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Artificial intelligence reinforced upconversion nanoparticle-based lateral flow assay via transfer learning

Fundamental Research 2023年第4期3卷 544-556页

作者： Wei Wang kuo chen Xing Ma Jinhong Guo School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China The M.O.E.Key Laboratory of Laboratory Medical Diagnostics The College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China

The combination of upconverting nanoparticles(UCNPs)and immunochromatography has become a widely used and promising new detection technique for point-of-care testing(POCT).However,their low luminescence efficiency,non-specific adsorption,and image noise have always limited their progress toward practical ***,artificial intelligence(AI)has demonstrated powerful representational learning and generalization capabilities in computer *** report for the first time a combination of AI and upconversion nanoparticle-based lateral flow assays(UCNP-LFAs)for the quantitative detection of commercial internet of things(IoT)*** universal UCNPs quantitative detection strategy combines high accuracy,sensitivity,and applicability in the field detection *** using transfer learning to train AI models in a small self-built database,we not only significantly improved the accuracy and robustness of quantitative detection,but also efficiently solved the actual problems of data scarcity and low computing power of POCT ***,the trained AI model was deployed in IoT devices,whereby the detection process does not require detailed data preprocessing to achieve real-time inference of quantitative *** validated the quantitative detection of two detectors using eight transfer learning models on a small *** AI quickly provided ultra-high accuracy prediction results(some models could reach 100%accuracy)even when strong noise was ***,the high flexibility of this strategy promises to be a general quantitative detection method for optical *** believe that this strategy and device have a scientific significance in revolutionizing the existing POCT technology landscape and providing excellent commercial value in the in vitro diagnostics(IVD)industry.

关键词： Upconverting nanoparticles Lateral flow assays Transfer learning Internet of medical things Portable fluorescent sensor

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Pressure-induced bimetallic carbon nanotubes from metalorganic frameworks as optimized bifunctional electrocatalysts for water splitting

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Rare Metals 2023年第1期42卷 155-164页

作者： Hong-Xu chen Hui Xu Zhi-Rong Song Yi Liu Hui Cui Jun-kuo Gao Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesCollage of Optical and Electronic TechnologyChina Jiliang UniversityHangzhou310018China Institute of Functional Porous Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou310018China Institute for Composites Science Innovation School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Argonne National Laboratory Physics DivisionLemontIL60439USA Department of Chemistry and International Institute for Nanotechnology(IIN) Northwestern UniversityEvanstonIL60208USA

Carbon nanotubes(CNTs)have attracted great interest in numerous applications due to their excellent electronic and structural ***,harsh synthesis conditions and high energy consumption limit the further application of ***,we developed a facile and innovative strategy to generate CNTs by physically pressurizing metal-organic frameworks(MOFs)and then *** synthesized bimetallic nitrogen/sulfur double-doped carbon nanotubes are denoted as Fe_(x)Co_(1-x)P(x=0.5,0.6,0.7,0.8,0.9).The introduction of pressure not only revolutionized the morphology of the electrocatalysts,but also enhanced the activity of oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)in alkaline ***_(0.6)Co_(0.4)-P exhibits superior OER and HER performances in 1.0 mol·L^(-1)KOH solution with overpotentials of 364 and 346 mV at 10 mA·cm^(-2),which are 28 and 5 mV lower than unpressurized Fe0.6Co0.4.

关键词： Metal-organic frameworks(MOFs) Carbon nanotubes(CNTs) Bifunctional Pressurizing Oxygen evolution reaction(OER) Hydrogen evolution reaction(HER)

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镁液气压式定量输送方法研究

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特种铸造及有色合金 2024年第5期44卷 582-586页

作者：周计明耿兆伟廖阔陈宝林李小博齐乐华西北工业大学机电学院西安710072 陕西省纤维增强轻质复合材料重点实验室西安710072

为实现镁液气压式定量输送,设计了水力学模拟试验装置,通过物理模拟试验研究了气体压力、加压时间对水输送量的影响,建立了定量输送的数学模型。根据相似性原理,设计开发了镁液定量输送装置,并确定在气压恒定前提下进行加压时间控制,以... 详细信息

为实现镁液气压式定量输送,设计了水力学模拟试验装置,通过物理模拟试验研究了气体压力、加压时间对水输送量的影响,建立了定量输送的数学模型。根据相似性原理,设计开发了镁液定量输送装置,并确定在气压恒定前提下进行加压时间控制,以实现镁液定量输送。结果表明,基于定时定量法可实现定量输送,输送过程平稳无飞溅,修正后的定量输送预测模型的平均预测误差为1.5%,满足定量输送的要求。

关键词：镁合金定量输送水模拟试验自动化

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贵州苗族红酸汤对高脂饮食诱导型大鼠非酒精性脂肪肝的预防作用

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贵州医科大学学报 2024年第2期49卷 228-234页

作者：王乃经陈云云陈莎唐扩王惠群贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵州贵阳561113

目的研究贵州苗族红酸汤对高脂饮食诱导型大鼠非酒精性脂肪肝(NAFLD)的保护作用及其可能机制。方法根据国标法检测红酸汤抗氧化成分番茄红素、辣椒碱、乳酸及乙酸的含量;无特定病原体(SPF)级雄性SD大鼠30只,按照体质量随机分为酸汤组... 详细信息

目的研究贵州苗族红酸汤对高脂饮食诱导型大鼠非酒精性脂肪肝(NAFLD)的保护作用及其可能机制。方法根据国标法检测红酸汤抗氧化成分番茄红素、辣椒碱、乳酸及乙酸的含量;无特定病原体(SPF)级雄性SD大鼠30只,按照体质量随机分为酸汤组、模型组和正常组(每组10只),酸汤组大鼠喂养高脂饲料并根据体质量按照8 g/kg灌胃红酸汤,模型组大鼠喂养高脂饲料并灌胃等容积蒸馏水,正常组大鼠喂养普通饲料并灌胃等容积蒸馏水,每日记录大鼠体质量、摄食量;连续灌胃12周后,称量大鼠体质量并计算肥胖指数(Lee’s指数)和肝脏指数,测定血脂四项、谷丙转氨酶(ALT)及谷草转氨酶(AST)水平,血清总抗氧化能力(T-AOC)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)及白细胞介素6(IL-6)含量;取各组大鼠肝脏苏木素-伊红染色(HE染色)和油红O染色,显微镜观察脂质沉积及肝组织学特征。结果红酸汤抗氧化成分番茄红素、辣椒碱和有机酸的含量较丰富;动物实验结果表明,与模型组相比,酸汤组大鼠的体质量减轻,Lee’s指数和肝脏指数降低(P<0.05),血清甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)含量降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)含量升高(P<0.05),血清ALT和AST水平下降(P<0.05),血清T-AOC、MDA、TNF-α和IL-6含量降低(P<0.05);HE染色和油红O染色结果显示红酸汤干预能预防肝脏组织脂肪变性和肝细胞脂质沉积。结论贵州苗族红酸汤对NAFLD有一定预防作用,可能与其调节血脂紊乱、改善肝脏脂肪变性和脂质沉积、减轻机体氧化应激和慢性炎症有关。

关键词：红酸汤非酒精性脂肪肝脂质沉积氧化应激慢性炎症

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Trends of carbon and nutrient accumulation through time in the Andong salt marsh,Hangzhou Bay,China

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Journal of Oceanology and Limnology 2023年第6期41卷 2134-2145页

作者： Pei Sun LOH Aimin JIN Zhanghua LOU Xuegang chen Shuangyan HE chen-tung Arthur chen Stephanie PARKER Jianxiong HU Hongwei YUAN Longxiu chenG Department of Marine Sciences Ocean CollegeZhejiang UniversityZhoushan 316021China Department of Oceanography National Sun Yat-sen UniversityKaohsiung 804China

Salt marshes are important carbon and nutrient sinks that are threatened by climate changes and human *** this study,the accumulation rates of sedimentary total organic carbon(TOC),total nitrogen(TN),and total phosphorus(TP)from two cores in the Andong salt marsh,Hangzhou Bay,were investigated to determine whether TOC,TN,and TP show increasing or decreasing trends toward the *** TOC accumulation rates at the relatively lower marsh were lower during 1990-1996(1.63-2.37 g/(cm^(2)·a))than 1997-2014(1.15-4.30 g/(cm^(2)·a)).The TN accumulation rates increased from 1990(0.14 g/(cm^(2)·a))toward 2012(0.40 g/(cm^(2)·a)),then decreased toward 2014(0.16 g/(cm^(2)·a)).The TP accumulation rates were lower during 1990-1999(0.10-0.21 mg/(cm^(2)·a)),and decreased from 2000(0.32 mg/(cm^(2)·a))toward 2014(0.15 mg/(cm^(2)·a)).The TOC accumulation rates along the relatively upper marsh during 1982-1992(1.18-3.25 g/(cm^(2)·a))were lower than during 1998-2010(2.30-4.20 g/(cm^(2)·a)),and then decreased toward 2015(2.15 g/(cm^(2)·a)).TN increased from 1982(0.18 g/(cm^(2)·a))to 2005(0.41 g/(cm^(2)·a)),then decreased toward 2015(0.22 g/(cm^(2)·a)).TP accumulation rates fluctuated within a narrow range during 1982-1997(0.21-0.41 mg/(cm^(2)·a)),increased from 1998(0.50 mg/(cm^(2)·a))to 2004(0.87 mg/(cm^(2)·a)),then decreased to 2015(0.38 mg/(cm^(2)·a)).Thus,increases in accumulation rates of TOC,TN,and TP from the 1980s to 1990s indicates that the marsh likely served as carbon and nutrient sinks,then the rates decreased during 2000-2015 due probably to the reduced sediment inputs from rivers and intensified sea level rise.

关键词： wetland climate change anthropogenic activity marsh degradation

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Thermodynamic prediction of martensitic transformation temperature in Fe-C-X(X=Ni,Mn,Si,Cr)systems with dilatational coefficient model

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Journal of Materials Science & Technology 2022年第17期112卷 291-300页

作者： Hongcan chen Wei Xu Qun Luo Qian Li Yu Zhang Jingjing Wang kuo-Chih Chou State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China National Engineering Research Center for Magnesium Alloy Chongqing UniversityChongqing 400044China Ansteel Beijing Research Institute Co. LtdBeijing 102211China

Martensitic transformation is significant to strengthen steels,but its thermodynamic prediction is restricted to simple systems due to lacking multicomponent interaction *** driving forces of martensitic transformation can be divided into chemical and non-chemical driving *** magnetic parameters are carefully optimized because it affects the magnetic Gibbs free energy of austenite and ferrite,and have big impact on the chemical driving *** dilatational strain energy provides major contribution to non-chemical driving force,thus the integrated-models for dilatational coefficient are constructed in a wide composition and temperature range based on the experimental dilatational *** expands the scope of application of thermodynamic model and improved prediction accuracy of martensitic transformation temperature(M_(s)).The prediction error reaches 5.6%for Fe-C-X(X=Ni,Mn,Si,Cr)and6.5%for Fe-C-Mn-Si-X(X=Cr,Ni)steels.

关键词： Martensitic transformation Thermodynamics Dilatational strain energy Linear expansion coefficient Fe-C-X(X=Ni,Mn,Si,Cr)system

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Endometriosis coexisting with dermoid cyst in a single ovary： a case report

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Chinese Medical Journal 2011年第4期124卷 627-630页

作者： chen Tsai-chuan kuo Hsu-tung SHYU Shin-kuo CHU Chih-ping CHANG Tien-chang Department of Obstetrics and Gynecology Lin-Shin Medical Corporation Lin-Shin Hospital Department of Family Medicine Lin-Shin Medical Corporation Lin-Shin Hospital Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 408 TaiwanChina Department of Anatomical Pathology Lin-Shin Medical Corporation Lin-Shin Hospital Chang Tien-chang General Clinic Taichung 408 TaiwanChina

Endometriosis coexisting with a dermoid cyst of the ovary is extraordinarily rare, although these both benign conditions are said to be common in women in the reproductive age group. There are only two previous case reports, which is evident from our literature review from January 1960 through January 2010. Acute abdomen is one of the greatest diagnostic challenges and easily ignored by the clinicians to exclude the possibility of gynecologic illness. A 35-year-old woman was referred by the doctor in Family clinic. She experienced a three-day period of severe right lower abdominal pain and intermittent vomiting. Ultrasonography identified a bilocular, cystic, hypoechoic, and hyperechoic tumor, 7 cm×6 cm×6 cm in the right adnexal region. Laparoscopic cystectomy was performed under the impression of ovarian cyst with torsion or hemorrhage. The frozen section was benign and appendiceal status was adequate. Histopathologic examination described an ovarian cyst composed of endometrial-type lining with stroma cells （endometriosis） and benign terotoma tissue with plenty of skin appendages and sebaceous glands. We report this unusual and interesting ovarian mass to remind physicians that the usage of the Endobag after cystectomy, the benefits on minimizing operative time, spilled opportunity, and postoperative complications. Laparoscopic techniques for large ovarian masses might be considered. The experience of the surgeon is also very important to prevent misdiagnosis or complication. Further follow up is mandatory for this simultaneous finding of ovarian endometriosis with coincidental dermoid cyst as a separate pathology in single ovary of such a nature. It also presents a challenge to the clinicians and to the pathologists.

关键词： endometriosis dermoid cyst cystectomy endobag

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Characterization and application of Cu based superhydrophobic catalyst

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Progress in Natural Science:Materials International 2019年第4期29卷 371-378页

作者： Ramasamy Anbarasan Shanmugam Palanikumar Ayyadurai Anitha Devi Ping-Hei chen kuo Lun tung Department of Polymer Technology Kamaraj College of Engineering and Technology Department of Chemical Engineering National Taiwan University Department of Mechanical Engineering MEMS Thermal Control Lab National Taiwan University

Superhydrophobic（SH） Copper salt was prepared with the help of three different chemical etching agents and characterized by various analytical techniques like Fourier transform infrared（FTIR） spectroscopy,UV-visible spectroscopy,X-ray diffractogram（XRD）,X-ray photoelectron spectroscopy（XPS）,high resolution transmission electron microscopy（HRTEM） and scanning electron microscopy（SEM）.The SH nature of the material was confirmed by water contact angle（WCA） *** surface with the etching agent was made to produce SH Cu *** the chemical etching agents the system with Cl,F and Si exhibited the SH *** SH hierarchically structured heterogeneous materials produced were used as a catalyst for the reduction of Cr（Ⅵ） and 4-nitrophenol（NiP）.The catalytic activities of the materials were compared on the apparent rate constant(k;) and induction time（T;）.Among the catalyst systems used,the Cu-Trichoropentaflourooctylsilane（TCPFOSi） system exhibited the highest k;and T;values.

关键词： Superhydrophobicity Cu salts Characterization Catalytic reduction Water contact angle

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超声引导下腹股沟韧带上髂筋膜间隙阻滞在老年髋部骨折患者围术期镇痛中的应用研究

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老年医学与保健 2024年第3期30卷 846-852页

作者：谢娟王敏夏阔徐威陈亚萍复旦大学附属金山医院麻醉科上海201508 复旦大学附属金山医院骨科上海201508

目的髋部骨折患者围术期易出现剧烈疼痛,既往很多研究主要关注患者术后镇痛,而很少有人探究老年髋部骨折患者在术前使用髂筋膜间隙阻滞技术的镇痛效果。本研究拟分析超声引导下腹股沟韧带上髂筋膜间隙阻滞在老年髋部骨折患者围术期镇痛... 详细信息

目的髋部骨折患者围术期易出现剧烈疼痛,既往很多研究主要关注患者术后镇痛,而很少有人探究老年髋部骨折患者在术前使用髂筋膜间隙阻滞技术的镇痛效果。本研究拟分析超声引导下腹股沟韧带上髂筋膜间隙阻滞在老年髋部骨折患者围术期镇痛中的应用价值。方法选取2023年1月—2023年12月于复旦大学附属金山医院骨科就诊的老年髋部骨折患者80例,按照随机数字表法将其分为观察组(n=40)和对照组(n=40)。观察组采用超声引导下腹股沟韧带上髂筋膜间隙阻滞(suprainguinal fascia iliaca compartment block,S-FICB),对照组采用静脉注射帕瑞昔布钠常规镇痛。2组均进行术前镇痛。记录患者实施镇痛前即刻(T0)、镇痛后30 min(T1)和2 h(T2)、12 h(T3)、24 h(T4)、48 h(T5)的疼痛评分(VAS评分)、Ramsay镇静评分、平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO_(2))。比较2组追加静脉注射帕瑞昔布钠的例数。比较2组恶心呕吐、嗜睡、尿潴留、低血压等不良反应的发生例数及术前满意度、住院时间的情况。结果2组VAS评分除T0时间点外,其余时间点对照组VAS评分较观察组高(P0.05)。在行镇痛治疗后,观察组较对照组追加帕瑞昔布钠例数少(P0.05)。结论超声引导下腹股沟韧带上髂筋膜间隙阻滞(S-FICB)在老年髋部骨折患者的围术期镇痛效果显著,能够有效缓解术前疼痛,减少全身止痛药物的用量,降低恶心呕吐发生率,提高患者术前满意度。

关键词：老年髋部骨折腹股沟韧带上髂筋膜间隙阻滞超声引导

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FLASH放疗技术对正常组织保护效应和肿瘤治疗效果的研究进展

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国际放射医学核医学杂志 2024年第1期48卷 52-59页

作者：陈欢郇福奎门阔戴建荣任雯廷国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院放疗科北京100021

超高剂量率(FLASH)放疗是一种新型的放疗技术,其已成为近6年放疗领域备受关注的新兴革命性技术之一。FLASH放疗具有很好的正常组织保护效应且不影响肿瘤的放疗效果。同时,FLASH放疗的射线曝光时间极短,可消除器官或肿瘤运动对治疗精确... 详细信息

超高剂量率(FLASH)放疗是一种新型的放疗技术,其已成为近6年放疗领域备受关注的新兴革命性技术之一。FLASH放疗具有很好的正常组织保护效应且不影响肿瘤的放疗效果。同时,FLASH放疗的射线曝光时间极短,可消除器官或肿瘤运动对治疗精确度的影响,提升治疗的精准度和患者的舒适度,有可能彻底改变恶性肿瘤治疗的现状。目前,FLASH放疗对正常组织保护效应的内在机制尚不清楚。笔者从正常组织保护效应和肿瘤治疗效果两个方面归纳总结FLASH放疗的研究进展,概括了FLASH放疗对正常组织保护效应的可能的生物学机制,为FLASH放疗的进一步研究提供参考。

关键词：放射疗法超高剂量率正常组织肿瘤治疗

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