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Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors

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World Journal of Gastroenterology 2005年第40期11卷 6373-6380页

作者： Yen-Shen Lu Huang-Chun Lien Pei-Yen yeh kun-huei yeh Min-Liang Kuo Sung-Hsin Kuo Ann-Lii Cheng Department ofOncology National Taiwan University Hospital Graduate Instituteof Clinical Medicine National Taiwan University College ofMedicine Taipei Taiwan China Departments of Pathology National TaiwanUniversity Hospital Taipei Taiwan China Department of Oncology National Taiwan UniversityHospital Taipei Taiwan Department of Oncology and Departments of InternalMedicine National Taiwan University Hospital Departments ofInternal Medicine and Medical Research Far Eastern MemorialHospital Taipei Taiwan China Department of Oncology and Department ofInternal Medicine National Taiwan University Hospital TaipeiTaiwan China

AIM： To determine how glucocorticoids （GCs） may affect the growth and chemosensitivity of common carcinoma cells. METHODS： The effect of dexamethasone （DEX） on growth and chemosensitivity was assessed in 14 carcinoma cell lines. The function of GC receptors （GR） was assessed by MMTV reporter assay. Overexpression of GR was done by in vitro transfection and expression of a GR-expressing vector. Immunohistochemical stain of tissues and ceils were done by PA1-511A, an anti-GR monodonal antibody. RESULTS： DEX inhibited cell growth of four （MCF-7, MCF- 7/MXR1, MCF-7/TPT300, and HeLa）, increased cisplatin cytoxicity of one （SiHa）, and decreased dsplatin cytotoxicity of two （H460 and Hep3B） cell lines. The GR content of the seven cell lines affected by DEX was significantly higher than those of the seven cell lines unaffected by DEX （5.2±2.5×10^4 sites/cell vs1.3±1.4×10^4 sites/cell, P= 0.005）. Only two DEX-unresponsive cell lines {NPC-TW01 and NPC- TW04） oontained high GR amounts in the range （1.9-8.1×10^4 sites/cell） of the seven DEX-responsive cell lines. The GR function of NPC-TW01 and NPC-TW04, however, was foundto be impaired. The importance of high cellular amount of GR in mediating DEX susceptibility of the cells was further exemplified by GR dose-dependent drug resistance to cisplatin of AGS, a cell line with low GR content and was unaffected by DEX before transfection of GR-expressing vector. Immunohistochemical studies of human cancer tissues showed that 5 of the 45 （11.1%） breast cancer and 43 of the 85 （50.6%） non-small cell lung cancer had high GR contents at the ranges of the GC-responsive carcinoma cell lines. CONCLUSION： The growth and chemosensitivity of human carcinomas with high GR contents may be affected by GC. However, in light of the heterogeneous and even contradictive effects of GC on these cells, routine examination of GR contents of human carcinoma tissues may not be clinically useful until other markers that help predict the ultimate effect of

关键词： Glucocorticoids Glucocorticoid receptor Carcinoma Cell growth Chemosensitivility Drug resistance

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Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

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World Journal of Gastroenterology 2005年第28期11卷 4357-4362页

作者： Sung-Hsin Kuo Li-Tzong Chen Chi-Long Chen Shin-Lian Doong kun-huei yeh Hui-Chen Hsu Ming-Shiang Wu Jaw-Town Lin Hsiu-Po Wang Ann-Lii Cheng Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center and Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan China Division of Cancer Research National Health Research Institutes Taipei Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taipei Taiwan China Department of Pathologyl Taipei MedicalUniversity Taipei Taiwan China Graduate Institute of Microbiology National Taiwan University College of Medicine Taipei Taiwan China Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of Medicine Taipei Taiwan China Department of Internal Mcclicine National Taiwan University Hospital Taipei Taiwan China Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan China Department of internal Medicine and Department of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of MedicineTaipei Division of Cancer Research National Health Research Institutes Taipei Taiwan China

AIM： A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue （MALT） lymphomas remain Helicobacter pylori （ H pylori）-dependent. However,unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori- spedfic intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 （B7.2） and the infiltration of CD56 （＋） natural killer （NK） cells can be useful markers to predict Hpylori-dependent status of high-grade gastric MALT iymphoma.METHODS： Lymphoma biopsies from 26 patients who had participated in a prospective study of Hpylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade Ⅱ or less alter H pylori eradication were dassified as H pylori-dependent; others were dassified as H *** infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. RESULTS： There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 （68.8%） of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases （P = 0.001）.H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 （＋） NK cells than H pylori-independent cases （2.8±1.4% vs 1.1±0.8%, P = 0.003）. CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 （＋） NK cells compared to CD86-negative cases （2.9±1.1% vs 1.4±1.3%; P= 0.005）.CONCLUSION： These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with Hpylori-dependent state of early-stage high-grade gastric M

关键词： MALT lymphoma Hpylori CD86 CD56

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Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer

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World Journal of Gastroenterology 2016年第32期22卷 7275-7288页

作者： Shih-Hung Yang Ting-Chun Kuo Hsu Wu Jhe-Cyuan Guo Chiun Hsu Chih-Hung Hsu Yu-Wen Tien kun-huei yeh Ann-Lii Cheng Sung-Hsin Kuo Department of Oncology National Taiwan University Hospital and National Taiwan University Cancer Center Taipei 100 Taiwan Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Cancer Center Taipei 100 Taiwan Institute of Clinical Medicine National Taiwan University Hospital and National Taiwan University Cancer Center Taipei 100 Taiwan Department of Traumatology National Taiwan University Hospital and National Taiwan University Cancer Center Taipei 100 Taiwan Department of Oncology National Taiwan University Hospital Yun-Lin Branch Yunlin 655 Taiwan Graduate Institute of Oncology National Taiwan University College of Medicine Taipei 100 Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University Cancer Center Taipei 100 Taiwan

Pancreatic cancer is highly lethal. Current research that combines radiation with targeted therapy may dramatically improve prognosis. Cancerous cells are characterized by unstable genomes and activation of DNA repair pathways, which are indicated by increased phosphorylation of numerous factors, including H2 AX, ATM, ATR, Chk1, Chk2, DNA-PKcs, Rad51, and Ku70/Ku80 heterodimers. Radiotherapy causes DNA damage. Cancer cells can be made more sensitive to the effects of radiation(radiosensitization) through inhibition of DNA repair pathways. The synergistic effects, of two or more combined non-lethal treatments, led to coadministration of chemotherapy and radiosensitization in BRCA-defective cells and patients, with promising results. ATM/Chk2 and ATR/Chk1 pathways are principal regulators of cell cycle arrest, following DNA doublestrand or single-strand breaks. DNA double-stranded breaks activate DNA-dependent protein kinase, catalytic subunit(DNA-PKcs). It forms a holoenzyme with Ku70/Ku80 heterodimers, called DNA-PK, which catalyzes the joining of nonhomologous ends. This is the primary repair pathway utilized in human cells after exposure to ionizing radiation. Radiosensitization, induced by inhibitors of ATM, ATR, Chk1, Chk2, Wee1, PP2 A, or DNA-PK, has been demonstrated in preclinical pancreatic cancer studies. Clinical trials are underway. Development of agents that inhibit DNA repair pathways to be clinically used in combination with radiotherapy is warranted for the treatment of pancreatic cancer.

关键词： Radiotherapy Pancreatic cancer DNA damage DNA repair Molecular targets

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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： kun-Chen Lin Wen-Feng Fang Jui-Ning yeh John Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(P<0.001).The protein levels of inflammation[interleukin(IL)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all P<0.001).Animals were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all P<0.0001),whereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer

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World Journal of Gastroenterology 2012年第30期18卷 4051-4058页

作者： Tan-Hsia Chen Chi-Chou Huang kun-Tu yeh Shu-Hau Chang Shih-Wen Chang Wen-Wei Sung Ya-Wen Cheng huei Lee Institute of Medicine Chung Shan Medical UniversityTaichung 402TaiwanChina Department of Internal Medicine Chung Shan Medical University HospitalTaichung 402TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 402TaiwanChina Department of Surgery Chung Shan Medical University HospitalTaichung 402TaiwanChina Department of Pathology Changhua Christian HospitalChanghua 500TaiwanChina Department of Medical Research Chung Shan Medical University HospitalTaichung 402TaiwanChina PhD Program for Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical UniversityTaipei115TaiwanChina

AIM:To investigate the association between human papilloma virus(HPV) infection and colorectal ***:Sixty-nine patients with pathologically confirmed primary colorectal cancer including 6 stage Ⅰ,24 stage Ⅱ,21 stage Ⅲ,and 18 stage Ⅳ patients were enrolled in this study to investigate whether HPV 16 could be involved in colorectal ***-polymerase chain reaction(nested-PCR) was used to detect HPV16 DNA in colorectal tumor tissues and further confirmed by in situ hybridization(ISH).In addition,immunohistochemistry analysis was performed to examine the E6 oncoprotein in colorectal *** verify whether E6 could inactivate the p53 transcriptional function,the levels of p21 and Mdm2 mRNA expression were evaluated by real-time reverse transcription(RT)-***:Of the 69 colorectal tumors,HPV16 DNA was detected in 11(16%) by nested-PCR,and HPV16 DNA was present in 8 of the 11(73%) tumors which was confirmed by *** presence of HPV16 DNA in colorectal tumors was not associated with patients' clinical parameters including age,gender,smoking status,tumor site;however,HPV16 infection was more common in stage Ⅰ patients than in late-stages patients(Ⅱ,Ⅲ and Ⅳ).We next asked whether HPV16 infection could be linked with colorectal cancer *** data indicated that 8 of the 11 HPV16 DNA-positive tumors had E6 oncoprotein ***,we also observed that the adjacent normal tissues including endothelial cells,lymphocytes,fibroblasts,and gland cells in E6-positive tumors had E6 oncoprotein *** addition,3 of the 4(75%) E6-positive tumors carrying p53 wild-type had negative immunostaining,but one tumor had less p53 *** further examined whether E6-positive and/or p53 mutated tumors reduce p53 transcriptional ***-time RT-PCR analysis indicated that p21 and mdm2 mRNA expression levels in E6/p53-wildtype tumors were significantly lower than in their adjacent normal tissues;as expected,E6-

关键词： Human papilloma virus Colorectal cancer p53 p21 Blood lymphocytes

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Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate

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World Journal of Gastroenterology 2006年第13期12卷 2060-2064页

作者： kun-Chun Chiang Tsung-Wen Chen Chun-Nan yeh Hsiang-Lin Lee Department of Surgery and Nuclear Medicine Chang Gung Memorial Hospital Chang Gung UniversityTaoyuanTaiwanChina

AIM： Most gastrointestinal stromal tumors （GISTs） express constitutively activated mutant isoforms of kit kinase or platelet-derived growth factor receptor alpha （PDGFRA）, which are potential therapeutic targets for imatinib mesylate （Glivec）. Partial response occurred in almost two thirds of GIST patients treated with Glivec. However, complete response （CR） after Glivec therapy was sporadically reported. Here we illustrated advanced GIST patients with CR after Glivec treatment. METHODS： Between January 2001 and June 2005, 42 advanced GIST patients were treated with Glivec. Patients were administered 400 mg of Glivec in 100-mg capsules, taken orally daily with food. The response of the tumor to Glivec was evaluated after one month, three months, and every three months thereafter or whenever medical need was indicated. Each tumor of patients was investigated for mutations of kit or PDGFRA. RESULTS： The median follow-up time of the 42 ad-vanced GIST patients treated with Glivec was 16.9 months （range, 1.0- 47.0 months）. Overall, 3 patients had complete response CR （7.1%）, 26 partial response （67.8%）, 5 stationary disease （11.9%）, and 3 progressive disease （11.9%）. The median duration of Glivec administration for the three patients was 36 months （range, 23-36 months）. The median time to CR after Glivec treatment was 20 months （range, 9-26 months）. Deletion and insertion mutations of c-kit exon 11 and insertion mutation of c-kit exon 9 were found in two cases and one case, respectively. CONCLUSION： Complete response （CR） can be achieved in selected advanced GIST patients treated with Glivec. The median time to CR after Glivec treatment was 20 months. Deletion and insertion mutations of kit exon 11 and insertion mutation of kit exon 9 contribute to the genetic features in these selected cases.

关键词： GIST Complete response Imatinib mesylate

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AN AHP MODEL FOR BRINGING EXPERTS TO CONSENSUS ON MEDICAL PAYMENT STANDARDS

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Journal of Systems Science and Systems Engineering 2006年第2期15卷 247-255页

作者： Yuan-huei HUANG Pei-yeh CHANG Chih-Young HUNG Kuei-Ing WANG King-Jen CHANG Department of Surgery Hsin-Chu General HospitalTaiwanChina Department of Pediatric Surgery Chang Gung Children’s HospitalChang Gung UniversityCollege of MedicineTaiwanChina Institute of Management of Technology National Chiao Tung UniversityTaiwanChina Department of Information Management Ming Hsin University of Science and TechnologyTaiwanChina Department of Surgery National Taiwan University HospitalTaiwanChina

Many countries with health insurance systems conduct periodic payment standards reform. How to reach consensus in setting payment standards among different specialties with different agendas has become a critical issue. The purpose of this study is to construct an analytic hierarchy process （AHP） model to obtain judgments from experts about the importance of ＂factors related to establishing payment standards in the national health insurance program＂. Under this goal, the first tier contains four evaluation aspects, and the second tier contains sixteen evaluation criteria divided into four groups The AHP model was then used to collect and combine the opinions of experts through an empirical study. The results can be directly used to formulate standard values as the basis for establishing payment standards. The results of our study strongly support that an AHP model is effective in forming a consensus among surgical specialists.

关键词： National Health Insurance Analytic Hierarchy Process payment standards

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Radial nerve recovery following closed nailing of humeral shaft fractures without radial nerve exploration: A retrospective study

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World Journal of Clinical Cases 2021年第27期9卷 8044-8050页

作者： Kuei-Lin yeh Chen-kun Liaw Tai-Yin Wu Chung-Pei Chen Department of Orthopedics Shin Kong Wu-Ho Su Memorial HospitalTaipei City 111Taiwan Department of Orthopedics School of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11031Taiwan Department of Orthopedics Shuang Ho HospitalTaipei Medical UniversityNew Taipei City 23561Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical EngineeringResearch Center of Biomedical DeviceTaipei Medical UniversityTaipei City 11301Taiwan Department of Family Medicine Zhongxing BranchTaipei City HospitalTaipei City 10341Taiwan Institute of Epidemiology and Preventive Medicine National Taiwan UniversityTaipei City 10055Taiwan National Taipei University of Nursing and Health Science Taipei City 11219Taiwan Department of Orthopedics Cathay General HospitalNew Taipei City 221Taiwan

BACKGROUND Radial nerve palsy due to humeral shaft fracture is the most common peripheral nerve injury associated with long bone *** antegrade nailing surgical technique is becoming popular for the fixation of these fractures with minimal *** analyzed nerve recovery in patients with humeral shaft fracture and radial nerve palsy treated with humeral nail fixation without nerve *** To assess the radial nerve recovery rate and time from humeral shaft fracture with surgical treatment using close *** We retrospectively collected data of patients who underwent undergone surgical nail fixation for humeral shaft fractures between October 1,2016,and March 31,***,we analyzed the primary or secondary radial nerve palsy recovery rate and radial nerve motor function recovery *** The study included 70 patients who underwent surgical treatment for closed-or Gustilo type I open humeral shaft fractures using a nail fixation technique without radial nerve *** patients suffered from primary(n=5)and secondary(n=5)radial nerve palsy.A 100%radial nerve recovery rate was *** mean recovery time was 4.3 *** The study results indicate full recovery of radial nerve palsies from humeral shaft fracture using close nailing *** need not be concerned about the occurrence of permanent nerve palsies.

关键词： Humeral shaft fracture Radial nerve palsy Close nailing fixation Nerve exploration

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Prognostic analysis of patients with pancreatic head adenocarcinoma less than 2cm undergoing resection

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World Journal of Gastroenterology 2009年第34期15卷 4305-4310页

作者： kun-Chun Chiang Chun-Nan yeh Wei-Chen Lee Yi-Yin Jan Tsann-Long Hwang Pancreatic Cancer Team Department of SurgeryChang Gung Memorial Hospital Chang Gung University

AIM:To investigate the differences in clinicopathological features between patients with pancreatic cancer greater or less than 2 cm situated over the pancreatic head and the prognostic factors for survival of patients with pancreatic cancer2 cm)and 36 cases of small(S)-PAC(tumor≤2 cm).We compared the clinicopathological characteristics and prognosis of L-PAC and S-PAC *** clinicopathological characteristics of S-PAC were investigated to clarify the prognosis predictive factors of S-PAC. RESULTS:One hundred and fifty-nine PAC patients, aged 16-93 years(median,59.0 years)with a tumor at the pancreatic head undergoing intentional curative resection were *** S-PAC and L-PAC patients had similar demographic data,clinical features,and tumor markers(a similar positive rate of carcinoembryonic antigen and carbohy- drate antigen 19-9).There were also similar rates of lymph node metastasis,portal vein invasion,stage distribution,tumor differentiation,positive resection margin,surgical morbidity and mortality observedbetween the two *** a follow-up period ranging from 1.0 to 122.7 mo(median,10.9 mo), S-PAC and L-PAC patients had a similar prognosis after resection(P=0.4805).Among the S-PAC patients group,patients with higher albumin level(>3.5 g/dL) had more favorable survival than those with lower albumin levels,which was the only favorable predictive prognostic ***,early-staged(stageⅠ,Ⅱ) S-PAC patients tended to have a more favorable outcome than late-stage(stageⅢ,Ⅳ)S-PAC patients, but this was not statistically significant. CONCLUSION:S-PAC patients should not be regarded as early *** higher albumin level(>3.5 g/dL) an

关键词： Prognostic factor Pancreas Pancreatic head area Pancreatic cancer

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Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study

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World Journal of Clinical Cases 2021年第31期9卷 9509-9519页

作者： Kuei-Lin yeh Szu-Hsien Wu Chen-kun Liaw Sheng-Mou Hou Shing-Sheng Wu Department of Orthopedics Shin Kong Wu Ho-Su Memorial HospitalTaipei 11101Taiwan Department of Physical Medicine and Rehabilitation Taipei Veterans General HospitalTaipei 11217Taiwan Department of Orthopedics School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan Department of Orthopedics Shuang Ho HospitalTaipei Medical UniversityNew Taipei 23561Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical EngineeringResearch Center of Biomedical DeviceTaipei Medical UniversityTaipei 11301Taiwan

BACKGROUND Osteoporosis with vertebral compression fractures is increasingly common in the elderly *** augmentation is one of the effective surgical treatments for these ***,there are several different types of cement augmentation *** studies have compared the safety and efficacy of different cement augmentation types for the treatment of such fractures;thus,we retrospectively compared vertebroplasty,balloon kyphoplasty,and kyphoplasty with SpineJack or an intravertebral expandable *** To compare the postoperative safety and efficacy of each surgical intervention in treating vertebral compression *** We retrospectively analyzed 354 patients with acute vertebral compression fractures,defined as signal changes in the T1 weighted magnetic resonance imaging,and randomly divided the patients into five *** visual analog scale scores for pain,kyphotic angle,average body height,rate of cement leakage,and occurrence of adjacent vertebral compression fractures were followed for 1 ***-way analysis of variance,the post hoc Bonferroni test,and Fisher exact probability test were used for statistical *** All pain scores significantly improved 12 mo postoperatively;however,there was no significant difference between the groups(P=0.325).Kyphoplasty with SpineJack significantly reduced the kyphotic angle(P=0.028)and restored the height of the vertebral body(P=0.02).The rate of adjacent compression fractures was the highest in the vertebroplasty group,with a statistically significant difference according to the Fisher exact probability test(P=0.02).The treatment with the lowest cement leakage rate cannot be identified because of the small sample size;however,kyphoplasty with SpineJack,an IVEP,and vesselplasty resulted in lower rates of cement leakage than balloon kyphoplasty and *** Kyphoplasty with SpineJack has good outcomes in kyphotic angle reduction and body height restora

关键词： Vertebral compression fracture Vertebroplasty Kyphoplasty Osteoporosis Observational study

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