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RuO2 alleviates dextran sulfate sodium-induced colitis in zebrafish(Danio rerio)

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RuO2 alleviates dextran sulfate sodium-induced colitis in ze...

Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population

中国毒理学会第十次全国毒理学大会

作者： Xiaofang Che Yong Huang Zhou Liu kun jia Keyuan Zhong Huiqiang Lu Ganzhou Key Laboratory for Drug Screening and Discovery School of Geography and Environmental Engineering Gannan Normal University College of Chemistry and Chemical Engineering Gannan Normal University jiangxi Key Laboratory of Developmental Biology of Organs Jinggangshan University

Inflammatory bowel disease(IBD) is a chronic intestinal disease with destruction, which threatens the health of animals and humans. Traditional therapies for the treatment of IBD have limited efficacy. Thus, there is an urgent need for novel therapies that can effectively treat IBD. RuO, an antioxidant, has various biological activities, including anti-inflammatory activity. However, its effects on experimental colitis remain unknown. Zebrafish(Danio rerio) was used to explore the therapeutic effect and mechanism of RuOon dextran sulfate sodium sulfate(DSS) induced colitis. We found that RuOsaved the phenotype of neutrophil infiltration into the intestinal epithelium and downregulated the high expression levels of inflammatory-related genes interferon-γ(IFN-γ), pro-inflammatory cytokines(interleukin-1β(IL-1β), interleukin-8(IL-8), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α)) and apoptosis-related genes(bcl2-associated X(bax) and b-cell lymphoma-2(bcl2)) in DSS group. Histological analysis showed that RuOalleviated pathological damage to colon tissue and rescued the number of goblet cells to release acidic mucus to protect the gut. Our findings show that RuOcan effectively treat colitis and provide a novel medicine for the treatment of colitis.

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Biomedical and Environmental Sciences 2007年第1期20卷 41-46页

作者： CONG-RONG WANG CHENG HU RONG ZHANG QI-CHEN FANG XIAO-JING MA WEI-PING jia kun-SAN XIANG Shanghai Diabetes Institute Department of Endocrinology and Metabolism Shanghai Jiaotong University Affiliated Sixth People＇s Hospital Shanghai 200233China

Objective To analyze the association of variants of hepatocyte nuclear factor-1α （HNF-1α） gene with type 2 diabetes in Chinese population. Methods In 152 unrelated type 2 diabetes patients and 93 unrelated controls, eleven single nucleotide polymorphisms （SNPs） were identified and genotyped. Statistical analyses were performed to investigate whether these SNPs were associated with diabetes status in our samples. Results In the individual SNP study, no SNP differed significantly in frequency between type 2 diabetes patients and controls. In the haplotype analysis, two haplotype blocks were identified. In haplotype block 1, no evidence was found between common HNF-1α haplotypes and type 2 diabetes. However, in haplotype block 2, a common haplotype GCGC formed by four tagging SNPs （tSNPs） was found to be associated with decreased risk of type 2 diabetes （odds ratio [OR] 0.6011, 95% confidence interval [CI] 0.4138-0.8732, P=0.0073, empirical P=0.0511, permutation test）. A similar trend was also observed in the diplotype analysis, indicating that the increasing copy number of the haplotype GCGC was associated with the decreased frequency of diabetes （P=0.0193）. Conclusion The results of this study provide evidence that the haplotype of HNF-1α decreases the risk of type 2 diabetes in Chinese individuals.

关键词： Hepatocyte nuclear factor-1α Type2 diabetes SNP Haplotype analysis

Cross electro-nape-acupuncture ameliorates cerebral hemorrhageinduced brain damage by inhibiting necroptosis

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World Journal of Clinical Cases 2020年第10期8卷 1848-1858页

作者： Guo-Feng Cai Zhong-Ren Sun Zhe Zhuang Hai-Chun Zhou Shan Gao Kai Liu Li-Li Shang kun-Ping jia Xiu-Zhen Wang Hui Zhao Guo-Liang Cai Wen-Li Song Sheng-Nan Xu Hanan Branch of Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin 150001Heilongjiang ProvinceChina Postdoctoral Research Station of Heilongjiang Academy of Traditional Chinese Medicine Harbin 150001Heilongjiang ProvinceChina Heilongjiang University of Traditional Chinese Medicine Harbin 150040Heilongjiang ProvinceChina Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin 150000Heilongjiang ProvinceChina First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin 150040Heilongjiang ProvinceChina Harbin Sport University Harbin 150001Heilongjiang ProvinceChina Graduate School of Heilongjiang University of Traditional Chinese Medicine Harbin 150040Heilongjiang ProvinceChina

BACKGROUND Receptor interacting protein kinase 1(RIPK1)-mediated cell death,including apoptosis and necroptosis,belongs to programmed cell *** has been reported that RIPK1-mediated necroptosis exists in lesions of cerebral hemorrhage(CH).Electroacupuncture,a treatment derived from traditional Chinese medicine,could improve neurological impairment in patients with brain *** To investigate the protective role of cross electro-nape acupuncture(CENA)in CH,and clarify the potential *** CH rat models were established,and CENA was applied to the experimental *** functions and encephaledema were then *** cells in the brain of rats with CH were evaluated by propidium iodide *** was assessed by *** of the necroptosisrelated pathway was detected by western *** of brain tissue,cerebrospinal fluid and serum samples was conducted to measure the expression and secretion of inflammatory cytokines by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent *** The necroptotic marker p-MLKL was detectable in the brains of rats with ***,we found that CENA could ameliorate neurological functions in rat models of ***,the upregulation of RIPK1-mediated necroptosis-related molecules in the brains of rats with CH were inhibited by *** investigation revealed that CENA partially blocked the interaction between RIPK1 and ***,in vivo assays showed that CENA decreased the expression of the inflammatory cytokines tumor necrosis factor-α,interleukin-6 and interleukin-8 in CH rat *** These findings revealed that CENA exerts a protective role in CH models by inhibiting RIPK1-mediated necroptosis.

关键词： Cross electro-nape acupuncture Cerebral hemorrhage Receptor interacting protein kinase 1 Necroptosis Quantitative real-time polymerase chain reaction Enzymelinked immunosorbent assay

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遥感影像分类方法研究进展

光谱学与光谱分析 2011年第10期31卷 2618-2623页

作者：贾坤李强子田亦陈吴炳方中国科学院遥感应用研究所北京100101 中国科学院研究生院北京100049

遥感影像分类是遥感信息提取的重要手段,是目前遥感技术中的热点研究内容。分类方法是遥感影像分类的重要内容,有效地选择合适的分类方法是提高分类精度的关键。随着遥感技术的发展,传统的非参数分类方法已经难以满足分类精度需求,基于... 详细信息

遥感影像分类是遥感信息提取的重要手段,是目前遥感技术中的热点研究内容。分类方法是遥感影像分类的重要内容,有效地选择合适的分类方法是提高分类精度的关键。随着遥感技术的发展,传统的非参数分类方法已经难以满足分类精度需求,基于智能算法的非参数分类方法得到了迅速发展,并在遥感影像分类中发挥着重要作用。近年来,组合分类器由于能够利用单一分类器的互补信息,成为了遥感影像分类的一个新热点。本文综合分析了各种分类方法的特点和优势,及分类方法的发展趋势,为遥感影像分类技术的发展提供科学的参考依据。

关键词：遥感分类分类器

安仁建川博物馆群落工程“文革之钟”展馆设计

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建筑与文化 2007年第4期 68-69页

作者： jia kun Studio 家琨工作室

四川安仁建川博物馆（群落）文革之钟博物馆及周边商住工程基地位于聚落中部“记忆”广场以南．基地占据九片用地所属的北．中、南三个地块．处于“文革艺术品线”和“抗战线”的交汇点，承担着“文革艺术品线”一层单廊和“抗战线”二... 详细信息

四川安仁建川博物馆（群落）文革之钟博物馆及周边商住工程基地位于聚落中部“记忆”广场以南．基地占据九片用地所属的北．中、南三个地块．处于“文革艺术品线”和“抗战线”的交汇点，承担着“文革艺术品线”一层单廊和“抗战线”二层步道之间交通转换的功能。

关键词：博物馆工程群落安仁设计展馆艺术品用地

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伦理先行:生成式人工智能的治理策略

云南社会科学 2024年第4期 60-71页

作者：支振锋刘佳琨中国社会科学院法学研究所中国社会科学院大学法学院

生成式人工智能的迅猛发展为数字经济发展提供新动力,为社会民生创造新福祉,同时也引发了一系列现实挑战。中国现行立法已为生成式人工智能的发展划定了基本的安全保障底线,但该技术的发展方向和产业发展均处在高度不确定性当中,部分安... 详细信息

生成式人工智能的迅猛发展为数字经济发展提供新动力,为社会民生创造新福祉,同时也引发了一系列现实挑战。中国现行立法已为生成式人工智能的发展划定了基本的安全保障底线,但该技术的发展方向和产业发展均处在高度不确定性当中,部分安全风险可能是被制造的焦虑,以国家立法形式进行规制为时尚早。生成式人工智能的治理需要伦理先行,坚持激励相容精神,为人工智能新技术新应用创新留下充分空间,以伦理治理的方式推动技术社区、产业群体、社会组织、社会公众、治理机构共同进行探索磨合,凝聚共识,待实践经验充足、立法时机成熟时,再将共识性规范纳入法律框架之中。

关键词：生成式人工智能伦理治理科技伦理多元治理

中外个人数据保护标准研究进展与未来趋势分析

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情报杂志 2020年第2期39卷 85-94页

作者：相丽玲贾昆山西大学经济与管理学院

[目的/意义]大数据时代,个人数据保护标准正在成为中外企业规避“数据合规”风险的行动指南,了解中外个人数据保护标准的发展进程,分析目前学术研究现状与未来趋势具有重要的理论与现实意义。[方法/过程]运用文献研究法及CiteSpace和Ex... 详细信息

[目的/意义]大数据时代,个人数据保护标准正在成为中外企业规避“数据合规”风险的行动指南,了解中外个人数据保护标准的发展进程,分析目前学术研究现状与未来趋势具有重要的理论与现实意义。[方法/过程]运用文献研究法及CiteSpace和Excle工具分析了中外个人数据保护标准的发展历程、研究动态及其主要研究内容与学术观点。[结论/结果]国内外个人数据保护标准的发展均以本国的立法为基础,国际、区域、国家三位一体的个人数据保护标准体系正在形成,国际间标准的适用性问题,特别是企业面对“数据合规”风险的问题,将成为未来个人数据保护标准的研究方向。

关键词：数据保护 ISO 数据合规标准个人信息个人数据

我国最大的悬臂结构机库设计与竖向地震力的试验研究

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工业建筑 2005年第z1期35卷 150-153页

作者：陈家坤王军中国航空工业规划设计院北京100011

阐明如何在学习国外先进经验基础上,结合我国国情,设计出这个中国最大也是亚洲最大的悬臂结构机库。在许多关键性技术上,做出了较好的尝试。实践证明,完全可靠,为今后设计同类结构提供了宝贵经验,尤其是对长悬臂结构竖向地震力,做了较... 详细信息

阐明如何在学习国外先进经验基础上,结合我国国情,设计出这个中国最大也是亚洲最大的悬臂结构机库。在许多关键性技术上,做出了较好的尝试。实践证明,完全可靠,为今后设计同类结构提供了宝贵经验,尤其是对长悬臂结构竖向地震力,做了较系统的试验研究,提出了一批有价值的科学数据。这对今后悬臂结构竖向地震力的计算和规范修订都有参考依据。

关键词：悬臂结构机库竖向地震力地震波影响系数

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仿射空间中的抛物型螺旋面

东北大学学报（自然科学版） 2020年第12期41卷 1800-1804页

作者：于延华彭兰兰贾琨东北大学理学院辽宁沈阳110819

螺旋面是由一条平面曲线绕固定轴旋转的同时,沿轴的方向作匀速平移产生的曲面.由于旋转轴类型的不同,螺旋面可以分为椭圆型、双曲型和抛物型三种情况.在三维仿射空间中,利用Blaschke度量研究抛物型螺旋面,并对高斯曲率为零和平均曲率为... 详细信息

螺旋面是由一条平面曲线绕固定轴旋转的同时,沿轴的方向作匀速平移产生的曲面.由于旋转轴类型的不同,螺旋面可以分为椭圆型、双曲型和抛物型三种情况.在三维仿射空间中,利用Blaschke度量研究抛物型螺旋面,并对高斯曲率为零和平均曲率为零的抛物型螺旋面分别进行了分类.当符距h=0时,螺旋运动退化为旋转运动,在此情况下,进一步分类了平坦和极小的抛物型旋转曲面,并得出此时抛物型旋转曲面所满足的方程,最后画出其相应的图像.

关键词：仿射空间抛物型螺旋面平坦 Blaschke度量极小曲面