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Distinct phosphorylation optimizes pathogen-induced PA and ROs bursts

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Molecular Plant 2024年第4期17卷 525-527页

作者： Kaihuai lil Ruize Zhang Yong Wang Fengquan Liu Zheng Qing Fu Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025China Department of Biological Sciences University of South CarolinaColumbiaSC29208USA Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu 210014China

Phospholipids hold a multifaceted function in cellular *** primary function of phospholipids is to serve as essential building blocks of cell membranes,which gives cells crucial structural support and facilitates cellular *** that,phospholipids also act as key signaling molecules that coordinate vital cellular processes such as organismal development,homeostasis,and adaptation to environmental *** being the smallest and simplest phospholipid,phosphatidic acid(PA)plays a crucial role as a metabolic intermediate and second messenger.

关键词： homeostasis lipids smallest

Single-Component Color-Tunable Smart Organic Emitters with Simultaneous Multistage Stimuli-Responsiveness and Multimode Emissions

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Research 2024年第2期2023卷 719-728页

作者： Yu Yan Chengfang Liu Jianzhong Fan Yusheng Li Huanling Liu Qian Wang Xiangchun lil Junfeng Li Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&Telecommunications9 Wenyuan RoadNanjng 210023China Shandong Province Key Laboratory of Medical Physics and Image Processing Technology School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

Achieving color-tunable emission in single-component organic emitters with multistage stimuli-responsiveness is of vital significance for intelligent optoelectronic applications,but remains enormously ***,we present an unprecedented example of a color-tunable single-component smart organic emitter(DDOP)that simultaneously exhibits multistage stimuli-responsiveness and multimode *** based on a highly twisted amide-bridged donor-tcceptor-donor structure has been found to facilitate intersystem crossing,form multimode emissions,and generate multiple emissive species with multistage *** pristine crystalline powders exhibit abnormal excitation-dependent emissions from a monomer-dominated blue emission centered at 470 nm to a dimer-dominated yellow emission centered at 550 nm through decreasing the ultraviolet(UV)excitation wavelengths,whereas DDOP single crystals show a wide emission band with a main emission peak at 585 nm when excited at different *** emission behaviors of pristine crystalline powders and single crystals are different,demonstrating emission features that are closely related to the aggregation *** work has developed color-tunable single-component organic emitters with simultaneous multistage stimuli-responsiveness and multimode emissions,which is vital for expanding intelligent optoelectronic applications,including multilevel information encryption,multicolor emissive patterns,and visual monitoring of UV wavelengths.

关键词： donor excitation Smart

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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国医大师潘敏求从脾胃论治食管癌经验

中华中医药杂志 2024年第7期39卷 3448-3451页

作者：王莉宋程唐蔚湖南省肿瘤医院长沙410031 湖南中医药大学长沙410208 湖南省中医药研究院附属医院长沙410006

食管癌是我国常见的消化道肿瘤之一,中医药治疗有着独特的优势。潘敏求教授从医五十余载,总结出其病位在食管,属脾胃所主,病机以脾胃亏虚为本,痰瘀毒结为标,病机传变在肝与肾;治疗上始终把握脾胃枢机之根本,以健脾理气、和胃降浊为主要... 详细信息

食管癌是我国常见的消化道肿瘤之一,中医药治疗有着独特的优势。潘敏求教授从医五十余载,总结出其病位在食管,属脾胃所主,病机以脾胃亏虚为本,痰瘀毒结为标,病机传变在肝与肾;治疗上始终把握脾胃枢机之根本,以健脾理气、和胃降浊为主要治则,参用化痰、祛瘀、解毒,同时重视补脾疏肝、培补脾肾,灵活化裁,系统调治,以恢复脾胃功能,则气机调畅,生机得复。

关键词：食管癌脾胃经验潘敏求国医大师

Strain-Rate-Dependent In-Plane Compressive Properties of 3D Fine Weave Pierced C/C Composite:Failure Mechanism and Constitutive Model

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Acta Mechanica Solida Sinica 2022年第1期35卷 63-78页

作者： Fei Guo Qingguo Fei Yanbin lil Nikhil Gupta Jiangsu Engineering Research Center of Aerospace Machinery Southeast UniversityNanjing 211189China Department of Engineering Mechanics Southeast UniversityNanjing 211189China School of Mechanical Engineering Southeast UniversityNanjing 211189China Composite Materials and Mechanics Laboratory Department of Mechanical and Aerospace EngineeringTandon School of EngineeringNew York UniversityBrooklynNY 11201USA

In-plane compression experiments are performed on 3D fine weave pierced C/C composite at a wide strain rate range of 0.0001/s-1000/*** in-plane compressive failure mechanism of the composite at quasi-static and high strain rates is analyzed by a scanning electron *** results show that the in-plane compressive modulus,maximum stress and the corresponding strain increase with increasing strain *** quasi-static in-plane compressive failure mode of the 3D fine weave pierced C/C composite is characterized by the shear failure at the angle of 45°and the local buckling of the^direction fiber *** comparison,the high strain rate in-plane compression failure mode of the composite is characterized by the compressive fracture of the interlaminar matrix and the progressive compression failure of the a>direction fiber bundles.A strain-rate-dependent in-plane compressive constitutive model is proposed to predict the dynamic in-plane compressive response of the *** proposed constitutive model is verified by experimental data.

关键词： C/C composite Compression Failure mechanism Constitutive model

A network based efficient drug repurposing strategy for targeting diabesity

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Genes & Diseases 2023年第2期10卷 340-343页

作者： Subhajit Dutta Ted Natoli deep Chanda Sindhuja Rajavelu Debojyoti De Laboratory of Cellular Differentiation & Metabolic Disorder Department of BiotechnologyNational Institute of TechnologyDurgapurWest Bengal 713209India Cancer Program Broad Institute of MIT and HarvardCambridgeMA 02142USA

Type II diabetes and obesity are two of the most prevalent metabolic disorders effecting a huge population throughout the world. Research over the last decade has unequivocally established considerable molecular links between them and hence they are often described in conjugation as ‘diabesity’. The hallmarks of type II diabetes are primarily reduced insulin sensitivity, progressive insulin resistance and consequent hyperinsulinemia.1 Whereas, hyperinsulinemia promotes a plethora of fat synthesis from excess circulating carbohydrate and hyperactive fat storage mechanisms, ultimately inducing hepatic steatosis, myosteatosis and pancreatic steatosis.1 This in turn, aggravates the insulin sensitivity further, inflicting more insulin resistance and even more hyperinsulinemia. Needless to mention that the vicious process in turn, promotes uncontrolled weight gain1 and many secondary metabolic disorders. The prevalent anti-diabetic and anti-obesity medications comes with several limitations ranging from inefficiency to adverse side effects.2 Here, we report an efficient strategy of repositioning previously approved drugs with novel indication in the context of diabesity by investigating deregulated signalling axes affecting patients with both the disorders. Our approach relies extensively on deciphering the strength of gene association in various interactomes, as it is known that within networks, genes linked to similar disease phenotypes tend to be functionally similar3 and remain proximal to each other.4 Moreover, the potential drug targets associated to a disease pathway also cluster proximal to the disease pathways.

关键词： hence primarily network

Fourier Collocation and Reduced Basis Methods for Fast Modeling of Compressible Flows

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Communications in Computational Physics 2022年第8期32卷 595-637页

作者： Jian Yu deep Ray Jan S.Hesthaven School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Laboratory of Aero-thermal Protection Technology for Aerospace Vehicles China Aerospace Science and Technology CorporationBeijing 100048China School of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Chair of ComputationalMathematics and Simulation Schience Ecole Polytechnique Federale de LausanneLausanne CH-1015Switzerland

A projection-based reduced order model(ROM)based on the Fourier collocation method is proposed for compressible *** incorporation of localized artificial viscosity model and filtering is pursued to enhance the robustness and accuracy of the ROM for shock-dominated ***,for Euler systems,ROMs built on the conservative and the skew-symmetric forms of the governing equation are *** ensure efficiency,the discrete empirical interpolation method(DEIM)is *** alternative reduction approach,exploring the sparsity of viscosity is also investigated for the viscous terms.A number of one-and two-dimensional benchmark cases are considered to test the performance of the proposed *** show that stable computations for shock-dominated cases can be achieved with ROMs built on both the conservative and the skew-symmetric forms without additional stabilization components other than the viscosity model and *** the same parameters,the skew-symmetric form shows better robustness and accuracy than its conservative counterpart,while the conservative form is superior in terms of efficiency.

关键词： Projection-based reduced order modeling Fourier collocation artificial viscosity compressible flow

长链非编码核糖核苷酸HLA-DQA2与不明原因复发性流产的关联

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中国优生与遗传杂志 2024年第4期32卷 674-680页

作者：杨丽杨静卜国森韩锐腊晓琳新疆医科大学第一附属医院生殖医学中心新疆乌鲁木齐830011 生殖疾病与出生缺陷综合防治研究中心新疆乌鲁木齐830011 新疆医科大学第一附属医院新疆生殖免疫临床医学研究中心新疆乌鲁木齐830011 新疆医科大学第五附属医院妇科新疆乌鲁木齐830011 新疆医科大学第一附属医院神经内科新疆乌鲁木齐830011 新疆医科大学省部共建中亚高发病成因与防治国家重点实验室新疆乌鲁木齐830011

目的通过对不明原因复发性流产(URSA)孕妇绒毛组织的lncRNA比对参考基因组进行注释,探究URSA中潜在的lncRNA生物学靶点。方法收集4例URSA(实验组)和4例选择性终止妊娠(ETP)孕妇(对照组)的绒毛组织样本,使用StringTie处理并预测各转录本,... 详细信息

目的通过对不明原因复发性流产(URSA)孕妇绒毛组织的lncRNA比对参考基因组进行注释,探究URSA中潜在的lncRNA生物学靶点。方法收集4例URSA(实验组)和4例选择性终止妊娠(ETP)孕妇(对照组)的绒毛组织样本,使用StringTie处理并预测各转录本,DESeq2获得差异表达lncRNA,Kyoto Encyclopedia of Genes and Genomes(KEGG)富集分析对lncRNA反式调控及lncRNA顺式调控潜在通路进行探索。结果使用4种编码潜能分析方法对候选lncRNA进行进一步的筛选,共有474个共表达转录本,接着DESeq2获得差异表达lncRNA,有705个显著上调lncRNA数目和107个显著下调表达lncRNA数目,对差异表达的lncRNA和所有差异表达的基因进行共表达分析,其中lncRNA反式调控分子功能主要作用在蛋白结合,生物过程发生在细胞外基质组织,存在于细胞表面。KEGG结果显示其主要是作用于lncRNA HLA-DQA2进而富集在金黄色葡萄球菌感染通路。lncRNA顺式调控分子功能主要作用在蛋白结合,生物过程发生在RNA聚合酶对转录的调节,存在于核染色质。KEGG富集结果显示其主要是作用于lncRNA HLA-DQA2以及BIRCT进而富集在弓形体病感染通路。结论lncRNA HLA-DQA2可能通过调控炎症感染信号通路导致不明原因复发性流产,其可能成为潜在的治疗靶点。

关键词：不明原因复发性流产绒毛组织长链非编码RNA 转录组测序

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齿轮啮合周期内摩擦载荷变化有限元仿真分析

计算机仿真 2024年第4期41卷 512-516页

作者：闫晓丽崔钺孟丽丽河北省智能装备数字化设计及过程仿真重点实验室河北唐山063000 唐山学院河北唐山063000 华北理工大学机械工程学院河北唐山063000

为能更好地分析齿轮啮合周期中摩擦载荷变化,建立齿轮分析模型,研究齿轮间传动关系,区分齿轮输入端和输出端的阻力扭矩,搭建有限元分析模型。为保证模型的精确度,在前期预处理阶段针对齿轮不同位置的实际情况构建对应网格,区分不同位置... 详细信息

为能更好地分析齿轮啮合周期中摩擦载荷变化,建立齿轮分析模型,研究齿轮间传动关系,区分齿轮输入端和输出端的阻力扭矩,搭建有限元分析模型。为保证模型的精确度,在前期预处理阶段针对齿轮不同位置的实际情况构建对应网格,区分不同位置的网格密度,根据齿轮的轮动比和角位移得出旋转自由度。在齿轮啮合过程中,搭建动力学分析模型,研究摩擦载荷的变化情况,考虑齿轮啮合频率,根据长度线条确定摩擦因数,利用摩擦函数明确齿轮间的最大接触应力和弯曲应力,完成摩擦载荷变化分析。经仿真验证可知,所研究方法能准确描述齿轮啮合周期内摩擦载荷的实时变化。

关键词：齿轮转动啮合周期摩擦载荷主动轴齿轮接触面