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Design and performance evaluation of a large field-of-view dual-particle time-encoded imager based on a depth-of-interaction detector

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Nuclear Science and Techniques 2024年第4期35卷 1-14页

作者： Dong Zhao Xu-Wen Liang Ping-kun Cai Wei Cheng Wen-Bao jia Da-Qian Hei Qing Shan Yong-Sheng Ling Chao Shi Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Radiation Medicine of jiangsu Higher Education Institutions Suzhou 215000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a *** this study,a large field-of-view time-encoded imager was developed for gamma-ray and neutron source hotspot imaging based on a depth-of-interaction(DOI)*** imager primarily consists of a DOI detector system and a rotary dual-layer cylindrical coded *** EJ276 plastic scintillator coupled with two SiPMs was designed as the DOI detector to increase the field of view and improve the imager *** difference in signal time at both ends and the log of the signal amplitude ratio were used to calculate the interaction position *** position resolution of the DOI detector was calibrated using a collimated Cs-137 source,and the full width at half maximum of the reconstruction position of the Gaussian fitting curve was approximately 4.4 *** DOI detector can be arbitrarily divided into several units to independently reconstruct the source distribution *** unit length was optimized via Am-Be source-location experiments.A multidetector filtering method is proposed for image *** method can effectively reduce image noise caused by poor DOI detector position *** vertical field of view of the imager was(-55°,55°)when the detector was placed in the center of the coded mask.A DT neutron source at 20 m standoff could be located within 2400 s with an angular resolution of 3.5°.

关键词： Time-encoded imager Depth-of-interaction detector Dual-particle imaging Hotspot imaging

基于生物信息学的烟气暴露对大鼠肺脏基因表达谱的影响

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陕西科技大学学报 2024年第2期42卷 79-86页

作者：逯晓宇徐达孙鸽苏加坤袁慧蔡继宝秦秀军山西医科大学公共卫生学院山西太原030001 中国辐射防护研究院放射医学与环境医学研究所山西太原030006 药物毒理与放射损伤药物山西省重点实验室(中核放射毒理与放射性药物临床前评价重点实验室) 山西太原030006 江西中烟工业有限责任公司江西南昌330096

利用基因芯片技术研究两种不同烟气暴露30 d后对大鼠肺脏基因表达的影响,并寻找其潜在miRNA、转录因子及药物.6只雄性SD大鼠分为普通卷烟烟气暴露组(n=3)和含本草香成分卷烟(金圣4)烟气暴露组(n=3),每天烟气暴露1次,连续30 d,结束后取... 详细信息

利用基因芯片技术研究两种不同烟气暴露30 d后对大鼠肺脏基因表达的影响,并寻找其潜在miRNA、转录因子及药物.6只雄性SD大鼠分为普通卷烟烟气暴露组(n=3)和含本草香成分卷烟(金圣4)烟气暴露组(n=3),每天烟气暴露1次,连续30 d,结束后取大鼠肺脏进行差异表达基因筛选.基于Metascape数据库和Cytoscape 3.10.0软件对差异基因进行基因本体和京都基因与基因组百科全书生物信息学分析.STRING数据库获取蛋白质相互作用(protein-protein interaction,PPI)网络后筛选核心基因.依托于核心基因,通过miRDB和microT-CDS数据库预测潜在的miRNA,应用GTRD和JASPAR数据库预测潜在转录因子,基于DGIdb数据库预测潜在药物.与普通卷烟组比较,含本草香组筛选出差异表达1倍以上的基因1434个,其中上调表达767个,下调表达667个.差异表达基因富集于384种生物过程,59种细胞成分和51类分子功能以及20个信号通路.10个核心基因分别为Pik3r1、Fn1、Itgb3、Lrp5、Dvl3、Fgf2、Lrp6、Flt4、Tln1及Jun.预测结果显示,可能控制最多数量的DEGs的miRNA是rno-miR-200b-3p、rno-miR-429和rno-miR-200c-3p;预测到49种转录因子(Transcriptionfactors,TF);预测到111种药物小分子化合物.研究结果表明烟气暴露30 d所致大鼠肺脏的异常表达基因涉及多个miRNA、转录因子及药物,为烟草暴露致肺脏损伤研究提供实验依据.

关键词：吸烟本草香大鼠肺脏差异基因生物信息学

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外科植入物用钛及钛合金金相试样制作浅谈

金属热处理 2009年第4期34卷 69-71页

作者：董加坤上海医疗器械(集团)有限公司手术器械厂上海200072

对钛及钛合金金相试样制样用的砂纸、抛光织物、抛光试剂和侵蚀剂的合理选择以及制样方法和侵蚀方法作了叙述。

关键词：钛及钛合金砂纸抛光织物抛光试剂侵蚀剂

制作奥氏体不锈钢金相试样的高效侵蚀剂配方及使用方法

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金属热处理 2011年第5期36卷 133-135页

作者：董加坤乐嘉文高合金钢技术(上海)有限公司上海201108

在钢的金相试样制作方面,每当提到奥氏体不锈钢,绝大部分人会觉得其试样制作太难。主要困难是①奥氏体不锈钢抛光难,这主要与钢的硬度太低有关;②奥氏体晶界不易被侵蚀出来或者总是侵蚀不到位;③因为奥氏体基体呈白色,所以侵蚀后的试面... 详细信息

在钢的金相试样制作方面,每当提到奥氏体不锈钢,绝大部分人会觉得其试样制作太难。主要困难是①奥氏体不锈钢抛光难,这主要与钢的硬度太低有关;②奥氏体晶界不易被侵蚀出来或者总是侵蚀不到位;③因为奥氏体基体呈白色,所以侵蚀后的试面看上去像是脏兮兮的,很难将试面弄得很清洁。关于奥氏体不锈钢侵蚀剂的资料很多,但常用的侵蚀剂不过4种,就目前来讲还没有一种侵蚀剂能够克服上述3种困难。现有的常用金相侵蚀剂主要为FeCl3＋HCl水溶液、王水或王水稀释液和HCl＋CuCl2水溶液3种,在侵蚀效果上均存在弊端。

关键词：奥氏体不锈钢金相试样试样制作侵蚀剂配方奥氏体晶界奥氏体基体水溶液

Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： jia-Li Chen Lu Guo Zhen-Ying Wu kun He Han Li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and *** regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of *** time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

维普期刊数据库评论

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延迟容忍网络自适应差错控制方法

电讯技术 2010年第7期50卷 86-90页

作者：贾坤中国西南电子技术研究所成都610036

根据延迟容忍网络的时延较大、误码率较高等特点,在现有的传输控制层和MAC层差错控制的基础上改进,结合IEEE 802.11 DCF机制的特点,提出一种基于MAC层丢包率的自适应差错控制方案。该方案能有效改善延迟容忍网络的传输时延,满足对时延... 详细信息

根据延迟容忍网络的时延较大、误码率较高等特点,在现有的传输控制层和MAC层差错控制的基础上改进,结合IEEE 802.11 DCF机制的特点,提出一种基于MAC层丢包率的自适应差错控制方案。该方案能有效改善延迟容忍网络的传输时延,满足对时延要求比较敏感的业务的要求。

关键词：延迟容忍网络自适应差错控制误码率

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航管二次雷达数据处理

电讯技术 2011年第6期51卷 78-81页

作者：贾坤中国西南电子技术研究所成都610036

为了持续稳定跟踪和询问到空中客机,基于航管二次雷达工作原理,设计了航管二次雷达数据处理功能模块。在Vxworks嵌入式操作系统上采用交互多模滤波技术完成了对客机改变航道或转弯时的航迹跟踪和数据处理。外场试验结果表明,通过航管二... 详细信息

为了持续稳定跟踪和询问到空中客机,基于航管二次雷达工作原理,设计了航管二次雷达数据处理功能模块。在Vxworks嵌入式操作系统上采用交互多模滤波技术完成了对客机改变航道或转弯时的航迹跟踪和数据处理。外场试验结果表明,通过航管二次雷达数据处理功能模块的合理划分以及采用交互多模滤波跟踪技术能实现对空中客机的实时监视,并与其保持正常通信。

关键词：二次雷达航迹处理询问模式航迹关联交互多模滤波

从《十三个小故事》看叶·波波夫笔下的“两个世界”

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解放军外国语学院学报 2005年第4期28卷 110-114页

作者：贾锟南京大学中文系江苏南京210093

叶甫盖尼·波波夫是俄罗斯当代著名作家。他的作品以现实主义、讽刺性、悲剧性和怪诞的特点成功地再现了俄罗斯当代人民复杂、多彩、充满戏剧性的生活。《十三个小故事》是波波夫创作于20世纪70年代末的一组短篇小说,揭示了当时存在于... 详细信息

叶甫盖尼·波波夫是俄罗斯当代著名作家。他的作品以现实主义、讽刺性、悲剧性和怪诞的特点成功地再现了俄罗斯当代人民复杂、多彩、充满戏剧性的生活。《十三个小故事》是波波夫创作于20世纪70年代末的一组短篇小说,揭示了当时存在于苏联社会中的“两个世界”,表达了作者对民间世界的同情和热爱以及对官方世界的憎恶,为我们了解和研究波波夫的创作提供了重要线索。

关键词：波波夫故事 20世纪70年代著名作家现实主义短篇小说民间世界俄罗斯讽刺性悲剧性戏剧性当代创作怪诞

Iron-based layered double hydroxide packed with metal-organic frameworks for enhanced overall water-splitting electrocatalysis

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Tungsten 2024年第4期6卷 859-868页

作者： Long Chen Yun Luo Zhi-Peng Yu Yi-kun Cheng Yang Zheng Li He jia-Hao Xiong Wen-Wen Kong Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Institute of Scientific Research Luzhou North Chemistry Industry Co.Ltd International Iberian Nanotechnology Laboratory (INL) CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering Xinjiang Technical Institute of Physics and Chemistry of CAS

Designing hybrid materials with numerous catalytic active sites,high specific surface area,and interfacial interactions is an effective strategy to improve electrocatalytic *** this work,iron-based metal organic frameworks（Fe-MOFs）@（Co,Ni）Fe-layered double hydroxide（LDH） is successfully constructed using the similar "MOF growing on LDH" strategy for oxygen evolution reaction and hydrogen evolution reaction in the alkaline *** synthesized hybrid materials in this particular way show excellent electrochemical overall water-splitting performance with the cell voltage of 1.62 V at10 mA·cm-2in the alkaline environment due to the optimized adsorption/desorption properties of metal ions on oxygencontaining species and interfacial effects of hybrid ***-MOFs@（Co,Ni）Fe-LDH also exhibits excellent hydrogen and oxygen production efficiency of 370 and 175 μL·min-1,*** work draws on an effective approach to the fabrication of MOF@LDH structures and provides new insights into overall water-splitting in alkaline conditions.

关键词： Electrocatalysis Interfacial interactions Layered double hydroxide Metal–organic frameworks (MOFs) Water splitting