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Immune Regulatory Networks and Therapy of yδT Cells in Liver Cancer:Recent Trends and Advancements

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 287-297页

作者： kun-Li yin Kai-Jian Chu Ming Li Yu-Xin Duan Yan-Xi Yu Mei-Qing Kang Da Fu Rui Liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Biliary Surgical Department I the Eastern Hepatobiliary Surgical HospitalNaval Medical UniversityShanghaiChina General Surgery Institute of Pancreatic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

The roles of γδ T cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research *** re-view briefly describes the basic characteristics of γδ T cells,focusing on their diverse effects on liver *** particular,different subtypes of γδ T cells have diverse or even opposite effects on liver *** provide a detailed description of the immune regulatory network of γδ T cells in liver can-cer from two aspects:immune components and nonimmune *** interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ T cells in liver *** also integrate the current knowledge of γδ T-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.

关键词： Liver cancer γδT cells Immunotherapy Tumor microenvironment

Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents

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World Journal of Pediatrics 2024年第4期20卷 392-403页

作者： Li-Wang Gao Yi-Wen Huang Hong Cheng Xi Wang Hong-Bo Dong Pei Xiao yin-kun Yan Xin-ying Shan Xiao-Yuan Zhao Jie Mi Center for Non-Communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 Nanlishi RoadXicheng DistrictBeijing100045China Department of Epidemiology Capital Institute of PediatricsNo.2 Yabao RoadChaoyang DistrictBeijing100020China Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background The age of onset of hypertension(HTN)is decreasing,and obesity is a significant risk *** prevalence and racial disparities in pediatric HTN and the association between body composition and blood pressure are insufficiently *** study aimed to evaluate the prevalence of HTN in Chinese and American children and adolescents and to assess the relationship between various body composition indices and *** Seven thousand,five hundred and seventy-three Chinese and 6239 American children and adolescents aged 8–18 years from the 2013–2015 China Child and Adolescent Cardiovascular Health study and the 2011–2018 National Health and Nutrition Examination Surveys were *** pressure and body composition(fat and muscle)were measured by trained *** crude prevalence and age-standardized prevalence rate(ASPR)of primary HTN and its subtypes[isolated systolic hypertension(ISH)and isolated diastolic hypertension(IDH)]were calculated based on 2017 American Academy of Pediatrics ***-adjusted linear regression coefficients and odds ratios(ORs)were calculated to assess the associations of body composition indicators with HTN,ISH and *** The ASPR of HTN was 18.5%in China(CN)and 4.6%in the United States(US),whereas the obesity prevalence was 7.4%and 18.6%,and the population attributable risk of HTN caused by overweight and obesity was higher in the US than in *** fat mass,muscle mass and body fat percentage mass were associated with a higher risk of HTN in both *** percent of muscle body mass had a protective effect on HTN and ISH in both countries[HTN(CN:OR=0.83,95%CI=0.78–0.88;US:OR=0.72,95%CI=0.64–0.81);ISH(CN:OR=0.87,95%CI=0.80–0.94;US:OR=0.71,95%CI=0.62–0.81)],and the protective effect was more common among children and adolescents with high levels of physical *** The burden of HTN in Chinese children and adolescents was substantial and much greater than that in the US,and th

关键词： Body composition Children and adolescents China Child and Adolescent Cardiovascular Health Hypertension National Health and Nutrition Examination Surveys

Sesamol: a novel quorum sensing inhibitor and colistin accelerator against Pseudomonas aeruginosa

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Food Science and Human Wellness 2024年

作者： Peng-Cheng Ji kun-Yuan yin Yue Jiang Yu-Lu Sun Wen-Qi Luo Jin-Wei Zhou School of Food and Biological Engineering， Xuzhou University of Technology

We assessed the quorum sensing (QS) inhibitory impact of sesamol against the foodborne bacterium Pseudomonas aeruginosa. At concentrations ranging from 50 to 200 μg/mL， sesamol significantly inhibited the production of virulence factors such as protease， elastase， pyocyanin， rhamnolipid， and chemotaxis， and improved the susceptibility of bacterial and biofilm cells to colistin. Integrated transcriptomics， metabolomics， and docking analyses indicated that exposure to sesamol destroyed the QS system and down regulated the expressions of genes encoding virulence and antioxidant enzymes. The downregulation of genes encoding antioxidant enzymes intensified oxidative stress， as demonstrated by the enhancement of reactive oxygen species (ROS) and H2O2. The enhanced oxidative stress changed the components of the cell membrane， improved its permeability， and ultimately enhanced the susceptibility of bacterial and biofilm cells to colistin. Moreover， exposure to sesamol also led to the disorder of amino acid metabolism and energy metabolism， eventually attenuating the pathogenicity of P. aeruginosa. These findings indicated that sesamol can function as a potent anti-virulence agent to defend against food spoilage caused by P. aeruginosa.

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基于底栖动物生物完整性指数的黄河干流生态健康评价

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湖泊科学 2024年第2期36卷 512-522页

作者：冯治远侯易明阴琨金小伟韩谞潘保柱西安理工大学西北旱区生态水利国家重点实验室西安710048 中国环境监测总站北京100012

黄河为世界上最长的多沙河流,全河段水沙异质性及其生态健康的空间差异明显。本文基于黄河干流全河段44个断面春秋两季(2019年)底栖动物的系统调查数据,构建黄河底栖动物生物完整性评价体系。该体系融入指示水沙过程变化的ASPT指数及EP... 详细信息

黄河为世界上最长的多沙河流,全河段水沙异质性及其生态健康的空间差异明显。本文基于黄河干流全河段44个断面春秋两季(2019年)底栖动物的系统调查数据,构建黄河底栖动物生物完整性评价体系。该体系融入指示水沙过程变化的ASPT指数及EPT分类单元个体相对丰度,且参照点与受损点得分差异显著,适用于多沙河流生态健康评价。评价结果显示:黄河干流亚健康及以上状态的断面占比为秋季(75.0%)高于春季(54.5%);自源区沿河而下,底栖动物生物完整性指数值呈下降趋势;库区断面底栖动物生物完整性指数低于临近自然河段。回归分析表明,黄河干流底栖动物生物完整性指数与盐度、总氮、城镇及农田用地占比呈显著负相关,与林地及草地占比呈显著正相关。本研究结果可为黄河生态保护与管理提供科学依据。

关键词：黄河干流大型底栖无脊椎动物生物完整性生态健康评价

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大跨度暗挖拱盖车站施工技术研究与应用

中国市政工程 2024年第5期 127-131,168页

作者：王银坤中建青岛投资建设有限公司山东青岛266000

文章依托山东省青岛市轨道交通L6海港路站和石山路站2座暗挖拱盖车站为工程背景,详细阐述和分析了基于新型预应力锚杆的主动支护技术、受力支护体系转换技术和“半包防水+限量排水”技术在大跨度暗挖拱盖车站施工中的应用。研究表明:这... 详细信息

文章依托山东省青岛市轨道交通L6海港路站和石山路站2座暗挖拱盖车站为工程背景,详细阐述和分析了基于新型预应力锚杆的主动支护技术、受力支护体系转换技术和“半包防水+限量排水”技术在大跨度暗挖拱盖车站施工中的应用。研究表明:这3项技术在施工过程中切实达到了既安全优质、又高效施工的目的;其成功经验值得在后续施工中进行推广应用,并为其他同类工程提供借鉴和参考。

关键词：大跨度暗挖拱盖车站主动支护变形控制新型预应力锚杆受力支护体系转换

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环保工程水处理中超滤膜技术的应用探讨

皮革制作与环保科技 2024年第7期5卷 24-26页

作者：尹坤姜蕤泰安市生态环境局新泰分局山东泰安271200 新泰市廉政教育中心山东泰安271200

水是一切生命赖以生存的基础,淡水资源更是人类进行正常社会活动的保证。但随着工业化进程的加快与行业发展,对水资源的需求量逐步提高,每天排出的工业废水量与生活污水对现有水资源造成较为严重的污染。随着经济水平与生活质量的提升,... 详细信息

水是一切生命赖以生存的基础,淡水资源更是人类进行正常社会活动的保证。但随着工业化进程的加快与行业发展,对水资源的需求量逐步提高,每天排出的工业废水量与生活污水对现有水资源造成较为严重的污染。随着经济水平与生活质量的提升,越来越多的人开始注重水资源保护。超滤膜技术便是在此背景下诞生的新型污水处理技术,在实践应用中对污水的净化与处理有着不同凡响的表现。本文重点针对超滤膜技术的原理、技术特点与优劣势进行详细阐述,并对超滤膜技术在环保工程水处理工作中的具体应用策略进行深入分析。

关键词：环保工程水处理工作超滤膜技术

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抗弓形虫药物靶点研究进展

中国病原生物学杂志 2024年第2期19卷 237-240,247页

作者：谢环环王琦代莉莎朱文菊尹昆山东省寄生虫病防治研究所山东第一医科大学(山东省医学科学院)山东济宁272033

弓形虫是人畜共患寄生虫之一,对优生优育、食品安全、免疫缺陷人群健康、人类精神卫生和畜牧产业均造成严重危害,但目前仍缺乏高效低毒、靶点专一、机制明确的抗弓形虫药物,导致临床弓形虫的标准治疗方案落后、无有效防治措施。因此,本... 详细信息

弓形虫是人畜共患寄生虫之一,对优生优育、食品安全、免疫缺陷人群健康、人类精神卫生和畜牧产业均造成严重危害,但目前仍缺乏高效低毒、靶点专一、机制明确的抗弓形虫药物,导致临床弓形虫的标准治疗方案落后、无有效防治措施。因此,本文就近年来报道的新型抗弓形虫药物靶点及其相关化合物进行综述。

关键词：刚地弓形虫抗弓形虫药物药物靶点综述

Thermodynamic properties of calcium ferrite-type MgAl_2O_4:A first principles study

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Science China Earth Sciences 2016年第4期59卷 831-839页

作者： yin kun ZHOU HuiQun LU XianCai State Key Lab for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University

The diamond anvil cell experiments have revealed that the calcium ferrite(CF)-type aluminous phase is probably an important component of subducted mid-oceanic ridge basalt(MORB) in the lower mantle. In this study, we have performed first principles lattice dynamics calculations for the Mg Al_2O_4 end-member of the aluminous phase based on density functional perturbation theory using two functionals within the local density approximation(LDA) and generalized gradient approximation(GGA) for bracketing the calculated properties at their lower and upper limits, respectively. A simple empirical pressure correction at zero temperature has been applied to both LDA and GGA. The results of room-temperature equation of state(EOS) and zero-pressure thermal expansion calculated by GGA with pressure correction have shown the best agreement with available experimental data. The high-pressure and temperature thermodynamic properties have been obtained using the GGA with correction method. The pressure-volume relations are fitted with a third-order high-temperature Birch-Murnaghan EOS. The isobaric heat capacity, the coefficient of thermal expansion and isothermal bulk modulus are fitted with polynomials and their coefficients are reported in the range of 0–40 GPa and 300–2000 K. The density profile of MORB estimated using the computational thermo-elastic constants supports the hypothesis that the subducted oceanic slabs could gain enough downwelling forces into the lower mantle.

关键词： CaFe2O4-type MgAl2O4 Density functional perturbation theory Thermodynamic properties First principles

水生生物监测质量保证、质量控制与标准化:动态与展望

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湖泊科学 2024年第4期36卷 975-986页

作者：熊莉赵先富贾世琪阴琨许人骥王备新王业耀金小伟四川省宜宾生态环境监测中心站宜宾644000 水利部中国科学院水工程生态研究所水利部水工程生态效应与生态修复重点实验室武汉430079 中国环境监测总站北京100012 南京农业大学昆虫系南京210095

水生生物监测是流域水生态状况评价的重要基础,监测数据的准确性和可靠性直接影响水生态环境质量评价与流域水生态管理成效。目前我国水生生物监测质量保证和质量控制体系尚处于持续完善的阶段,关键环节的控制要求和质控目标等亟待明确... 详细信息

水生生物监测是流域水生态状况评价的重要基础,监测数据的准确性和可靠性直接影响水生态环境质量评价与流域水生态管理成效。目前我国水生生物监测质量保证和质量控制体系尚处于持续完善的阶段,关键环节的控制要求和质控目标等亟待明确和细化。本文总结了欧美发达国家水生生物监测质量保证与质量控制体系建设中的经验,通过梳理我国水生生物监测工作基础与进展,较为系统地提出了适合我国现状的水生生物监测质量保证与质量控制体系标准化建设对策建议,包括实验室内部和外部质量保证与质量控制、水生生物监测质控数据库、人工智能识别和环境DNA新技术质控要点等标准化建议,为实现水生生物监测业务化运行,准确评估我国流域水生态质量状况的变化提供技术支撑。

关键词：水生态水生生物监测标准化质量控制质量保证