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Gene Body CG and CHG Methylation and Suppression of Centromeric CHH Methylation are Mediated by DECREASE IN DNA METHYLATION1 in Rice

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Molecular Plant 2015年第10期8卷 1560-1562页

作者： Hisataka numa Katsushi Yamaguchi Shuji Shigenobu Yoshiki Habu Agrogenomics Research Center National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8602 Japan Functional Genomics Facility NIBB Core Research Facilities National Institute for Basic Biology Qkazaki Aichi 444-0867 Japan CREST JST Kawaguchi Saitama 332-0012 Japan

Dear Editor,DECREASE IN DNA METHYLATION1 （DDM1） is a chromatin remodeling protein required for maintenance of cytosine and histone H3K9 methylation in heterochromatin regions in the genome of Arabidopsis thaliana （Gendrel et al., 2002）. A ddm 1 mutant also increases the rate of meiotic recombination in euchromatic but not heterochromatic regions of A. thaliana （Melamed-Bessudo and Levy, 2012）, and changes the state of cytosine methylation of a gene flanked by a LINE element located in a region of euchromatin （Saze and Kakutani, 2007）. These studies indicate that the function of DDM1 is not limited to heterochromatin regions and show that it also acts on euchromatic regions in the genome, although the mechanism determining its target specificity remains obscure. Toward understanding the function of DDM1 in the maintenance of global epigenetic state of the genome in higher plants, we performed a genome-wide analysis of cytosine methylation in an antisense-mediated DDMl-knockdown rice line （asDDM1） that exhibits similar characteristics to that of ddml in A. thaliana （Higo et al., 2012; Habu et al., 2015）. Some intrinsic properties of rice genome differ greatly from those of A. thaliana, for example, the content of repeated sequences and their distribution, and therefore rice provides an opportunity to examine the effect of DDM1 deficiency on genomes with a higher content and broader distribution of repeats.

关键词： genomes broader distribution

Land cover change and carbon stores in a tropical montane cloud forest in the Sierra Madre Oriental,Mexico

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Journal of Mountain Science 2018年第10期15卷 2136-2147页

作者： Edgar G.LEIJA-LOREDO numa P.PAVóN Arturo SáNCHEZ-GONZáLEZ Rodrigo RODRIGUEZ-LAGUNA GregorioáNGELES-PéREZ Center for Biological Research Autonomous University of Hidalgo.42184 HidalgoMexico Institute oJ:Ag ricultural Sciences Academic Area of Forestry EngineeringAutonomous University of Hidalgo.43600 HidalgoMexico Postgraduate School Campus MontecilloPostgraduate in Forest Sciences.56230 Estado de MexicoMexico

Tropical montane cloud forest is one of the ecosystems with the highest biomass worldwide, representing an important carbon store. Globally its deforestation index is –1.1%, but in Mexico it is higher than –3%. Carbon estimates are scarce globally, particularly in Mexico. The objective of this study was to simulate future land-cover scenarios for the Sierra Madre Oriental in Mexico, by analyzing past forest cover changes. Another objective was to estimate stored carbon in the two study areas. These objectives involve the generation of information that could be useful inputs to anti-deforestation public policy such as the REDD+ strategy. Remote sensing was used to measure land cover change and estimate carbon stocks. Satellite images from 2015, 2000 and 1986 were used, and Dinamica EGO freeware generatedmodels of future projections. Between 1986 and 2015, 5171 ha of forest were converted to pasture. The annual deforestation rates were –1.5% for Tlanchinol and –1.3% for the San Bartolo Tutotepec sites. Distance to roads and marginalization were highly correlated with deforestation. By 2030, an estimated 3608 ha of forest in these sites will have been converted to pasture. Stored carbon was estimated at 16.35 Mg C ha-1 for the Tlanchinol site and 12.7 Mg C ha-1 for the San Bartolo site. In the Sierra Madre Oriental deforestation due to land cover change(–1.4%) is higher than levels reported worldwide. Besides having high values of stored carbon(14.5 Mg C ha-1), these forests have high biodiversity. The models' outputs show that the deforestation process will continue if action is not taken to avoid the expansion of livestock pasturing. This can be done by paying incentives for forest conservation to the owners of the land. The results suggest that REDD+ is currently the most viable strategy for reducing deforestation rates in tropical montane cloud forests in Sierra Madre Oriental.

关键词：东方人墨西哥森林陆地山区热带碳区域估计

Master Techniques in Rhinoplasty

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Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

2011年

作者： Azizzadeh, Babak, MD, FACS Murphy, Mark R., MD Johnson, Calvin M., MD, FACS numa, William, MD, FACS

Master Techniques in Rhinoplasty ▪ BABAK AZIZZADEH, MD, FACS Director The Center for Advanced Facial Plastic Surgery; Associate Clinical Professor David Geffen School of Medicine at UCLA; Attending Surgeon Cedars-Sina...

ISBN: (纸本)9781416062622

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来源：畅想之星图书光盘版（南... 评论

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Open Journal of Ophthalmology 2014年第3期4卷 79-85页

作者： Yuji Kumano Yumi Soejima Shinichiro numa Hiroyasu Matsui Ikuko Zushi Masahito Shigematsu Takaaki Matsui Teruo Nishida Department of Oral and Maxillofacial Surgery Saga University Saga Japan Ohshima Hospital of Ophthalmology Fukuoka Japan Zushi Eye Clinic Fukuoka Japan

Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

关键词： BSCVA LASEK Loss of Two or More Lines Preoperative Myopia Re-Evaluation

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盐酸与碳酸盐岩反应速率的影响因素

世界石油科学 1992年第3期 42-53页

作者： numa.,NA 时收信

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社会主义与和平:欧洲历史语境中的考察

马克思主义与现实 2020年第3期72卷 162-168页

作者： [法]让-努马·迪康热法国《今日马克思》杂志法国《马恩大典》

本文通过对19世纪80年代至今欧洲共产主义和社会主义历史的回顾,阐述了这两种思潮对“和平运动”概念的理解以及实践中经历的变化,并运用马克思主义观点对其进行了分析。从早期对“和平运动”的批判,到后来理论界的争论,从大规模的群众... 详细信息

本文通过对19世纪80年代至今欧洲共产主义和社会主义历史的回顾,阐述了这两种思潮对“和平运动”概念的理解以及实践中经历的变化,并运用马克思主义观点对其进行了分析。从早期对“和平运动”的批判,到后来理论界的争论,从大规模的群众运动走向衰落,到20世纪80年代的再度兴起,和平既是一个政治问题,也是一个社会和经济问题,面对21世纪出现的新情况和新矛盾,应当对其进行重新审视,并赋予其应有的意义。

关键词：和平运动社会主义共产主义

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如何评价巴黎公社:从马克思到列宁

国外理论动态 2021年第4期 86-89页

作者：让-努马·迪康热姚岚(译) 法国鲁昂-诺曼底大学同济大学外国语学院同济大学法语区域研究中心

1871年的巴黎公社是一次独特的政治经历,为19世纪末至20世纪初欧洲工人运动的发展开辟了道路。欧洲的许多政治团体深受巴黎公社的影响,每年3月18日都会组织隆重的纪念活动。不过,对于巴黎公社的政治遗产,不同的社会主义流派,其评价也不... 详细信息

1871年的巴黎公社是一次独特的政治经历,为19世纪末至20世纪初欧洲工人运动的发展开辟了道路。欧洲的许多政治团体深受巴黎公社的影响,每年3月18日都会组织隆重的纪念活动。不过,对于巴黎公社的政治遗产,不同的社会主义流派,其评价也不尽相同。马克思恩格斯肯定了巴黎公社是"无产阶级专政"的伟大尝试,但在随后的批判性反思中又指出,缺少集中与权威是其失败的原因。社会改良主义者对巴黎公社起义的武装斗争形式持否定态度,提出了用选举和罢工的手段夺取政权的理论观点。列宁总结了巴黎公社经验对苏维埃政权建立的重要意义。当前,欧洲对巴黎公社的研究趋势是回归其本身,同时关注社会转型的政治议题。

关键词：巴黎公社欧洲社会主义思潮工人运动

人N-ras癌基因细胞型特异DNA结合蛋白

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生物化学杂志 1989年第4期5卷 348-353页

作者：王智 Lepeyer Jean-numa Becker F.F 中国医学科学院基础医学研究所 Department of Molecular Pathology M.D.Anderson Hospital and Tumor Insfitute.The University of Texas System Cancer CenterHoustonTexas 77030U.S.A.

本文利用Southwestern印迹技术发现人肿瘤HT1080细胞染色质蛋白中一组与N-ras基因结合的蛋白,分子量约为150,105,95,90KDa,而与Ha-ras基因结合的一组蛋白,分子量约为160,115,100,55KDa,其中150KDa蛋白是N-ras基因特异的DNA结合蛋白,具... 详细信息

本文利用Southwestern印迹技术发现人肿瘤HT1080细胞染色质蛋白中一组与N-ras基因结合的蛋白,分子量约为150,105,95,90KDa,而与Ha-ras基因结合的一组蛋白,分子量约为160,115,100,55KDa,其中150KDa蛋白是N-ras基因特异的DNA结合蛋白,具有细胞型特异性,在HT1080细胞中含量最多,T24细胞次之,而在人HeLa细胞,淋巴细胞、肠细胞以及未转化的NTH3T3细胞中未被发现。此种蛋白可能与N-ras基因在HT1080细胞内的激活有密切关系。

关键词： N-ras癌基因 DNA 结合蛋白癌

采用被动吸烟法建立胎仔宫内发育迟缓大鼠模型

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上海实验动物科学 1999年第1期19卷 14-17页

作者：段涛毕奴玛杨幼明黄敏丽上海医科大学

将雌性ＳＤ大鼠分为４组，Ａ组交配后第一天起，Ｂ组交配后第１０天起每天在隔离器内被动吸烟２ｈ至第２０天，Ｃ组为普通环境不吸烟对照组，Ｄ组为每天在隔离器内饲养２ｈ不吸烟对照组。实验结果显示，Ａ，Ｂ，Ｃ组胎内活仔体重分别为... 详细信息

将雌性ＳＤ大鼠分为４组，Ａ组交配后第一天起，Ｂ组交配后第１０天起每天在隔离器内被动吸烟２ｈ至第２０天，Ｃ组为普通环境不吸烟对照组，Ｄ组为每天在隔离器内饲养２ｈ不吸烟对照组。实验结果显示，Ａ，Ｂ，Ｃ组胎内活仔体重分别为２．０±０．７，２．８±０．５，３．７±０．４ｇ；宫内发育迟缓（ＩＵＧＲ）发生率分别为８７％，５９．６％，５％；体长分别为２．８４±０．４２，３．２４±０．３０，３．９４±０．２２ｃｍ；尾长分别为０．９６±０．１６，１．０７±０．１４，１．３４±０．１０ｃｍ；胎盘重量分别为０．４８±０．１２，０．５０±０．１１，０．６２±０．４０ｇ；Ｄ组各项指标与Ｃ组比较无显著差异。正常对照Ｃ组和不吸烟对照组Ｄ组胚胎早期吸收或死胎率仅为３．４５％和４．１９％，而被动吸烟的Ａ，Ｂ组分别为３２．４％与１６．１％，均明显高于对照组，表明被动吸烟对胚胎的存活也有很大的威胁。本研究结果提示，利用隔离器和大鼠建立被动吸烟致ＩＵ－ＧＲ动物模型，具有吸烟环境易控制，重复性好，实验周期短。

关键词：大鼠被动吸烟宫内发育迟缓动物模型