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Regulations of m^(6)A and other RNA modifications and their roles in cancer

Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-Hui Chen kun-xiong guo Jing Li Shu-Hui Xu Huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

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Multi-Objective Multi-Variable Large-Size Fan Aerodynamic Optimization by Using Multi-Model Ensemble Optimization Algorithm

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Journal of Thermal Science 2024年第3期33卷 914-930页

作者： xiong Jin guo Penghua LI Jingyin School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

The constrained multi-objective multi-variable optimization of fans usually needs a great deal of computational fluid dynamics(CFD)calculations and is *** this study,a new multi-model ensemble optimization algorithm is proposed to tackle such an expensive optimization *** multi-variable and multi-objective optimization are conducted with a new flexible multi-objective infill *** addition,the search direction is determined by the multi-model ensemble assisted evolutionary algorithm and the feature extraction by the principal component analysis is used to reduce the dimension of optimization ***,the proposed algorithm and other two optimization algorithms which prevail in fan optimizations were compared by using test *** the same number of objective function evaluations,the proposed algorithm shows a fast convergency rate on finding the optimal objective function ***,this algorithm was used to optimize the rotor and stator blades of a large axial fan,with the efficiencies as the objectives at three flow rates,the high,the design and the low flow ***-two variables were included in the optimization *** results show that compared with the prototype fan,the total pressure efficiencies of the optimized fan at the high,the design and the low flow rate were increased by 3.35%,3.07%and 2.89%,respectively,after CFD simulations for 500 fan candidates with the constraint for the design *** optimization results validate the effectiveness and feasibility of the proposed algorithm.

关键词： multi-objective optimization surrogate-assisted evolutionary algorithm axial fan computational fluid dynamics aerodynamic optimization

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Carbonation of Pure Minerals in Portland Cement:Evolution in Products as a Function of Water-to-solid Ratio

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1214-1222页

作者： xiong kun SHANG Xiaopeng LI Hongyan WANG Dan Zhengzhou Lutong Highway Construction Co. Ltd.Zhengzhou 450052China (Special Glass Key Lab of Hainan Province)&(State Key Laboratory of Marine Resource Utilization in South China Sea) Hainan UniversityHaikou 570228China Department of Architectural Engineering Shandong Urban Construction Vocational CollegeJinan 250103China (State Key Laboratory of High Performance Civil Engineering Materials Jiangsu Sobute New Materials Co.Ltd.)&(School of Material Science and EngineeringSoutheast UniversityNanjing 211189China)

Minerals in Portland cement including tricalcium silicate(C_(3)S),β-dicalcium silicate(β-C_(2)S),tricalcium aluminate(C_(3)A),and tetracalcium ferroaluminate(C_(4)AF),show a significantly different activity and product evolution for CO_(2)curing at various water-to-solid *** pure minerals were synthesized and subject to CO_(2)curing in this study to make an in-depth understanding for the carbonation properties of cement-based *** showed that the optimum water-to-solid ratios of C_(3)S,β-C_(2)S,C_(3)A and C_(4)AF were 0.25,0.15,0.30 and 0.40 for carbonation,corresponding to 2 h carbonation degree of 38.5%,38.5%,24.2%,and 21.9%,*** produced calcite duringβ-C_(2)S carbonation decreased as the water-to-solid ratio increased,with an increase in content of metastable CaCO_(3)of vaterite and *** thermodynamic stability of CaCO_(3)produced during carbonation was C_(3)A>C_(4)AF>β-C_(2)S>C_(3)*** carbonation degree of Portland cement was predicted based on the results of pure minerals and the composition of cement,and the error of predicted production of CaCO_(3)was only 1.1%,which provides a potential method to predict carbonation properties of systems with a complex mineral composition.

关键词： accelerated carbonation portland cement calcium carbonate water-to-solid ratio

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Fullerenes and derivatives as electrocatalysts: Promises and challenges

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Green Energy & Environment 2024年第1期9卷 7-27页

作者： kun guo Ning Li Lipiao Bao Xing Lu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China

Carbon-based metal-free nanomaterials are promising alternatives to precious metals as electrocatalysts of key energy storage and conversion *** paramount signiﬁcance are the establishment of design principles by understanding the catalytic mechanisms and identifying the active *** from sp2-conjugated graphene and carbon nanotube,fullerene possesses unique characteristics that are growingly being discovered and exploited by the electrocatalysis *** instance,the well-deﬁned atomic and molecular structures,the good electron afﬁnity to tune the electronic structures of other substances,the intermolecular self-assembly into superlattices,and the on-demand chemical modiﬁcation have endowed fullerene with incomparable advantages as electrocatalysts that are otherwise not applicable to other carbon *** increasing studies are being reported on this intriguing topic,it is necessary to provide a state-of-the-art overview of the recent *** review takes such an initiative by summarizing the promises and challenges in the electrocatalytic applications of fullerene and its *** content is structured according to the composition and structure of fullerene,including intact fullerene(e.g.,fullerene composite and superlattices)and fullerene derivatives(e.g.,doped,endohedral,and disintegrated fullerene).The synthesis,characterization,catalytic mechanisms,and deﬁciencies of these fullerene-based materials are explicitly *** conclude it by sharing our perspectives on the key aspects that future efforts shall consider.

关键词： Fullerene Fullerene derivative Metal-free catalyst Structural defect Electrocatalyst

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Insight of enriched basalts into the nature and evolution of mantle lithosphere beneath craton margins

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Science China Earth Sciences 2024年第10期67卷 3128-3142页

作者： Hong-kun DAI Jianping ZHENG Qing xiong Linlin HU Xiang ZHOU State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China

Refractory lithospheric deep roots are the cornerstone for the prolonged stability of cratons and mantle xenoliths are normally the key targets for study on the evolution of such deep roots. In regions with few mantle xenoliths, the basalts enriched in radiogenic isotopic compositions due to marked lithospheric mantle contribution are crucial to unmask the lithospheric mantle evolution based on a comprehensive study involving petrology, geochemistry and thermodynamic modelling. Here, the Early Cretaceous basalts from the northwest North China Craton with few mantle xenoliths are taken as an example to show the significance of enriched basalts on the study of lithospheric mantle. These basalts are characterized by high silica and alkali contents(SiO_(2)=45.8–59.8 wt.%, K_(2)O+Na_(2)O=4.81–9.88 wt.%), arc-type trace-element patterns and enriched radiogenic isotope compositions(e.g., ε_(Nd)=-2.64–-12.88,^(87)Sr/^(86)Sr=0.7063–0.7093). The TiO_(2) and FeO(total) contents are higher than those of natural and experimental melts from refractory mantle peridotite but comparable to those of partial melts of fertile mantle *** high contents of fluid-loving elements(e.g., Rb and Ba) suggest source metasomatism by aqueous fluids. Combined with thermodynamic modelling and regional tectonic history, these enriched basalts likely record simultaneous decompression melting of asthenosphere and low-extent melting of thin and fertile lithospheric mantle fluxed by aqueous fluids from the subducted Paleo-Asian oceanic slab. The newly unmasked lithospheric mantle under the western NCC contrasts with the coeval thick and refractory one supporting the eastern NCC, and highlights that the craton destruction, especially the loss of its ancient refractory mantle root, should take place in a diachronous manner related to the craton-girded subduction episodes. Our study illustrates the potential of enriched basalts to recover the nature and evolution of mantle lithosphere beneath craton m

关键词： Enriched basalts Lithospheric mantle Northwest North China Craton Tectonic histories Early Cretaceous

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Precise determination of the pole position of the exotic Z_(c)(3900)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： Yun-Hua Chen Meng-Lin Du Feng-kun guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

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Effect of slag composition on kinetic behavior of deep deoxidation of 5 wt.% Si high-silicon austenitic stainless steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1873-1885页

作者： Guan-xiong Dou Han-jie guo Jing guo Xue-cheng Peng Qing-yun Chen School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing 100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing 100083China

Based on a thermodynamic study of 5 wt.%Si high-silicon austenitic stainless steel(SS-5Si)smelting using CaF_(2)-CaO-Al_(2)0_(3)-Mg-Si0_(2) slag to obtain a low oxygen content of less than 10×10^(-4) wt.%,a kinetic mass transfer model for deep deoxidation was established through laboratory studies,and the effects of slag components and temperature on deoxidation during the slag-steel reaction process of sS-5Si were systematically *** experimental data verified the accuracy of the model *** results showed that the final oxygen content in the steel at 1873 K was mainly controlled by the oxygen content derived from the activity of SiO_(2) regulated by the[Si]-[O]equilibrium reaction in the slag system;in particular,when the slag basicity R(R=w(CaO)/w(SiO2),where w(CaO)and w(SiO_(2))are the contents of CaO and SiO_(2) in the slag,respectively)is 3,the Al2O3 content in the slag needs to be less than 2.7%.The mass transfer rate equation for the kinetics of the deoxidation reaction revealed that the mass transfer of oxygen in the liquid metal is the rate-controlling step under different slag conditions at 1873 K,and the oxygen transfer coefficient ko.m increases with increasing the slag basicity from 4.0×10^(-6)m s^(-1)(R=1)to 4.3×10^(-5) m s^(-1)(R=3).ko.m values at R=2 and R=3 are almost the same,indicating that high slag basicity has little *** integral of the mass transfer rate equation for the deoxidation reaction of SS-5Si under different slag conditions is *** total oxygen content of the molten steel decreases with increasing basicity from an initial content of 22×10^(-4) to 3.2×10^(-4) wt.%(R=3),consistent with the change in ko.m with slag *** R=2,the slag-steel reaction takes 15 min to reach equilibrium(w[O]=5.5×10^(-4) wt.%),whereas at R=3,the slag-steel reaction takes 30 min to reach equilibrium(w[0]=3.2×10^(-4) wt.%).Considering the depth of deoxidation and reaction time of SS-5Si smelting,it is recommended the slag b

关键词： Slag-steel reaction Kinetics Rate-controlling step Deep deoxidation Transfer coefficient

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Lateral photovoltaic effect in the Ni-SiO_(2)-Si structure with bias

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Optoelectronics Letters 2024年第5期20卷 257-264页

作者： LING Xiang ZHU Pengfei ZHU kun SONG Pei LI xiong School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201600China School of Electrical Engineering Liupanshui Normal UniversityLiupanshui 553004China School of Railway Telecommunication Hunan Technical College of Railway High-speedHengyang 421002China

We designed a clamping device to study lateral photovoltaic effect (LPE) in Ni-SiO_(2)-Si structure with bias due to the appropriate barrier *** LPE has a prominent sensitivity and linearity with 532 nm wavelength *** transient response time is 450μs and the relaxation time is 2 250μs in the Ni-SiO_(2)-Si structure without *** LPE sensitivity has a significant improvement with *** transient response time is 6μs and the relaxion time is 47μs with-7 V bias,not only improving the LPE sensitivity,but also increasing the response speed with *** research shows that the Schottky barrier structure can improve the sensitivity and linearity of LPE with bias effectively,and thus it can be used in position sensitive sensors.

关键词： LPE structure effect

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Ultralow-phase-noise and broadband frequency-hopping coupled optoelectronic oscillator under quiet point operation

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Photonics Research 2024年第8期12卷 1785-1793页

作者： HUI LIU MINGYANG guo TIAN ZHANG JIAN DAI kun XU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Advancements in microwave photonics have yielded novel approaches for generating high-purity microwave *** these,optoelectronic oscillators(OEOs)and coupled optoelectronic oscillators(COEOs)have demonstrated the capability to generate frequency-independent microwaves with exceptionally low phase ***,the tunability of the oscillators is rather limited due to the necessity for narrowband electronic bandpass filters,presenting challenges in achieving both wide and rapid tuning ***,we present a COEO featuring ultralow phase noise,flexible tuning capability,and high *** is achieved through a quiet point(QP)-operated harmonic mode-locked fiber laser,which effectively mitigates optical amplifier noise and supermode competition,thus significantly diminishing the necessity for ultra-narrow electronic *** to the liberated tuning ability,we present an oscillator that can be tuned from 2 GHz to 18 GHz,with phase noise as low as-140 d Bc/Hz at 10 k Hz under the QP *** then illustrate the practical application of the proposed oscillator in generating frequency-hopping signals with consistent spurious modes less than-85 d Bc,absolute phase noise below-135 d Bc/Hz at 10 k Hz,hopping resolution of 1.25 MHz,and fractional frequency stability below 6.1×10^(-12)at 1 s averaging time when locked to a *** presented COEO structure emerges as a compelling solution for agile and low-noise microwave sources in advanced wireless communication and radar systems.

关键词： optoelectronic tuning amplifier

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MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge

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Microsystems & Nanoengineering 2024年第3期10卷 421-432页

作者： Xiaowei guo Wuhao Yang Xingyin xiong Zheng Wang Xudong Zou The State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijingChina QILU Aerospace Information Research Institute JinanChina

Reservoir computing(RC)is a bio-inspired neural network structure which can be implemented in hardware with *** has been applied across various fields such as memristors,and electrochemical reactions,among which the microelectro-mechanical systems(MEMS)is supposed to be the closest to sensing and computing *** previous MEMS RCs have demonstrated their potential as reservoirs,the amplitude modulation mode was found to be inadequate for computing directly upon *** achieve this objective,this paper introduces a novel MEMS reservoir computing system based on stiffness modulation,where natural signals directly influence the system stiffness as *** this innovative concept,information can be processed locally without the need for advanced data collection and *** present an integrated RC system characterized by small volume and low power consumption,eliminating complicated setups in traditional MEMS RC for data discretization and *** simulation and experiment were conducted on our *** performed nonlinearity tuning for the resonator and optimized the post-processing algorithm by introducing a digital mask ***,our MEMS RC is capable of both classification and forecasting,surpassing the capabilities of our previous non-delay-based *** method successfully processed word classification,with a 99.8%accuracy,and chaos forecasting,with a 0.0305 normalized mean square error(NMSE),demonstrating its adaptability for multi-scene data *** work is essential as it presents a novel MEMS RC with stiffness modulation,offering a simplified,efficient approach to integrate sensing and *** approach has initiated edge computing,enabling emergent applications in MEMS for local computations.

关键词： computing hardware stiffness

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