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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Chinese Journal of Cancer Research 2017年第3期29卷 172-178页

作者： Pei-Hung Chang Cheng-Hsu Wang Eric Yen-Chao Chen Shih-Wei Yang Wen-Chi Chou Jason Chia-Hsun Hsieh Feng-Che Kuan kun-yun yeh Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445 TaiwanChina Cancer Center Chang Gung Memorial HospitalKeelung 20445TaiwanChina Department of Radiation Oncology Chang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Otolaryngology Head and Neck SurgeryChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Division of Medical Oncology Department of Internal MedicineChang Gung Memorial Hospital at LinkouTaoyuan 33305TaiwanChina Department of Hematology and Oncology Department of MedicineChang-Gung Memorial HospitalChiayi 61363TaiwanChina

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

关键词： Glasgow prognostic score (GPS) head and neck cancer chemoradiation inflammation cachexia nutrition

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Nutritional Therapy for Head and Neck Cancer

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Journal of Nutritional Oncology 2017年第3期2卷 103-113页

作者： Pei-Hung Chang kun-yun yeh Zhaoping Li Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&College of MedicineChang Gung UniversityTaiwanChina Department of medicine Center for Human NutritionDavid Geffen School of Medicine at UCLALos AngelesCA90095 USA

Patients with head and neck cancer face great challenges in maintaining optimal nutrition since both the disease itself and treatments,especially surgery and concurrent chemoradiotherapy,have a significant negative impact on the nutritional status.A fundamental understanding of the nutrient metabolism of patients with head and neck cancer will aid in treatment *** this review,metabolic abnormalities presented in patients with head and neck cancer are discussed,together with methods of nutritional support,dietary intervention,and potential roles of phytonutrients,probiotics,and exercise in nutritional therapy for head and neck cancer patients.

关键词： Nutritional Therapy Malnutrition Chemoradiotherapy Head and neck cancer

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Comprehensive Nutrition Intervention with Omega-3 Fatty Acid, Micronutrient, and Probiotic-Enriched Regimens Improves Malnutrition in Patients with Head and Neck Cancers

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Journal of Nutritional Oncology 2016年第1期1卷 45-51页

作者： kun-yun yeh Simon Hsia Pei-Hung Chang Cheng-Hsu Wang Division of Hemato-oncology Department of Internal Medicine Chang Gung Memorial Hospital Keelung & Chang Gung University College of Medicine Keelung Taiwan China Taiwan Nutraceutical Association Taipei Taiwan China

Malnutrition is a common and unavoidable medical issue in patients with head and neck cancer during and after the treatment period, which deserves an intensive medical attention since nutrition status is often related with patients’ prognosis and treatment outcomes. In review of literature and our recent research, we found that an early and intensive nutrition intervention, including nasogastric tube feeding, minimized body weight loss, reduced treatmentinduced adverse effects, and increased survival benefits. Patients with BMI < 19 kg/m2 and were received the Ethanwell/ Ethanzyme regimen enriched with omega-3 fatty acids, micronutrients, and probiotics showed significantly less body weight loss. Patients with the malnourished status at the time of 3 months after treatment completion showed early recurrence and had significant negative effect on overall survival. In conclusion, comprehensive nutrition intervention should be started as early as the treatment begins and be continued following therapy completion, in order to prevent or overcome malnutrition in patients with head and neck cancer.

关键词： Head and neck cancer Nutrition support Cancer cachexia Ethanwell/Ethanzyme Body mass index

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Radial nerve recovery following closed nailing of humeral shaft fractures without radial nerve exploration: A retrospective study

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World Journal of Clinical Cases 2021年第27期9卷 8044-8050页

作者： Kuei-Lin yeh Chen-kun Liaw Tai-Yin Wu Chung-Pei Chen Department of Orthopedics Shin Kong Wu-Ho Su Memorial HospitalTaipei City 111Taiwan Department of Orthopedics School of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11031Taiwan Department of Orthopedics Shuang Ho HospitalTaipei Medical UniversityNew Taipei City 23561Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical EngineeringResearch Center of Biomedical DeviceTaipei Medical UniversityTaipei City 11301Taiwan Department of Family Medicine Zhongxing BranchTaipei City HospitalTaipei City 10341Taiwan Institute of Epidemiology and Preventive Medicine National Taiwan UniversityTaipei City 10055Taiwan National Taipei University of Nursing and Health Science Taipei City 11219Taiwan Department of Orthopedics Cathay General HospitalNew Taipei City 221Taiwan

BACKGROUND Radial nerve palsy due to humeral shaft fracture is the most common peripheral nerve injury associated with long bone *** antegrade nailing surgical technique is becoming popular for the fixation of these fractures with minimal *** analyzed nerve recovery in patients with humeral shaft fracture and radial nerve palsy treated with humeral nail fixation without nerve *** To assess the radial nerve recovery rate and time from humeral shaft fracture with surgical treatment using close *** We retrospectively collected data of patients who underwent undergone surgical nail fixation for humeral shaft fractures between October 1,2016,and March 31,***,we analyzed the primary or secondary radial nerve palsy recovery rate and radial nerve motor function recovery *** The study included 70 patients who underwent surgical treatment for closed-or Gustilo type I open humeral shaft fractures using a nail fixation technique without radial nerve *** patients suffered from primary(n=5)and secondary(n=5)radial nerve palsy.A 100%radial nerve recovery rate was *** mean recovery time was 4.3 *** The study results indicate full recovery of radial nerve palsies from humeral shaft fracture using close nailing *** need not be concerned about the occurrence of permanent nerve palsies.

关键词： Humeral shaft fracture Radial nerve palsy Close nailing fixation Nerve exploration

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Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study

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World Journal of Clinical Cases 2021年第31期9卷 9509-9519页

作者： Kuei-Lin yeh Szu-Hsien Wu Chen-kun Liaw Sheng-Mou Hou Shing-Sheng Wu Department of Orthopedics Shin Kong Wu Ho-Su Memorial HospitalTaipei 11101Taiwan Department of Physical Medicine and Rehabilitation Taipei Veterans General HospitalTaipei 11217Taiwan Department of Orthopedics School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan Department of Orthopedics Shuang Ho HospitalTaipei Medical UniversityNew Taipei 23561Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical EngineeringResearch Center of Biomedical DeviceTaipei Medical UniversityTaipei 11301Taiwan

BACKGROUND Osteoporosis with vertebral compression fractures is increasingly common in the elderly *** augmentation is one of the effective surgical treatments for these ***,there are several different types of cement augmentation *** studies have compared the safety and efficacy of different cement augmentation types for the treatment of such fractures;thus,we retrospectively compared vertebroplasty,balloon kyphoplasty,and kyphoplasty with SpineJack or an intravertebral expandable *** To compare the postoperative safety and efficacy of each surgical intervention in treating vertebral compression *** We retrospectively analyzed 354 patients with acute vertebral compression fractures,defined as signal changes in the T1 weighted magnetic resonance imaging,and randomly divided the patients into five *** visual analog scale scores for pain,kyphotic angle,average body height,rate of cement leakage,and occurrence of adjacent vertebral compression fractures were followed for 1 ***-way analysis of variance,the post hoc Bonferroni test,and Fisher exact probability test were used for statistical *** All pain scores significantly improved 12 mo postoperatively;however,there was no significant difference between the groups(P=0.325).Kyphoplasty with SpineJack significantly reduced the kyphotic angle(P=0.028)and restored the height of the vertebral body(P=0.02).The rate of adjacent compression fractures was the highest in the vertebroplasty group,with a statistically significant difference according to the Fisher exact probability test(P=0.02).The treatment with the lowest cement leakage rate cannot be identified because of the small sample size;however,kyphoplasty with SpineJack,an IVEP,and vesselplasty resulted in lower rates of cement leakage than balloon kyphoplasty and *** Kyphoplasty with SpineJack has good outcomes in kyphotic angle reduction and body height restora

关键词： Vertebral compression fracture Vertebroplasty Kyphoplasty Osteoporosis Observational study

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Manufacture of a hollow corner cube retroreflector for next generation of lunar laser ranging

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Research in Astronomy and Astrophysics 2018年第11期18卷 55-62页

作者： yun He Qi Liu Hui-Zong Duan Jing-Jing He Yuan-Ze Jiang Hsien-Chi yeh TIANQIN Research Center for Gravitational Physics School of Physics and Astronomy Sun Yat-sen University MOE Key Laboratory of Fundamental Quantities Measurement School of Physics Huazhong University of Science and Technology Key Laboratory of Gravitation and Quantum Physics of Hubei Province School of Physics Huazhong University of Science and Technology

Lunar laser ranging has made significant contributions to the study of gravitational physics and the Earth-Moon system. The best results for fundamental gravitational experiments have been achieved using lunar laser ranging data accumulated so far. However, corner cube retroreflector arrays placed on the Moon currently set a limit on the laser-ranging precision, which is approximately several centimeters for a single photon received. To achieve millimeter precision, next generation of lunar laser ranging using a single hollow retroreflector with a large aperture has been proposed. We developed a prototype hollow retroreflector with a 100-mm aperture using silicate bonding together with a new fabrication method. Dihedral angle offsets of 0.5′′, 0.8′′and 1.9′′were realized, which partly come close to meeting the requirements(offset of 0.6′′for each dihedral angle) for lunar laser ranging. Fluctuation of the wavefront is approximately 1.038λ at 633 nm. A thermal cycle test ranging from -40℃ to +75℃ was carried out for 18.5 periods(approximately 5 d). After this test, the dihedral angle offsets were measured to be 0.39′′, 1.00′′and 2.06′′. The results indicate the potential application of our method for manufacturing a hollow retroreflector with a large aperture to realize lunar laser ranging.

关键词： gravitation: instrumentation miscellaneous: Moon

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Nonverbal deficit to understand others’minds in high function autism spectrum disorders

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Chinese Science Bulletin 2010年第7期55卷 594-599页

作者： yeh Zai-Ting LIU Shen-Ing WANG Jia-En HUANG Hui-Chun CHEN kun-Hu WANG Peng-Chin Department of Clinical Psychology Fu Jen Catholic University Taipei Taiwan China Department of Psychiatry Mackay Memorial Hospital Taipei Taiwan China Department of Medical Research Mackay Memorial Hospital Taipei Taiwan China Mackay Medical Nursing and Management College Taipei Taiwan China

Deficits in understanding others'minds,evident in most individuals with autism spectrum disorders,have been suggested as a core deficit of ***,nonverbal ability has gone untested because most theory of mind measurement has involved verbal materials such as reading *** raises the possibility that children with high function autism spectrum disorder would distinguish verbal and nonverbal component ***-two participants diagnosed with autism spectrum disorder by a trained psychiatrist and 34 matched controls were recruited for this *** assessment included verbal and non-verbal materials *** result showed that nonverbal ability of theory of mind is impaired in the individuals with autism spectrum disorders.

关键词：语言能力高功能自闭谱系心灵测量理论心理材料

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On the number of matchings of graphs formed by a graph operation

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Science China Mathematics 2006年第10期49卷 1383-1391页

作者： yeh Yeong-Nan Institute of Mathematics Academia Sinica

Let G be a simple graph. Define R(G) to be the graph obtained from G by adding a new vertex e* corresponding to each edge e = (a, b) of G and by joining each new vertex e* to the end vertices a and b of the edge e corresponding to it. In this paper, we prove that the number of matchings of R(G) is completely determined by the degree sequence of vertices of G.

关键词： matching, Hosoya index, matching polynomial, oriented incident matrix,skew adjacency matrix.

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Discovery of transition rules for geographical cellular automata by using ant colony optimization

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Science China Earth Sciences 2007年第10期50卷 1578-1588页

作者： Anthony Gar-On yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new intelligent algorithm of geographical cellular automata (CA) based on ant colony optimization (ACO) is proposed in this paper. CA is capable of simulating the evolution of complex geographical phenomena, and the core of CA models is how to define transition rules. However, most of the transition rules are defined by mathematical equations, and are hence not explicit. When the study area is complicated, it is much more difficult to extract parameters for geographical CA. As a result, ACO is applied to geographical CA to automatically and intelligently obtain transition rules in this paper. The transition rules extracted by ACO are defined as logical expressions rather than implicit mathematical equations to describe the complex relationships of the nature, and easy for people to understand. The ACO-CA model was applied to simulating rural-urban land conversions in Guangzhou City, China, and appropriate simulation results were generated. Compared with See5.0 decision tree model, ACO-CA is more suitable to discovering transition rules for geographical CA.

关键词： ant colony optimization, CA, geographical simulation, artificial intelligence

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Knowledge discovery for geographical cellular automata

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Science China Earth Sciences 2005年第10期48卷 1758-1767页

作者： Anthony Gar-On yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

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