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Does size matter for resection of giant versus non-giant hepatocellular carcinoma?A meta-analysis

World Journal of Gastrointestinal Surgery 2023年第2期15卷 273-286页

作者： Aaron JL Lee Andrew GR Wu kuo chao yew Vishal G Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Hepato-Pancreatico-Biliary Surgery Tan Tok Seng HospitalSingapore 308433Singapore

BACKGROUND Research on long-term survival after resection of giant(≥10 cm)and non-giant hepatocellular carcinoma(HCC)(<10 cm)has produced conflicting *** This study aimed to investigate whether oncological outcomes and safety profiles of resection differ between giant and non-giant *** PubMed,MEDLINE,EMBASE,and Cochrane databases were *** designed to investigate the outcomes of giant vs non-giant HCC were *** primary endpoints were overall survival(OS)and disease-free survival(DFS).The secondary endpoints were postoperative complications and mortality *** studies were assessed for bias using the Newcastle–Ottawa *** 24 retrospective cohort studies involving 23747 patients(giant=3326;non-giant=20421)who underwent HCC resection were *** was reported in 24 studies,DFS in 17 studies,30-d mortality rate in 18 studies,postoperative complications in 15 studies,and post-hepatectomy liver failure(PHLF)in six *** HR was significantly lower for non-giant HCC in both OS(HR 0.53,95%CI:0.50-0.55,P<0.001)and DFS(HR 0.62,95%CI:0.58-0.84,P<0.001).No significant difference was found for 30-d mortality rate(OR 0.73,95%CI:0.50-1.08,P=0.116),postoperative complications(OR 0.81,95%CI:0.62-1.06,P=0.140),and PHLF(OR 0.81,95%CI:0.62-1.06,P=0.140).CONCLUSION Resection of giant HCC is associated with poorer long-term *** safety profile of resection was similar in both groups;however,this may have been confounded by reporting *** staging systems should account for the size differences.

关键词： Hepatectomy Giant hepatocellular carcinoma Resection Meta-analysis

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Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella(MMAF)and ICSI outcomes

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Asian Journal of Andrology 2024年第1期26卷 91-98页

作者： Zhong-Mei Shao Yu-Tong Zhu Meng Gu Sen-chao Guo Hui Yu kuo-kuo Li Dong-Dong Tang Yu-Ping Xu Ming-Rong Lv Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Obstetrics and Gynecology Fuyang Hospital of Anhui Medical UniversityFuyang 236112China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People'sRepublicof ChinaHefei 230032China

Variations in the dynein axonemal heavy chain gene,dynein axonemal heavy chain 6(DNAH6),lead to multiple morphological abnormalities of the *** studies have reported that these deficiencies may result in sperm head ***,whether DNAH6 is also involved in human acrosome biogenesis remains *** purpose of this study was to investigate DNAH6 gene variants and their potential functions in the formation of defective sperm heads and ***-exome sequencing was performed on a cohort of 375 patients with asthenoteratozoospermia from the First Affiliated Hospital of Anhui Medical University(Hefei,China).Hematoxylin and eosin staining,scanning electron microscopy,and transmission electron microscopy were performed to analyze the sperm morphology and *** staining and Western blot analysis were conducted to examine the effects of genetic *** identified three novel deleterious variants in DNAH6 among three unrelated *** absence of inner dynein arms and radial spokes was observed in the sperm of patients with DNAH6 ***,deficiencies in the acrosome,abnormal chromatin compaction,and vacuole-containing sperm heads were observed in these patients with DNAH6 *** decreased levels of the component proteins in these defective structures were further confirmed in sperm from patients with DNAH6 variants using Western *** intracytoplasmic sperm injection(ICSl)treatment,the partner of one patient with a DNAH6 variant achieved successful ***,novel variants in DNAH6 genes that contribute to defects in the sperm head and flagella were identified,and the findings indicated Icsl as an effective clinical treatment for such patients.

关键词： asthenoteratospermia DNAH6 intracytoplasmic sperm injection male infertility

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Benchmark experiment on slab^(238)U with D-T neutrons for validation of evaluated nuclear data

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Nuclear Science and Techniques 2024年第2期35卷 145-159页

作者： Yan-Yan Ding Yang-Bo Nie Yue Zhang Zhi-Jie Hu Qi Zhao Huan-Yu Zhang kuo-Zhi Xu Shi-Yu Zhang Xin-Yi Pan Chang-Lin Lan Jie Ren Xi-chao Ruan Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 62100China

A benchmark experiment on^(238)U slab samples was conducted using a deuterium-tritium neutron source at the China Institute of Atomic *** leakage neutron spectra within energy levels of 0.8-16 MeV at 60°and 120°were measured using the time-of-flight *** samples were prepared as rectangular slabs with a 30 cm square base and thicknesses of 3,6,and 9 *** leakage neutron spectra were also calculated using the MCNP-4C program based on the latest evaluated files of^(238)U evaluated neutron data from CENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5.0,and *** on the comparison,the deficiencies and improvements in^(238)U evaluated nuclear data were *** results showed the following.(1)The calculated results for CENDL-3.2 significantly overestimated the measurements in the energy interval of elastic scattering at 60°and 120°.(2)The calculated results of CENDL-3.2 overestimated the measurements in the energy interval of inelastic scattering at 120°.(3)The calculated results for CENDL-3.2 significantly overestimated the measurements in the 3-8.5 MeV energy interval at 60°and 120°.(4)The calculated results with JENDL-5.0 were generally consistent with the measurement results.

关键词： Leakage neutron spectra Uranium D-T neutron source Evaluated nuclear data

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Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： kuo-SHYANG JENG PO-YU CHENG YUEH-HSIEN LIN PO-CHUN LIU PING-HUI TSENG YU-chao WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

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超低温内喷式数控铣床开放式数控系统开发

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工具技术 2024年第5期58卷 123-126页

作者：朱俊澄刘阔张超王永青大连理工大学机械工程学院辽宁省大连市116024

传统数控加工系统难以满足超低温灵活加工的试验需求,通过研发开放式数控系统以兼容更加多样的加工条件。基于“工业计算机(IPC)+PMAC”架构开发了超低温内喷铣床的开放式数控系统,并在数控系统中开发了G代码运动控制功能,实现了液氮调... 详细信息

传统数控加工系统难以满足超低温灵活加工的试验需求,通过研发开放式数控系统以兼容更加多样的加工条件。基于“工业计算机(IPC)+PMAC”架构开发了超低温内喷铣床的开放式数控系统,并在数控系统中开发了G代码运动控制功能,实现了液氮调控功能。在机床上进行的运动精度测试结果表明,开发的开放式数控系统及相关功能满足超低温加工需求。

关键词：超低温加工 PMAC 开放式数控系统运动控制

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GH4169合金叶片本体取样的性能对比研究

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汽轮机技术 2024年第3期66卷 236-240页

作者：董自超于连超刘明坤胡鹏张开阔中国航发沈阳发动机研究所沈阳110015

某型航空发动机用GH4169合金叶片在试验过程中发生了叶身弯曲变形故障,为了解叶片本体的材料性能,在故障叶片榫头处取样后进行组织成分分析和布氏硬度、室温拉伸、650℃高温拉伸以及持久寿命的测试,并与同批次锻件取样的性能数据进行对... 详细信息

某型航空发动机用GH4169合金叶片在试验过程中发生了叶身弯曲变形故障,为了解叶片本体的材料性能,在故障叶片榫头处取样后进行组织成分分析和布氏硬度、室温拉伸、650℃高温拉伸以及持久寿命的测试,并与同批次锻件取样的性能数据进行对比。试验结果表明,故障叶片本体的成分和组织无明显异常;榫头处的布氏硬度与锻件取样测试结果相差不大;与锻件采用标准试棒测试结果相比,榫头处取出的小尺寸工字形试样的室温拉伸和高温拉伸的抗拉强度分别下降约4%和8%,持久寿命则大幅降低,下降约64%,但仍略高于设计要求,初步排除了叶片异常变形的材料原因;取自不同故障叶片试样的拉伸和持久性能相差不大,批次叶片本体性能稳定。从叶片本体取出试样获得的基础数据为叶片变形故障分析提供了试验数据支撑,试验方法也可推广应用于相关的对比测试研究。

关键词：航空发动机 GH4169合金叶片本体取样材料性能

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Tunable dispersion relations manipulated by strain in skyrmion-based magnonic crystals

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Chinese Physics B 2024年第1期33卷 692-696页

作者：金兆年何宣霖于超方贺男陈琳陶志阔 Bell Honors School Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering&College of Flexible Electronics Nanjing University of Posts and TelecommunicationsNanjing 210003China

We theoretically investigate the propagation characteristics of spin waves in skyrmion-based magnonic crystals. It is found that the dispersion relation can be manipulated by strains through magneto-elastic coupling. Especially, the allowed bands and forbidden bands in dispersion relations shift to higher frequency with strain changing from compressive to tensile,while shifting to lower frequency with strain changing from tensile to compressive. We also confirm that the spin wave with specific frequency can pass the magnonic crystal or be blocked by tuning the strains. The result provides an advanced platform for studying the tunable skyrmion-based spin wave devices.

关键词： skyrmion magnonic crystal spin wave dispersion relation

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试论新出曾国铜器与《诗经·召南》问题

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浙江大学学报（人文社会科学版） 2024年第3期54卷 150-159页

作者：吴超浙江大学文学院浙江杭州310058 浙江大学数字出版研究中心浙江杭州310028

叶家山西周早期曾国墓地的发现具有十分重要的学术价值。其中,M111出土铸铭“南公”和“太保”等铜器,且其墓所出曾侯器中有铸铭“父乙”日名的现象,为深入探讨曾国与周王室、南宫氏家族与召公家族等的关系提供了新的证据。再结合相关... 详细信息

叶家山西周早期曾国墓地的发现具有十分重要的学术价值。其中,M111出土铸铭“南公”和“太保”等铜器,且其墓所出曾侯器中有铸铭“父乙”日名的现象,为深入探讨曾国与周王室、南宫氏家族与召公家族等的关系提供了新的证据。再结合相关出土文献材料,发现曾国与召公家族存在使用日名、与“南国”关系密切、出土大量族氏铭文铜器等诸多相似之处。由此可对《诗经·召南》相关问题进行探讨,明确《甘棠》中的“召伯”为“召公奭”,“召南”之“南”为“南土”,即“南方诸国”。这为进一步探讨曾国与召公关系以及叶家山出土铜器族氏铭文的来源问题提供了新的思路,也为全面探讨曾国历史提供了新的路径。

关键词：曾国铜器新出文献南公召公《诗经·召南》

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Effect of calcium content on inclusions during the ladle furnace refining process of AISI 321 stainless steel

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International Journal of Minerals,Metallurgy and Materials 2020年第11期27卷 1499-1507页

作者： chao Pan Xiao-jun Hu Jian-chao Zheng Ping Lin kuo-chih Chou State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgy Northeastern UniversityShenyang 110819China Ruipu Technology Group Co. Ltd.Qingtian 323903China

The effect of three heat processes with different calcium contents on the evolution of inclusions during the ladle furnace refining process of AISI 321 stainless steel was *** size,morphology,and composition of the inclusions were analyzed by scanning electron microscopy and energy-dispersive X-ray *** the addition of aluminum and titanium,the primary oxide in the AISI 321 stainless steel was an AbOs—MgO—TiOx complex oxide,in which the mass ratio of AbOs/MgO was highly consistent with spinel(MgO・AbO3).After calcium treatment,the calcium content in the oxide increased *** calculations show that when the Ti content was 0.2wt%,the Al and Ca contents were less than 0.10wt%and 0.0005wt%,respectively,which was beneficial for the formation of liquid inclusions in molten ***,the modification mechanism of calcium on TiN-wrapped oxides in combination with temperature changes was discussed.

关键词： inclusions stainless steel calcium treatment thermodynamic calculation

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一种同相供电装置功率模块的结构设计

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新技术新工艺 2024年第1期433卷 40-44页

作者：王阔孙健翟超祁招河南许继电力电子有限公司河南许昌461000

针对市场上现有同相供电功率模块体积大、能量密度小、散热效果差、维护不方便等缺点,介绍了一种新型同相供电装置功率模块的总体结构设计思路,阐述了该功率模块结构设计的具体细节,对模块散热器进行了流阻和散热有限元分析,对功率模块... 详细信息

针对市场上现有同相供电功率模块体积大、能量密度小、散热效果差、维护不方便等缺点,介绍了一种新型同相供电装置功率模块的总体结构设计思路,阐述了该功率模块结构设计的具体细节,对模块散热器进行了流阻和散热有限元分析,对功率模块的装配工艺进行了描述,为同相供电功率模块的优化设计提供了新思路。

关键词：电气化铁路贯通式同相供电功率模块结构设计

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