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尼可地尔治疗急性心衰患者的有效性和安全性

首都食品与医药 2016年第12期23卷 96-96页

作者： Akihiro Shirakabe Noritake Hata Shinya Yokoyama Takuro Shinada Nobuaki Kobayashi kuniya asai Kyoichi Mizuno 刘栋不详 fjcc 北京四环科宝制药有限公司 100070

（接5月下）我们通过超声心动显像仪来评价左心室的几何结构变化，包括实验组和对照组的左心室体积变化。第三实验目的通过监测给药尼可地尔后血液动力学的变化来确定尼可地尔的安全性。

关键词：尼可地尔安全性心衰患者有效性急性治疗血液动力学结构变化

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尼可地尔治疗急性心衰患者的有效性和安全性

首都食品与医药 2016年第18期23卷 104-104页

作者： Akihiro Shirakabe(日本) Noritake Hata(日本) Shinya Yokoyama(日本) Takuro Shinada(日本) Nobuaki Kobayashi(日本) kuniya asai(日本) Kyoichi Mizuno(日本) 刘栋(译) 不详北京四环科宝制药有限公司 100079

急性心衰(AHF)患者由于急性肺水肿造成急性呼吸衰竭性供氧不足逐渐或者快速转变为心衰(HF)的信号或症状。欧洲心脏病协会出版的指导原则推荐未合并极低血压的患者应用扩血管药物优于离子通道药物。急性心衰急性期运用硝酸酯类药物治疗... 详细信息

急性心衰(AHF)患者由于急性肺水肿造成急性呼吸衰竭性供氧不足逐渐或者快速转变为心衰(HF)的信号或症状。欧洲心脏病协会出版的指导原则推荐未合并极低血压的患者应用扩血管药物优于离子通道药物。急性心衰急性期运用硝酸酯类药物治疗是黄金定律,然而却少有报道尼可地尔治疗急性心衰的有效性。尼可地尔既具有类硝酸酯特性又能激活ATP-敏感的钾离子通道从而平衡静脉和动脉的舒张。文献证明肺动脉导管介入动态监测的慢性心衰患者静脉快滴尼可地尔可改善血液流变学参数。Minami等进一步研究表明,使用非介入心脏血流变监测的急性心衰患者在急性期使用尼可地尔的治疗有效性。

关键词：急性心衰尼可地尔有效性安全性

Global stability for a delayed multi-group SIRS epidemic model with cure rate and incomplete recovery rate

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International Journal of Biomathematics 2015年第4期8卷 97-126页

作者： Yoshiaki Muroya Toshikazu kuniya Department of Mathematics Waseda University 3-4-10hkubo Shinjuku-ku Tokyo 169-8555 Japan Graduate School of System Informatics Kobe University 1-1 Rokkodai-cho Nada-ku Kobe 657-8501 Japan

In this paper, by applying Lyapunov functional approach, we establish a sufficient condition on the global stability of a ＂delayed＂ multi-group SIRS epidemic model with cure rate and incomplete recovery rate which does not depend on the delays and is an extension of the ＂light drug model＂ studied in the recent paper [Muroya, Li and kuniya, Complete global analysis of an SIRS epidemic model with graded cure rate and incomplete recovery rate, J. Math. Anal. Appl. 410 （2014） 719-732] to a multi-group model. Applying a Lyapunov functional on total population of each compartment, we offer new techniques for the delayed system, how to prove the permanence, the existence of the endemic equilibrium and the global stability of disease-free equilibrium for the reproduction number R0 ≤ 1 and endemic equilibrium forR0 ≥ 1.

关键词： Multi-group SIRS epidemic model delay permanence global stability Lya-punov functional.

ON GLOBAL STABILITY OF A NONRESIDENT COMPUTER VIRUS MODEL

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Acta Mathematica Scientia 2014年第5期34卷 1427-1445页

作者： Yoshiaki MUROYA Huaixing LI Toshikazu kuniya Department of Mathematics Waseda University 3-4-1 Ohkubo Shinjuku-ku Tokyo 169-8555 Japan College of Sciences Tianjin University of Technology Graduate School of Mathematical Sciences University of Tokyo 3-8-1 Komaba Meguro-ku

In this paper, we establish new sufficient conditions for the infected equilibrium of a nonresident computer virus model to be globally asymptotically stable. Our results extend two kind of known results in recent lit... 详细信息

关键词： nonresident computer virus model permanence global asymptotic stability Lyapunov function

GLOBAL STABILITY OF EXTENDED MULTI-GROUP SIR EPIDEMIC MODELS WITH PATCHES THROUGH MIGRATION AND CROSS PATCH INFECTION

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Acta Mathematica Scientia 2013年第2期33卷 341-361页

作者： Yoshiaki MUROYA Yoichi ENATSU Toshikazu kuniya Department of Mathematics Waseda University3-4-1OhkuboShinjuku-kuTokyo 169-8555Japan Graduate School of Fundamental Sciences and Engineering Waseda University3-4-1OhkuboShinjuku-kuTokyo 169-8555Japan Graduate School of Mathematical Sciences University of Tokyo3-8-1KomabaMeguro-kuTokyo 153-8914Japan

In this article, we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models, which have not only an exchange of individuals between patches through migration but also cross patch in... 详细信息

关键词： multi-group SIR epidemic model patch global asymptotic stability Lyapunovfunction

Evaluation of the effect of the state of emergency for the first wave of COVID-19 in Japan

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Infectious Disease Modelling 2020年第1期5卷 580-587页

作者： Toshikazu kuniya Graduate School of System Informatics Kobe University1-1 Rokkodai-choNada-kuKobe657-8501Japan

In this paper,we evaluate the effect of the state of emergency for the first wave of COVID-19 in Japan,2020 from the viewpoint of mathematical *** Japan,it was announced during the period of the state of emergency from April 7 to May 25,2020 that the 80%reduction of the contact rate is needed to control the *** numerical simulation,we show that the reduction rate seems to have reached up to 86%.Moreover,we estimate the control reproduction number R c during the period of the state of emergency as R c?0:36(95%CI,0.34e0.39),and show that the effective reproduction number R e after the lifting of the state of emergency could be greater than *** result suggests us that the second wave of COVID-19 in Japan could possibly occur if any effective intervention will not be taken again.

关键词： COVID-19 SEIR epidemic model Basic reproduction number State of emergency

An international expert consensus of management of recurrent hepatocellular carcinoma: a viewpoint

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 394-396页

作者： kuniya Tanaka Yuki Takahashi Tetsuji Wakabayashi Department of Gastroenterological and General Surgery Showa University Fujigaoka HospitalYokohamaJapan

We read with great interest the article titled "Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection: an international expert consensus" (1) published in Hepato Biliary Sur... 详细信息

关键词： Surgery hepatocellular carcinoma

Two-stage treatment of an unusual haemobilia caused by intrahepatic pseudoaneurysm

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World Journal of Hepatology 2010年第1期2卷 52-54页

作者： Kazuhisa Takeda kuniya Tanaka Itaru Endo Shinji Togo Hiroshi Shimada Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine

A 84-year-old man with a surgical history of subtotal gastrectomy for gastric cancer was transferred to our department because of a disorder of consciousness. Septic shock due to obstructive suppurative cholangitis secondary to choledocholithiasis was diagnosed. Anemia was also present,and upper gastrointestinal tract endoscopy revealed blood emerging from the Papilla of *** cause of the anemia was identified as *** showed a small aneurysm over the artery on segment 3(A3) .The cause of the haemobilia was suspected to be the bleeding into the biliary tree from this *** the patient's general condition was poor,minimally invasive therapy was *** arterial embolization(TAE) was selected ***,lateral sectionectomy was performed in order to remove the aneurysm on A3. No surgical complication occurred and,after surgery,no haemobilia was *** conclusion,a twostage treatment,namely,surgery following TAE,is recommended for patients in a physically poor condition who have haemobilia due to intrahepatic aneurysm.

关键词： Two-stage treatment Haemobilia Intrahepatic pseudoaneurysm

Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst

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World Journal of Gastroenterology 2008年第5期14卷 805-807页

作者： Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima Division of Gastroenterology Yokohama city University Hospital Yokohama 236-0004 Japan Division of Surgery Yokohama city University Hospital Yokohama 236-0004 Japan

The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver.

关键词： Liver cyst Cystadenocarcinoma Simple cyst Galactose acid palmitique Levovist