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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Compositional modeling and simulation of dimethyl ether (DME)-enhanced waterflood to investigate oil mobility improvement

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Petroleum Science 2018年第2期15卷 297-304页

作者： Jinhyung Cho Tae hong Kim kun Sang lee Department of Earth Resources and Environmental Engineering Hanyang University

Dimethyl ether （DME） is a widely used industrial compound, and Shell developed a chemical EOR technique called DME- enhanced waterflood （DEW）. DME is applied as a miscible solvent for EOR application to enhance the performance of conventional waterflood. When DME is injected into the reservoir and contacts the oil, the first-contact miscibility process occurs, which leads to oil swelling and viscosity reduction. The reduction in oil density and viscosity improves oil mobility and reduces residual oil saturation, enhancing oil production. A numerical study based on compositional simulation has been developed to describe the phase behavior in the DEW model. An accurate compositional model is imperative because DME has a unique advantage of solubility in both oil and water. For DEW, oil recovery increased by 34% and 12% compared to conventional waterflood and CO2 flood, respectively. Compositional modeling and simulation of the DEW process indicated the unique solubility effect of DME on EOR performance.

关键词： Dimethyl ether (DME) DME-enhanced waterflood (DEW) Solubility Oil mobility

Geochemical evaluation of low salinity hot water injection to enhance heavy oil recovery from carbonate reservoirs

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Petroleum Science 2019年第2期16卷 366-381页

作者： Ji Ho lee kun Sang lee Department of Earth Resources and Environmental Engineering Hanyang University

Although low salinity water injection(LSWI) has recovered residual oil after the conventional waterflood, highly viscous oil has remained in heavy oil reservoirs. Hot water injection is an economic and practical method to improve oil mobility for viscous oil reservoirs. It potentially controls temperature-dependent geochemical reactions underlying the LSWI mechanism and oil viscosity. Therefore, this study has modeled and evaluated a hybrid process of low salinity hot water injection(hot LSWI) to quantify synergistic effects in heavy oil reservoirs. In comparison to seawater injection(SWI) and LSWI, hot LSWI results in more cation ion-exchange(Ca^(2+) and Mg^(2+)) and more wettability modification. Hot LSWI also reduces oil viscosity. In core-scaled systems, it increases oil recovery by 21% and 6% over SWI and LSWI. In a pilotscaled reservoir, it produces additional oil by 6% and 3% over SWI and LSWI. Probabilistic forecasting with uncertainty assessment further evaluates the feasibility of hot LSWI to consider uncertainty in the pilot-scaled reservoir and observes enhanced heavy oil production. This study confirms the viability of hot LSWI due to synergistic effects including enhanced wettability modification and oil viscosity reduction effects.

关键词： Low salinity water injection Hot water injection Wettability modification Geochemical reaction Viscosity reduction

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

MODELING ON THE CYCLIC OPERATION OF STANDING COLUMN WELLS UNDER REGIONAL GROUNDWATER FLOW

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Journal of Hydrodynamics 2011年第3期23卷 295-301页

作者： lee kun Sang Department of Natural Resources and Environmental Engineering Hanyang University

Coupled hydrogeological-thermal simulation of the Standing Column Well （SCW） system is essential to provide an optimized configuration and operation schedule for boreholes on the site. This paper presents numerical investigations and thermo-hydraulic evaluation of standing column well system operating under cyclic flow regime. A three-dimensional numerical model for groundwater flow and heat transport is used to analyze the heat exchange in the ground. The model includes the effects of convective and conductive heat transfer, heat loss to the adjacent confining strata, and hydraulic anisotropy. The operation scenario consists of cyclic injection and recovery and four periods per year to simulate the seasonal temperature conditions. For different parameters of the system, performances have been evaluated in terms of variations in recovery temperature. The calculated temperatures at the producing pipe are relatively constant within a certain range through the year and fluctuating quarterly a year. Pipe-to-pipe distance, injection/production rate, ground thickness, and permeability considered in the model are shown to impact the predicted temperature profiles at each stage and the recovery water temperature. The influence of pressure gradient, which determines the velocity of regional groundwater flow, is most substantial.

关键词： standing column well thermo-hydraulic evaluation cyclic regime numerical simulation

ZnO-Embedded Expanded Graphite Composite Anodes with Controlled Charge Storage Mechanism Enabling Operation of Lithium-Ion Batteries at Ultra-Low Temperatures

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Energy & Environmental Materials 2023年第4期6卷 31-39页

作者： kun Ryu Michael J.lee Kyungbin lee Seung Woo lee George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

As lithium(Li)-ion batteries expand their applications,operating over a wide temperature range becomes increasingly ***,the lowtemperature performance of conventional graphite anodes is severely hampered by the poor diffusion kinetics of Li ions(Li^(+)).Here,zinc oxide(ZnO) nanoparticles are incorporated into the expanded graphite to improve Li^(+)diffusion kinetics,resulting in a significant improvement in lowtemperature *** ZnO-embedded expanded graphite anodes are investigated with different amounts of ZnO to establish the structurecharge storage mechanism-performance relationship with a focus on lowtemperature *** analysis reveals that the ZnOembedded expanded graphite anode with nano-sized ZnO maintains a large portion of the diffusion-controlled charge storage mechanism at an ultra-low temperature of-50℃ Due to this significantly enhanced Li^(+)diffusion rate,a full cell with the ZnO-embedded expanded graphite anode and a LiNi_(0.88)Co_(0.09)Al_(0.03)O_(2)cathode delivers high capacities of 176 mAh g^(-1)at20℃ and 86 mAh g^(-1)at-50℃ at a high rate of 1 *** outstanding low-temperature performance of the composite anode by improving the Li^(+)diffusion kinetics provides important scientific insights into the fundamental design principles of anodes for low-temperature Li-ion battery operation.

关键词： diffusive and capacitive charge storages expanded graphite composites anode lithium-ion battery low-temperature operation transition metal oxide

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network