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Efficient removal of U(VI) from wastewater by a sponge-like 3D porous architecture with hybrid electrospun nanofibers

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Water Science and Engineering 2024年第2期17卷 150-156页

作者： lin Hu lin Chen Xian-kun Wu Rui Luo Rong-guan Lv Zheng-hao Fei Feng Yang School of Chemistry and Environmental Engineering Yancheng Teachers UniversityYancheng 224051China Jiangsu Province Engineering Research Center of Agriculural Breeding Pollution Control and Resource Yancheng 224051China Jiangsu Nanda Huaxing Science and Technology of Environmental Protection Co.Ltd. Yancheng 224001China

Removal of uranium(VI)from nuclear wastewater is urgent due to the global nuclear energy *** study synthesized novel sponge-like 3D porous materials for enhanced uranium adsorption by combining electrospinning and fibrous freeze-shaping *** materials possessed an organic-inorganic hybrid architecture based on the electrospun fibers of polyacrylonitrile(PAN)and SiO_(2).As a sup-porting material,the surface of fibrous SiO_(2) could be further functionalized by cyano groups via(3-cyanopropyl)*** the cyano groups were turned into amidoxime(AO)groups to obtain a amidoxime-functionalized sponge(PAO/SiO_(2)-AO)through the subsequent ami-doximation *** proposed sponge exhibited enhanced uranium adsorption performance with a high removal capacity of 367.12 mg/g,a large adsorption coefficient of 4.0×10^(4)mL/g,and a high removal efficiency of 97.59%.The UO_(2)^(2+)adsorption kinetics perfectly conformed to the pseudo-second-order *** sorbent also exhibited an excellent selectivity for UO_(2)^(2+) with other interfering metal ions.2023 Hohai *** and hosting by Elsevier B.V.

关键词： Uranium removal Sponge Amidoximation Organic-inorganic hybrid structure Electrospinning

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黏性骨在口腔临床治疗中的应用研究进展

口腔颌面修复学杂志 2024年第3期25卷 213-216页

作者：徐林坤杨扬何东宁李薏孙淑琪山西医科大学口腔医院·山西省口腔医院种植科太原030000

在口腔医学领域中,黏性骨(sticky bone)一般指由第二代血浆基质制品可注射型富血小板纤维蛋白(injectable platelet rich fibrin,i-PRF)与一定质量的骨增量材料(bone grafting materials)混合制备而成的凝胶团块状骨移植物。黏性骨既富... 详细信息

在口腔医学领域中,黏性骨(sticky bone)一般指由第二代血浆基质制品可注射型富血小板纤维蛋白(injectable platelet rich fibrin,i-PRF)与一定质量的骨增量材料(bone grafting materials)混合制备而成的凝胶团块状骨移植物。黏性骨既富含血浆基质所提供的生长因子和纤维蛋白支架等组织再生所需基本要素,又具备一定的可塑性,在骨增量、上颌窦底提升和牙槽嵴保存等临床治疗中有着广阔的应用前景。本文总结临床经验和相关研究,对黏性骨的基本情况和目前在临床治疗中应用作一介绍,以期为后续研究提供参考。

关键词：可注射型富血小板纤维蛋白骨增量材料凝血骨增量上颌窦底提升种植牙

Recent Studies on the Biochemical Mechanisms of Anti-Obesity and Cancer Chemopreventive Effects of Tea and Tea Polyphenols

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Recent Studies on the Biochemical Mechanisms of Anti-Obesity...

Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells

第四届海峡两岸茶业学术研讨会

作者： Jen-kun lin Institute of Biochemistry College of Medicine Taiwan University Taipei Taiwan

＜正＞The health benefits associated with tea consumption have been corroborated in animal studies of cancer chemoprevention, hypercholesterolemia, artherosclerosis, neurodegenerative diseases and other age-related disorders. Recent studies have been demonstrated that some fermented teas such as black, oolong and puerh teas are comparable and equally effective as compared with non-fermented green tea in these health benefits. However, the use of tea as a cancer chemopreventive or for other health benefits has been confounded by the low oral bioavailability of its active polyphenols catechins based on the preliminary pharmacokinetic studies. It appeared that the problem has been complicated by the very rapid biotransformation reactions occurred during the course of study. One should characterize the structures and biological activities of these transformed metabolites that could lead to the complete understanding on the bioactivity of the administered tea or tea polyphenols. Recently, tremendous progress has been made in elucidating the molecular mechanisms of cancer chemoprevention by tea and tea polyphenols. The suppression of various tumor biomarkers including growth factor receptor tyrosine kinases, cytokine receptor kinases, PI3K, phosphatases, ras, raf, MAPK cascades, NF κ B, I κ B kinase （IKK） , PKA, PKB, PKC, c-jun, c-fos, c-myc, cdks, cyclins, cdkIs, and related signal transducing proteins by tea polyphenols has been studied in our laboratory and *** results suggested that tea polyphenols blocked phosphorylation of I κ B from the cytosolic fraction, inhibited NF κ B activity and inhibited increase in inducible nitric oxide synthase （iNOS） levels in activated macrophage. Tea polyphenols also inhibited strongly the activities of xanthine oxidase, cyclooxygenase, EGF-receptor tyrosine kinase and PKC. These results suggest that tea polyphenols may exert their cancer chemoprevention through suppressing tumor promotion and inflammation by blocking signal trans

关键词： Tea polyphenols signal transduction EGF receptor tyrosine kinases phosphatase MAPK cascade apoptosis iNOS FAS xanthine oxidase NFκB. IKK

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World Journal of Gastroenterology 2005年第29期11卷 4461-4464页

作者： kun Wu lin-Hong Yuan Wei Xia Department of Nutrition and Food Hygiene Public Health College Harbin Medical University Harbin 150001 Heilong jiang Province China

AIM： To explore the growth inhibition and apoptosisinducing effect of apigenin on human gastric carcinoma SGC-7901 cells. METHODS： The effects of apigenin on the growth, clone formation and proliferation of human gastric carcinoma SGC-7901 cells were observed by N-rr, done-forming assay, and morphological observation. Fluorescent staining and flow cytometry analysis were used to detect apoptosis of cells. RESULTS： Apigenin obviously inhibited the growth, clone formation and proliferation of SGC-7901 cells in a dosedependent manner. Inhibition of growth was observed on d 1 at the concentration of 80 μmol/L, while after 4 d, the inhibition rate （IR） was 90%. The growth IRs at the concentration of 20, 40, and 80 μmol/L were 38%, 71%, and 99% respedJvely on the 7^th d. After the cells were treated with apigenin for 48 h, the number of clone-forming in control, 20, 40, and 80 μmol/L groups was 217±16.9, 170±11.1 （P〈0.05）, 98±11.1 （P〈0.05）, and 25±3.5 （P〈0.05） respectively. Typical morphological changes of apoptosis was found by fluorescent staining. The cell nuclei had lost its smooth boundaries, chromatin was condensed, and cell nuclei were broken. Flow cytometry detected typical apoptosis peak. After the cells were treated with apigenin for 48 h, the apoptosis rates were 5.76%, 19.17%, and 29.30% respectively in 20, 40, and 80 μmol/L groups. CONCLUSION： Apigenin shows obvious inhibition on the growth and clone formation of SGC-7901 cells by inducing apoptosis.

关键词： Apigenin Apoptosis Anti-cancer effect Gastric carcinoma

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血友病性关节炎动物模型的研究进展

中国实验动物学报 2024年第4期32卷 523-529页

作者：林锟何宪顺田佳庆陆舜何敏聪林天烨何晓铭范帅杨宏光于天启张大光何伟魏秋实广州中医药大学第三临床医学院广州510006 广州中医药大学第三附属医院关节中心广州510378 广东省中医骨伤研究院广州510378 广州中医药大学第三附属医院骨质疏松科广州510378 广州中医药大学第三附属医院区域中医血液病诊疗中心广州510378 吉林大学第一医院长春130061

血友病的反复出血并发血友病性关节炎(hemophilia arthritis, HA),严重影响患者生活,消耗大量社会医疗资源,受限于伦理要求,需要建立HA动物模型进行研究。为了总结血友病性关节炎动物模型的研究进展,本文查阅近年国内外有关动物HA模型... 详细信息

血友病的反复出血并发血友病性关节炎(hemophilia arthritis, HA),严重影响患者生活,消耗大量社会医疗资源,受限于伦理要求,需要建立HA动物模型进行研究。为了总结血友病性关节炎动物模型的研究进展,本文查阅近年国内外有关动物HA模型的研究文献,从物种选择、建模方法以及组织病理学、影像学评价方法等方面进行综述。物种选择上包括啮齿类鼠类、新西兰兔、比格犬、小型猪、食蟹猴等;造模方法包括基因敲除创伤模型、基因敲除自发模型和注射模型,其中基因敲除自发模型最接近人类HA的自发出血并发关节炎的病理生理过程,更贴近人类HA,但是由于造模成本高、表型不稳定、成活率低等因素,该模型并不作为动物实验研究的首选;相比之下,基因敲除创伤模型具有造模时间短、稳定性强、成功率高等特点,因此被广泛应用。HA模型的评价除了多种大体评分方法外,还包括MRI、micro-CT、MSKUS/PD等多种影像学方法可供选择。通过对HA模型研究进展的综述,为研究其发病机制和疗效验证提供更多依据,弥补HA临床数据的匮乏,特别是中医药治疗方面。

关键词：血友病性关节炎动物模型评价方法组织病理学影像学

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木棉叶生物炭辅助水电解制氢研究

广州化工 2024年第1期52卷 68-73页

作者：罗兆淇林宗华戚可蓝周永强林坤鸿陈楷东张玉媛佛山科学技术学院材料科学与氢能学院广东佛山528000

生物炭辅助水电解(BAWE)制氢是将生物炭的化学能和提供的电能集成为氢能的方法,即生物炭在阳极发生氧化反应(BOR)代替阳极析氧反应(OER),起始电位(Eonset)显著降低,电流密度增加,进而达到降低能耗的效果。通过对木棉叶生物炭阳极氧化(B... 详细信息

生物炭辅助水电解(BAWE)制氢是将生物炭的化学能和提供的电能集成为氢能的方法,即生物炭在阳极发生氧化反应(BOR)代替阳极析氧反应(OER),起始电位(Eonset)显著降低,电流密度增加,进而达到降低能耗的效果。通过对木棉叶生物炭阳极氧化(BOR)进行线性扫描伏安法(LSV)、电化学阻抗谱(EIS)和电流-时间曲线(i-t)等电化学性能的考察,发现适当增加炭浆浓度、提高电解温度、添加氯化钠均能提高体系的电流密度和降低起始电位。对热解制备的木棉叶生物炭样品进行表征,得知氢氧化钾活化热解制备的BC-K600具有较大的比表面积和孔隙度,使其在较高的电位下反应活性增强。当料浆浓度为20 g/L,电解温度为75℃时,BC-K600表现出最低电解液欧姆电阻和较低电荷转移阻力,具有最大的电流密度,在1 V偏压下1 h产氢量为1.2 mL。

关键词：生物炭辅助水电解制氢电化学

福建省莆田市115 455例女性HPV感染及宫颈病变流行病学分析

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福建医科大学学报 2024年第2期58卷 135-142页

作者：林堃黄洁香洪奇阳胡雅静黄敏君陈明桥莆田学院附属医院产前诊断中心莆田351100 莆田市妇幼保健院妇女保健科莆田351100

目的分析福建省莆田市35~64岁女性人乳头瘤病毒(HPV)的感染特征及HPV相关宫颈病变的流行病学特点。方法回顾性分析2018年1月—2022年12月莆田市115455例女性的HPV分型及宫颈细胞学检查结果。分析HPV亚型和宫颈病变的流行病学特征,探讨... 详细信息

目的分析福建省莆田市35~64岁女性人乳头瘤病毒(HPV)的感染特征及HPV相关宫颈病变的流行病学特点。方法回顾性分析2018年1月—2022年12月莆田市115455例女性的HPV分型及宫颈细胞学检查结果。分析HPV亚型和宫颈病变的流行病学特征,探讨单一感染和多重感染对宫颈病变的影响,评估年龄对感染和患病风险的影响,并采用χ^(2)检验进行组间率的比较。结果HPV感染总阳性率为8.41%,主要流行亚型有HPV 52、58、16、39、18型;浸润性宫颈癌(ICC)患者最常见的感染亚型有HPV 16、33、18型。宫颈细胞学检查正常者97632例(84.56%),宫颈炎症865例(0.75%),意义不明确的不典型鳞状细胞(ASC-US)985例(0.85%),不能排除高度鳞状上皮内瘤变的不典型鳞状细胞(ASC-H)348例(0.30%),低级别鳞状上皮内病变(LSIL)668例(0.58%),高级别鳞状上皮内病变(HSIL)313例(0.27%),ICC 37例(0.03%)。1597例(16.46%)女性存在多重HPV感染,最常见的合并感染亚型为52、58、16型。多重HPV感染在宫颈炎症中最常见,占比25.15%。随着年龄增长,HPV感染的阳性率呈上升趋势。40~44岁和50~54岁的ICC患者感染HPV33的阳性率最高。结论HPV 16、33、18是ICC患者的主要感染亚型;对HPV33感染应采取更加积极的防治措施。

关键词：人乳头瘤病毒宫颈病变宫颈癌筛查流行病学特征莆田市

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Neutron diffraction study on anomalous thermal expansion of CrB_(2)

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Chinese Journal of Structural Chemistry 2023年第5期42卷 8-12页

作者： Yong Xu Xin Chen Yili Cao kun lin Chin-Wei Wang Qiang Li Jinxia Deng Jun Miao Xianran Xing Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing100083China Neutron Group National Synchrotron Radiation Research CenterHsinchu30076TaiwanChina

Thermal expansion is an essential issue in the field of materials science and *** of anomalous thermal expansion is beneficial to controlling it and developing related ***,we report disitinctly anisotropic thermal expansion of CrB_(2)via temperature dependence of neutron diffraction,in which positive thermal expansion is observed within basal plane whereas negative thermal expansion emerges along the c ***,zero thermal expansion of unit cell volume is determined from 5 to 130 K with the coefficient of thermal expansion ofāv=0.4(1)×10^(-6)K^(-1).Magnetization measurement shows there is an antiferromagnetic-paramagnetic transition near 90 K,which may correlate to the thermal expansion *** calculations identify no chemical binding of Cr-Cr pair,implying such antiferromagnetic ordering originates from the double exchange interaction of Cr-B-Cr.

关键词： Negative thermal expansion Neutron diffraction Diboride

A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing

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Neural Regeneration Research 2023年第8期18卷 1827-1833页

作者： kun-Zhang lin Lei Li Wen-Yu Ma Xin Yang Zeng-Peng Han Neng-Song Luo Jie Wang Fu-Qiang Xu The Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhenKey Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhenGuangdong ProvinceChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei ProvinceChina University of Chinese Academy of Sciences BeijingChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ShenzhenGuangdong ProvinceChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Analyzing the structure and function of the brain's neural network is critical for identifying the working principles of the brain and the mechanisms of brain *** rabies viral vectors allow for the retrograde labeling of projection neurons and cell type-specific trans-monosynaptic tracing,making these vectors powerful candidates for the dissection of synaptic *** several attenuated rabies viral vectors have been developed,their application in studies of functional networks is hindered by the long preparation cycle and low yield of these *** overcome these limitations,we developed an improved production system for the rapid rescue and preparation of a high-titer CVS-N2c-ΔG *** results showed that the new CVS-N2c-ΔG-based toolkit performed remarkably:(1)N2cG-coated CVS-N2c-ΔG allowed for efficient retrograde access to projection neurons that were unaddressed by rAAV9-Retro,and the efficiency was six times higher than that of rAAV9-Retro;(2)the trans-monosynaptic efficiency of oG-mediated CVS-N2c-ΔG was 2–3 times higher than that of oG-mediated SAD-B19-ΔG;(3)CVS-N2c-ΔG could delivery modified genes for neural activity monitoring,and the time window during which this was maintained was 3 weeks;and(4)CVS-N2c-ΔG could express sufficient recombinases for efficient transgene *** findings demonstrate that new CVS-N2c-ΔG-based toolkit may serve as a versatile tool for structural and functional studies of neural circuits.

关键词： functional studies neural activity neural circuits projection neurons rAAV9-Retro rabies virus recombination retrograde labeling synaptic inputs trans-monosynaptic tracing