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第一军医大学学报 1993年第3期13卷 208-211页

作者：彭朝晖 kuniko kusama-eguchi KazueiIgarashi 第一军医大学生物化学教研室日本千叶大学

用高效液相色谱法(HPLC)分析了纯化的牛肝tRNA^(He)核苷酸组成成份,并根据各成份的峰的面积计算了它们的近似数量。实验表明牛肝tRNA^(He)有76个核苷酸,其中含9种14个稀有碱基。t^6A不能被发现。

关键词：牛肝核苷酸高效液相色谱 tRNA

The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

Verification of the Physiological Therapeutic Effects of Harvesting Activities in a Patient with Moderate Alzheimer’s Disease with Long-Term Agricultural Experience

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 236-244页

作者： Kikuo eguchi Seigo Koura Nao eguchi Akihiko Kondou Faculty of Occupational Therapy School of Rehabilitation Reiwa Health Sciences University Fukuoka City Japan Faculty of Rehabilitation Nishikyusyu University Kanzaki City Japan Clinical Art Class Studio Takanabe City Japan

Background: Harvesting activities have proven effective in reducing stress in patients with dementia. At a psychiatric hospital, occupational therapists (OT) made patients with dementia perform vegetable harvesting activities as a part of their treatment. The patients became calmer and began to smile not only after but also before and during harvesting activity. Therefore, this study aimed to measure autonomic nervous system (ANS) responses over time in a female patient in her 80s with moderate Alzheimer’s disease (AD) who had experience in farming when performing harvesting activities. Additionally, this study aimed to consider factors associated with changes in ANS responses over time and to verify the physiological therapeutic effects of harvesting activities. Methods: An OT with more than 10 years of experience and a good relationship with the patient conducted one-on-one sessions with the patient. Harvesting activity was performed in a courtyard with trees. The patient harvested lettuce (three lettuce plants) grown in a planter while sitting on a chair. Additionally, the planter was set up on a desk. ANS responses were measured over time from before to after the activity for different events at six time periods. Changes in the patient’s ANS responses were assessed during each period. Results: With the involvement of environmental factors and OT during harvesting activities, parasympathetic nervous system (PNS) activity significantly increased. This may lead to improved mental stability. Conclusion: The findings of this study indicate that implementing harvesting activities may have a positive effect on the PNS in patients with AD with long-term agricultural experience. However, further studies with a larger sample size and multidimensional evaluations are needed.

关键词： Alzheimer’s Disease Autonomic Nervous Response Harvesting Activity Therapeutic Effects

Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP

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The Journal of Biomedical Research 2015年第3期29卷 176-188页

作者： Shinji Yokoyama kuniko Okumura-Noji Rui Lu Nutritional Health Science Research Center Chubu University

Schistosoma japonicum,once endemic all the East Asia,remains as a serious public health problem in certain *** egg embryonation in the liver causes granulomatosis and eventually fatal cirrhosis,so that prevention of this process is one of the keys to reduce its *** embryonation requires cholesteryl ester from HDL of the host blood for egg yolk formation,and this reaction is impaired from the abnormal large HDL in genetic cholesteryl ester transfer protein(CETP) *** CETP was expressed in mice that otherwise lack this protein,granulomatosis of the liver was shown increased compared to the wild type upon infection of Schistosoma *** CETP deficiencies accumulated exclusively in East Asia,from Indochina to Siberia,so that Shistosomiasis can be a screening factor for this ***36 related protein(CD36RP) was identified as a protein for this reaction,cloned from the cDNA library of Schistosoma japonicum with 1880-bp encoding 506 amino *** antibody against the extracellular loop of CD36 RP inhibited cholesteryl ester uptake from HDL and suppressed egg embryonation in ***,inhibition of CETP is a potential approach to prevent liver granulomatosis and thereby fatal liver cirrhosis in the infection of Schistosoma japonicum.

关键词： Schistosoma japonicum liver cirrhosis granulomatosis CETP deficiency HDL cholesteryl ester

An experimental study on self-output-control characteristics of micro downwind rotor with coning soft blades

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Science China(Technological Sciences) 2010年第1期53卷 100-104页

作者： eguchi Hidenori YOSHIDA Kouichi NISHI Michihiro Sophia Engineering CO. Ltd.Kikugaoka 1-15-25KokuraminamiKitakyushu 802-0981Japan Mechanical Engineering Department Kyushu Institute of TechnologySensui-cho 1TobataKitakyushu 804-8550Japan Senior Academy Kyushu Institute of TechnologySensui-cho 1TobataKitakyushu 804-8550Japan

In this short paper,we have treated the aerodynamic performance of micro downwind rotor with coning soft blades *** test wind rotor has the tip diameter of 1.5 m and three two-dimensional NACA0018 blades of 0.15 m chord whose material is light,soft and pliable foam plastic for perfect *** the wind tunnel test,it is realized that the performance is manageable by the coning angle of the rotor *** the present case,an improvement of the performance in lower wind speeds is achieved by using the coning blade of 20°.Besides,owing to the torsional deformation of very soft blade,the self-power control characteristic is observed in every test rotor regardless of coning angle in the range of 0°-20° under the wind speed less than 12 m/s.

关键词： micro wind turbine downwind self-output-control coning angle soft blade aerodynamic performance

Surface manipulation of a triple-conducting cathode for protonic ceramic fuel cells to enhance oxygen reduction activity and CO_(2) tolerance

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Journal of Energy Chemistry 2023年第12期87卷 450-459,I0012页

作者： Wenwen Zhang Hiroki Muroyama Yuichi Mikami Toshiaki Matsui Koichi eguchi Department of Energy and Hydrocarbon Chemistry Graduate School of EngineeringKyoto UniversityNishikyo-kuKyoto 615-8510Japan Technology Division Panasonic Holdings Corporation3-1-1 Yagumo-naka-machiMoriguchi CityOsaka 570-8501Japan

One of the main obstacles limiting the performance of protonic ceramic fuel cells(PCFCs) is the sluggish kinetics of the oxygen reduction reaction(ORR) at reduced ***,the surface manipulation of a triple-conducting cathode BaCe_(0.5)Pr_(0.3)Y_(0.2)O_(3-δ)(BCPY) by an efficient catalyst coating PrNi_(0.5)Co_(0.5)O_(3-δ)(PNC) to enhance the ORR activity and CO_(2) tolerance is *** developed PNC-coated BCPY cathode achieves the polarization resistance of 0.25 and 1.00 Ω cm^(2) at 600 and 500 ℃,respectively,approximately 1/5 of that for the pristine BCPY cathode(0.99 and 4.79 Ω cm^(2)),while maintaining an excellent CO_(2) *** single cell on a BaZr_(0.8)Yb_(0.2)O_(3-δ) electrolyte also exhibits a high peak power density of 0.79 W cm^(-2)at 700 ℃ and a stable operation for 200 h at 600 ℃.Such high ORR activity is mainly attributed to the synergistic effect of BCPY support and PNC ***,BCPY provides a tripleconducting path(mainly protons),and PNC nanoparticles facilitates surface oxygen exchange and steam adsorption/desorption processes due to the enriched surface oxygen *** study will provide a new design strategy for developing high-performance PCFCs cathode.

关键词： Triple-conducting cathode Surface manipulation Oxygen reduction reaction CO_(2)tolerance Protonic ceramicfuel cells

Selective CO_(2) reduction into formate using Ln-Ta oxynitrides combined with a binuclear Ru(Ⅱ)complex under visible light

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Journal of Energy Chemistry 2021年第4期30卷 176-182页

作者： Kanemichi Muraoka Miharu eguchi Osamu Ishitani Francois Chevire Kazuhiko Maeda Department of Chemistry School of ScienceTokyo Institute of TechnologyMeguro-ku152-8550 TokyoJapan Japan Society for the Promotion of Science Chiyoda-ku102-0083 TokyoJapan Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan Univ Rennes CNRSISCR-UMR 6226Rennes F-35000France

Hybrid materials constructed from a visible-light-absorbing semiconductor and a functional metal complex have attracted attention as efficient photocatalysts for CO_(2) reduction with high selectivity to a desired *** this work,defect fluorite-type Ln-Ta oxynitrides LnTaO_(x)N_(y)(Ln=Nd,Sm,Gd,Tb,Dy and Ho)were examined as the semiconductor component in a hybrid photocatalyst system combined with known Ag nanoparticle promoter and binuclear ruthenium(Ⅱ)complex(RuRu’).Among the LnTaO_(x)N_(y) examined,TbTaO_(x)N_(y) gave the highest performance for CO_(2) reduction under visible light(k>400 nm),with a Ru Ru0-based turnover number of 18 and high selectivity to formate(>99%).Physicochemical analyses indicated that high crystallinity and more negative conduction band potential of Ln Ta O_(x)N_(y)with the absence of Ln-4 f states in the band gap structure contributed to higher activity of the hybrid photocatalyst.

关键词： Artificial photosynthesis Heterogeneous photocatalysis Mixed anion compounds Solar fuels

Control of Distributed Generation Using Non-Sinusoidal Pulse Width Modulation

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Computers, Materials & Continua 2023年第2期74卷 4149-4164页

作者： Mehrdad Ahmadi Kamarposhti Phatiphat Thounthong Ilhami Colak Kei eguchi Department of Electrical Engineering Jouybar BranchIslamic Azad UniversityJouybar***Iran Renewable Energy Research Centre(RERC) Department of Teacher Training in Electrical EngineeringFaculty of Technical EducationKing Mongkut’s University of Technology North Bangkok1518Pracharat 1 RoadBangsueBangkok10800Thailand Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitecturesNisantasi UniversityIstanbul34398Turkey Department of Information Electronics Fukuoka Institute of TechnologyFukuoka811-0295Japan

The islanded mode is one of the connection modes of the grid distributed generation *** this study,a distributed generation resource is connected to linear and nonlinear loads via a three-phase inverter where a control method needing no current sensors or compensator elements is applied to the distribute generation system in the islanded *** control method has two main loops in each *** first loop controls the voltage control loops that adjust the three-phase point of common coupling,the amplitude of the non-sinusoidal reference waveform and the near-state pulse width modulation(NSPWM)*** next loop compensates the harmonic compensator loop that calculates the voltage harmonics of the point of common coupling in each phase,and injects them to compensate the non-sinusoidal reference waveforms of each *** simulation results in MATLAB/SIMULINK show that this method can generate balanced threephase sinusoidal voltage with an acceptable total harmonic distortion(THD)at the joint connection point.

关键词： Islanded mode distributed generation resource the point of common coupling voltage total harmonic distortion

Modeling and Simulation of DVR and D-STATCOM in Presence of Wind Energy System

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Computers, Materials & Continua 2023年第2期74卷 4547-4570页

作者： Mehrdad Ahmadi Kamarposhti Ilhami Colak Phatiphat Thounthong Kei eguchi Department of Electrical Engineering Jouybar BranchIslamic Azad UniversityJouybarIran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitecturesNisantasi UniversityIstanbulTurkey Renewable Energy Research Centre(RERC) Department of Teacher Training in Electrical EngineeringFaculty of Technical EducationKing Mongkut’s University of Technology North Bangkok1518Pracharat 1 RoadBangsueBangkok10800Thailand Department of Information Electronics Fukuoka Institute of TechnologyFukuokaJapan

The present study suggests that series voltage injection is more effective than parallel current injection to improve voltage quality on the load *** line voltage can be accurately symmetrized at the connection point by creating and controlling a series voltage component in each *** is more reliable and effective than parallel current injection.A dynamic voltage restorer(DVR)and a distribution static synchronous compensator(DSTATCOM)were utilized to provide the required *** DVR is an effective andmodern device utilized in parallel within the grid and can protect sensitive loads from voltage problems in the grid by injecting *** DVR and D-STATCOM were used to improve voltage stability in faults.A standard 13-bus system was studied in the presence of a wind *** simulation results demonstrated that single and three-phase overloads dramatically altered the voltage of the system,making it necessary to use compensators to improve voltage *** DVR and D-STATCOM showed similar performance under normal conditions and somewhat improved grid voltage ***,the DVR outperformed D-STATCOM under asymmetric faults conditions and led to lower voltage variations.

关键词： Power quality distribution system DVR D-STATCOM wind turbine