检索结果-南通市图书馆

Multi-alleles predict primary non-response to infliximab therapy in Crohn’s disease

Gastroenterology Report 2021年第5期9卷 427-434,I0002页

作者： Cai-Bin Zhang Jian Tang Xue-Ding Wang kun-sheng Lyu Min Huang Xiang Gao Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Southern China Center for Statistical Science School of Mathematics Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Infliximab(IFX)is the first-line treatment for patients with Crohn’s disease(CD)and is noted for its relatively high *** therapeutic efficacy of IFX has noticeable individual *** single-gene polymorphisms(SNPs)are inadequate for predicting non-response to *** this study,we aimed to identify new genetic factors associated with IFX-therapy failure and to predict non-response to IFX by developing a multivariate predictive ***:In this retrospective study,we collected and analysed the data of Chinese patients with CD who received IFX therapy at one hospital between June 2013 and June *** non-response(PNR)and non-durable response(NDR)were evaluated using a simple endoscopic score for CD(SES-CD).A total of 125 SNPs within 44 genes were genotyped.A multivariate logistic-regression model was established to predict non-response to *** area-under-the-receiver-operatingcharacteristics curve(AUROC)was applied to evaluate the predictive model ***:Forty-two of 206(20.4%)patients experienced PNR and 15 of 159(9.4%)patients experienced *** SNPs were associated with PNR(P<0.05).A PNR predictive model was established,incorporating 2-week high-sensitivity C-reactive protein(hs-CRP),rs61886887,rs61740234,rs357291,rs2269330,and rs111504845,and the AUROC on training and testing data sets were 0.818(P<0.001)and 0.888(P<0.001),*** week 14,hs-CRP levels≥2.25 mg/L were significantly associated with NDR(AUROC=0.815,P<0.001).PNR-associated SNPs were not mutually associated with NDR,suggesting distinct mechanisms between PNR and ***:Genetic polymorphisms are significantly associated with response to IFX among Chinese CD patients.

关键词： infliximab Crohn’s disease single nucleotide polymorphism therapeutic response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of overthrust nappe structure and its geodynamic mechanism along the southeastern margin of Nansha Trough

引用

China Geology 2018年第4期1卷 459-465页

作者： Guang-xue Zhang Zhen Yang Li Zhang Wei Yan kun-sheng Qiang MLR Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological SurveyGuangzhou 510075China Marine Petroleum and Gas geological Research Center (China Geological Survey) Guangzhou Marine Geological SurveyGuangzhou 510075China

On the basis of interpretation of comprehensive geophysical data and foreign data analysis,there existed a lot of overburden detachment shear thrust faults along the southeastern margin of Nansha Trough,which composed imbricated overthrust nappe ***-faulted nappe structure pattern is determined in this area,which consists of frontal fault zone,thrust fault-folded zone and root zone structures,and presents regularly zonation on *** detail description of the structural geometrical characteristics is given in shallow thrust fault zone,and the kinematical mechanism of thrust fault nappe structure is furtherly *** nappe structure in this area is resulted from island arc-continent collision and orogenic activities.

关键词： Overthrust Structure Geodynamic Mechanism Nansha Trough

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-exponentially Photoelectric Response of Bacteriorhodopsin

引用

Chinese Physics Letters 2001年第1期18卷 134-136页

作者： YAO Bao-Li XU Da-Lun HOU Xun HU kun-sheng WANG Ao-Jin State Key Laboratory of Transient Optics and Technology Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710068 Institute of Biophysics Chinese Academy of SciencesBeijing 100101

A thin oriented bacteriorhodopsin(bR)film is deposited on a stainless steel slide by use of the electrophoretic sedimentation method.A junction is made with electrolyte gels having a counterelectrode to construct a bR-based photoelectric *** photoelectric response signal to a 10ns laser pulse is measured.A theory on the photoelectric kinetics of bR is developed based on the concept of the charge displacement current and the bR photocycle rate *** between the theoretical and experimental results proves that the bR photoelectric response to a short laser pulse is a multi-exponential *** decay time constants and amplitudes of each exponential component are obtained by data fitting.

关键词： exponential photoelectric kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Focal lymphoblastic transformation of chronic myelogenous leukemia develops into erythroid leukemia:A case report

引用

World Journal of Clinical Cases 2023年第24期11卷 5780-5788页

作者： Wei Wang Ya-Ling Chen Pan-Pan Gou Pei-Lin Wu kun-sheng Shan Dong-Liang Zhang Department of Hematology The 909th Hospital of PLA(Southeast Hospital Affiliated to Xiamen University)Zhangzhou 363000Fujian ProvinceChina Department of Hematology The 175th Hospital of PLA(Southeast Hospital Affiliated to Xiamen University)Zhangzhou 363000Fujian ProvinceChina

BACKGROUND We present a case of focal lymphoblastic transformation to erythroid leukemia following acute myeloblastic transformation in a patient with chronic myelogenous leukemia(CML)and discuss its mechanism of occurrence and *** SUMMARY The presence of the Philadelphia(Ph)chromosome was identified through karyotype analysis,while the BCR-ABL fusion gene was detected using quantitative real-time polymerase chain reaction of the peripheral blood *** in situ hybridization was used to detect the expression of the BCRABL gene in the *** expression and gene mutations in the primitive cells were detected by flow *** analysis confirmed the presence of CML along with focal lymphoblastic transformation to erythroid ***,the patient was found to have secondary erythroid leukemia,along with multiple new gene mutations and abnormalities in complex karyotypes of *** Our findings suggest a possible molecular basis for the focal lymphoblastic transformation secondary to myeloblastic transformation in patients with CML.

关键词： Chronic myelogenous leukemia Blast crisis Focal lymphoblastic transformation Pure erythroid leukemia Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of polymorphisms in C1orf106,IL1RN,and IL10 with post-induction infliximab trough level in Crohn’s disease patients

引用

Gastroenterology Report 2020年第5期8卷 367-373,I0002页

作者： Jian Tang Cai-Bin Zhang kun-sheng Lyu Zhong-Ming Jin Shao-Xing Guan Na You Min Huang Xue-Ding Wang Xiang Gao Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouGuangdongP.R.China Southern China Center for Statistical Science School of Mathematics Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Trough levels of the post-induction serum infliximab(IFX)are associated with short-term and long-term responses of Crohn’s disease patients to IFX,but the inter-individual differences are *** aimed to elucidate whether single gene polymorphisms(SNPs)within FCGR3A,ATG16L1,C1orf106,OSM,OSMR,NF-jB1,IL1RN,and IL10 partially account for these differences and employed a multivariate regression model to predict patients’post-induction IFX ***:The retrospective study included 189 Crohn’s disease patients undergoing IFX ***-induction IFX levels were measured and 41 tag SNPs within eight genes were *** between SNPs and IFX levels were ***,a multivariate logistic-regression model was developed to predict whether the patients’IFX levels achieved the threshold of therapy(3 lg/mL).Results:Six SNPs(rs7587051,rs143063741,rs442905,rs59457695,rs3213448,and rs3021094)were significantly associated with the post-induction IFX trough level(P=0.015,P<0.001,P=0.046,P=0.022,P=0.011,P=0.013,respectively).A multivariate prediction model of the IFX level was established by baseline albumin(P=0.002),rs442905(P=0.025),rs59457695(P=0.049),rs3213448(P=0.056),and rs3021094(P=0.047).The area under the receiver operating characteristic curve(AUROC)of this prediction model in a representative training dataset was *** result was verified in a representative testing dataset,with an AUROC of ***:Polymorphisms in C1orf106,IL1RN,and IL10 play an important role in the variability of IFX post-induction levels,as indicated in this multivariate prediction model of IFX levels with fair performance.

关键词： infliximab inflammatory bowel disease single nucleotide polymorphism trough level multivariate prediction model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-phospholipase A2 receptor-associated membranous nephropathy with human immunodeficiency virus infection treated with telitacicept:A case report

引用

World Journal of Clinical Cases 2023年第22期11卷 5309-5315页

作者： Jin-Ling Wang Yan-Ling Sun Zhe Kang sheng-kun Zhang Chun-Xin Yu Wan Zhang Hua Xie Hong-Li Lin Department of Nephrology Dalian Renal Care HospitalDalian 116000Liaoning ProvinceChina Department of Nephrology The First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND The co-occurrence of Anti-phospholipase A2 receptor-associated membranous nephropathy(anti-PLA2R-MN)and human immunodeficiency virus(HIV)infection is a rare clinical scenario,presenting significant challenges in terms of management and *** SUMMARY A 32-year-old Chinese male diagnosed with HIV infection presented with a clinical history of proteinuria persisting for over two years.A kidney biopsy demonstrated subepithelial immune complex deposition and a thickened glomerular basement membrane,indicative of stage I-II membranous *** staining revealed granular deposition of PLA2R(3+)along the glomerular capillary loops,corroborated by a strongly positive anti-PLA2R antibody test(1:320).Initial treatment involving losartan potassium,rivaroxaban,tacrolimus,and rituximab was discontinued due to either poor effec-tiveness or the occurrence of adverse *** a regimen of weekly subcutaneous injections of telitacicept(160 mg),a marked decline in the 24 h urine protein was observed within a three-month period,accompanied by a rise in serum albumin *** significant reductions in peripheral blood CD3+CD4+T and CD3+CD8+T cell counts were *** patient's physical and psychological conditions showed significant improvements,with no adverse events reported during the treatment *** Telitacicept might offer a potential therapeutic avenue for patients diagnosed with anti-PLA2R-MN concomitant with HIV infection.

关键词： Membranous nephropathy PLA2R Human immunodeficiency virus Proteinuria Telitacicept Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analyzing the transient effects of 60Co gamma rays in a CIS by Monte Carlo method

引用

Nuclear Science and Techniques 2019年第7期30卷 100-106页

作者： Yuan-Yuan Xue Zu-Jun Wang Min-Bo Liu Rui Xu Hao Ning Wen Zhao Bao-Ping He Zhi-Bin Yao Jiang-kun sheng Wu-Ying Ma Guan-Tao Dong The State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology Xi’an 710613 China School of Materials Science and Engineering Xiangtan University Xiangtan 411105 China

The objective of this work is to analyze the transient effects of ^60Co gamma rays in the CMOS image sensor (CIS) using the Monte Carlo method, based on Geant4. The track, energy spectrum, and angle of produced electrons when gamma rays traversed a silicon or silicon dioxide cube were calculated. A simplified model of a 500 × 500 CIS array was established, and the transient effects of gamma rays in the CIS were simulated. The raw images were captured when the CIS was irradiated by gamma rays. The experimental results were compared with the simulation results. The characteristics of the typical events induced by transient effects were analyzed.

关键词： ^60Co gamma rays Transient effects CMOS image sensor (CIS) Geant4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于可靠性的结构鲁棒设计

引用

上海交通大学学报 2000年第1期34卷 60-62页

作者：周继胜张圣坤魏东上海交通大学船舶与海洋工程学院上海200030

采用赵国藩提出的近似计算方法计算结构的系统失效概率,并推导了相应的敏度计算公式,由此进行基于可靠性的鲁棒设计.计算实例证明,基于可靠性的鲁棒设计对提高结构的可靠性非常有效,而且在生命周期内。

关键词：结构力学鲁棒设计可靠性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A POSSIBLE REGULATORY FACTOR(CALMODULIN) IN THE PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS

引用

Chinese Science Bulletin 1989年第2期34卷 174-175页

作者：卢坤平赵昇皓王道生 Department of Biochemistry Xuzhou Medical College Department of Pharmacology Suzhou Medical College

The proliferation of vascular smooth muscle cells accompanies the pathogenesis of atherosclerosis and hypertension. It is known that Ca2+ion controls the proliferation of several lines of cells. However, whether Ca2+ ... 详细信息

关键词： calmodulin pathogenesis fetal cultivated rabbit diphenyl thymidine blocker embryo antagonist

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多形核白细胞上嘌呤受体的初步研究

引用

生物化学与生物物理进展 1999年第4期26卷 366-368页

作者：陈涉聂玉生胡坤生中国科学院生物物理研究所北京100101

ＡＴＰ和ＡＤＰ能激活多型核白细胞引起细胞内［Ｃａ２＋］ｉ的明显升高，ＡＭＰ则无此作用．多型核白细胞对ＡＴＰ和ＡＤＰ具有不同的浓度依赖性．当细胞外的钙离子被螯合后，ＡＴＰ和ＡＤＰ仍能引... 详细信息

ＡＴＰ和ＡＤＰ能激活多型核白细胞引起细胞内［Ｃａ２＋］ｉ的明显升高，ＡＭＰ则无此作用．多型核白细胞对ＡＴＰ和ＡＤＰ具有不同的浓度依赖性．当细胞外的钙离子被螯合后，ＡＴＰ和ＡＤＰ仍能引起细胞内游离钙浓度的升高．结果表明多形核白细胞存在着对ＡＴＰ和ＡＤＰ敏感的Ｐ２型嘌呤受体，并且属于Ｐ２型受体中的Ｐ２Ｙ

关键词：白细胞嘌呤受体 ATP 钙

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：