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Trends and frontiers in signal amplification for aptamer-based tumor detection:A bibliometric analysis

World Journal of clinical cases 2024年第21期12卷 4726-4741页

作者： Dan cai Gui-lin c.en Ting Wang kun-He Zhang Department of Gastroenterology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Institute of Gastroenterology and Hepatology Nanchang 330006Jiangxi ProvinceChina Department of Anorectal Surgery The 908th Hospital of the Chinese People's Liberation Army Joint Logistics Support ForceNanchang 330000Jiangxi ProvinceChina

BAcKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social *** detection is the key to improving cure rates and reducing mortality rates,which requires the development of sensitive early detection *** amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from *** To investigate the current research status,developmental trajectories,and hotspots in signal amplification for aptamer-based tumor detection through bibliometric *** english publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Sc.ence core collection *** and citeSpace software were employed to analyze various information within this field,including countries,institutions,authors,co-cited authors,journals,co-cited journals,cited references,and *** A total of 757 publications were included in this *** accounted for 85.47%of all publications,with Nanjing University(china)emerging as the institution with the highest publication *** most influential authors and journals were Hasanzadeh *** Iran and"Biosensors and Bioelectronics",*** and carcinoembryonic antigen(cEA)stood out as the most researched tumor-related ***,the predominant signal amplification technique,nanomaterial,and signal transduction method were identified as hybridization chain reactions,gold nanoparticles,and electrochemical methods,*** the past 3 years,exosomes,cEA,electrochemical biosensors,and nanosheets have emerged as research hotspots,exhibiting a robust burst of *** This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status,hotspots,and prospective research directions within this ***,i

关键词： Aptamer Signal amplification Tumor Bibliometrics Electrochemistry Nanosheet

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论行政处罚决定公开的判定规则

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行政法学研究 2024年第4期 97-111页

作者：马琳昆常州大学史良法学院江苏常州213164

因原则性条款与特殊性条款规则冲突、不确定法律概念识别困难以及规范功能与实际功能匹配矛盾,行政处罚决定公开在执法层面适用的准确性存疑。立足现有规范体系,行政处罚决定公开具有监督、警告、制裁等多重目的,而行政处罚决定又涉及... 详细信息

因原则性条款与特殊性条款规则冲突、不确定法律概念识别困难以及规范功能与实际功能匹配矛盾,行政处罚决定公开在执法层面适用的准确性存疑。立足现有规范体系,行政处罚决定公开具有监督、警告、制裁等多重目的,而行政处罚决定又涉及个人利益、社会利益与国家利益,是否公开就需要对不同主体间复杂的利益关系进行衡量。行政处罚决定公开不能简单适用政府信息公开之规定,而是应先根据公开之目的择准利益偏向,判断分属应当公开或应当不公开之类型后,再对公开与豁免公开之理由进行辨别。“具有一定社会影响”作为应当不公开类型的豁免理由,需要结合行为标准、主体标准、时间标准进行解释,以此构建行政处罚决定公开的理性判定规则。

关键词：行政处罚决定公开个人利益公共利益具有一定社会影响

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New advances in the study of Tethyan Geodynamic System

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Sc.ence china Earth Sc.ences 2024年第3期67卷 874-878页

作者： lin DING State Key Laboratory of Tibetan Plateau Earth System Sc.ence(LATPES) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Tethyan Ocean was initially proposed by Austrian geologist Eduard Suess in 1893. The study of the Tethyan evolution by European geologists has led to the development of modern geology, but not to the establishment of plate tectonics theory(Trümpy, 2001). With the progress in various studies, the concept of Tethys has evolved from a Mesozoic ocean into three long-term evolving oceans:Proto-Tethys, Paleo-Tethys, and Neo-Tethys (Figure 1), and their life cycles cover the entire Phanerozoic era (Wu et al., 2020).

关键词： geology Mesozoic ocean

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A classification scheme for inorganic cluster compounds based on their electronic structures and bonding characteristics

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chinese Journal of Structural chemistry 2024年第5期43卷 30-37页

作者： Zhenyang lin Department of chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPR China

A novel classification scheme for inorganic cluster compounds is presented based on the characteristics of their electronic *** the classification scheme,five distinct categories have been introduced,including Jellium clusters,Wadian clusters,electron-precise clusters,π-donor ligated metal-metal bonded clusters,and antiferro-magnetically coupled high-spin metal clusters.

关键词： Inorganic cluster compounds Structure and bonding Electron counting rules Superatomic clusters

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Optimal structural design for a certain near-space composite propeller of airship using adaptive region division blending model

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chinese Journal of Aeronautics 2024年第5期37卷 301-316页

作者： Weigang AN Tianyu lin Shigen WANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

Near-space airship is a frontier and hotspot in current military research and development,and the near-space composite propeller is the key technology for its *** order to obtain higher aerodynamic effic.ency at an altitude of 22 km,a certain near-space composite propeller is designed as a long and slender aerodynamic shape with a 10 m diameter,which brings many challenges to the composite structure *** initial design is obtained by the composite structure variable stiffness design method using based on fixed region division blending ***,it weighs 23.142 kg,exceeding the required 20 *** order to meet the structural design requirements of the propeller,a variable stiffness design method using the adaptive region division blending model is proposed in this *** with the methods using the fixed region division blending model,this method optimizes region division,stacking thickness and stacking sequence in a single level,considering the coupling effect among *** a more refined region division,this method can provide a more optimal design for composite tapered ***,to improve the effic.ency of optimization subjected to manufacturing constraints,a hierarchical penalty function is proposed to quickly filter out the solutions that do not meet manufacturing *** above methods combined with a Genetic Algorithm(GA)using specific.encoding are adopted to optimize the near-space composite *** optimal design of the structure weighs 18.831 kg,with all manufacturing constraints and all structural response constraints being *** with the initial design,the optimal design has a more refined region division,and achieves a weight reduction of 18.6%.This demonstrates that a refined region division can significantly improve the mechanical performance of the composite tapered structure.

关键词： Structural optimization composite tapered structure Genetic algorithm Adaptive region division Manufacturing constraint Near-space composite propeller

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Immunomodulatory Function of Pien Tze Huang in T cell-Mediated Anti-tumor Activity against B16-F10,Mc38 and Hep1-6 Tumor Models

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chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU Yu-bing LIU c.en-feng WANG Jin-jia JI Xiao-lin TANG Rong-han LIAO kun-yu c.en ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien State Key Laboratory of cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze Huang enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,Mc38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma *** Various tumor models,including B16–F10,Mc38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of *** growth was assessed by measuring tumor size and weight of solid tumors isolated from c57BL/6 *** cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH *** PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(Pent with PZH resulted in a reduction in tumor size in subcutaneous Mc38 colon adenocarcinoma and B16–F10 melanoma models,and decreased pulmonary metastasis of B16–F10 melanoma and Hep1-6 hepatoma(Pents showed that PZH only had slight impact on the cell proliferation and survival of tumor cells(P>0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in cD4^(+)T cells in vitro(Pcell exhaustion and boosted cytokine production by tumor-infiltrating cD8^(+)T cells(Pconclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints chinese medicine

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Mechanism study of cu(Ⅱ) adsorption from acidic wastewater by ultrasonic-modified municipal solid waste incineration fly ash

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chinese Journal of chemical engineering 2024年第3期67卷 157-165页

作者： Shunda lin Yang Lu lin Zheng ling Long Xuguang Jiang Jianhua Yan State Key Laboratory of clean energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China Zhejiang University Qingshanhu energy Research center Hangzhou 310027China Hangzhou Xiaoshan Jinjiang Green energy co. Ltd.XiaoshanHangzhou 310000China

High concentrations of copper ions(cu(Ⅱ)) in water will pose health risks to humans and the ecological environment. Therefore, this study aims to utilize ultrasonic-cured modified municipal solid waste incineration(MSWI) fly ash for cu(Ⅱ) adsorption to achieve the purpose of “treating waste by waste.” The effects of p H, adsorption time, initial concentration, and temperature on the modified MSWI fly ash’s adsorption effic.ency were systematically studied in this article. The adsorption performance of the modified MSWI fly ash can be enhanced by the ultrasonic modification. At pH = 2, 3 and 4, the adsorption capacity of the modified MSWI fly ash for cu(Ⅱ) increased by 2.7, 1.9 and 1.2 times, respectively. Furthermore, it was suggested that the adsorption process of the modified MSWI fly ash can be better simulated by the pseudo-second-order kinetic model, with a maximum adsorption capacity calculated by the Langmuir model of 24.196 mg.g-1. Additionally, the adsorption process is spontaneous,endothermic, and chemisorption-dominated from the thermodynamic studies(ΔH and ΔS > 0, ΔG enhanced adsorption performance of the modified MSWI fly ash for cu(Ⅱ) may be attributed to electrostatic interaction and chelation effects.

关键词： Ultrasound MSWI fly ash cu(Ⅱ) Wastewater Adsorption

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Set Stabilization of Large-Scale Stochastic Boolean Networks:A Distributed control Strategy

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IEEE/cAA Journal of Automatica Sinica 2024年第3期11卷 806-808页

作者： lin lin Jinde cao Jianquan Lu Leszek Rutkowski the Department of Mechanical engineering the University of Hong KongHong Kong China the School of Mathematics Southeast UniversityNanjing 210096China IEEE the School of Mathematics and the Frontiers Sc.ence center for Mobile Information communication and Security Southeast UniversityNanjing 210096China the School of Mathematics the Southeast UniversityNanjing 210096 the School of Electronic Information and Electrical engineering Chengdu UniversityChengdu 610106China the Systems Research Institute of the Polish Academy of Sc.ences Warsaw 01-447 the Institute of computer Sc.ence AGH University of Science and TechnologyKraków 30-059 the Information Technology Institute University of Social SciencesŁódź90-113Poland

Dear Editor,This letter deals with the set stabilization of stochastic Boolean control networks(SBcNs)by the pinning control strategy,which is to realize the full control for systems by imposing control inputs on a fr... 详细信息

关键词： Boolean stabilization letter

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The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan Wu Wensheng lin Department of Neurosc.ence University of MinnesotaMinneapolisMNUSA Institute for Translational Neurosc.ence University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded *** UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein *** also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum *** research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous ***,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

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A Self-Attention Based Dynamic Resource Management for Satellite-Terrestrial Networks

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china communications 2024年第4期21卷 136-150页

作者： lin Tianhao Luo Zhiyong School of Electronics and communication engineering Sun Yat-Sen UniversityShenzhen 518107China Peng c.eng Laboratory Shenzhen 518107China

The satellite-terrestrial networks possess the ability to transcend geographical constraints inherent in traditional communication networks,enabling global coverage and offering users ubiquitous computing power support,which is an important development direction of future *** this paper,we take into account a multi-scenario network model under the coverage of low earth orbit(LEO)satellite,which can provide computing resources to users in faraway areas to improve task processing ***,LEO satellites experience limitations in computing and communication resources and the channels are time-varying and complex,which makes the extraction of state information a daunting ***,we explore the dynamic resource management issue pertaining to joint computing,communication resource allocation and power control for multi-access edge computing(MEc).In order to tackle this formidable issue,we undertake the task of transforming the issue into a Markov decision process(MDP)problem and propose the self-attention based dynamic resource management(SABDRM)algorithm,which effectively extracts state information features to enhance the training *** results show that the proposed algorithm is capable of effectively reducing the long-term average delay and energy consumption of the tasks.

关键词： mobile edge computing resource management satellite-terrestrial networks self-attention

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