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Prevalence,patterns,risk factors and outcomes of peritoneal metastases after laparoscopic hepatectomy for hepatocellular carcinoma:a multicenter study from China

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 3-15,I0001-I0004页

作者： Yuan-Xiang Lu Jian-Ping Zhao Guan-Dou Yuan Ming-Gen Hu Chuan-Dong Sun kun-lun chen Yao chen Yong-Yi Zeng Zhi-Ying Yang Wan-Guang Zhang Hepatic Surgery Center Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningChina Faculty of Hepato-Pancreato-Biliary Surgery Chinese PLA General HospitalBeijingChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Radiology Intervention The Affiliated Tumor Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouChina Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Department of General Surgery China-Japan Friendship HospitalBeijingChina

Background:We aim to investigate the prevalence,patterns,risk factors,and outcomes of peritoneal metastases(PM)after curative laparoscopic hepatectomy(LH)for hepatocellular carcinoma(HCC).Methods:A multicenter cohort of 2,138 HCC patients who underwent curative LH from August 2010 to December 2016 from seven hospitals in China was retrospectively *** incidence of PM following LH was evaluated and compared with that in open hepatectomy(OH)after 1:1 propensity score matching(PSM).Results:PM prevalence was 5.1%(15/295)in the early period[2010-2013],2.6%(47/1,843)in the later period[2014-2016],and 2.9%(62/2,138)in all LH patients,which was similar to 4.0%(59/1,490)in the OH *** recurrence patterns,timing,and treatment did not significantly vary between the LH and OH patients(P>0.05).Multivariate logistic regression revealed that tumor diameter>5 cm,non-anatomical resection,presence of microvascular invasion,and lesions<2 cm from major blood vessels were independent risk factors of PM after *** the 62 cases with PM,26(41.9%)had PM only,34(54.9%)had intrahepatic recurrence(IHR)and PM,and 2(3.2%)had synchronous extraperitoneal metastases(EPM).Patients with resectable PM had a 5-year overall survival(OS)of 65.0%compared to 9.0%for unresectable PM(P=0.001).Conclusions:The prevalence,patterns and independent risk factors of PM were identified for HCC patients after *** was not associated with increased incidence of PM in HCC patients for experienced *** re-excision of PM was associated with prolonged survival.

关键词： Prevalence hepatocellular carcinoma(HCC) peritoneal metastases(PM) laparoscopic hepatectomy(LH) open hepatectomy(OH)

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P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome

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World Journal of Gastroenterology 2017年第34期23卷 6339-6349页

作者： Jie Wu Yan cheng Rong Zhang Dong Liu Yu-mei Luo kun-lun chen Song Ren Jun Zhang Department of Gastroenterology The Second Affiliated Hospital of School of MedicineXi’an Jiaotong University Department of Gastroenterology Shaanxi Provincial People’s Hospital Department of Gastroenterology The First Affiliated Hospital of School of MedicineXi’an Jiaotong University Fourth Cadre ward The Second Affiliated Hospital of School of MedicineXi’an Jiaotong University

AIM To evaluate the role of P2Y1 R in visceral hypersensitivity in rats with experimental irritable bowel *** A rat model of irritable bowel syndrome was generated by intra-colonic administration of acetic acid(AA) and assessed by histology and myeloperoxidase(m PO) activity assay. Then P2Y1 R expression in the colonic tissue was detected by Western blot. In order to explore the regulatory role of P2Y1 R in visceral hypersensitivity, an agonist(m RS2365) and an antagonist(m RS2179) of P2Y1 R were intra-colonically administered and effects were tested through a colorectal distension test. The abdominal withdrawal reflex and abdominal electromyography were tested during the course. RESULTS model assessment tests showed an obvious inflammatoryreaction that appeared on the 2^(nd) d after the AA injection, and the inflammatory reaction gradually recovered and almost disappeared on the 7^(th) d. The model finished on day 8 and showed a clear feature of IBS that had no organic lesion. The average expression of P2Y1 R was significantly higher in the AA group than in the na?ve group(0.319 ± 0.02 vs 0.094 ± 0.016, P < 0.001). m RS2365 could effectively raise the colonic hypersensitivity status at intervention doses of 10(AUC value from 0.30 ± 0.089 to 1.973 ± 0.127 mv?s, P < 0.01) and 100 μmol/L(AUC value from 0.290 ± 0.079 to 1.983 ± 0.195 mv?s, P < 0.01); m RS2179 could effectively reduce the hypersensitivity status at intervention dose of 100 μmol/L(from a mean baseline AUC value of 1.587 ± 0.099 mv?s to 0.140 ± 0.089 mv?s, P < 0.0001). Differences between the m RS2179 group(1.88 ± 1.45) and either the m RS2365 group(3.96 ± 0.19) or the combined treatment(m RS2179 and m RS2365) group(3.28 ± 0.11) were significant(P < 0.01).CONCLUSION P2Y1 R plays a regulatory role in visceral hypersensitivity in rats with experimental IBS. Specific antagonists of P2Y1 R may have potential therapeutic value in treating abdominal pain in IBS.

关键词： Irritable bowel syndrome P2Y1 receptor Regulation Therapy visceral hypersensitivity

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Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： kun Lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

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A froth velocity measurement method based on improved U-Net++semantic segmentation in flotation process

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1816-1827页

作者： Yiwei chen Degang Xu kun Wan School of Automation Central South UniversityChangsha 410083China

During flotation,the features of the froth image are highly correlated with the concentrate grade and the corresponding working *** static features such as color and size of the bubbles and the dynamic features such as velocity have obvious differences between different working *** extraction of these features is typically relied on the outcomes of image segmentation at the froth edge,making the segmentation of froth image the basis for studying its visual ***,the absence of scientifically reliable training data with label and the necessity to manually construct dataset and label make the study difficult in the mineral *** solve this problem,this paper constructs a tungsten concentrate froth image dataset,and proposes a data augmentation network based on Conditional Generative Adversarial Nets(cGAN)and a U-Net++-based edge segmentation *** performance of this algorithm is also evaluated and contrasted with other algorithms in this *** the results of semantic segmentation,a phase-correlationbased velocity extraction method is finally suggested.

关键词： froth flotation froth segmentation froth image data augmentation velocity extraction image features

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Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

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Nano Research 2024年第3期17卷 1818-1826页

作者： kun chen Shengqiu Liu Yujun Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic ***,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated *** administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat *** treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight *** addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by *** data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

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Generalized Inverses and Units in a Unitary Ring

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1000-1014页

作者： Yu kun ZHOU Jian Long chen School of Mathematics Southeast UniversityNanjing 210096P.R.China

Let R be a unitary ring and a,b∈R with ab=*** find the 2/3 property of Drazin invertibility:if any two of a,b and a+b are Drazin invertible,then so is the third ***,we combine the 2/3 property of Drazin invertibility to characterize the existence of generalized inverses by means of *** applications,the need for two invertible morphisms used by You and chen to characterize the group invertibility of a sum of morphisms is reduced to that for one invertible morphism,and the existence and expression of the inverse along a product of two regular elements are obtained,which generalizes the main result of Mary and Patricio(2016)about the group inverse of a product.

关键词： Leftπ-regular element stronglyπ-regular element group inverse Drazin inverse inverse along an element

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Numerical and experimental investigation into the evolution of the shock wave when a muzzle jet impacts a constrained moving body

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Defence Technology（防务技术） 2024年第3期33卷 317-326页

作者： Zijie Li Hao Wang Changshun chen kun Jiang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210016China

The gun-track launch system is a new special launch device that connects the track outside the *** it is constrained by the track,the characteristics of development of the muzzle jet differ from those of the traditional muzzle ***,it changes from freely developing to doing so in a constrained manner,where this results in an asymmetric direction of flow as well as spatio-temporal coupling-induced interference between various shock waves and the formation of *** this background,the authors of this article formulate and consider the development and characteristics of evolution of the muzzle jet as it impacts a constrained moving *** designed simulations to test the gun-track launch system,and established a numerical model based on the dynamic grid method to explore the development and characteristics of propagation of disturbances when the muzzle jet impacted a constrained moving *** also considered models without a constrained track for the sake of *** results showed that the muzzle jet assumed a circumferential asymmetric shape,and tended to develop in the area above the *** the test platform was close to the ground,the muzzle jet was subjected to reflections from it that enhanced the development and evolution of various forms of shock waves and vortices in the muzzle jet to exacerbate its rate of distortion and asymmetric *** in turn led to significant differences in the changes in pressure at symmetric points that would otherwise have been *** results of a comparative analysis showed that the constrained track could hinder the influence of reflections from the ground on the muzzle jet to some extent,and could reduce the velocity of the shock waves inducing the motion of the muzzle as well as the Mach number of the moving *** work here provides a theoretical basis and the requisite technical support for applications of the gun-track launch *** also sheds light on the

关键词： Shock wave/vortex interference Muzzle jet Constrained boundary Dynamic grid

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Transient long-range distance measurement by a Vernier spectral interferometry

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Photonics Research 2024年第6期12卷 1107-1114页

作者： LIANG XU kun WANG chen LIU WENYING chen CHI ZHANG XINLIANG ZHANG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Rapid and long-range distance measurements are essential in various industrial and scientific applications,and among them,the dual-comb ranging system attracts great attention due to its high ***,the tem-poral asynchronous sampling results in the tradeoff between frame rate and ranging precision,and the non-ambiguity range(NAR)is also limited by the comb cycle,which hinders the further advancement of the dual-comb ranging *** this constraint,we introduce a Vernier spectral interferometry to improve the frame rate and NAR of the ranging ***,leveraging the dispersive time-stretch technology,the dual-comb interferometry becomes spectral ***,the asynchronous time step is unlimited,and the frame rate is improved to 100 ***,dual-wavelength bands are introduced to implement a Vernier spectral interferometry,whose NAR is enlarged from 1.5 m to 1.5 ***,this fast and long-range system also demonstrated high precision,with a 22.91-nm Allan deviation over 10-ms averaging *** a result,the proposed Vernier spectral interferometry ranging system is promising for diverse applications that necessitate rapid and extensive distance measurement.

关键词： interferometry spectral system

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Precise determination of the pole position of the exotic Z_(c)(3900)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： Yun-Hua chen Meng-Lin Du Feng-kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

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Flux phases in the extended Hubbard model on the triangular lattice

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 148-153页

作者： Yuge chen kun Jiang Yi Zhang Jiangping Hu Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Department of Physics and Institute for Quantum Science and Technology Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of High Temperature Superconductors and International Center of Quantum and Molecular Structures Shanghai UniversityShanghai 200444China Kavli Institute of Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China New Cornerstone Science Laboratory Beijing 100190China

Using the unrestricted Hartree-Fock variational method,we study the extended Hubbard model in the triangular lattice at 3/4 *** to the nesting instability of the Fermi surface,various density wave states compatible with the 2×2 supercell are found as the ground state by tuning the onsite and nearest neighbor repulsions U and ***,the flux phases with complex bond order parameters are realized in a wide range of the U-V phase *** also acquire nontrivial topological properties due to the spontaneous breaking of the time-reversal *** study suggests that the flux phases can be stabilized by the interplay between short-range repulsive interactions in correlated electron systems.

关键词： flux state triangular lattice Hubbard model

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