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Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： kun-peng Ma Jin-Xin Fu Feng Duan Mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April *** survival(OS)and progression-free survival(PFS)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

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A hybrid machine learning optimization algorithm for multivariable pore pressure prediction

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Petroleum Science 2024年第1期21卷 535-550页

作者： Song Deng Hao-Yu Pan Hai-Ge Wang Shou-kun Xu Xiao-peng Yan Chao-Wei Li Ming-Guo peng Hao-Ping peng Lin Shi Meng Cui Fei Zhao School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164JiangsuChina Tubular Goods Research Institute of CNPC Beijing102249China CNPC Engineering Technology R&D Company Limited Beijing102206China

Pore pressure is essential data in drilling design,and its accurate prediction is necessary to ensure drilling safety and improve drilling *** methods for predicting pore pressure are limited when forming particular structures and *** this paper,a machine learning algorithm and effective stress theorem are used to establish the transformation model between rock physical parameters and pore *** study collects data from three *** 1 had 881 data sets for model training,and Wells 2 and 3 had 538 and 464 data sets for model *** this paper,support vector machine(SVM),random forest(RF),extreme gradient boosting(XGB),and multilayer perceptron(MLP)are selected as the machine learning algorithms for pore pressure *** addition,this paper uses the grey wolf optimization(GWO)algorithm,particle swarm optimization(PSO)algorithm,sparrow search algorithm(SSA),and bat algorithm(BA)to establish a hybrid machine learning optimization algorithm,and proposes an improved grey wolf optimization(IGWO)*** IGWO-MLP model obtained the minimum root mean square error(RMSE)by using the 5-fold cross-validation method for the training *** the pore pressure data in Well 2 and Well 3,the coefficients of determination(R^(2))of SVM,RF,XGB,and MLP are 0.9930 and 0.9446,0.9943 and 0.9472,0.9945 and 0.9488,0.9949 and *** achieves optimal performance on both training and test data,and the MLP model shows a high degree of *** indicates that the IGWO-MLP is an excellent predictor of pore pressure and can be used to predict pore pressure.

关键词： Pore pressure Grey wolf optimization Multilayer perceptron Effective stress Machine learning

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Correlation between longitudinal crack occurrence and mold heat transfer in continuous casting based on process data mining

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Journal of Iron and Steel Research International 2024年第5期31卷 1139-1152页

作者： Zhi-qiang peng Zi-bing Hou Kai Yi kun-hui Guo Dong-wei Guo Guang-hua Wen College of Materials Science and Engineering Chongqing UniversityChongqing400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing400044China

The correlation between the longitudinal crack occurrence and integrated heat transfer of the mold with data mining methods was ***,three kinds of support vector machine models based on principal component analysis with different input features were established to explore the effect of integrated heat transfer on the accuracy of the prediction model for the longitudinal *** results show that the accuracy was improved while features including mean and standard deviation of integrated heat transfer were ***,the difference in integrated heat transfer between defect and normal samples under the same process parameters was quantitatively *** with normal samples,the temperature difference of cooling water for defect samples decreased by 0.65%,and the temperature difference fluctuation increased by 31.1%.Finally,the literature data were used to provide support for the quantitative correlation according to defect formation mechanism.A new criterion for the prediction of longitudinal crack and a discovering method for correlation between product quality and process parameters in the manufacturing industry have been provided.

关键词： Continuous casting slab Longitudinal surface crack Heat transfer Data mining Quantitative correlation

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Overlapping infections of Mycobacterium canariasense and Nocardia farcinica in an immunocompetent patient:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2079-2085页

作者： Hai-Yan Huang kun-peng Bu Jin-Wei Liu Jing Wei Department of Comprehensive Internal Medicine The Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Doppler Ultrasound The Second Nanning People's HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent *** canariasense(***)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since *** is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales *** methods for diagnosis of NTM are *** next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare *** NTM and Nocardia infections occur in immunocompromised patients with atypical clinical *** are no previous reports of infection by *** and Nocardia farcinica(***),especially in immunocompetent *** case report describes an immunocompetent 52-year-old woman who had overlapping infections of ***,***,and Candida parapsilosis(***)based on *** SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 *** received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain *** collected samples of a lung lesion and alveolar lavage fluid for *** lung tissue was positive for ***,***,and ***,and the alveolar lavage fluid was positive for *** diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the *** Etiological diagnosis is critical for patients with infectious *** can identify rare and novel pathogens,and does not require a priori knowledge.

关键词： Overlapping infection Mycobacterium canariasense Nocardia farcinica Metagenomic next-generation sequencing technology Case report

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Low-concentration and multi-component NMHCs capture from oil field exhaust using porous ZIF-8/iso-hexadecane slurry

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Green Chemical Engineering 2024年第2期5卷 245-256页

作者： kun Li Han Tang Jin Cai Chun Deng Bei Liu Yunlei peng Changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Non-methane hydrocarbons(NMHCs)are a common type of volatile organic compounds(VOCs)pollutant in the petrochemical industry and have attracted widespread attention because of their adverse health effects and environmental *** this paper,we report a new porous slurry formed with zeolitic imidazolate framework-8(ZIF-8)and iso-hexadecane to capture the low-concentration and multi-component NMHCs(mainly ethane(C_(2)H_(6)),propane(C_(3)H_(8)),and n-butane(n-C_(4)H_(10)))from the oil field *** sorption capacity of C_(2)H_(6)in the slurry is significantly higher than that of nitrogen(N_(2))and methane(CH_(4)).Moreover,the slurry demonstrated a clear advantage for C_(2)H_(6)over N_(2)and CH_(4)in competitive adsorption through the pressure-drop *** the NMHCs capture experiments,the C_(3)H_(8)and n-C_(4)H_(10)concentrations after purification can be reduced to below 100 ppm,while the C_(2)H_(6)concentration can reach approximately 180 *** encouragingly,in the breakthrough tests,the slurry exhibits a perfect kinetic separation selectivity for multi-component ***,to avoid structural collapse of ZIF-8 material during long-term use in acidic and wet environments,a certain amount of 2-methylimidazole was retained in the slurry as a protective agent in the material synthesis *** this way,the ZIF-8 materials in the slurry can retain the stable characteristic structure in an aqueous and acidic environment and keep the capture capacity for NMHCs without *** believe the porous ZIF-8/iso-hexadecane slurry is a promising capture agent for low-concentration and multi-component NMHCs with strong purification capacity and stability.

关键词： VOCs capture NMHCs capture MOFs ZIF-8 Porous slurry

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Visible-Light-Mediated Photocatalyst-Free Hydroacylation of Azodicarboxylic Acid Derivatives with 4-Acyl-1,4-dihydropyridines

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Chinese Journal of Chemistry 2024年第11期42卷 1230-1236页

作者： Li Liu Jing Wang Xiaoying Feng kun Xu Wei Liu Xia peng Hongguang Du Jiajing Tan Department of Organic Chemistry College of ChemistryBeijing University of Chemical TechnologyBeijing100029 China Sinopec Beijing Research Institute of Chemical Industry Beijing100013 China Faculty of Environment and Life Beijing University of TechnologyBeijing100124 China

A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was *** radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(acyl-DHP)reagents that besides being as radical reservoirs,they also enabled the conversion of radical adducts to anion intermediates via ***“catalyst-oxidant-additive free”conditions,a wide range of structurally different acyl hydrazide products were readily obtained in 56%—99%*** utility of this transformation was further demonstrated by the scale-up synthesis and downstream derivatization.

关键词： Azo compounds Radicals Acylation 4-Acyl-1,4-dihydropyridine Photochemistry

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Biomimetic design of highly flexible metal oxide nanofibrous membranes with exceptional mechanical performance for superior phosphopeptide enrichment

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Nano Research 2024年第5期17卷 4270-4278页

作者： Xue Mao Zhen-Zhen Li Dong-Lian Hao Wei-Dong Han Gao-peng Li Yao-Yu Wang kun Zhang School of Textile Science and Engineering Key Laboratory of Functional Textile Material and Product(Ministry of Education)Xi’an Polytechnic UniversityXi’an 710048China Key Laboratory of Magnetic Molecules&Magnetic Information Materials of the Ministry of Education School of Chemistry&Material ScienceShanxi Normal UniversityTaiyuan 030031China Department of Clinical Laboratory The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Shanghai iProteome Biotechnology Co. LtdShanghai 201210China College of Chemistry&Materials Science Northwest UniversityXi'an 710127China

Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches,but still a significant challenge in materials *** this end,we firstly constructed highly flexible ZrTiO_(4) nanofibrous membranes(NFMs)with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination ***,to further increase the enrichment capacity of the phosphopeptide,the biomimetic TiO_(2)@ZrTiO_(4) NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO_(4) NFMs through growing unfurling TiO_(2) nanosheets onto the ZrTiO_(4) ***,remarkable flexibility and mechanical stability enable the resulting TiO_(2)@ZrTiO_(4) NFMs excellent practicability,while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer ***,6770 phosphopeptides can be enriched by TiO_(2)@ZrTiO_(4) NFMs(2205 corresponding phosphoproteins can be identified),and the value is much higher than that of ZrTiO_(4) NFMs(6399 phosphopeptides and 2132 identified phosphoproteins)and commercial high-performance TiO_(2) particles(4525 phosphopeptides and 1811 identified phosphoproteins).These results demonstrate the super ability of TiO_(2)@ZrTiO_(4) NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.

关键词： inorganic nanofibers flexible ceramic nanofibrous membranes biomimetic materials exceptional mechanical performance flexibility

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Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant

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Rare Metals 2024年第3期43卷 1288-1300页

作者： Xin Hu Xian-Ping Luo Zi-Shuai Liu Yong-Bing Zhang He-peng Zhou Zhi-Zhao Yang Xue-kun Tang Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Yichun Lithium New Energy Industry Research Institute Jiangxi University of Science and TechnologyYichun336000China

The physical and chemical properties of feldspar and quartz are highly similar,thus they cannot be easily separated *** this work,the flotation separation of feldspar from quartz using sodium fluosilicate(Na_(2)SiF_(6);SF)as a selective depressant was ***,the influence mechanism of SF on the selective flotation separation of feldspar and quartz was investigated via flotation tests,chemical analysis of flotation solution,Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and contact angle *** results of the flotation tests show that feld spar and quartz without SF treatment have good *** SF treatment,feldspar still has good floatability,whereas quartz has significantly reduced *** solution chemical analysis shows that the functional group plays an important role in depressing the quartz is[SiF_(6)]^(2-).FTIR,XPS and contact angle analysis results show that[SiF_(6)]^(2-)is adsorbed only on the surface of ***,a thin hydrophilic SiOF layer is generated on the surface,which interferes with the adsorption of the collector on the surface of the *** phenomenon leads to a significant reduction in quartz's ***,SF has a good ability to separate feldspar from quartz by flotation.

关键词： Flotation separation Depressants Sodium fluorosilicate Quartz Feldspar

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Dynamic mechanical characteristics of deep Jinping marble in complex stress environments

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 630-644页

作者： Chendi Lou Heping Xie Ru Zhang Hai Ren Hao Luo kun Xiao Yuan peng Qiang Tan Li Ren Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610207China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science&Engineering Sichuan UniversityChengdu610065China Yalong River Hydropower Development Company Ltd.Chengdu610051China (Chongqing)International Engineering Technology Company Ltd.Chongqing401121China

To reveal the dynamic mechanical characteristics of deep rocks,a series of impact tests under triaxial static stress states corresponding to depths of 300-2400 m were *** results showed that both the strain rates and the stress environments in depth significantly affect the mechanical characteristics of *** sensitivity of strain rate to the dynamic strength and deformation modulus shows a negative correlation with depth,indicating that producing penetrative cracks in deep environments is more difficult when damage *** dynamic strength shows a tendency to decrease and then increase slightly,but decreases sharply *** demonstrates a similar trend as that of strength,whereas reflectivity indicates the opposite ***,two critical depths with high dynamically induced hazard possibilities based on the China Jinping Underground Laboratory(CJPL)were proposed for deep *** first critical depth is 600-900 m,beyond which the sensitivity of rock dynamic characteristics to the strain rate and restraint of circumferential stress decrease,causing instability of surrounding rocks under axial stress *** second one lies at 1500-1800 m,where the wave impedance and dynamic strength of deep surrounding rocks drop sharply,and the dissipation energy presents a negative *** suggests that the dynamic instability of deep surrounding rocks can be divided into dynamic load dominant and dynamic load induced types,depending on the second critical depth.

关键词： Rock mechanics Split-Hopkinson pressure bar Coupled static‒dynamic loading Different depths Holmquist-Johnson-Cook(HJC)model

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Spatial Analysis of the Aging Population and Socio-economic Factors of China:Global and Local Perspectives

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Journal of Geodesy and Geoinformation Science 2024年第2期7卷 37-51页

作者： LU Binbin DONG Zheyi YUE peng QIN kun School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430072China

Population aging has become an inevitable trend and exerted profound influences on socio-economic development in *** this study,we utilized data from national population census and statistical yearbooks in 2010 and 2020 to explore spatio-temporal patterns of aging population and its coupling correlations with socio-economic factors from both global and local *** results from Local Indicators of Spatial Association(LISA)uncover notable spatial disparities in aging population rates,with higher rates concentrated in the eastern regions and lower rates in the western areas of the Chinese *** results from the global correlation analysis with the changes in aging population rates show significant positive correlations with government interventions and industrial structures,but negatively correlated with economic development,social consumption,and medical *** a local perspective,a Geographically Weighted(GW)correlation analysis is employed to uncover local correlations between aging trends and socio-economic *** insights gained from this technique not only underscore the complexity and diversity of economic implications stemming from population aging,but also provide invaluable guidance for crafting region-specific economic policies tailored to various stages of population aging.

关键词： spatial heterogeneity local technique GWmodelS GW correlation analysis,spatial autocorrelation

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