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A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms

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Journal of Materials Science & Technology 2024年第2期169卷 209-219页

作者： Haixin Zhang Yi Zou kunyan lu Yan Wu Yuancheng Lin Jingjing Cheng Chunxia Liu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China

Bacterial biofilms,especially those caused by multidrug-resistant bacteria,have emerged as one of the greatest dangers to global public health.The acceleration of antimicrobial resistance to conventional an-tibiotics and the severe lack of new drugs necessitates the development of novel agents for biofilm eradication.Photodynamic therapy(PDT)is a promising non-antibiotic method for treating bacterial infections.However,its application in biofilm eradication is hampered by the hypoxic microenvironment of biofilms and the physical protection of extracellular polymeric substances.In this study,we develop a composite nanoplatform with oxygen(O_(2))self-supplying and heat-sensitizing capabilities to improve the PDT efficacy against biofilms.CaO_(2)/ICG@PDA nanoparticles(CIP NPs)are fabricated by combining calcium peroxide(CaO_(2))with the photosensitizer indocyanine green(ICG)via electrostatic interactions,followed by coating with polydopamine(PDA).The CIP NPs can gradually generate O_(2)in response to the acidic microenvironment of the biofilm,thereby alleviating its hypoxic state.Under near-infrared(NIR)irradiation,the nanoplatform converts O_(2)into a significant amount of singlet oxygen(^(1)O_(2))and heat to eradicate biofilm.The generated heat enhances the release of O_(2),accelerates the generation of^(1)O_(2)in PDT,increases cell membrane permeability,and increases bacterial sensitivity to^(1)O_(2).This nanoplatform significantly improves the efficacy of PDT in eradicating biofilm-dwelling bacteria without fostering drug resistance.Experiments on biofilm eradication demonstrate that this nanoplatform can eradicate over 99.9999%of methicillin-resistant Staphylococcus aureus(MRSA)biofilms under 5-min NIR irradiation.Notably,these integrated advantages enable the system to promote the healing of MRSA biofilm-infected wounds with negligible toxicity in vivo,indicating great promise for overcoming the obstacles associated with bacterial biofilm eradication.

关键词： Bacterial biofilm Multidrug-resistant bacteria Photodynamic therapy Oxygen supplying Photothermal therapy

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Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction

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Journal of Materials Science & Technology 2023年第36期167卷 50-58页

作者： Yuanyuan Wang Jingjing Wang Chunxia Liu Jingjing Li kunyan lu Qian Yu Yanxia Zhang Zhenya Shen Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction(MI).In this work,an in-jectable composite hydrogel integrating natural biomaterials,exosomes,and bioactive molecules is de-veloped to prevent or alleviate cardiac fibrosis.Curcumin,a natural molecule with antifibrotic activity,is encapsulated in the exosomes that are isolated from bone marrow-derived mesenchymal stem cells to enhance its water solubility and bioavailability.These composite exosomes are efficiently internalised by fibroblasts and effectively inhibit their transition to myofibroblasts in vitro.Decellularized porcine cardiac extracellular matrix(dECM)hydrogel is used as the carrier for delivering these composite exosomes to the infarcted myocardium,not only improving the retention of exosomes but also providing mechani-cal support and structural protection.Injection of this hydrogel into the infarcted heart of a mouse MI model leads to a decrease in collagen deposition,alleviation of fibrosis,a reduction in infarct size,and an improvement in cardiac function.The reported composite hydrogel comprising natural materials and biomolecules exhibits good biocompatibility and bioactivity.Altogether,this study demonstrates that the dECM hydrogel is a suitable platform for the local delivery of antifibrotic biomolecule-encapsulating exo-somes to prevent myocardial fibrosis after MI and have great potential for the treatment of MI in clinical settings.

关键词： Myocardial fibrosis Myocardial infarction Decellularized extracellular matrix Exosomes Curcumin

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Photothermal scaffolds/surfaces for regulation of cell behaviors

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Bioactive Materials 2022年第2期7卷 449-477页

作者： Yangcui Qu kunyan lu Yanjun Zheng Chaobo Huang Guannan Wang Yanxia Zhang Qian Yu College of Biomedical Engineering&the Key Laboratory for Medical Functional Nanomaterials Jining Medical UniversityJining272067PR China Joint Laboratory of Advanced Biomedical Materials(NFU-UGent) College of Chemical EngineeringNanjing Forestry UniversityNanjing210037PR China Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Soochow UniversitySuzhou215006PR China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123PR China

Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue engineering.During the past decades,diverse methods have been developed to regulate cell behaviors such as applying external stimuli,delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells adhere.Photothermal scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength(usually in near infrared region)and convert light energy to heat;the generated heat shows great potential for regulation of cell behaviors in different ways.In the current review,we summarize the recent research progress,especially over the past decade,of using photothermal scaffolds/surfaces to regulate cell behaviors,which could be further categorized into three types:(i)killing the tumor cells via hyperthermia or thermal ablation,(ii)engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes,and(iii)releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to heat.In the end,challenges and perspectives in these areas are commented.

关键词： Photothermal scaffolds Photothermal surfaces Tumor ablation Intracellular delivery Cell detachment

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Superhydrophobic photothermal coatings based on candle soot for prevention of bioﬁlm formation

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Journal of Materials Science & Technology 2023年第1期132卷 18-26页

作者： Yuancheng Lin Haixin Zhang Yi Zou kunyan lu luohuizi Li Yan Wu Jingjing Cheng Yanxia Zhang Hong Chen Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China

Bacterial biofilms formed on the material surfaces have posed a series of serious problems for human health and industries.The treatment of mature biofilms is particularly difficult because they are inher-ently highly resistant against antibiotics and other adverse factors.The prevention is strategically advan-tageous over the treatment,and thus the development of innovative surfaces with capability to inhibit biofilm formation is highly demanded.In this work,we developed a superhydrophobic photothermal coating for prevention of biofilm formation,which was based on candle soot with hierarchical structure and excellent light-to-heat conversion ability.This coating was fabricated by deposition of a candle soot layer on the substrate,followed by sequential chemical vapor deposition of tetraethoxysilane and immo-bilization of fluorinated silane to make the coating robust and superhydrophobic.The resulted coating could repel a majority of bacteria from the surface at the early stage,and then eradicate a small number of bacteria remained on the surface under a short-term irradiation of near-infrared laser.The combi-nation of anti-adhesive property and photothermal bactericidal property endowed the coating with good antibiofilm property to prevent biofilm formation for at least 2 weeks.This coating is facile for deposition on various substrates with good storage stability,showing great potential for diverse practical applications to solve the biofilm-associated problems of materials and devices.

关键词： Antibiofilm Candle soot Superhydrophobic surface Anti-adhesive Photothermal surface

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An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment

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Journal of Materials Science & Technology 2023年第12期143卷 198-206页

作者： Chunxia Liu Yong Wu Hong Yang kunyan lu Haixin Zhang Yuanyuan Wang Jingjing Wang Linan Ruan Zhenya Shen Qian Yu Yanxia Zhang Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function Soochow UniversitySuzhou 215123China

Myocardial infarction(MI)is one of the typical cardiovascular diseases,which persist as the leading cause of death globally.Due to the poor regenerative capability of endogenous cardiomyocytes(CMs),the transplantation of exogenous CMs becomes a promising option for MI treatment.However,the low retention and survival of transplanted cells still limit the clinical translation of cell therapy.Herein,an alginate/fibrin-based injectable hydrogel was prepared for the delivery of neonatal CMs and an angiogen-esis agent vascular endothelial growth factor(VEGF)locally to the infarcted area of the heart.This hydro-gel combined the specific advantages of alginate and fibrin with proper mechanical properties and cell affinity,showing good biocompatibility to support the retention and integration of the transplanted CMs to the host myocardium.Moreover,the delivered VEGF was favorable for the blood recovery to mitigate the ischemic microenvironment of the infarcted area and thus improved the survival of the transplanted CMs.Intramyocardial injection of this hydrogel to the infarcted area of the heart promoted angiogenesis,inhibited fibrosis,and improved cardiac function,exhibiting great potential for MI treatment.

关键词： Injectable hydrogel Alginate Fibrin Cardiomyocytes VEGF Myocardial infarction

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Dual-functional bacterial cellulose modified with phase-transitioned proteins and gold nanorods combining antifouling and photothermal bactericidal properties

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Journal of Materials Science & Technology 2022年第15期110卷 14-23页

作者： luohuizi Li Guize Li Yong Wu Yuancheng Lin Yangcui Qu Yan Wu kunyan lu Yi Zou Hong Chen Qian Yu Yanxia Zhang State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China College of Biomedical Engineering&the Key Laboratory for Medical Functional Nanomaterials Jining Medical UniversityJining 272067China

Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dualfunctional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradiation of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated processes and toxic organic solvents.Moreover,because all the components were biocompatible,the resulting membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.

关键词： Bacterial cellulose Gold nanorods Phase-transitioned proteins Antifouling Antibacterial Photothermal therapy

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Bacterial cellulose-based dressings with photothermal bactericidal activity and pro-angiogenic ability for infected wound healing

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Journal of Materials Science & Technology 2023年第29期160卷 76-85页

作者： Yan Wu Dongxu Jia kunyan lu Haixin Zhang Chunxia Liu Yuancheng Lin Jingjing Cheng Yi Zou Hu Xu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215000China

For most traditional wound dressings,it is challenging to simultaneously eliminate bacteria and promote angiogenesis to accelerate the healing process of bacteria-infected wounds.In this work,we develop a multifunctional dressing based on bacterial cellulose(BC)deposited with a tannic acid/Cu^(2+)ion/Mg^(2+)ion(TCM)complex film.Overall,the TCM complex exhibits robust interfacial adhesion to modify BC and good photothermal properties to effectively eradicate bacteria in the wound area under near-infrared(NIR)irradiation.The individual components of the TCM complex have several advantageous features for wound healing,such as antibacterial ability and negligible cytotoxicity;in particular,the released Cu^(2+)and Mg^(2+)ions are favorable for the proliferation,migration,and tube formation of endothelial cells in vitro.The results of in vivo experiments demonstrated that with the assistance of NIR irradiation,this composite dressing is more effective than traditional gauze or pristine BC dressing in promotion of angiogenesis and collagen deposition without causing remarkable inflammation,thereby accelerating the healing process of bacteria-infected full-thickness skin wounds.This work thus provides a simple and facile way to fabricate multifunctional BC-based dressings that could be potentially used for treating infected wounds.

关键词： Bacterial cellulose Metal-phenolic network Photothermal therapy Antibacterial Angiogenesis Wound dressing

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Biomaterials based cardiac patches for the treatment of myocardial infarction

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Journal of Materials Science & Technology 2021年第35期94卷 77-89页

作者： Tianqi Chang Chunxia Liu kunyan lu Yong Wu Mingzhu Xu Qian Yu Zhenya Shen Tingbo Jiang Yanxia Zhang Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Soochow University.Suzhou 215006China Department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Myocardial infarction(MI)is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium,resulting in a lifethreatening condition.To repair the damaged myocardium in MI,researchers are looking forwards to new ways to postpone the progression of myocardial injury.Cardiac patches,the scaffolds layered on the heart surface,can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells,showing considerable curative effect in the treatment of MI.Biomaterials with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac patches.In this review,we focus on the recent progress on these biomaterialsbased cardiac patches,which could be categorized into two types according to the sources of materials including(ⅰ)natural materials and(ⅱ)synthetic materials.The major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented.

关键词： Biomaterials Cardiac patches Myocardial infarction

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埃克替尼联合恩度对EGFR突变阳性肺腺癌患者疗效及预后的影响

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中南医学科学杂志 2024年第3期52卷 449-452页

作者：卢春霞邢燕飞崔宝生陈坤燕启东市人民医院启东肝癌防治研究所南通大学附属启东医院呼吸与危重症医学科江苏南通226200 启东市人民医院启东肝癌防治研究所南通大学附属启东医院肿瘤内科江苏南通226200 启东市人民医院启东肝癌防治研究所南通大学附属启东医院胸外科江苏南通226200

目的观察埃克替尼联合恩度对表皮生长因子受体(EGFR)突变阳性肺腺癌患者的临床效果及预后的影响。方法回顾性选取124例晚期EGFR突变阳性肺腺癌患者为研究对象,根据治疗方案分为埃克替尼组(单用埃克替尼)及恩度联合组(埃克替尼联合恩度)... 详细信息

目的观察埃克替尼联合恩度对表皮生长因子受体(EGFR)突变阳性肺腺癌患者的临床效果及预后的影响。方法回顾性选取124例晚期EGFR突变阳性肺腺癌患者为研究对象,根据治疗方案分为埃克替尼组(单用埃克替尼)及恩度联合组(埃克替尼联合恩度)。比较两组患者治疗前和治疗4周期时肿瘤标记物和免疫功能指标水平;比较两组近期疗效;观察两组治疗期间不良反应发生情况;采用Kaplan-Meier法比较两组患者远期疗效无进展生存时间(PFS)及总生存时间(OS)生存曲线。结果治疗4周期时,两组患者肿瘤指标及CD8^(+)水平均较治疗前明显降低(P0.05)。结论埃克替尼联合恩度的二线治疗方案有助于提高EGFR突变阳性肺腺癌患者的总生存期,且安全性良好。

关键词： EGFR突变肺腺癌埃克替尼恩度肿瘤标记物

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Size-self-adaptive recognition method of vehicle manufacturer logos based on feature extraction and SVM classifier

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Frontiers of Electrical and Electronic Engineering in China 2010年第1期5卷 77-84页

作者： Wenting lu Honggang ZHANG kunyan LAN Jun GUO Pattern Recognition and Intelligent System Laboratory Beijing University of Posts and TelecommunicationsBeijing 100876China

Besides their decorative purposes,vehicle manufacturer logos can provide rich information for vehicle verification and classification in many applications such as security and information retrieval.However,unlike the license plate,which is designed for identification purposes,vehicle manufacturer logos are mainly designed for decorative purposes such that they might lack discriminative features themselves.Moreover,in practical applications,the vehicle manufacturer logos captured by a fixed camera vary in size.For these reasons,detection and recognition of vehicle manufacturer logos are very challenging but crucial problems to tackle.In this paper,based on preparatory works on logo localization and image segmentation,we propose a size-self-adaptive method to recognize vehicle manufacturer logos based on feature extraction and support vector machine(SVM)classifier.The experimental results demonstrate that the proposed method is more effective and robust in dealing with the recognition problem of vehicle logos in different sizes.Moreover,it has a good performance both in preciseness and speed.

关键词： vehicle manufacturer logo recognition feature extraction support vector machine(SVM) size-selfadaptive

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