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Xinfuli improves cardiac function, histopathological changes and attenuate cardiomyocyte apoptosis in rats with doxorubicin-induced cardiotoxicity

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Journal of Geriatric Cardiology 2016年第12期13卷 968-972页

作者： Pei-Pei LU Jie MA Xiao-Peng LIANG Cai-Xia GUO Yan-kun yang kun-qi yang qi-Ming SHEN Li-Hong MA Xian-Liang ZHOU Department of Traditional Chinese Medicine State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular D&eases Chinese Acad-emy of Medical Sciences and Peking Union Medical College Beijing China

Background Xinfuli Granule （XG）, a compound Chinese herbal medicine, has been effectively used in China for the treatment of heart failure for more than fifty years. This study aimed to investigate the effects and the underlying mechanisms of Xinfuli in rats with dox- orubicin-induced cardiotoxicity. Methods Sprague-Dawley rats were treated with intraperitoneal injection of Doxorubicin （DOX, 2.5 mg/kg per week） for six weeks, and then randomly divided into four groups which received intragastrically administration of normal saline （control group） or different dosage of XG （0.675 g/kg per day, 1.35 g/kg per day, and 2.7g/kg per day, respectively） for six weeks. Transtho- racic echocardiography was performed to evaluate the left ventricular fractional shortening （LVFS） and left ventricular ejection fraction （LVEF） before and after the XG treatment and histopathologic changes were also examined. Myocardial cell apoptosis was detected by TUNEL staining. The expression of related genes and proteins were analyzed using immunohistochemical staining. Results Compared to those in the control group, rats in XG treated groups showed significantly improved cardiac function and milder cardiac histopathological changes, lower cardiomyocyte apoptosis index, higher expression of Bcl-2 and lower expression of Bax. Conclusions Administration of XG improves cardiac function and histopathological changes in rats with doxorubicin-induced cardiotoxicity. These effects are associated with inhibition of cardiomyocyte apoptosis, perhaps via regulation of Bcl-2 and Bax protein expression.

关键词： Apoptosis Doxorubicin Heart failure Herbal medicine

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Clinical Characteristics and Prognosis of End-stage Hypertrophic Cardiomyopathy

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Chinese Medical Journal 2015年第11期128卷 1483-1489页

作者： Yan Xiao kun-qi yang Yan-kun yang Ya-Xin Liu Tao Tian Lei Song Xiong-Jing Jiang Xian-Liang Zhou Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： End-stage hypertrophic cardiomyopathy （HCM） is complicated by substantial adverse events. However, few studies have focused on electrocardiographic features and their prognostic values in HCM. This study aimed to evaluate the clinical manifestations and prognostic value of electrocardiography in patients with end-stage HCM. Methods： End-stage HCM patients were enrolled from a total of 1844 consecutive HCM patients from April 2002 to November 2013 at Fuwai Hospital. Clinical data, including medical history, electrocardiography, and echocardiography, were analyzed. Cox hazards regression analysis was used to assess the risk factors for cardiovascular mortality. Results： End-stage HCM was identified in 99 （5.4%） patients, averaged at 52 ± 16 years old at entry. Atrial fibrillation was observed in 53 patients and mural thrombus in 19 patients. During 3.9 ±3.0 years of follow-up, embolic stroke, refractory heart failure, and death or transplantation were observed in 20, 39, and 51 patients, respectively. The incidence of annual mortality was 13.2%. Multivariate Cox hazards regression analysis identified New York Heart Association Class （NYHA） Ill/IV at entry （hazard ratio [HR]： 1.99; 95% confidence interval [C/I： 1.05-3.80; P = 0.036）, left bundle branch block （LBBB）（HR： 2.80; 95% CI： 1.47-5.31; P = 0.002）, and an abnormal Q wave （HR： 2.21; 95% CI： 1.16-4.23; P = 0.016） as independent predictors of cardiovascular death, in accordance with all-cause death and heart failure-related death. Conclusions： LBBB and an abnormal Q wave are risk factors of cardiovascular mortality in end-stage HCM and provide new evidence for early intervention. Susceptibility of end-stage HCM patients to mural thrombus and embolic events warrants further attention.

关键词： End-stage Hypertrophic Cardiomyopathy Left Bundle Branch Block Prognosis Q wave

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A novel phenotype with splicing mutation identified in a Chinese family with desminopathy

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Chinese Medical Journal 2019年第2期132卷 127-134页

作者： Peng Fan Chao-Xia Lu Xue-qi Dong Di Zhu kun-qi yang Ke-qiang Liu Di Zhang Ying Zhang Xu Meng Hui-qiong Tan Li-Tian YU Ke-Fei DOU Ya-Xin Liu Xue Zhang Xian-Liang Zhou Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Emergency and Cdtical Care Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background:Desminopathy, a hereditary myofibrillar myopathy, mainly results from the desmin gene (DES) *** involves various phenotypes, mainly including different cardiomyopathies, skeletal myopathy, and *** with genotype, it helps us precisely diagnose and treat for ***:Sanger sequencing was used to characterize DES variation, and then a minigene assay was used to verify the effect of splice-site mutation on pre-mRNA *** were analyzed based on clinical characteristics associated with ***:A splicing mutation (c.735+1G>T) in DES was detected in the proband.A minigene assay revealed skipping of the whole exon 3 and transcription of abnormal pre-mRNA lacking 32 *** affected family member who carried the identical mutation, was identified with a novel phenotype of desminopathy, non-compaction of ventricular *** were 2 different phenotypes varied in cardiomyopathy and skeletal myopathy among the 2 patients, but no significant correlation between genotype and phenotype was ***:We reported a novel phenotype with a splicing mutation in DES, enlarging the spectrum of phenotype in *** studies of desminopathy should promote our understanding of its pathogenesis and provide a precise molecular diagnosis of this disorder, facilitating clinical prevention and treatment at an early stage.

关键词： Desminopathy Cardiomyopathy Desmin gene Splicing mutation

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Toughening of polypropylene with hybrid-filler calcium carbonate particles

Toughening of polypropylene with hybrid-filler calcium carbo...

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2006年全国高分子材料科学与工程研讨会

作者： kun yang, qi yang, qingquan Yu, Yanlong Feng, Guangxian Li College of Polymer Science and Engineering The State Key Laboratory for Polymer Materials Engineering, Sichuan University Chengdu 610065, P.R.China

＜正＞Recently, a method that incorporating two types of particulate fillers simultaneously into the PP matrix has been put forward. Silva et al. studied the mechanical properties of PP filled with CaCO3 and talc. From their data, when the filler content was the same, it could be obtained that incorporating CaCO3 and talc simultaneously into the PP matrix made the impact strength slightly higher than that of incorporating single-filler CaCO3 or talc into PP matrix. Leong et al. observed

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Treatment of coke plant wastewater by SND fixed biofilm hybrid system

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Journal of Environmental Sciences 2007年第2期19卷 153-159页

作者： qi Rong yang kun YU Zhao-xiang Department of Chemistry Tongji University Shanghai 200092 China

In this article, coke plant wastewater was treated by a simultaneous nitrifying and denitrifying （SND） fixed biofilm hybrid system. The results showed that suitable parameters of the system were important for the performance of the bio-degradation system. The chemical oxygen demand （COD） removal efficiency in this system was satisfactory, higher than 94%, and ammonia nitrogen was higher than 95%. The effluent COD concentration could meet the discharge standard, except for very few situations. The results showed that a sufficient carbon source was important for making ammonia nitrogen concentration meet the discharge standard. Then the TiN removal efficiency in this system can be brought higher than 94%. Dissolved oxygen （DO） is very important to the performance of the SND bio-degradation system, and the suitable DO is about 3.5-4.0 mg/L at the forepart of reactor. In addition, the performance of the system was almost not affected by pH value. The results show that the system is feasible to treat coke plant wastewater.

关键词： coke plant wastewater SND fixed biofilm ammonia nitrogen COD carbon source

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Method development for estimating soil organic carbon content in an alpine region using soil moisture data

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Science China Earth Sciences 2020年第4期63卷 591-601页

作者： qi LUO kun yang Yingying CHEN Xu ZHOU Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Earth System Science Tsinghua UniversityBeijing 100084China CAS Center for Excellence in Tibetan Plateau Earth System Beijing 100101China

The high soil organic carbon(SOC) content in alpine meadow can significantly change soil hydrothermal properties and further affect the soil temperature and moisture as well as the surface water and energy budget. Therefore, this study first introduces a parameterization scheme to describe the effect of SOC content on soil hydraulic and thermal parameters in a land surface model(LSM), and then the SOC content is estimated by minimizing the difference between observed and simulated surface-layer soil moisture. The accuracy of the estimated SOC content was evaluated using in situ observation data at a soil moisture and temperature-measuring network in Naqu, central Tibetan Plateau. Sensitivity experiments show that the optimum time window for stabilizing the estimation results cannot be shorter than three years. In the experimental area, the estimated SOC content can generally reflect the spatial distribution of the measurements, with a root mean square error of 0.099 m^3 m^(-3), a mean bias of 0.043 m^3 m^(-3), and a correlation coefficient of 0.695. The estimated SOC content is not sensitive to the temporal frequency of the soil moisture data input. Even if the temporal frequency is as low as that of current soil moisture products derived from passive microwave satellites, the estimation result is still stable. Therefore, by combining a high-quality satellite soil moisture product and a parameter optimization method, it is possible to obtain grid-scale effective parameter values, such as SOC content,for an LSM and improve the simulation ability of the LSM.

关键词： Land surface model Soil organic carbon content Soil porosity Soil parameter estimation

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A critical review on the application of biochar in environmental pollution remediation:Role of persistent free radicals(PFRs)

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Journal of Environmental Sciences 2021年第10期33卷 201-216页

作者： kun Luo Ya Pang Dongbo Wang Xue Li Liping Wang Min Lei qi Huang qi yang Department of Bioengineering and Environmental Science Changsha UniversityChangsha 410003China College of Environmental Science and Engineering Hunan UniversityChangsha 410082China

Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ***,there are abundant persistent free radicals(PFRs)in biochar,so the direct and indirect PFRs-mediated removal of organic and inorganic contaminants by biochar was widely *** order to comprehend deeply the formation of PFRs in biochar and their interactions with contaminants,this paper reviews the formation mechanisms of PFRs in biochar and the PFRs-mediated environmental applications of biochar in recent ***,future challenges in this field are also *** review provides a more comprehensive understanding on the emerging applications of biochar from the viewpoint of the catalytic role of PFRs.

关键词： Biochar Organic and inorganic contaminants Persistent free radicals Degradation Reactive oxygen species

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两种入路在全胸腔镜下原发性肺癌根治术中的对比研究

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临床医学研究与实践 2018年第19期3卷 4-5,8页

作者：雷尚昆王军岐杨智付小伟杨力涛李海鹏宝鸡市中心医院胸外科陕西宝鸡721008

目的对比分析单孔及三孔两种入路在全胸腔镜下原发性肺癌根治术中的临床效果。方法回顾性分析宝鸡市中心医院2014年1月至2017年6月120例行全胸腔镜下原发性肺癌根治术患者的临床资料。试验组58例,采用单孔全胸腔镜入路;对照组62例,采用... 详细信息

目的对比分析单孔及三孔两种入路在全胸腔镜下原发性肺癌根治术中的临床效果。方法回顾性分析宝鸡市中心医院2014年1月至2017年6月120例行全胸腔镜下原发性肺癌根治术患者的临床资料。试验组58例,采用单孔全胸腔镜入路;对照组62例,采用传统三孔全胸腔镜入路。对比分析两组围手术期临床指标、卫生经济学指标及生活质量。结果两组术中出血量、手术时间、淋巴结清扫数目、术后胸腔引流液体量、引流时间及术后并发症发生率比较,无统计学差异(P>0.05),试验组术中中转率显著高于对照组(P0.05)。术后3个月,两组患者的各项生活质量评分均优于术前,试验组情感状态、功能状态及整体评价评分优于对照组(P<0.05)。试验组切口麻木发生率明显低于对照组,切口外观满意度则显著高于对照组(P<0.05)。结论与传统三孔对比,采用单孔全胸腔镜入路应用于肺癌根治术安全可靠,术后生活质量高,可供临床应用。

关键词：手术入路全胸腔镜原发性肺癌肺癌根治术

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Effect of grain structure on the mechanical properties of a Monel alloy fabricated by laser-based directed energy deposition

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Journal of Materials Science & Technology 2023年第33期164卷 129-139页

作者： Ze Chen Wei Fan Shubo Gao yang qi Sastry Yagnanna Kandukuri kun Zhou Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore DNV AS HøvikOslo 1363Norway

Monel K-500 is a Ni–Cu alloy widely used in the marine and offshore industry due to their superior resistance to corrosion in seawater and hence easily *** address this problem,laser-based directed energy deposition(LDED)is used to repair or refabricate these high-value worn *** optimize the mechanical properties of repaired parts,the commonly applied solution and aging is not ideal because it also changes the properties of the base ***,in situ control of the grain structures during the LDED process becomes an effective approach for high-performance *** this study,we fabricated a duplex grain structure with small grain size and low texture intensity using low laser power and scanning *** duplex microstructure consists of short columnar grains and zigzag-distributed fine equiaxed *** formation of this grain structure is dependent on both the solidification and recrystallization *** strength of this grain structure is improved to 523.5 MPa without the sacrifice of ductility,which is instead 20%higher than that of the counterpart consisting of typical columnar grains due to the grain refinement and crack *** mechanical properties of the alloy with the duplex grain structure are even comparable to heat-treated Monel K-500 fabricated by wire arc additive *** work provides valuable insights into the in situ optimization of the microstructure and mechanical properties of LDED-fabricated parts.

关键词： Additive manufacturing Directed energy deposition Monel alloy Grain structure Mechanical properties

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