzyme elevations. Serum creatine kinase （CK） elevation can be observed in 57%-90% of patients with hypothyroidism. Skeletal muscle is affected more profoundly in cases of overt hypothyroidism,

关键词： hypothyroidism rhabdomyolysis myopathy

Finding of Neoproterozoic （～775 Ma） magmatism recorded in metamorphic complexes from the North Qilian orogen： Evidence from SHRIMP zircon U-Pb dating

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Chinese Science Bulletin 2006年第8期51卷 963-970页

作者： Chien-Yuan Tseng Houng-Yi Yang WAN Yusheng LIU Dunyi Da-Jen Wen Tzung-Chi Lin kuo-an tung Department of Earth Sciences National Cheng Kung University Tainan 701 China Beijing SHRIMP Centre Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China Department of Geosciences National Taiwan University Taipei 106 China

标明日期的虾 U-Pb 从 Niuxinshan 片麻岩的花岗石和 Leigongshan 在锆石上被执行在北方 Qilian orogen 的片麻岩的吨子盐， NW 中国。结果分别地产出 776+-10 妈和 774 +-23 妈的加权的平均 ~(206 )Pb/~(238 ) U 年龄。Igneousmorphol... 详细信息

标明日期的虾 U-Pb 从 Niuxinshan 片麻岩的花岗石和 Leigongshan 在锆石上被执行在北方 Qilian orogen 的片麻岩的吨子盐， NW 中国。结果分别地产出 776+-10 妈和 774 +-23 妈的加权的平均 ~(206 )Pb/~(238 ) U 年龄。Igneousmorphology，摆动的 zonings，和为这些锆石的相对高的 Th/U 比率建议 magmaticorigin。这些年龄作为岩浆炮兵阵地预定并且因此代表 aNeoproterozoic (约 775 妈) 被解释在北方 Qilian 区域的 magmatic 事件。thismagmatism 可能与超级大陆 Rodinia 的决裂有关，这被建议。这发现，和 750 ～ 800 妈的类似的年龄为南方中央的 Qilian 和北方 Qaidam 的附近的岩层报导了，具有到在韦斯特中国的 Rodinia 进化的理解的意义。

关键词：岩浆造山带 SHRIMP 锆石年代测定

Endometriosis coexisting with dermoid cyst in a single ovary： a case report

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Chinese Medical Journal 2011年第4期124卷 627-630页

作者： CHEN Tsai-chuan kuo Hsu-tung SHYU Shin-kuo CHU Chih-ping CHANG Tien-chang Department of Obstetrics and Gynecology Lin-Shin Medical Corporation Lin-Shin Hospital Department of Family Medicine Lin-Shin Medical Corporation Lin-Shin Hospital Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 408 TaiwanChina Department of Anatomical Pathology Lin-Shin Medical Corporation Lin-Shin Hospital Chang Tien-chang General Clinic Taichung 408 TaiwanChina

Endometriosis coexisting with a dermoid cyst of the ovary is extraordinarily rare, although these both benign conditions are said to be common in women in the reproductive age group. There are only two previous case reports, which is evident from our literature review from January 1960 through January 2010. Acute abdomen is one of the greatest diagnostic challenges and easily ignored by the clinicians to exclude the possibility of gynecologic illness. A 35-year-old woman was referred by the doctor in Family clinic. She experienced a three-day period of severe right lower abdominal pain and intermittent vomiting. Ultrasonography identified a bilocular, cystic, hypoechoic, and hyperechoic tumor, 7 cm×6 cm×6 cm in the right adnexal region. Laparoscopic cystectomy was performed under the impression of ovarian cyst with torsion or hemorrhage. The frozen section was benign and appendiceal status was adequate. Histopathologic examination described an ovarian cyst composed of endometrial-type lining with stroma cells （endometriosis） and benign terotoma tissue with plenty of skin appendages and sebaceous glands. We report this unusual and interesting ovarian mass to remind physicians that the usage of the Endobag after cystectomy, the benefits on minimizing operative time, spilled opportunity, and postoperative complications. Laparoscopic techniques for large ovarian masses might be considered. The experience of the surgeon is also very important to prevent misdiagnosis or complication. Further follow up is mandatory for this simultaneous finding of ovarian endometriosis with coincidental dermoid cyst as a separate pathology in single ovary of such a nature. It also presents a challenge to the clinicians and to the pathologists.

关键词： endometriosis dermoid cyst cystectomy endobag

柴达木盆地北缘锡铁山副片麻岩所记录的多期构造热事件

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地质通报 2007年第6期26卷 631-638页

作者：张建新孟繁聪董国安中国地质科学院地质研究所北京100037 台湾成功大学地球科学系

在柴达木盆地北缘中段的锡铁山地区,夹有榴辉岩或退变榴辉岩透镜体的2个副片麻岩样品的锆石被用于SHRIMP U pb测定。2个片麻岩样品具有类似的特征,主要由石榴子石、夕线石、长石、黑云母和石英组成,这些矿物组合形成的变质条件, 0.6～0.... 详细信息

在柴达木盆地北缘中段的锡铁山地区,夹有榴辉岩或退变榴辉岩透镜体的2个副片麻岩样品的锆石被用于SHRIMP U pb测定。2个片麻岩样品具有类似的特征,主要由石榴子石、夕线石、长石、黑云母和石英组成,这些矿物组合形成的变质条件, 0.6～0.9GPa和710～820℃,显示两处片麻岩经历了中压麻粒岩相条件的变质作用。锆石的SHRIMP U-Pb测定显示,2个样品获得近一致的早古生代变质年龄(分别为437Ma±6Ma和441Ma±15Ma),代表早古生代的高温变质作用时代。样品XTS-1还得890Ma±14Ma的年龄,所测定的锆石具有明显的变质作用成因特征,代表了新元古代早期的变质事件,反映了这些副片麻在早古生代造山旋回之前可能还经历了晋宁期的变质作用。

关键词：柴达木盆地北缘锡铁山副片麻岩锆石SHRIMP U-Pb定年多期构造热事件

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低速圆筒型直线异步电动机电磁设计方法

西安交通大学学报 1978年第3期 79-94页

作者：顾积栋

本文提出了一种结构简单、易于加工制造的圆筒型直线感应电动机的设计。此种电机适用于推力为数十公斤的场合。文中推导了此种电机的主要尺寸、初级与次级电磁参数的计算公式。应用这些公式对研制的数台电机进行了计算,结果表明计算与... 详细信息

本文提出了一种结构简单、易于加工制造的圆筒型直线感应电动机的设计。此种电机适用于推力为数十公斤的场合。文中推导了此种电机的主要尺寸、初级与次级电磁参数的计算公式。应用这些公式对研制的数台电机进行了计算,结果表明计算与试验基本符合。

关键词：圆筒型圆筒型直线电机异步电动机感应电动机电磁设计气隙长度行波磁场磁势磁通势低速

靝馨茶商的周转困局——乾嘉年间广州贸易与婺源绿茶商

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海洋史研究 2017年第1期 393-434页

作者：陈国栋台湾中研院历史与语言研究所

一前言婺源与徽州府的其他县份各自位在黄山余脉大障山的两侧,大障山即是鄱阳湖水系之乐安江与钱塘江水系之新安江的分水岭。婺源县独居一侧,因此现在被划人江西省。但在明清时期,婺源实为安徽省徽州府的一个属县。婺源是个多山的县,民... 详细信息

一前言婺源与徽州府的其他县份各自位在黄山余脉大障山的两侧,大障山即是鄱阳湖水系之乐安江与钱塘江水系之新安江的分水岭。婺源县独居一侧,因此现在被划人江西省。但在明清时期,婺源实为安徽省徽州府的一个属县。婺源是个多山的县,民间有＂八分半山一分田,半分水路和庄园＂的说法。

关键词：婺源县绿茶钱塘江水系贸易广州周转明清时期分水岭

上海市徐匯区中学敎室自然采光调查的初步报告

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上医学报 1959年第3期 231-235页

作者：张國棟上海第一医学院卫生系学校卫生教研组

外界环境对机体的发育和健康有巨大的影响,特别是学生们经常学习的教室,它的自然采光是否良好关系到他们的视觉器官发育。早在1870年俄国学者就注意到这方面的问題,他在彼得堡调查15所中小学校的学生4,538人,发现从预备班至七年级的学... 详细信息

外界环境对机体的发育和健康有巨大的影响,特别是学生们经常学习的教室,它的自然采光是否良好关系到他们的视觉器官发育。早在1870年俄国学者就注意到这方面的问題,他在彼得堡调查15所中小学校的学生4,538人,发现从预备班至七年级的学生近视率由13.6％递升至42.8％,认为这些学校不良的学习条件对视力有影响。作者对现有的学校教室自然采光进行了解,以便提供主管部门对存在的缺点加以改善,并作为今后新建、扩建和利用住宅改作校舍时的参考。

关键词：自然采光开角学校采光系数上海市

基于光纤光栅传感技术的地基基础健康监测研究

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土木工程学报 2010年第6期43卷 109-115页

作者：朱鸿鹄殷建华靳伟古冬明香港理工大学 LMM工程咨询有限公司

建筑物地基、基础的现场监测技术一直存在着精度低、稳定性差、不易安装等缺陷。论证光纤光栅传感技术在地基和基础结构健康监测中的应用可行性,并研制光纤光栅应变计、温度计、沉降仪和水平测斜仪等监测仪器,用于监测地基、基础的应变... 详细信息

建筑物地基、基础的现场监测技术一直存在着精度低、稳定性差、不易安装等缺陷。论证光纤光栅传感技术在地基和基础结构健康监测中的应用可行性,并研制光纤光栅应变计、温度计、沉降仪和水平测斜仪等监测仪器,用于监测地基、基础的应变、温度、位移等。室内标定试验结果显示,这些仪器具有分辨率高、稳定性好等优点。在香港某建筑物的施工过程中,在地基和筏式基础中安装了以上的光纤光栅监测仪器,构成准分布式的地基、基础健康监测系统,并实现监测的自动化、远程化。分析初期的监测结果,并针对监测系统实施可能出现的问题提出了解决途径。

关键词：地基基础光纤传感技术光纤光栅健康监测