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Lipocalin-2 as a biomarker for diabetic nephropathy

World Journal of Meta-Analysis 2023年第4期11卷 92-101页

作者： Kiran Dahiya Praveen Prashant Rakesh dhankhar kumud dhankhar Sushil Kumar Sonia Vashist Department of Biochemistry Pt BD Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Radiation Oncology Pt BD Sharma Post Graduate Institute of Medical SciencesRohtak 124001India Phase III JSS Medical CollegeMysuru 570015KarnatakaIndia Civil Hospital Jhajjar 124103HaryanaIndia Department of Dermatology Dr Sonia’s Dermatology ClinicRewari 123401HaryanaIndia

Diabetes is a major global public health *** prevalence of type 1 diabetes is comparatively static,as hereditary and genetic causes are involved,while type 2 diabetes(T2D)prevalence is increasing day by day.T2D is associated with chronic complications,including diabetic neuropathy(DN),nephropathy,retinopathy,and other complications like diabetic *** is the main complication of both types of *** can be diagnosed by routine laboratory tests,microalbuminuria>300 mg/24 h,and a gradual decrease in glomerular filtration *** the appearance of microalbuminuria is a late manifestation,an early marker for renal damage is ***-2,also known as neutrophil gelatinaseassociated lipocalin(NGAL),is a small protein purified from neutrophil granules and a good marker for kidney *** is a transporter protein responsible for many physiological processes,such as inflammation,generation of the immune response,and metabolic *** has been reported to depict the early changes in renal damage when urine microalbumin is still ***,elucidating the role of NGAL in detecting DN and understanding its mechanism can help establish it as a potential early marker for DN.

关键词： Type 1 diabetes Type 2 diabetes Diabetic nephropathy Lipocalin-2 Early biomarkers for kidney disease Acute kidney injury

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