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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3781-3797页

作者： yu-kun zhang Ran Shi Ruo-yu Meng Shui-Li Lin Mei Zheng Department of Rehabilitation Medicine The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina Department of Minimally Invasive Comprehensive Treatment of Cancer Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Ana and Intestinal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

Erythropoietin-induced hepatocyte receptor A2(EphA2)is a receptor tyrosine kinase that plays a key role in the development and progression of a variety of *** article reviews the expression of EphA2 in gastrointestinal(GI)colorectal cancer(CRC)and its regulation of *** is a form of programmed cell death that plays an important role in tumor *** have shown that EphA2 regulates pyrodeath through various signaling pathways,affecting the occurrence,development and metastasis of GI *** overexpression of EphA2 is closely related to the aggressiveness and metastasis of GI CRC,and the inhibition of EphA2 can induce pyrodeath and improve the sensitivity of cancer cells to *** addition,EphA2 regulates intercellular communication and the microenvironment through interactions with other cytokines and receptors,further influencing cancer *** role of EphA2 in GI CRC and its underlying mechanisms provide us with new perspectives and potential therapeutic targets,which have important implications for future cancer treatment.

关键词： Colorectal cancer Pyroptosis Erythropoietin-induced hepatocyte receptor A2 Tumor metastasis Drug resistance

Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19

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World Journal of Gastroenterology 2022年第48期28卷 6811-6826页

作者： Yang Yao Zhu-Jun Liu yu-kun zhang Hui-Jun Sun Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area College of Basic MedicalChongqing 404120China Department of Clinical Pharmacology College of PharmacyDalian 116044Liaoning ProvinceChina Ministry of Public Infrastructure Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Basic Medicine Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Business Administration Metropolitan College of Science and TechnologyChongqing 404120China State Key Laboratory of Natural and Biomimetic Drugs Department of PharmacologyPeking UniversityBeijing 100191China Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044Liaoning ProvinceChina

The global coronavirus disease 2019(COVID-19)has become one of the biggest threats to the world since *** respiratory and gastrointestinal tracts are the main targets for severe acute respiratory syndrome coronavirus 2 infection for they highly express angiotensin-converting enzyme-2 and transmembrane protease serine *** patients suffering from COVID-19,gastrointestinal symptoms have ranged from 12%to 61%.Anorexia,nausea and/or vomiting,diarrhea,and abdominal pain are considered to be the main gastrointestinal symptoms of *** has been reported that the direct damage of intestinal mucosal epithelial cells,malnutrition,and intestinal flora disorders are involved in ***,the underlying mechanisms remain ***,in this study,we reviewed and discussed the correlated mechanisms that cause gastrointestinal symptoms in order to help to develop the treatment strategy and build an appropriate guideline for medical workers.

关键词： COVID-19 Angiotensin-converting enzyme-2 Transmembrane protease serine 2 Gastrointestinal symptom Mechanism Intestinal barrier permeability

Refractive Index Engineering as a Novel Strategy toward Highly Transparent and Tough Sustainable Polymer Blends

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Chinese Journal of Polymer Science 2020年第12期38卷 1335-1344页

作者： Si-Ting Sun Hang Wang Dong Huang Ying-Li Ding Yang zhang Dong-Po Song kun-yu zhang Li Pan yue-Sheng Li Department of Polymer Science and Engineering School ofChemical Engineering and TechnologyTianjin UniversityTianin 300350China Department of Chemical Engineering Xiamen UniversityXiamen 361005China Tianjin Key Laboratory ofComposite and Functional Materials School ofMaterials Science and EngineeringTianjin UniversityTlanin 300350 China Cllaborotive lovation Center ofChemical Science and Engineering(injin) Tianjin 300072 China

High transparency and toughness are prerequisites for sustainable polymers if they are to find wide application as alternatives to petroleum-based ***,the utility of sustainable polymers such as commercially available polylactide(PLA)is limited by their inherent brittleness and high ***,toughening PLA-based materials via cost-effective blending strategies without sacrificing transparency remains a ***,we report a novel strategy involving active refractive index matching for creation of highly transparent and tough PLA ***,we engineered the refractive index of a promising renewable poly(epichlorohydrin-co-ethylene oxide)elastomer by introducing polar ionic moieties via a simple chemical method,and we blended the resulting ionomers with *** best blend showed an impact strength of>80 kJ/m2,an elongation at break of 400%,and high transparency(90%).These characteristics are of great importance for potential applications such as *** strategy offers a versatile new way to prepare high-performance sustainable polymer materials with excellent transparency.

关键词： Polylactide Blending strategies Refraaive index matching Poly(epichlorohydrin-co-ethylene oxide) Ionomers

Toughening Poly(lactic acid) with Imidazolium-based Elastomeric Ionomers

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Chinese Journal of Polymer Science 2018年第12期36卷 1342-1352页

作者： Lu Chen Kuan Hu Si-Ting Sun Hai Jiang Dong Huang kun-yu zhang Li Pan yue-Sheng Li Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300350 China School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 China

Imidazolium-based elastomeric ionomers （i-BIIR） were facilely synthesized by ionically modified brominated poly（isobutylene-co-isoprene）（BIIR） with different alkyl chain imidazole and thoroughly explored as novel toughening agents for poly（lactic acid）（PLA）. The miscibility, thermal behavior, phase morphology and mechanical property of ionomers and blends were investigated through dynamic mechanical analyses （DMA）, differential scanning calorimetry （DSC）, scanning electron microscopy （SEM）, tensile and impact testing. DMA and SEM results showed that better compatibility between the PLA and i-BIIR was achieved compared to the PLA/unmodified BIIR elastomer. A remarkable improvement in ductility with an optimum elongation at break up to 235% was achieved for the PLA/i-BIIR blends with 1-dodecylimidazole alkyl chain （i-BIIR-12）, more than 10 times higher than that of pure PLA. The impact strengths of PLA were enhanced from 1.9 kJ/m2 to 4.1 k J/m2 for the PLA/10 wt% i-BIIR-12 blend. Toughening mechanism had been established by systematical analysis of the compatibility, intermolecular interaction and phase structures of the blends. Interracial cavitations initiated massive shear yielding of the PLA matrix owing to a suitable interfacial adhesion which played a key role in the enormous toughening effect in these blends. We believed that introducing imidazolium group into the BIIR elastomer was vital for the formation of a suitable interfacial adhesion.

关键词： Imidazolium-based ionomer Poly(lactic acid) Brominated poly(isobutylene-co-isoprene) Toughening Blend

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腐殖酸对富勒烯C_60的悬浮作用(英文)

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第8期15卷 634-642页

作者： Lu-qing zhang yu-kun zhang Xiu-chun LIN kun YANG Dao-hui LIN Department of Environmental Science Zhejiang University College of Environmental and Biological Engineering Putian University Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control

研究目的:腐殖酸(HA)对富勒烯(C60)粉末的悬浮作用以及pH、离子强度对HA-C60悬浮性能的影响。创新要点:研究水质条件对C60悬浮性能的影响。研究方法:测定C60粉末在HA溶液中的zeta电位,水力学粒径和悬浮浓度;HA存在下,C60悬浮体系的zeta... 详细信息

研究目的:腐殖酸(HA)对富勒烯(C60)粉末的悬浮作用以及pH、离子强度对HA-C60悬浮性能的影响。创新要点:研究水质条件对C60悬浮性能的影响。研究方法:测定C60粉末在HA溶液中的zeta电位,水力学粒径和悬浮浓度;HA存在下,C60悬浮体系的zeta电位与水力学粒径随pH的变化及C60悬浮体系团聚动力学随离子强度的变化。重要结论:HA对C60粉末起到一定的分散作用,但不能使其长时间稳定悬浮于水中。当pH<4时,C60水悬液开始沉淀;而当HA存在时,C60水悬液在pH 3–11范围内都保持稳定,这是由于HA吸附于C60表面,通过静电排斥和空间位阻作用,促进C60分散悬浮。C60水悬液的稳定性随盐离子价位和浓度升高而降低。HA会抑制Na+对C60水悬液的脱稳作用;但高价离子Ca2+和La3+存在时,HA与C60之间会发生桥联从而促进C60水悬液脱稳沉淀。

关键词：富勒烯腐殖酸胶体稳定性天然有机质纳米材料

Upregulated insulin receptor tyrosine kinase substrate promotes the proliferation of colorectal cancer cells via the bFGF/AKT signaling pathway

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Gastroenterology Report 2021年第2期9卷 166-175,I0002,I0003页

作者： Song Wang Zheng Liu Yi-Ming Ma Xu Guan Zheng Jiang Peng Sun En-Rui Liu yu-kun zhang Hong-Ying Wang Xi-Shan Wang Department of Colorectal Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Colorectal Surgery Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China State Key Laboratory of Molecular Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China

Background:Some recent studies on insulin receptor tyrosine kinase substrate(IRTKS)have focused more on its functions in ***,there is a lack of research on the role of IRTKS in carcinomas and its mechanism remains *** this study,we aimed to clarify the role and mechanism of IRTKS in the carcinogenesis of colorectal cancer(CRC).Methods:We analysed the expression of IRTKS in CRC tissues and normal tissues by researching public *** tissues and adjacent tissues of 67 CRC patients who had undergone radical resection were collected from our *** real-time polymerase chain reaction and immunohistochemistry were performed in 52 and 15 pairs of samples,*** vitro and in vivo experiments were conducted to observe the effect of IRTKS on CRC *** Set Enrichment Analysis and Metascape platforms were used for functional annotation and enrichment *** detected the protein kinase B(AKT)phosphorylation and cell viability of SW480 transfected with small interfering RNAs(siRNAs)with or without basic fibroblast growth factor(bFGF)through immunoblotting and proliferation ***:The expression of IRTKS in CRC tissues was higher than that in adjacent tissues and normal tissues(all P<0.05).Disease-free survival of patients with high expression was *** of IRTKS significantly increased the proliferation rate of CRC cells in vitro and the number of tumor xenografts in *** phosphorylation level of AKT in CRC cells transfected with pLVX-IRTKS was higher than that in the control ***,siRNA-IRTKS significantly decreased the proliferation rate of tumor cells and the phosphorylation level of AKT induced by ***:IRTKS mediated the bFGF-induced cell proliferation through the phosphorylation of AKT in CRC cells,which may contribute to tumorigenicity in vivo.

关键词： colorectal cancer proliferation IRTKS AKT bFGF

Whole-genome resequencing reveals molecular imprints of anthropogenic and natural selection in wild and domesticated sheep

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Zoological Research 2022年第5期43卷 695-705页

作者： De-Yin zhang Xiao-Xue zhang Fa-Di Li Lv-Feng yuan Xiao-Long Li yu-kun zhang yuan Zhao Li-Ming Zhao Jiang-Hui Wang Dan Xu Jiang-Bo Cheng Xiao-Bin Yang Wen-Xin Li Chang-Chun Lin Bu-Bo Zhou Wei-Min Wang State Key Laboratory of Grassland Agro-Ecosystems Key Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouGansu 730020China College of Animal Science and Technology Gansu Agricultural UniversityLanzhouGansu 730070China Engineering Laboratory of Sheep Breeding and Reproduction Biotechnology in Gansu Province MinqinGansu 733300China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhouGansu 730046China

The abundance of domesticated sheep varieties and phenotypes is largely the result of long-term natural and artificial selection. However, there is limited information regarding the genetic mechanisms underlying phenotypic variation induced by the domestication and improvement of sheep. In this study, to explore genomic diversity and selective regions at the genome level, we sequenced the genomes of 100 sheep across 10 breeds and combined these results with publicly available genomic data from 225 individuals, including improved breeds, Chinese indigenous breeds,African indigenous breeds, and their Asian mouflon ancestor. Based on population structure, the domesticated sheep formed a monophyletic group,while the Chinese indigenous sheep showed a clear geographical distribution trend. Comparative genomic analysis of domestication identified several selective signatures, including IFI44 and IFI44L genes and PANK2 and RNF24 genes, associated with immune response and visual *** genomic analysis of improvement demonstrated that candidate genes of selected regions were mainly associated with pigmentation,energy metabolism, and growth ***, the IFI44 and IFI44L genes showed a common selection signature in the genomes of 30domesticated sheep breeds. The IFI44 c. 54413058C>G mutation was selected for genotyping and population genetic validation. Results showed that the IFI44 polymorphism was significantly associated with partial immune traits. Our findings identified the population genetic basis of domesticated sheep at the whole-genome level, providing theoretical insights into the molecular mechanism underlying breed characteristics and phenotypic changes during sheep domestication and improvement.

关键词： Sheep Whole-genome resequencing Selection signature analysis Immunity IFI44 gene

区域生产性服务业生态化建设研究——以辽宁省为例

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特区经济 2011年第3期 59-60页

作者：于琨张展沈阳化工大学经济管理学院辽宁沈阳110142

随着我国经济结构和增长方式的加快调整,资源和环境的可持续发展问题越来越受重视。辽宁省物流、金融、信息服务、商业服务、科技等生产性服务业在发展过程中存在生态化发展问题。与此同时,由于服务业与制造业的渐次融合趋势,生产性服... 详细信息

随着我国经济结构和增长方式的加快调整,资源和环境的可持续发展问题越来越受重视。辽宁省物流、金融、信息服务、商业服务、科技等生产性服务业在发展过程中存在生态化发展问题。与此同时,由于服务业与制造业的渐次融合趋势,生产性服务业成为辽宁工业生态产业链的必备环节。因此,应通过支持和引导绿色物流业、推进绿色金融发展、建设公共服务平台、优化生产性服务业的产业结构等措施进一步发挥生产性服务业在辽宁生态省建设中的作用。

关键词：生产性服务业制造业生态省

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A3铁、304钢和201钢光谱发射率

光谱学与光谱分析 2017年第11期37卷 3594-3599页

作者：许开品于坤张凯华刘玉芳河南师范大学物理与电子工程学院河南新乡453007 北京理工大学光电学院北京100081

随着科学技术日新月异的发展,红外测量技术在遥感、辐射测温、红外隐身、农业、医疗等领域都展现出了重要的应用前景。在花样众多的辐射测量中,材料的发射率是重要的参数之一。为满足材料发射率数据的需求,根据一套自主研制的光谱发射... 详细信息

随着科学技术日新月异的发展,红外测量技术在遥感、辐射测温、红外隐身、农业、医疗等领域都展现出了重要的应用前景。在花样众多的辐射测量中,材料的发射率是重要的参数之一。为满足材料发射率数据的需求,根据一套自主研制的光谱发射率测量装置对A3铁、304钢以及201钢在不同温度下的光谱发射率进行了精确的测量,并对影响发射率的几个因素做了深入的探究。结果显示:这三种钢材的发射率随温度升高而变大,同等温度下A3铁的发射率要高于304钢和201钢,且材料中的铬含量会降低材料的发射率值。采用XRD分析了三种材料表面氧化后的成分,并探讨了表面成分变化对发射率的影响。结果表明:A3铁氧化后生成不稳定的四氧化三铁Fe_3O_4和氧化亚铁FeO,各种成分的相互转变会导致光谱发射率发生较大的变化,而304钢和201钢表面氧化后主要生成氧化铬,因而光谱发射率也相对比较稳定。另外使用辐射光叠加原理和Christiansen效应成功解释了三种材料的发射率在大约10μm处出现极大值的现象。该研究极大地丰富了三种材料的光谱发射率数据,为辐射测量技术在三种材料中的应用提供了强有力的数据支撑。

关键词：光谱发射率 A3铁 201钢 304钢氧化温度

Numerical Study for Turbulent Flow of Drag and Flow Noise with Wavy Wall

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Journal of Shanghai Jiaotong university(Science) 2011年第1期16卷 45-54页

作者：孟堃宇张怀新史勇林潘雨村 School of Naval Architecture Ocean and Civil EngineeringShanghai Jiaotong University

In this paper,a numerical simulation of flow-induced noise by the low Mach number turbulent flow with a sinusoidal wavy wall was presented based on the unsteady incompressible Navier-Stokes equations and Lighthill's acoustic *** eddy simulation (LES) was used to investigate the space-time flow field and the Smagorinsky sub-grid scale (SGS) model was introduced for turbulence *** Lighthill's acoustics analogy,the flow field simulated by LES was taken as near-field sound sources and radiated sound from turbulent flow was computed by the Curle's integral formulation under the low Mach number *** spanwise wavy wall and streamwise wavy wall with various wall wave amplitudes were discussed to investigate their effects on reducing the drag and flow *** relationship between flow noise and drag on the wavy wall is also studied.

关键词： large eddy simulation (LES) wavy wall riblets turbulent flow flow noise