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Nano Research 2024年第3期17卷 1818-1826页

作者： kun chen Shengqiu Liu Yujun Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic ***,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated *** administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat *** treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight *** addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by *** data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

Metal-to-insulator transition in platinum group compounds

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Rare Metals 2024年第8期43卷 3460-3474页

作者： Yu-Xuan Xia Jian-Gang He Nuo-Fu chen Ji-kun chen School of New Energy North China Electric Power UniversityBeijing102206China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for PostMoore Chips(Ministry of Education) School of Materials Science and EngineeringJniversity of Science and Technology BeijingBeijing 100083China

The metal-to-insulator transition(MIT) as usually achieved in 3d-orbital transitional metal(TM) compounds opens up a new paradigm in correlated electronics via triggering abrupt variations in their transportation *** to such 3d-orbital TM compounds,the MIT within the platinum group(Pg) element compounds based on the 4d-and 5d-orbital configurations is more complicated,owing to their elevation in the spinorbit coupling and meanwhile weakened intra-atomic Coulomb *** brings in a new freedom to regulate the balance in their metallic or semiconductive orbital configurations,while their MIT properties can be potentially combined with their spintronic properties to enable new electronic ***,we review the electronic transport and MIT behaviors within the existing family of Pg-containing compounds,particularly those showing first-order MIT behaviors that can be useful in correlated *** is also hoped that summarizing the presently reported Pg-containing MIT compounds will lead to the discovery of more new material families and/or new mechanisms associated with the Pg-containing compounds showing MIT properties.

关键词： Metal-to-insulator transition Platinum group compounds Electron correlation Spin-orbital coupling

A neural branch-and-price for truck scheduling in cross-docks

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Science China Mathematics 2024年第6期67卷 1341-1358页

作者： Rahimeh Neamatian Monemi Shahin Gelareh Nelson Maculan Wei-kun chen Sharkey Predictim Globe Villeneuve d’Ascq59650France Département R&T IUT de BéthuneUniversitéd’ArtoisBéthuneF-62000France Federal University of Rio de Janeiro COPPE-PESCRio de JaneiroRJ 21941-972Brazil School of Mathematics and Statistics Beijing Institute of TechnologyBeijing100081China

In this paper,we address the complex problem of dock-door assignment and truck scheduling within cross-docking *** is a problem that requires frequent resolution throughout the operational day,as disruptions often invalidate the optimal *** the problem's highly combinatorial nature,finding an optimal solution demands significant computational time and ***,the distribution of data across problem instances over a lengthy planning horizon remains consistently stable,with minimal concern regarding distribution *** factors collectively establish the problem as an ideal candidate for a learn-to-optimize solution *** propose a Dantzig-Wolfe reformulation,solving it via both a conventional branch-and-price approach and a neural branch-and-price approach,the latter of which employs imitation ***,we introduce some classes of valid inequalities to enhance and refine the pricing problem through a branch-and-cut *** computational experiments demonstrate that this methodology is not only feasible but also presents a viable alternative to the traditional branch-and-price algorithms typically utilized for such challenges.

关键词： cross-docking MILP modeling Dantzig-Wolfe decomposition graph convolutional network

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Thermal performance of cast-in-place piles with artificial ground freezing in permafrost regions

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Journal of Mountain Science 2024年第4期21卷 1307-1328页

作者： WANG Xinbin chen kun YU Qihao GUO Lei YOU Yanhui JIN Mingyang State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

During the construction of cast-in-place piles in warm permafrost,the heat carried by concrete and the cement hydration reaction can cause strong thermal disturbance to the surrounding *** the bearing capacity of the pile is quite small before the full freeze-back,the quick refreezing of the native soils surrounding the cast-in-place pile has become the focus of the infrastructure construction in *** solve this problem,this paper innovatively puts forward the application of the artificial ground freezing(AGF)method at the end of the curing period of cast-in-place piles in permafrost.A field test on the AGF was conducted at the Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment(34°51.2'N,92°56.4'E)in the Qinghai Tibet Plateau(QTP),and then a 3-D numerical model was established to investigate the thermal performance of piles using AGF under different engineering ***,the long-term thermal performance of piles after the completion of AGF under different conditions was *** experiment results demonstrate that AGF is an effective method to reduce the refreezing time of the soil surrounding the piles constructed in permafrost terrain,with the ability to reduce the pile-soil interface temperatures to below the natural ground temperature within 3 *** results further prove that AGF still has a good cooling effect even under unfavorable engineering conditions such as high pouring temperature,large pile diameter,and large pile ***,the application of this method is meaningful to save the subsequent latency time and solve the problem of thermal disturbance in pile construction in *** research results are highly relevant for the spread of AGF technology and the rapid building of pile foundations in permafrost.

关键词： Permafrost engineering Cast-in-place pile Artificial ground freezing Thermal performance.

Quasi-two dimensional Ruddlesden−Popper halide perovskites for laser applications

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Frontiers of physics 2024年第2期19卷 53-71页

作者： kun chen Qianpeng Zhang Yin Liang Jiepeng Song Chun Li Shi chen Fang Li Qing Zhang School of Mechanical and Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China School of Materials Science and Engineering Peking UniversityBeijing 100871China Institute of Applied Physics and Materials Engineering Macao UniversityMacao 999078China

Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical *** review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and *** materials,structures and fabrications are introduced in the first ***,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface ***,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are *** last,the challenges and perspectives would be provided.

关键词： two-dimensional materials metal halide perovskite Ruddlesden−Popper halide perovskites lasing emission

Exploring the transformative impact of traditional Chinese medicine on depression:Insights from animal models

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World Journal of Psychiatry 2024年第5期14卷 607-623页

作者： Yan Yang Yan-kun chen Meng-Zhou Xie School of Nursing Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Precision Medicine R&D Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina School of Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of TCM Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina

Depression,a prevalent and complex mental health condition,presents a significant global health *** is one of the most frequent mental disorders;deaths from it account for 14.3%of people *** recent years,the integration of complementary and alternative medicine,including traditional Chinese medicine(TCM),has gained attention as a potential avenue for addressing *** comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive *** in-depth look at different research studies,clinical trials,and meta-analyses is used in this review to look into how TCM practices like herbal formulations,acupuncture,and mindbody practices *** review looks at the quality of the evidence,the rigor of the methods,and any possible flaws in the current *** gives us an idea of where TCM stands right now in terms of treating *** comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive *** order to learn more about their possible healing effects,the study also looks into how different types of TCM work,such as herbal formulas,acupuncture,and mind-body practices.

关键词： Traditional Chinese medicine Depression Efficacy Treatment Holistic approach

The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary

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Genes & Diseases 2024年第3期11卷 39-42页

作者： Haoyu Ruan Zhe Wang Xuemei Tang Qiong Zhan kun chen Lu Gao Ming Guan Department of Laboratory Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Physiology Naval Medical UniversityShanghai 200433China Department of Oncology Huashan HospitalFudan UniversityShanghai 200040China

Cancer of unknown primary(CUP)is a rare disease characterized by metastases in which the primary tumor is of unknown *** cerebrospinal fluid(CSF)tumor microenvironment of CUP is still unknown.A Chinese male was diagnosed with leptomeningeal metastases from CUP(CUP-LM)based on the following medical examination results:partial leptomeningeal enhancement by brain magnetic resonance imaging,few malignant cells of diverse morphology in CSF,and no abnormalities or lymphadenopathy by systemic examination.

关键词： metastases cerebrospinal fluid

COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer:An allicin-based nanomedicine approach

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Chinese Chemical Letters 2024年第8期35卷 449-454页

作者： Huijiao Fu Peiqin Liang Qianwen chen Yan Wang Guang Li Xuzi Cai Shengtao Wang kun chen Shengying Shi Zhiqiang Yu Xuefeng Wang Department of Obstetrics and Gynecology The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630China Department of Obstetrics and Gynecology Huizhou Central People’s HospitalHuizhou 516001China Affiliated Foshan Maternity&Child Healthcare Hospital Southern Medical University(Foshan Maternity&Child Healthcare Hospital)Foshan 528000China Guangdong Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Nursing Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchThe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523018China

Recently,the utilization of nonsteroidal anti-inflammatory drugs(NSAIDs)to sensitize cisplatin(CDDP)has gained substantial traction in the treatment of ovarian cancer(OC).However,even widely employed NSAIDs such as celecoxib and naproxen carry an elevated risk of cardiovascular events,notably ***,the diminished sensitivity to CDDP therapy in OC is multifactorial,rendering the ap-plication of NSAIDs only partially effective due to their cyclooxygenase-2(COX-2)inhibiting ***,in this study,reactive oxygen species(ROS)-responsive composite nano-hydrangeas loaded with the Chinese medicine small molecule allicin and platinum(IV)prodrug(DTP@AP NPs)were prepared to achieve comprehensive *** one front,allicin achieved COX-2 blocking therapy,en-compassing the inhibition of proliferation,angiogenesis and endothelial mesenchymal transition(EMT),thereby mitigating the adverse impacts of CDDP ***,synergistic chemosensi-tization was achieved from multifaceted mechanisms by decreasing CDDP inactivation,damaging mito-chondria and inhibiting DNA *** essence,these findings provided an optimized approach for syner-gizing CDDP with COX-2 inhibitors,offering a promising avenue for enhancing OC treatment outcomes.

关键词： COX-2 blocking therapy CDDP Chemosensitization Allicin Ovarian cancer

Enhanced Crystallization of Poly(butylene adipate-co-terephthalate)by a Self-assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第5期42卷 663-674,I0010页

作者： cheng Zhou kun chen Zi-Heng Zhang Meng-Fan Jing Chun-Tai Liu Chang-Yu Shen Ya-Ming Wang State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou450002China

Poly(butylene adipate-co-terephthalate)(PBAT)is a promising biodegradable flexible polymer but suffers from slow crystallization rate,making it less attractive for some applications like the injection-molded products in comparison with low-density polyethylene(LDPE).This work aimed to accelerate the crystallization of PBAT by adding a self-assembly nucleating agent octamethylenedicarboxylic dibenzoylhydrazide(OMBH).PBAT/OMBH composites with various OMBH contents(0 wt%,0.5 wt%,0.7 wt%,1 wt%,2 wt%,3 wt%and 5 wt%)were prepared through *** effect of OMBH on the crystallization behavior,morphologies and mechanical properties of PBAT was *** highest nucleation efficiency value of 59.6%was achieved for PBAT with 0.7 wt%OMBH,much higher than that of 22.7%for PBAT with 0.7 wt%*** force microscopy results showed that OMBH formed fine fibers and induced the formation of transcrystalline layers of *** transform infrared spectroscopy(FTIR)combined with two-dimensional correlation spectra suggested that the intermolecular dipole-dipole N—H…O=C interactions but not hydrogen bond between OMBH and PBAT promoted the crystallization of PBAT in the initial period of *** presence of OMBH did not change the crystal form of PBAT but had positive contribution in enhancing its crystallinity and mechanical *** work is essential for preparing PBAT with high crystallization rate,enhancing its potential applications in injection-molded products.

关键词： Poly(butylene adipate-co-terephthalate) Biodegradable Self-assembly nucleating agent Crystallization

Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2024年第2期14卷 211-224页

作者： Jingjing Wang Qi Su kun chen Qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu cheng cheng Kaihui Tu Huaizhen He Yanmin Zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an710061China

Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.

关键词： Pyrimethamine BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib