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混合动力汽车超级电容能量控制研究

电源技术 2015年第4期39卷 798-800页

作者：陈坤华孙玉坤王富良项倩雯江苏大学电气信息工程学院江苏镇江212013

超级电容的高功率密度特性可作为混合动力汽车辅助电源。研究了超级电容数学模型,给出了超级电容荷电状态估计方法,在分析升降压双向直流功率电路基础上,提出了超级电容能量存储系统控制策略,在超级电容荷电状态允许范围内,该控制策略... 详细信息

超级电容的高功率密度特性可作为混合动力汽车辅助电源。研究了超级电容数学模型,给出了超级电容荷电状态估计方法,在分析升降压双向直流功率电路基础上,提出了超级电容能量存储系统控制策略,在超级电容荷电状态允许范围内,该控制策略满足混合动力汽车启动、加速、制动要求,实验证明该能量存储系统能适应各种负载变换情况。

关键词：超级电容能量控制混合动力汽车荷电状态升降压双向变换器

Transfer of disulfide bond formation modules via yeast artificial chromosomes promotes the expression of heterologous proteins in Kluyveromyces marxianus

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mLife 2024年第1期3卷 129-142页

作者： Pingping Wu Wenjuan Mo Tian Tian kunfeng Song Yilin Lyu Haiyan Ren Jungang Zhou Yao yu Hong Lu State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghaiChina Shanghai Engineering Research Center of Industrial Microorganisms ShanghaiChina

Kluyveromyces marxianus is a food-safe yeast with great potential for producing heterologous *** the yield in *** remains a challenge and incorporating large-scale functional modules poses a technical obstacle in *** address these issues,linear and circular yeast artificial chromosomes of ***(KmYACs)were constructed and loaded with disulfide bond formation modules from Pichia pastoris or *** modules contained up to seven genes with a maximum size of 15 *** carried telomeres either from *** or *** were transferred successfully into *** and stably propagated without affecting the normal growth of the host,regardless of the type of telomeres and configurations of *** increased the overall expression levels of disulfide bond formation genes and significantly enhanced the yield of various heterologous *** high-density fermentation,the use of KmYACs resulted in a glucoamylase yield of 16.8 g/l,the highest reported level to date in *** and metabolomic analysis of cells containing KmYACs suggested increased flavin adenine dinucleotide biosynthesis,enhanced flux entering the tricarboxylic acid cycle,and a preferred demand for lysine and arginine as features of cells overexpressing heterologous ***,supplementing lysine or arginine further improved the ***,KmYAC provides a powerful platform for manipulating large modules with enormous potential for industrial applications and fundamental *** the disulfide bond formation module via YACs proves to be an efficient strategy for improving the yield of heterologous proteins,and this strategy may be applied to optimize other microbial cell factories.

关键词： disulfide bond formation expression of heterologous proteins Kluyveromyces marxianus telomere yeast artificial chromosome

Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein(QPCTL)with antitumor efficacy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 44-46页

作者： Lei yu Pengcheng Zhao Yaoliang Sun Zening Zheng Wenhao Du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping Wang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various ***47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and ***47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side *** contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy.

关键词： anemia overcome eliminate

超声引导下甲状腺FNAB联合BRAF V600E基因检测对甲状腺微小结节的诊断价值

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宜春学院学报 2023年第6期45卷 76-78,119页

作者：朱莉莎杜朝阳黎兵喻昆霖宜春市人民医院功能科宜春学院附属医院宜春市人民医院普外科江西宜春336000

目的:探讨超声引导下甲状腺细针穿刺活检(FNAB)联合丝/苏氨酸特异性激酶基因突变基因V600E(BRAF V600E)检测对甲状腺微小结节的诊断价值。方法:选取2020年10月~2021年10月于我院进行甲状腺切除术患者67例,术前均接受甲状腺FNAB及BRAF V6... 详细信息

目的:探讨超声引导下甲状腺细针穿刺活检(FNAB)联合丝/苏氨酸特异性激酶基因突变基因V600E(BRAF V600E)检测对甲状腺微小结节的诊断价值。方法:选取2020年10月~2021年10月于我院进行甲状腺切除术患者67例,术前均接受甲状腺FNAB及BRAF V600E基因检测,并与术后病理结果进行比对分析。结果:与术前单一进行FNAB相比,术前FNAB联合BRAF V600E基因检测的术后病理符合率(94.03%),特异度(97.14%),敏感度(90.63%)均高于单一FNAB检查,差异有统计学意义(P<0.05)。结论:超声引导下甲状腺FNAB联合BRAF V600E检测可提高甲状腺微小结节术前检出率,对患者治疗及疾病诊断具有较高的参考价值。

关键词：甲状腺微小结节超声引导细针穿刺活检丝/苏氨酸特异性激酶基因突变基因V600E 病理诊断

MoS2 as a cocatalyst applied in advanced oxidation processes for enhancing degradation of organic pollutants: a review

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Tungsten 2024年第3期6卷 473-487页

作者： Ming-Hao Fan Cong-Hui Wang Xiang yu Jun Ding Ao-Qi Xiao yue Li Wei-Ya Huang School of Material Science and Engineering Henan Polytechnic University School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite Materials Henan University of Engineering School of Chemistry and Chemical Engineering Jiangxi University of Science and Technology Department of Chemical and Environmental Engineering University of Cincinnati

Fenton technology,as a typical advanced oxidation processes（AOPs）,can generate reactive oxygen species（ROS） of strong oxidation capacity to degrade organic pollutants,which has attracted wide ***,it is accompanied by the slow Fe3+/Fe2+cycle rate,easy to generate iron sludge and so ***,it has been proven that the inorganic cocatalysts represented by MoS2can effectively solve the above ***,MoS2can accelerate the activation of peroxy mono sulfate（PMS） and peroxodisulfate（PDS） by Fe2+.In this paper,MoS2as the cocatalyst in H2O2+Fe2+,PMS+Fe2+and PDS+Fe2+were comprehensively ***,the cycling processes of Fe3+/Fe2+in different systems,the cocatalytic effect of MoS2by the exposed active sites,the ROS generation mechanism as well as the microscopic mechanism during the reaction were elaborated *** results indicate that the reductive active sites on the surface of MoS2can promote the regeneration of Fe2+through the cycle between Fe3+/Fe2+and Mo4+/Mo5+/Mo6+.Thus,ROS such as ·OH,SO4·-and1O2with strong oxidizing property can be produced to improve the degradation efficiency of organic *** last,the challenges and developments of MoS2cocatalysts in AOPs for practical applications were *** review contributes to a deeper understanding of the cocatalytic effect of two-dimensional metal sulfides in AOPs and facilitates their industrial application.

关键词： Cocatalyst Fenton reaction Degradation of organic pollutant Molybdenum disufide Reactive oxygen species

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接触氧化除铁除锰工艺中微生物的协同作用

中国环境科学 2024年第4期44卷 2044-2053页

作者：聂鑫于娜陈禹杭吕育锋李斌刘庆玉孟凡彬魏欢欢孙毅王伟奇沈健高玉波于占勇沈阳农业大学工程学院辽宁沈阳110161 中国水利水电科学研究院北京100038 聊城大学地理与环境学院山东聊城252000 安徽科技学院资源与环境学院安徽滁州233100 辽宁省水利事务服务中心辽宁沈阳11000 沈阳近海水务发展有限公司辽宁辽中110200

以辽宁农村地区二个典型接触氧化除铁除锰水厂为研究对象,采用16S rRNA高通量测序技术对工艺各单元的微生物群落结构进行分析.结果发现,接触氧化除铁除锰工艺各处理单元中的微生物群落结构显著不同,Proteobacteria(43.86%)是接触氧化除... 详细信息

以辽宁农村地区二个典型接触氧化除铁除锰水厂为研究对象,采用16S rRNA高通量测序技术对工艺各单元的微生物群落结构进行分析.结果发现,接触氧化除铁除锰工艺各处理单元中的微生物群落结构显著不同,Proteobacteria(43.86%)是接触氧化除铁除锰工艺中的优势菌门,Gallionella和Flavobacterium是主要的除铁锰功能菌属.相关性分析结果表明,Rhodoferax(0.71%)和Sulfurospirillum(0.75%)等菌属与菌落总数,铁和锰浓度之间呈显著正相关关系,说明尽管其相对丰度较低,但仍在系统中发挥着不可或缺的作用.通过分子生态网络与拓扑特性的深入分析以及COGs功能预测,揭示了Gallionella,Flavobacterium,Pseudomonas和Rhodoferax等菌属间的协同作用关系.不同处理单元对微生物群落结构产生了显著影响,但对这些微生物的代谢影响较小,表明形成的微生物共存系统相对稳定,对水中铁锰离子的高效稳定去除有着重要作用.

关键词：接触氧化除铁除锰工艺微生物群落动态变化协同作用

Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder

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World Journal of Psychiatry 2024年第1期14卷 88-101页

作者： Zhong-yu Huang Zi-Pan Lyu Hong-Gui Li Hua-Zhi You Xiang-Na Yang Cai-Hui Cha Center for Medical Research on Innovation and Translation Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biological Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Department of Pediatrics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Pediatric Traditional Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Department of Psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely *** presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for *** To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental *** A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy *** in plasma were set as exposures with ASD as the main *** causal relationships were estimated using the inverse variant weight(IVW)*** also performed leave-one-out sensitivity tests to validate the robustness of the *** on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and *** Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and *** Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and *** findings offer perspectives for the discovery of diagnos

关键词： Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization Metabolite Enrichment analysis

The role of intraoperative neurophysiological monitoring in intramedullary spinal cord tumor surgery

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Chinese Neurosurgical Journal 2024年第1期10卷 57-66页

作者： Kai Liu Chengyuan Ma Dapeng Li Haisong Li Xuechao Dong Bo Liu Ying yu yuxiang Fan Hongmei Song Department of Neurosurgery Bethune First Hospital of Jilin UniversityChangchunJilinChina

Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is *** recent years,many surgeons have performed electrophysiological monitoring to effectively reduce the occurrence of post-operative neurological *** electrophysiological monitoring technology has advanced considerably,leading to the development of many monitoring methods,such as SSEPs,MEPs,DCM,and EMG,to monitor intramedullary ***,electrophysiological monitoring in tumor resection is still being *** this article,we discussed the different monitoring methods and their role in monitoring intramedullary tumors by reviewing previous *** tumors need to be monitored for a summary of the condition of the *** by using various monitoring methods flexibly and through clear communication between surgeons and neurophysiological experts can good decisions be made during surgery and positive surgical results be achieved.

关键词： Intramedullary spinal cord tumor Intraoperative neurophysiological monitoring D-wave

三维ZnO/CdS/NiFe层状双金属氢氧化物光电催化氧化甲烷

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工程科学学报 2021年第8期43卷 1064-1072页

作者：刘佳张英华黄志安白智明高玉坤北京科技大学土木与资源工程学院北京100083

将甲烷以低能耗的方式直接转化为甲醇等高附加值的化学品一直是可持续化工产业的重要目标和重大挑战.本文制备了三维(3D)ZnO/CdS/NiFe层状双金属氢氧化物(LDH)核/壳/分层纳米线阵列(NWAs)结构材料并将其用于室温、模拟阳光照射下甲烷的... 详细信息

将甲烷以低能耗的方式直接转化为甲醇等高附加值的化学品一直是可持续化工产业的重要目标和重大挑战.本文制备了三维(3D)ZnO/CdS/NiFe层状双金属氢氧化物(LDH)核/壳/分层纳米线阵列(NWAs)结构材料并将其用于室温、模拟阳光照射下甲烷的光电催化氧化.结果表明3D ZnO/CdS/NiFe-LDH具有优异的光电化学性能及催化活性,甲烷气氛下的光电流密度达到了6.57 mA·cm^(−2)(0.9 V vs RHE),其催化甲烷生成甲醇及甲酸产量分别是纯ZnO的5.0和6.3倍,两种主要产物的总法拉第效率达到54.87%.CdS纳米颗粒(NPs)的沉积显著提升了复合物对可见光的吸收,促进了光生载流子的分离.而具有三维多孔结构的NiFe-LDH纳米片的引入改善了甲烷氧化表面反应动力学,起到了优异的助催化作用;并且有效抑制了O_(2)^(•-)的产生,防止O_(2)^(•-)进一步将甲醇及甲酸氧化为CO_(2),提高了甲醇及甲酸的选择性.最后,提出了三维ZnO/CdS/NiFe-LDH复合材料光电催化甲烷转化为甲醇及甲酸的机理,为甲烷低能耗转化为高价值化学品提供了新思路.

关键词：光电催化甲烷甲醇 ZnO NiFe-LDH