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Science China(Information Sciences) 2023年第8期66卷 254-262页

作者： Haochen ZHANG Yue SUN kunpeng hu Lei YANG Kun LIANG Zhanyong XING hu WANG Mingshuo ZHANG huabin YU Shi FANG Yang KANG Haiding SUN School of Microelectronics University of Science and Technology of China

Wide bandgap GaN-based HEMTs have shown great potential as key components in various power electronic systems but still face challenges in the pursuit of devices with stable operation capability especially in harsh environments. Here, we report a high-performance double heterojunction(DH) based Al Ga N/Ga N HEMT by incorporating a decreasing-Al-composition(DAC) graded Al Ga N back barrier(BB)beneath the Ga N channel. Thanks to the improved electron confinement enabled by graded BB, the DHHEMT exhibits significantly improved on-state drain current density and off-state breakdown voltage compared with a single heterojunction(SH) based HEMT. More intriguingly, with an additional Si Nx passivation layer, the surface states of the DH-HEMTs can be effectively suppressed, leading to an almost constant offstate leakage current and negligible gate contact degradation across the temperature range from 25℃ to 150℃. These results highlight the superiority and reliability of the proposed graded AlGaN BB to boost device characteristics for applications under high temperatures and harsh conditions.

关键词： AlGaN/GaN HEMT graded AlGaN back barrier SiN$_x$ passivation DHHEMT high temperature stability

The expression status of ZIC2 is an independent prognostic marker of hepatocellular carcinoma

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Liver Research 2020年第1期4卷 40-46页

作者： Qinglei Kong Wenchao Li Pan hu hua Zeng Yuhang Pan Taicheng Zhou kunpeng hu Emergency Department The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina General Surgery Department The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Breast Cancer Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Pathology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouChina

Background:Zinc finger protein of cerebellum 2(ZIC2)is a transcriptional activator or repressor that is important for the organogenesis of the central nervous *** studies have reported that ZIC2 is widely upregulated in a variety of ***:Oncomine database was used to evaluate the expression levels of ZIC2 in hepatocellular car-cinoma(HCC)and normal liver *** real-time polymerase chain reaction and immu-nohistochemistry were conducted to validate the results from the *** regression analysis and survival curves were performed to assess the survival effect of ZIC2 in ***:Increased expression of ZIC2 was detected in HCC tissues compared with normal liver *** addition,patients with high ZIC2 levels had a poor *** analysis showed that clinical stage(T or M classification)and ZIC2 levels were independent prognostic factors for overall ***,a subgroup analysis revealed that patients with moderate or poor grade tumors,T1e2 tumors,N0 tumors,early American Joint Committee on Cancer(AJCC)stage,and old age were more likely to present with overexpression of *** conclude,ZIC2 is upregulated in HCC and associated with the histology and survival of HCC patients.

关键词： Zinc finger protein of cerebellum 2(ZIC2) Prognosis Hepatocellular carcinoma(HCC) Liver Biomarker

CR假体与PS假体治疗膝骨性关节炎的效果比较

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实用医学杂志 2024年第9期40卷 1251-1256页

作者：王上增张北王禛马尚阮张德阳殷志颖朱云麒胡昆鹏程韶河南省中医院(河南中医药大学第二附属医院)关节科郑州450002 河南中医药大学郑州450046

目的比较CR假体与PS假体在人工膝关节置换术后应用效果。方法随机选取2021年6月至2022年6月在我科收治且符合选择标准的膝骨性关节炎患者64例,随机分为观察组和对照组(n=32)。观察组使用CR假体实施TKA,对照组使用PS假体实施TKA。记录两... 详细信息

目的比较CR假体与PS假体在人工膝关节置换术后应用效果。方法随机选取2021年6月至2022年6月在我科收治且符合选择标准的膝骨性关节炎患者64例,随机分为观察组和对照组(n=32)。观察组使用CR假体实施TKA,对照组使用PS假体实施TKA。记录两组患者的手术时间、术后引流量、手术前后HGB差值、术后住院时间,术后7 d、14 d、45 d、3个月、1年膝关节ROM、VAS评分、HSS评分、膝关节最大前后向位移,并定期复查X线片。结果两组患者在手术时间、术后住院时间、VAS评分、膝关节最大前后向位移方面相当;和对照组相比,观察组术后引流量明显更少,差异有统计学意义(P<0.05);和对照组相比,观察组在HGB差值上明显更低,差异有统计学意义(P<0.05);手术之前两组患者ROM、HSS评分无明显差异,和观察组比较,术后7 d、14 d、45 d时对照组ROM以及HSS评分更高,差异有统计学意义(P<0.05),术后3个月时,两组ROM、HSS评分相当,术后6个月、1年时观察组的ROM、HSS评分明显更高,差异有统计学意义(P<0.05)。结论CR假体在手术失血量和术后引流量方面优于PS假体,可以降低手术风险,两种假体在术后均可获得良好的膝关节稳定性,而PS假体早期临床效果较好,CR假体长期临床效果更优。

关键词：膝关节膝骨性关节炎全膝关节表面置换术 PS假体 CR假体

Dynactin 2 acts as an oncogene in hepatocellular carcinoma through promoting cell cycle progression

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Liver Research 2022年第3期6卷 155-166页

作者： Wenchao Li Jiehuan Chen Zhiyong Xiong hui Zhou Shaozhuo huang Jie Ren Bo Liu Taicheng Zhou kunpeng hu Department of General Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Ultrasound Binhaiwan Central Hospital of DongguanDongguanGuangdongChina Department of Ultrasound The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouGuangdongChina

Background:Dynactin(DCTN)can activate cytoplasmic dynein and drive intracellular organelle transport containing six family members(DCTN1 to DCTN6).The DCTN family has been studied as cancer-related genes or biomarkers in various ***,in hepatocellular carcinoma(HCC),the functions and prognostic roles of the DCTN family have been ***:We evaluated the diagnostic and survival effects of DCTN subunits in HCC through bioinformatics analysis and validated the results of bioinformatics by our data to address this ***:The results of bioinformatics analysis found that DCTN2 was a significant prognostic factor in HCC,and high-level DCTN2 can predict poor patient survival in *** regression analysis also suggested that DCTN2(hazard ratio=1.748,95%confidence interval 1.190-2.568,P=0.004)is an independent prognostic factor for patient *** blot and quantitative reverse transcriptionpolymerase chain reaction assays confirmed that the protein and mRNA expression levels of DCTN2 were upregulated in HCC cell *** proliferation,invasion,and migration were decreased and cell apoptosis was enhanced after DCTN2 was knocked down in huh7 and Hep3B ***2 promoted the cell cycle progression through regulating the expression of cell cycle regulatory proteins cyclindependent kinase 4,Cyclin D1,and ***:We propose that DCTN2 can serve as a prognostic marker for ***2 acts as an oncogene and promotes the cell cycle progression through the G1/S phase-related signaling pathway.

关键词： Dynactin 2(DCTN2) Oncogene Hepatocellular carcinoma(HCC) Cell biology Cell cycle

CAV driving safety monitoring and warning via V2X-based edge computing system

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Frontiers of Engineering Management 2024年第1期11卷 107-127页

作者： Cheng CHANG Jiawei ZHANG kunpeng ZHANG Yichen ZHENG Mengkai SHI Jianming hu Shen LI Li LI Department of Automation Tsinghua UniversityBeijing 100084China College of Electrical Engineering Henan University of TechnologyZhengzhou 450001China Nebula Link Technology Co. Ltd.Beijing 100080China Department of Civil Engineering Tsinghua UniversityBeijing 100084China

Driving safety and accident prevention are attracting increasing global *** safety monitoring systems often face challenges such as limited spatiotemporal coverage and accuracy,leading to delays in alerting drivers about potential *** study explores the use of edge computing for monitoring vehicle motion and issuing accident warnings,such as lane departures and vehicle *** traditional systems that depend on data from single vehicles,the cooperative vehicle-infrastructure system collects data directly from connected and automated vehicles(CAVs)via vehicle-to-everything *** approach facilitates a comprehensive assessment of each vehicle’s *** propose algorithms and specific data structures for evaluating accident risks associated with different ***,we examine the prerequisites for data accuracy and transmission delay to enhance the safety of CAV *** efficacy of this framework is validated through both simulated and real-world road tests,proving its utility in diverse driving conditions.

关键词： driving safety accident prevention connected and automated vehicles edge computing

加味补肾壮筋汤对兔膝骨关节炎Wnt/β-catenin信号通路的影响

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中医学报 2024年第11期39卷 2432-2439页

作者：马金昕程韶李锦锦苏心哲张北胡昆鹏殷志颖朱云麒王上增河南中医药大学河南郑州450046 河南省中医院/河南中医药大学第二附属医院河南郑州450002 河南省工程研究中心河南郑州450002

目的:基于Wnt/β-catenin信号通路探讨加味补肾壮筋汤(modified Bushen Zhuangjin decoction,MBZD)治疗兔膝骨关节炎(knee osteoarthritis,KOA)的作用机制。方法:从36只大耳白兔中随机选取8只作为对照组(Control),其余白兔在右膝关节注射木瓜蛋白酶以建立KOA模型。将造模成功的白兔随机分为模型组(KOA)、加味补肾壮筋汤组(MBZD,3.29 g·kg^(-1))及塞来昔布组(celecoxib,CELE,9.33 mg·kg^(-1)),每组8只。MBZD和CELE组白兔按照相应剂量灌胃,Control和KOA组白兔给予等体积生理盐水,每日1次,连续28 d。取右侧膝关节进行Pelletier评分,HE染色观察软骨与滑膜组织病理形态,免疫组织化学法(immunohistochemistry,IHC)检测软骨与滑膜组织中基质金属蛋白酶-13(matrix metalloproteinase-13,MMP-13)、Ⅱ型胶原α1(collagen typeⅡalpha 1,COL2A1)表达水平,Western blot法检测软骨组织中白细胞介素-1β(interleukin 1β,IL-1β)、MMP-13、COL2A1、Wnt-3a、β-catenin、C-MYC蛋白表达水平,RT-qPCR法检测软骨组织中Wnt-3αmRNA、β-catenin mRNA、C-MYC mRNA表达水平。结果:与Control组比较,KOA组白兔Pelletier评分升高(P<0.05);与KOA组比较,MBZD组和CELE组白兔Pelletier评分降低(P<0.05)。HE染色显示,Control组白兔软骨和滑膜组织形态无明显异常。KOA组白兔软骨严重缺损,滑膜组织异常增生伴炎症细胞浸润。MBZD组和CELE组白兔软骨和滑膜组织损伤明显改善。IHC显示,与Control组比较,KOA组白兔软骨和滑膜组织MMP-13表达水平升高、COL2A1表达水平降低(P<0.05),经MBZD和CELE治疗后得到逆转(P<0.05)。Western blot显示,与Control组比较,KOA组白兔软骨组织IL-1β、MMP-13、Wnt-3α、β-catenin、C-MYC蛋白表达水平升高,COL2A1蛋白表达水平降低(P<0.05),经MBZD和CELE治疗后得到逆转(P<0.05)。RT-qPCR显示,与Control组比较,KOA组白兔软骨组织Wnt-3αmRNA、β-catenin mRNA、C-MYC mRNA水平升高,经MBZD和CELE治疗后得到逆转(P<0.05)。结论:MBZD可改善KOA白兔膝关节炎症反应和软骨细胞退变,其机制可能与调控Wnt/β-catenin信号通路有关。

关键词：膝骨关节炎加味补肾壮筋汤 Wnt/β-catenin信号通路软骨细胞滑膜组织白兔

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论警察激励机制的完善

江苏警官学院学报 2005年第3期20卷 175-180页

作者：胡锟鹏徐州市公安局刑警支队二大队

激励机制是在组织中用于调动人的积极性的激励方法和制度。公安队伍建设的重大改革成果是初步建立了竞争激励机制,开始触及并解决队伍管理中存在的“能进不能出、能上不能下、干与不干都一样、成绩大小无区别”等反复出现又屡禁不止的... 详细信息

激励机制是在组织中用于调动人的积极性的激励方法和制度。公安队伍建设的重大改革成果是初步建立了竞争激励机制,开始触及并解决队伍管理中存在的“能进不能出、能上不能下、干与不干都一样、成绩大小无区别”等反复出现又屡禁不止的“老大难”问题。但是,将竞争激励机制看做是激励机制和队伍管理的全部,这种观念是片面的、极端的。完善警察激励机制是一个系统工程,只有发挥机制中各组成部分的整合作用,才能有所作为。

关键词：警察管理激励机制公安工作

Predicting the strut forces of the steel supporting structure of deep excavation considering various factors by machine learning methods

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Underground Space 2024年第5期18卷 114-129页

作者： Haibo hu Xunjian hu Xiaonan Gong Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou 310058China

The application of steel strut force servo systems in deep excavation engineering is not widespread,and there is a notable scarcity of in-situ measured *** presents a significant research gap in the *** this,our study introduces a valuable dataset and application scenarios,serving as a reference point for future *** main objective of this study is to use machine learning(ML)methods for accurately predicting strut forces in steel supporting structures,a crucial aspect for the safety and stability of deep excavation *** employed five different ML methods:radial basis function neural network(RBFNN),back propagation neural network(BPNN),K-Nearest Neighbor(KNN),support vector machine(SVM),and random forest(RF),utilizing a dataset of 2208 measured *** points included one output parameter(strut forces)and seven input parameters(vertical position of strut,plane position of strut,time,temperature,unit weight,cohesion,and internal frictional angle).The effectiveness of these methods was assessed using root mean square error(RMSE),correlation coefficient(R),and mean absolute error(MAE).Our findings indicate that the BPNN method outperforms others,with RMSE,R,and MAE values of 72.1 kN,0.9931,and 57.4 kN,respectively,on the testing *** study underscores the potential of ML methods in precisely predicting strut forces in deep excavation engineering,contributing to enhanced safety measures and project planning.

关键词： Deep excavation Steel supporting structure Strut forces Machine learning Time Temperature

The super-cycle of the global land-monsoon system

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National Science Review 2024年第05期11卷 107-109页

作者： Yongyun hu Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic Sciences School of Physics Peking University

The modern monsoon system consists of six regional monsoons [1]. These regional monsoons demonstrate coherently annual variations of precipitation and atmospheric circulation patterns, although they have different characteristics. Therefore, these regional monsoons are unified in the context of the global monsoon [1,2], which reflects the dominant mode of coherent annual variations of precipitation and atmospheric circulations in the tropics and subtropics.

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R-matrix for the 8-Dimensional Spin Representation of Uq(so7)

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Acta Mathematica Sinica,English Series 2024年第2期40卷 485-497页

作者： Hong Mei hu Nai Hong hu School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009P.R.China School of Mathematical Sciences MOE Key Laboratory of Mathematics and Engineering Applications&Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241P.R.China

The purpose of the paper is to describe the solution to the quantum Yang-Baxter equation associated with the 8-dimensional spin representation Tsp of Uq(so7).The self-duality of Tsp and the symmetry of the corresponding braiding matrix are ***,the minimal polynomial of the braiding R-matrix of Tsp is presented explicitly in an ingenious method by taking advantage of nice features of the spin representation Tsp.

关键词： Braiding R-matrix spin module minimal polynomial