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A small D-A molecule with highly heat-resisting room temperature phosphorescence for white emission and anti-counterfeiting

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Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

结构化学 2024年第3期43卷 3-9页

作者： kun zhang Ni Dan Dan-Dan Ren Ruo-yu zhang Xiaoyan Lu Ya-Pan Wu Li-Lei zhang Hong-Ru Fu Dong-Sheng Li College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China

Achieving high heat-resisting room temperature phosphorescence(RTP)performance and robust white emission from pure small molecules is a meaningful but challenging ***,a simple donor-acceptor(D-A)molecule,9-(1H-benzotriazol-1-ylmethyl)-9H-carbazole(CzBtrz),was *** simple molecule not only exhibits multiple emissions including white light,thermally activated delayed fluorescence(TADF)and ultralong RTP with a lifetime of 988.54 ms at 545 nm,but also shows superhigh heat-resisting phosphorescence property which can maintain stability in a large temperature region from 77 to 350 K(ΔT=273 K),exceeding those of other RTP ***,this molecule shows the time-evolved dynamic *** experimental and theoretical an-alyses from CzBtrz crystal demonstrate that the intramolecular charge transfer(ICT)interaction and molecular stacking play an important role in the generation of ***,this work provides an efficient strategy to design ultrahigh heat-resistant RTP,ultralong RTP and single-phased white-light emitting materials.

关键词： Ultralong RTP TADF D-A molecule Heat-resisting White light

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Current Medical Science 2024年第1期44卷 28-50页

作者： Xiao-xia BAN Hao WAN Xin-xing WAN Ya-ting TAN Xi-min HU Hong-xia BAN Xin-yu CHEN kun HUANG Qi zhang kun XIONG Department of Human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

U-Pb zircon geochronology of basaltic pyroclastic rocks from the basement beneath the Xisha Islands in the northwestern South China Sea and its geological significance

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Acta Oceanologica Sinica 2024年第2期43卷 83-93页

作者： yu zhang Kefu yu Shiying Li Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Guangxi UniversityNanning 530004China Coral Reef Research Center of China Guangxi UniversityNanning 530004China School of Marine Sciences Guangxi UniversityNanning 530004China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou 510301China

As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding of the pre-Cenozoic basement of the Xisha Islands. Well CK-1, a kilometer-scale major scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal limestone(0–888.4 m) and the underlying basement rocks(888.4–901.4 m). In this study, we present the zircon U-Pb ages of basement basaltic pyroclastic rocks from Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basement nature of the Xisha microblock. The basement of Well CK-1 consists of basaltic pyroclastic rocks on the seamount. The zircon grains yielded apparent ages ranging from ca. 2 138.9 Ma to ca. 36 Ma. The old group of zircon grains from Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted mean 206Pb/238U age of(36.3 ± 1.1) Ma,Mean Squared Weighted Deviations(MSWD) = 1.2, which may represent the maximum age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 Ma and 146.1–130.2 Ma) from Well CK-1 are consistent with the zircons from Well XK-1, indicating that the basement of Chenhang Island may be similar to that of Well XK-1. We propose that the Xisha micro-block may have developed on a uniform Late Jurassic metamorphic crystalline basement, intruded by Cretaceous granitic magma.

关键词： South China Sea Xisha Islands basaltic pyroclastic rocks zircon

An ultrahigh energy storage efficiency and recoverable density in Bi_(0.5)Na_(0.5)TiO_(3)with the modification of Sr_(0.85)La_(0.1)TiO_(3)via viscous polymer process

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Journal of Materiomics 2024年第3期10卷 566-577页

作者： Fukang Chen Lishun Yang Haoran Feng Qin Li Xinyu Zeng kun yu Chunlin Song Yan Yan Li Jin Dou zhang School of Materials and Energy Southwest UniversityChongqing400715China Electronic Materials Research Laboratory Key Laboratory of the Ministry of EducationSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Currently,the development of dielectric ceramic capacitors is restricted by the contradiction between high efficiency and high recoverable ***,a novel strategy was designed to achieve a su-perior balance between ***,introducing Sr_(0.85)La_(0.1)TiO_(3)can enhance the content of the weak polar phase(P4bm)to become the main component,which can optimize the relaxor behaviour and improve ***,the electric breakdown strength was effectively enhanced by grain refinement and viscous polymer ***,a high recoverable energy density of~5.3 J/cm^(3)and an excellent efficiency of~92.2%were attained in 0.9Bi_(0.5)Na_(0.5)TiO_(3)-0.1Na_(0.8)Sr_(0.1)NbO_(3)ceramic with the addition of 0.35Sr_(0.85)La_(0.1)TiO_(3)after viscous polymer *** piezoelectric force microscope had been applied to prove the high activity of the polar nanoregions and finite element analysis was adopted to explain the reasons for the enhancing electric breakdown *** addition,this ceramic exhibits good tem-perature and frequency stability,and a fast discharging rate of 0.11 ms,making it a potential candidate for the actual application.

关键词： Lead-free ceramics Energy storage BNT Landau-free energy

Whole-genome resequencing reveals molecular imprints of anthropogenic and natural selection in wild and domesticated sheep

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Zoological Research 2022年第5期43卷 695-705页

作者： De-Yin zhang Xiao-Xue zhang Fa-Di Li Lv-Feng yuan Xiao-Long Li yu-kun zhang yuan Zhao Li-Ming Zhao Jiang-Hui Wang Dan Xu Jiang-Bo Cheng Xiao-Bin Yang Wen-Xin Li Chang-Chun Lin Bu-Bo Zhou Wei-Min Wang State Key Laboratory of Grassland Agro-Ecosystems Key Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouGansu 730020China College of Animal Science and Technology Gansu Agricultural UniversityLanzhouGansu 730070China Engineering Laboratory of Sheep Breeding and Reproduction Biotechnology in Gansu Province MinqinGansu 733300China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhouGansu 730046China

The abundance of domesticated sheep varieties and phenotypes is largely the result of long-term natural and artificial selection. However, there is limited information regarding the genetic mechanisms underlying phenotypic variation induced by the domestication and improvement of sheep. In this study, to explore genomic diversity and selective regions at the genome level, we sequenced the genomes of 100 sheep across 10 breeds and combined these results with publicly available genomic data from 225 individuals, including improved breeds, Chinese indigenous breeds,African indigenous breeds, and their Asian mouflon ancestor. Based on population structure, the domesticated sheep formed a monophyletic group,while the Chinese indigenous sheep showed a clear geographical distribution trend. Comparative genomic analysis of domestication identified several selective signatures, including IFI44 and IFI44L genes and PANK2 and RNF24 genes, associated with immune response and visual *** genomic analysis of improvement demonstrated that candidate genes of selected regions were mainly associated with pigmentation,energy metabolism, and growth ***, the IFI44 and IFI44L genes showed a common selection signature in the genomes of 30domesticated sheep breeds. The IFI44 c. 54413058C>G mutation was selected for genotyping and population genetic validation. Results showed that the IFI44 polymorphism was significantly associated with partial immune traits. Our findings identified the population genetic basis of domesticated sheep at the whole-genome level, providing theoretical insights into the molecular mechanism underlying breed characteristics and phenotypic changes during sheep domestication and improvement.

关键词： Sheep Whole-genome resequencing Selection signature analysis Immunity IFI44 gene

Coupled simulation of fluid-particle interaction for large complex granules:A resolved CFD-DEM method for modelling the airflow in a vertical fixed bed of irregular sinter particles

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Particuology 2024年第7期90卷 292-306页

作者： Chengzhi Li yu zhang Jiahe Shen Wei zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Centre for Bulk Solids and Particulate Technologies The University of NewcastleCallaghan NSW 2308Australia

A resolved CFD-DEM method is proposed to simulate the fluid-particle interaction for large complex *** airflow in a vertical sinter fixed bed is numerically studied using this *** multi-sphere clumped method is used to create irregular sinter particles in *** immersed boundary method and dynamic cell refinement are applied to describe the fluid flow around particles with higher resolution,by which the fluid-particle interaction can be simulated more *** simulation results presented the packing voidage distributions and the airflow fields in the sinter beds of different single and mixed particle size *** bed pressure drops were simulated and the results were compared with the corresponding experimental *** good agreement indicated that the proposed resolved CFD-DEM method is an effective tool to model the fluid-particle interaction for irregular large granules in the gas-solid multi-phase systems.

关键词： Resolved CFD-DEM method Irregular sinter particles Multi-sphere clumped method Immersed boundary method Dynamic cell refinement

Coupling analysis method of grouting construction with deformation response of adjacent existing tunnel

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Underground Space 2024年第2期15卷 312-330页

作者： Ping-wei Jiang Zhi-hong zhang Hong Zheng Jin-kun Huang Key Laboratory of Urban Security and Disaster Engineering of China Ministry of Education Beijing University of TechnologyBeijing 100124China China MCC17 Group Co.LTD MaanshanAnhui 243000China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In the new tunnel under close distance through the existing tunnel risk source,the grouting scheme developed to compensate for stratum losses is still based on empirical methods,relying on the overburden thickness of existing *** can potentially lead to an excessively high or low probability of uplift of existing *** a coupled deformation analysis method between the grouting construction and adjacent existing tunnels is of great theoretical significance for developing grouting *** order to reasonably limit the design parameters of grouting construction,based on the theory of fluid–solid coupling elastic pore-column expansion and the theory of random media,the calculation method of stratum displacement which simultaneously considers the coexistence of grout compaction expansion and permeability diffusion mode is derived,and the accuracy of the calculation method is verified by engineering *** accuracy of this calculation method was verified through engineering *** with the deformation coordination condition,the existing tunnel is regarded as an elastic Euler-Bernoulli continuous beam,and the finite element coupling balance equation of the interaction between the existing tunnel and the surrounding soil is *** on this,a coupling calculation model of the grouting construction and the deformation response of the adjacent existing tunnel is *** with three times of grouting construction examples in the shield tunneling project of Beijing Metro Line 12 under the existing airport line,the reliability of the coupling calculation model to determine the grouting construction parameters is *** calculation parameters in the coupling calculation model have clear physical meanings,which can provide a theoretical basis for the grouting design of similar risk source projects.

关键词： Grouting Close-range underpass Tunnel Random medium theory Euler-Bernoulli continuous beam

UAV maneuvering decision-making algorithm based on deep reinforcement learning under the guidance of expert experience

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Journal of Systems Engineering and Electronics 2024年第3期35卷 644-665页

作者： ZHAN Guang zhang kun LI Ke PIAO Haiyin School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Electro-Optic Control Laboratory Luoyang 471009China

Autonomous umanned aerial vehicle(UAV) manipulation is necessary for the defense department to execute tactical missions given by commanders in the future unmanned battlefield. A large amount of research has been devoted to improving the autonomous decision-making ability of UAV in an interactive environment, where finding the optimal maneuvering decisionmaking policy became one of the key issues for enabling the intelligence of UAV. In this paper, we propose a maneuvering decision-making algorithm for autonomous air-delivery based on deep reinforcement learning under the guidance of expert experience. Specifically, we refine the guidance towards area and guidance towards specific point tasks for the air-delivery process based on the traditional air-to-surface fire control ***, we construct the UAV maneuvering decision-making model based on Markov decision processes(MDPs). Specifically, we present a reward shaping method for the guidance towards area and guidance towards specific point tasks using potential-based function and expert-guided advice. The proposed algorithm could accelerate the convergence of the maneuvering decision-making policy and increase the stability of the policy in terms of the output during the later stage of training process. The effectiveness of the proposed maneuvering decision-making policy is illustrated by the curves of training parameters and extensive experimental results for testing the trained policy.

关键词： unmanned aerial vehicle(UAV) maneuvering decision-making autonomous air-delivery deep reinforcement learning reward shaping expert experience

Weight Analysis of Impact Factors of Interbedded Anti-Inclined Slopes Block-Flexure Toppling Based on Support Vector Regression

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Journal of Earth Science 2024年第2期35卷 568-582页

作者： Bocheng zhang Huiming Tang Yibing Ning kun Fang Ding Xia Department of Engineering Geology and Geotechnical Engineering Faculty of EngineeringChina University of GeosciencesWuhan430074China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China

Block-flexure toppling failure is frequently encountered in interbedded anti-inclined rock(IAR)slopes,and seriously threatens the construction of hydropower *** this study,we first investigated the Lean Reservoir area’s geological setting and the Linda landslide’s ***,uniform design and random design were used to design 110 training datasets and 31 testing datasets,***,the toppling response was obtained by using the discrete element ***,support vector regression was used to obtain the influence weights of 21 impact *** results show that the influence weight of the slope angle and rock formation dip angle on the toppling deformation among tertiary impact factors is 25.96%and 17.28%,respectively,which are much greater than the other 19 impact factors within the research *** the primary impact factors,the influence weight is sorted from large to small as slope geometry parameters,joints parameters,and rock mechanics *** parameters,especially the geometric parameters,cannot be ignored when evaluating the stability of IAR *** numerical simulation,it was qualitatively determined that failure surfaces of slopes were controlled by cross joints and that the rocks in the slope toe play a role in preventing slope deformation.

关键词： interbedded anti-inclined slopes block-flexure toppling impact factors numerical simulation support vector regression engineering geology