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Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

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Nano Research 2024年第3期17卷 1818-1826页

作者： kun Chen Shengqiu liu Yujun Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic ***,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated *** administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat *** treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight *** addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by *** data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

Using MsfNet to Predict the ISUP Grade of Renal Clear Cell Carcinoma in Digital Pathology Images

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Computers, Materials & Continua 2024年第1期78卷 393-410页

作者： kun Yang Shilong Chang Yucheng Wang Minghui Wang Jiahui Yang Shuang liu kun liu Linyan Xue College of Quality and Technical Supervision Hebei UniversityBaoding071002China National and Local Joint Engineering Research Center of Metrology Instrument and System Hebei UniversityBaoding071002China Hebei Technology Innovation Center for Lightweight of New Energy Vehicle Power System Hebei UniversityBaoding071002China

Clear cell renal cell carcinoma(ccRCC)represents the most frequent form of renal cell carcinoma(RCC),and accurate International Society of Urological Pathology(ISUP)grading is crucial for prognosis and treatment *** study presents a new deep network called Multi-scale Fusion Network(MsfNet),which aims to enhance the automatic ISUP grade of ccRCC with digital histopathology pathology *** MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel *** model was trained and tested using 90 Hematoxylin and Eosin(H&E)stained whole slide images(WSIs),which were all cropped into 320×320-pixel patches at 40×*** achieved a micro-averaged area under the curve(AUC)of 0.9807,a macro-averaged AUC of 0.9778 on the test *** Gradient-weighted Class Activation Mapping(Grad-CAM)visually demonstrated MsfNet’s ability to distinguish and highlight abnormal areas more effectively than *** t-Distributed Stochastic Neighbor Embedding(t-SNE)plot indicates our model can efficiently extract critical features from images,reducing the impact of noise and redundant *** results suggest that MsfNet offers an accurate ISUP grade of ccRCC in digital images,emphasizing the potential of AI-assisted histopathological systems in clinical practice.

关键词： Renal cell carcinoma computer-aided diagnosis pathology image deep learning machine learning

WSN Mobile Target Tracking Based on Improved Snake-Extended Kalman Filtering Algorithm

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Journal of Beijing Institute of Technology 2024年第1期33卷 28-40页

作者： Duo Peng kun Xie Mingshuo liu School of Computer and Communication of Lanzhou University of Technology Lanzhou Gansu 730050China

A wireless sensor network mobile target tracking algorithm(ISO-EKF)based on improved snake optimization algorithm(ISO)is proposed to address the difficulty of estimating initial values when using extended Kalman filtering to solve the state of nonlinear mobile target ***,the steps of extended Kalman filtering(EKF)are ***,the ISO is used to adjust the parameters of the EKF in real time to adapt to the current motion state of the mobile ***,the effectiveness of the algorithm is demonstrated through filtering and tracking using the constant velocity circular motion model(CM).Under the specified conditions,the position and velocity mean square error curves are compared among the snake optimizer(SO)-EKF algorithm,EKF algorithm,and the proposed *** comparison shows that the proposed algorithm reduces the root mean square error of position by 52%and 41%compared to the SOEKF algorithm and EKF algorithm,respectively.

关键词： wireless sensor network(WSN)target tracking snake optimization algorithm extended Kalman filter maneuvering target

Theoretical and numerical research on the dynamic launch response of carbon fiber composite cartridges

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Defence Technology（防务技术） 2024年第3期33卷 426-436页

作者： Ruijie Zhang Hui Xu Chenlei Huang kun liu Zhilin Wu School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

Understanding the dynamic response of composite material cartridges during the firing process is of great significance for improving their reliability and safety.A theoretical model describing the dynamic response of composite material cartridges is established based on the thick-walled cylinder theory and rate-dependent constitutive model of composite *** correctness of the theoretical model is validated through finite element simulations of cartridge *** influence of chamber pressure and cartridge wall thickness on the cartridge's deformation process and stress distribution is *** results indicate that the primary deformation of composite material cartridges inside the chamber is elastic *** to metal cartridges,composite material cartridges require higher pressure for touching-chamber and are more prone to developing gaps after unloading to ensure smooth *** the deformation process,the touching-chamber behavior of the cartridge can improve the stress *** the same chamber pressure,the touching-chamber behavior can reduce the circumferential stress by approximately 30%.The inner wall surface of the cartridge is a critical area that requires *** touching-chamber behavior can be facilitated by appropriately reducing the cartridge wall thickness while ensuring overall *** study can provide guidance for the optimization design of composite material cartridges.

关键词： Composite material cartridges Dynamic response Thick-walled cylinder theory Finite element simulation Toughing-chamber behavior

Discovering Latent Variables for the Tasks With Confounders in Multi-Agent Reinforcement Learning

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1591-1604页

作者： kun Jiang Wenzhang liu Yuanda Wang Lu Dong Changyin Sun the School of Automation Southeast UniversityNanjing 210096China the School of Artificial Intelligence Anhui UniversityHefei 230601China IEEE the School of Cyber Science and Engineering Southeast UniversityNanjing 211189China the Engineering Research Center of Autonomous Unmanned System Technology Ministry of EducationHefei 230601China

Efficient exploration in complex coordination tasks has been considered a challenging problem in multi-agent reinforcement learning(MARL). It is significantly more difficult for those tasks with latent variables that agents cannot directly observe. However, most of the existing latent variable discovery methods lack a clear representation of latent variables and an effective evaluation of the influence of latent variables on the agent. In this paper, we propose a new MARL algorithm based on the soft actor-critic method for complex continuous control tasks with confounders. It is called the multi-agent soft actor-critic with latent variable(MASAC-LV) algorithm, which uses variational inference theory to infer the compact latent variables representation space from a large amount of offline ***, we derive the counterfactual policy whose input has no latent variables and quantify the difference between the actual policy and the counterfactual policy via a distance function. This quantified difference is considered an intrinsic motivation that gives additional rewards based on how much the latent variable affects each agent. The proposed algorithm is evaluated on two collaboration tasks with confounders, and the experimental results demonstrate the effectiveness of MASAC-LV compared to other baseline algorithms.

关键词： Latent variable model maximum entropy multi-agent reinforcement learning(MARL) multi-agent system

A new era of mutation rate analyses: Concepts and methods

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Zoological Research 2024年第4期45卷 767-780页

作者： kun Wu Danqi Qin Yang Qian Haoxuan liu Center for Evolutionary&Organismal Biology and the Fourth Affiliated Hospital of Zhejiang University Zhejiang University School of MedicineHangzhouZhejiang 310058China

The mutation rate is a pivotal biological characteristic,intricately governed by natural selection and historically garnering considerable *** advances in high-throughput sequencing and analytical methodologies have profoundly transformed our understanding in this domain,ushering in an unprecedented era of mutation rate *** paper aims to provide a comprehensive overview of the key concepts and methodologies frequently employed in the study of mutation *** examines various types of mutations,explores the evolutionary dynamics and associated theories,and synthesizes both classical and contemporary ***,this review comprehensively explores recent advances in understanding germline and somatic mutations in animals and offers an overview of experimental methodologies,mutational patterns,molecular mechanisms,and driving forces influencing variations in mutation rates across species and ***,it proposes several potential research directions and pressing questions for future investigations.

关键词： Mutation rate Somatic mutations Germline mutations Animal

Efficient construction of calcium fluoride nanoaggregates for enhanced water vapor adsorption

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Particuology 2024年第6期89卷 191-197页

作者： Dan-Lei Yang Jing Cao Rong-kun liu Jie-Xin Wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing100029China Petrochemical Research Institute PetroChinaBeijing102206China

Calcium fluoride(CaF_(2))is an ideal adsorbent for the dehydration of gaseous hydrogen fluoride(HF)containing water *** this work,a novel CaF_(2)absorbent,spherical CaF_(2)nanoaggregates(NAs)with a closely packed structure,was proposed and efficiently fabricated by spray drying *** the building blocks of CaF_(2)NAs,the CaF_(2)nanoparticles(NPs)were prepared by the addition of excess calcium ions(Ca^(2+))or fluorine ions(F−)in the *** results indicated that the CaF_(2)NPs synthesized by excess Ca^(2+)and the corresponding NAs exhibited much better water vapor adsorption properties than their counterparts by excess F−,owing to higher zeta *** importantly,whether excess Ca^(2+)or F^(−),CaF_(2)NAs had further enhanced water vapor adsorption capacity compared to primary CaF_(2)NPs,possibly owing to their unique nano-micro secondary structures and higher surface *** work has great potential in the development of high-performance absorbents for separating moisture from corrosive gas HF.

关键词： CaF_(2)nanoaggregates Water vapor adsorption Spray drying

Efficacy and safety of Nafamostat mesylate in patients with endstage renal failure

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World Journal of Clinical Cases 2024年第1期12卷 68-75页

作者： kun liu Zhen-Hua Li Department of Critical Care Medicine The Third People's Hospital Of Hubei ProvinceWuhan 430030Hubei ProvinceChina Department of Critical Care Medicine General Hospital of The Yangtze River ShippingWuhan Brain HospitalWuhan 430015Hubei ProvinceChina

BACKGROUND Recent studies on dialysis anticoagulation therapy in patients with renal failure have shown that Nafamostat mesylate,a broad-spectrum potent serine protease inhibitor,has strong anticoagulation and anti-fiber *** To evaluate the efficacy and safety of Nafamostat mesylate in patients with end-stage renal *** Seventy-five patients with end-stage renal failure who received hemodialysis at our hospital between January 2020 and August 2021 were selected and divided into the observation group(Nafamostat mesylate for injection,n=33)and control group(heparin sodium injection,n=32).General patient data,indicators of clinical efficacy,dialyzer hemocoagulation parameters,coagulation function indices,and hemoglobin concentration and platelet count before and after treatment,and the occurrence of adverse reactions after treatment were compared between the two *** The two groups showed no significant differences in general patient data(P>0.05).The post-treatment effectiveness rate in the control group was lower than that in the observation group(P0.05),while the number of patients in grade 0 was lower in the control group,and the number of patients in grades II and III was higher in the control group(P0.05).The total number of post-treatment adverse reactions in the observation group was lower than that in the control group(P<0.05).CONCLUSION Treatment of patients showing end-stage renal failure with Nafamostat mesylate can s

关键词： End-stage renal failure Nafamostat mesylate Effectiveness Safety study Chronic kidney diseases

A multichannel thermal bubble-actuated impedance flow cytometer with on-chip TIA based on CMOS-MEMS

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Journal of Semiconductors 2024年第5期45卷 41-49页

作者： Shengxun Cai Jianqing Nie kun Wang Yimin Guan Demeng liu School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai AURE Technology Limited Company Shanghai 201800China

Electrochemical impedance spectroscopy(EIS)flow cytometry offers the advantages of speed,affordability,and portability in cell analysis and cytometry ***,the integration challenges of microfluidic and EIS read-out circuits hinder the downsizing of cytometry *** address this,we developed a thermal-bubble-driven impedance flow cytometric application-specific integrated circuit(ASIC).The thermal-bubble micropump avoids external piping and equipment,enabling high-throughput *** a total of 36 cell counting channels,each measuring 884×220μm^(2),the chip significantly enhances the throughput of flow *** cell counting channel incorporates a differential trans-impedance amplifier(TIA)to amplify weak biosensing *** eliminating the parasitic parameters created at the complementary metal-oxidesemiconductor transistor(CMOS)-micro-electromechanical systems(MEMS)interface,the counting accuracy can be *** on-chip TIA can adjust feedback resistance from 5 to 60 kΩto accommodate solutions with different *** chip effectively classifies particles of varying sizes,demonstrated by the average peak voltages of 0.0529 and 0.4510 mV for 7 and 14μm polystyrene beads,***,the counting accuracies of the chip for polystyrene beads and MSTO-211H cells are both greater than 97.6%.The chip exhibits potential for impedance flow cytometer at low cost,high-throughput,and miniaturization for the application of point-of-care diagnostics.

关键词： EIS flow cytometry CMOS-MEMS thermal bubble lab-on-chip