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露茜 2008年第1期 24-55页

作者： Masako kondo kumiko Nozaki Hitomi Takahasm Masoki Sone（摄影） Yoshihiro Sasaki（摄影） Hideyo Fukuda（摄影） Koji Yamada（摄影）

进入隆冬，新鲜的冬季搭配也容易变的毫无新意。选择和目前为止决不相同的单品，自在变换搭配。Style焕然一新！打造轮穿差异，将应时感握在手中！

关键词：时尚服饰搭配冬季应时感

Long-term disease-free survival in a dog with appendicular osteosarcoma

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畜牧与兽医 2012年第S2期44卷 62-62页

作者： kumiko Ishigaki Kazushi Asno Yoshiya Yoshida Rikiya Nishimura Hiromi Aoki Gentoku Iida Orie Yoshida Mamiko Seki Kenji Teshima Kazuya Edamura Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary Medicine College of Bioresource SciencesNihon University SHIMA Laboratories Co. LTD Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary Medicine College of Bioresource SciencesNihon University

Postoperative prognosis is generally poor even with adjuvant chemotherapy in dogs with an appendicular osteosarcoma. The purpose of this report was to present the long-term disease-free survival time in a dog with appendicular osteosarcoma receiving amputation,adjuvant chemotherapy and adoptive immunotherapy. A 12-year-old spayed Golden retriever was referred to our hospital with a suspicion of osteosarcoma in right distal radius. The patient underwent the computed tomography (CT) and incisional biopsy on the next day after the first presentation. The CT revealed the osteolysis in the right distal radius and no metastases in the lungs and lymph nodes. The histopathologic diagnosis was made as an osteosarcoma. On the 13th day after,the patient underwent right forelimb amputation. Six doses of carboplatin (250 mg / m2) were postoperatively administered every 3 weeks. The intravenous infusion of lymphokine-activated killer (LAK) cells suspension was performed every 3 ~ 4 weeks after the adjuvant chemotherapy. At the time of our writing this abstract (on the 880thday after the first presentation),no recurrences and metastases were observed after the 32 transfers of LAK cells. In canine appendicular osteosarcoma,some reports have described that postoperative median survival times were 235 ~ 540 d with adjuvant chemotherapy. In our report,the disease free interval and survival time were prolonged compared with the previous reports. We strongly believed that early diagnosis and surgical intervention and adoptive immunotherapy had a great impact on the improvement of survival time in canine appendicular osteosarcoma.

关键词： adoptive immunotherapy adjuvant chemotherapy appendicular osteosarcoma,dog long-term disease-free survival

Use of cone-shaped polypropylene mesh for perineal herniorrhaphy in dogs

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畜牧与兽医 2012年第S2期44卷 43-43页

作者： Kenji Teshima Kazushi Asano kumiko Ishigaki Mamiko Seki Takahiro Suzuki Seri Komazaki Gentoku Iida Orie Yoshida Kazuya Edamura Shigeo Tanaka Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Unilateral or bilateral perineal hernia results from the failure of the muscular pelvic diaphragm,and is commonly observed in male *** study aimed to investigate the outcome of herniorrhaphy technique with the cone-shaped polypropylene mesh in dogs with perineal hernia.1 Materials and Methods Between October 2008 and July 2012,39 dogs(71 perineal hernias)underwent herniorrhaphy with polypropylene mesh(PROLENE MeshJohnson&Johnson)formed in the shape of a *** apex of corn-shaped mesh was inserted into the hernia region,and the bottom was sutured to sacrotuberous ligament,internal obturator muscle,external anal sphincter and residual coccygeal muscle.

关键词： polypropylene shaped hernia muscular bilateral obturator sphincter inserted ligament diaphragm

Successful treatment of a large hepatocellular carcinoma and paraneoplastic hypoglycemia by central and left divisional hepatic lobectomy in a dog

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畜牧与兽医 2012年第S2期44卷 41-41页

作者： Rikiya Nishimura Kazushi Asano Mamiko Seki Gentoku Iida kumiko Ishigaki Kenji Kutara Chieko Ishikawa Orie Yoshida Kenji Teshima Kazuya Edamura Manabu Sakai Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Biore-source SciencesNihon University Laboratory of Veterinary Internal Medicine Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Hepatocellular carcinoma (HCC) is generally observed as a massive tumor originated from one lobe in *** is the treatment of choice in dogs with a massive HCC. However,complete resection is technically difficult in the cases with an extremely enlarged HCC pressing or involving the large vessels such as caudal vena cava and main hepatic veins. This study aimed to report the divisional hepatic lobectomy for complete resection of very large HCC and successful treatment of paraneoplastic hypoglycemic seizures in a dog.A 12-year-old spayed Yorkshire terrier was referred to our hospital with chief complaints of seizures and a very large hepatic mass. In the first presentation,serum liver enzymes levels increased,and serum glucose concentration was 29mg/dl. Computed tomography (CT) angiography revealed that a huge mass occurred in the right medial,quadrate,and left medial hepatic lobes and flattened caudal vena cava and main portal vein. The patient underwent surgical *** mass was approached with midline celiotomy,caudal median sternotomy,and bilateral paracostal laparotomy. En bloc resection of central and left divisional lobes including the mass was accomplished with surgical ligation of hepatic hilar vessels and hepatic veins. The hypoglycemic seizures were postoperatively resolved,and no clinical signs were *** hypoglycemic seizures were thought to be associated with the insulin-like growth factors (IGF). The right divisional lobes could serve the sufficient hepatic function. Divisional hepatic lobectomy based on CT angiography is very useful for the treatment of canine HCCs.

关键词： divisional hepatic lobectomy dog hepatocellular carcinoma hypoglycemia paraneoplastic syndrome

Computed tomography characteristics and complete resection of large thymoma in a cat

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畜牧与兽医 2012年第S2期44卷 31-31页

作者： Hiromi Aoki Kazushi Asano Rui Kano Kenji Teshima Kenji Kutara Chieko Ishikawa kumiko Ishigaki Mamiko Seki Gentoku Iida Orie Yoshida Kazuya Edamura Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Veterinary Pathobiology Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Thymoma is an intrathoracic malignant tumor occurring rarely in cats. Although surgery is the treatment of choice in feline thymomas,complete resection may be difficult in cases that the large vessels are involved into the ***,diagnostic imaging techniques including computed tomography( CT) are essential for the treatment of feline thymomas. This report aimed to present the CT characteristics and successful removal of very large thymoma in a cat with exfoliative *** 8-year-old spayed mongrel cat was referred to our hospital with chief complaints of chronic anorexia,alopecia,and desquamation. Tachypnea,tachycardia,and exfoliative dermatitis were observed in the first presentation. Thoracic radiography showed a very large mass in the craniomediastinal region. In the CT findings,the mass included multiple small cysts,and forced up the intrathoracic trachea,cranial vena cava,brachiocephalic trunk and left subclavian artery as well as heart and *** the 6th day after,the patient underwent a median sternotomy and diaphragmatic incision to expose the mass. The mass was completely resected with right phrenic nerve by using cautery and LigaSure. No postoperative complications were observed. The histopathologic diagnosis was made as a thymoma. Postoperative progress of the patient was excellent without the exfoliative *** enlarged thymoma could be completely resected in this patient,and the exfoliative dermatitis was postoperatively controlled. The paraneoplastic immune disorder was suggested to cause the dermatitis. CT has a great impact on the indication of surgery for the feline thymomas.

关键词： cat complete resection computed tomography exfoliative dermatitis thymoma

p38 mitogen-activated protein kinase regulates type-Ⅰ vs type-Ⅱ phenotyping of human vascular endothelial cells

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World Journal of Translational Medicine 2015年第3期4卷 101-112页

作者： Masako Nakahara Miwako Nishio Koichi Saeki Akira Yuo kumiko Saeki Department of Disease Control Research Institute National Center for Global Health and Medicine Section of Cell Engineering Department of Basic Research DNAVEC Center ID Pharma Co. Ltd. PRESTO Japan Science and Technology Agency

AIM: To identify kinases involved in phenotype regulation of vascular endothelial cells(VECs): Proproliferative G-protein signaling 5(RGS5)^(high)(typeⅠ) vs anti-proliferative RGS5^(low)(typeⅡ) ***: Proteomic kinase assays were performed to identify the crucial kinase involved in the phenotype regulation of human VECs using typeⅠ VECs, which promotes the proliferation of human vascular smooth muscle cells(VSMCs), and typeⅡ VECs, which suppress the proliferation of human VSMCs. The assays were performed using multiple pairs of typeⅠ and typeⅡ VECs to obtain the least number of candidates. The involvement of the candidate kinases was verified by evaluating the effects of their specific inhibitors on the phenotype regulation of human VECs as well as the expression levels of regulator of RGS5, which is the causative gene for the "typeⅡ to typeⅠ" phenotype conversion of human VECs. RESULTS: p38α mitogen-activated protein kinase(p38α MAPK) was the only kinase that showed distinctive activities between typeⅠ and typeⅡ VECs: p38α MAPK activities were low and high in type-Ⅰand typeⅡ VECs, respectively. We found that an enforced expression of RGS5 indeed lowered p38α MAPK activitiesin typeⅡ VECs. Furthermore, treatments with a p38α MAPK inhibitor nullified the anti-proliferative potential in typeⅡ VECs. Interestingly, MAPK inhibitor treatments enhanced the induction of RGS5 gene. Thus, there is a vicious cycle between "RGS5 induction" and "p38α MAPK inhibition", which can explain the unidirectional process in the stress-induced "typeⅡ to typeⅠ" conversions of human VECs. To understand the upstream signaling of RGS5, which is known as an inhibitory molecule against the G protein-coupled receptor(GPCR)-mediated signaling, we examined the effects of RGS5 overexpression on the signaling events from sphingosine-1-phosphate(S1P) to N-cadherin, because S1 P receptors belong to the GPCR family gene and N-cadherin, one of their downstream effectors, is reportedly involved in

关键词： vascular endothelial cells vascular smooth muscle cells proteomic kinase assay p38αmitogenactivated protein kinase regulator of G-protein signaling 5 sphingosine-1-phosphate N-cadherin

商品碱法皮明胶中所含的Ⅲ型胶原衍生的高分子组分的鉴定

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明胶科学与技术 2002年第4期22卷 215-215页

作者： Kuwabu,kumiko

In vitro and in vivo development of interspecies Asian elephant embryos reconstructed with pig enucleated oocytes

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In vitro and in vivo development of interspecies Asian eleph...

市川房枝与日本妇女选举运动——近现代日本政治暗流的形成

中国畜牧兽医学会动物繁殖学分会第二十次学术研讨会

作者： Tien Dat Nguyen Honghui Li Yiquan Zhuang Bowei Chen Keiji Kinoshita Muhammad Ameen Jamal Kaixiang Xu Jianxiong Guo Deling Jiao kumiko Tanabe Yunfang Wei Zhuo Li Wenming Cheng Yubo Qing Hong-Ye Zhao Hong-Jiang Wei

Purpose De-extinction to bring back the wooly mammoths would be a tremendous accomplishment for humanity and has always been the dream of *** revive them,three main strategies （ICSI,SCNT,gene-editing） using elephant oocytes are under *** the elephant oocytes seem to be an indispensable recipient for reviving the wooly ***,the elephant （Elephas maximus.L） is also categorized as an endangered *** somatic cell nuclear transfer（iSCNT） has an immense potential to rescue endangered animals and extinct species like mammoths.

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日本研究 2019年第3期 9-22页

作者：进藤久美子王鹏飞(译) 吴占军(译) 东洋英和女学院大学国际社会学部天津师范大学历史文化学院天津300387 辽宁大学日本研究所沈阳110136

市川房枝是近现代日本政治史上颇具代表性的妇女解放运动家和女性政治家。1924年12月,市川参与成立的"获得同盟"被视为战前日本妇女选举运动的摇篮,她作为妇女选举运动旗手始终坚持引领着为女性获得参政权的斗争。九一八事变的爆发使正... 详细信息

市川房枝是近现代日本政治史上颇具代表性的妇女解放运动家和女性政治家。1924年12月,市川参与成立的"获得同盟"被视为战前日本妇女选举运动的摇篮,她作为妇女选举运动旗手始终坚持引领着为女性获得参政权的斗争。九一八事变的爆发使正处于高峰期的妇女选举运动急转直下,市川在提出反战主张的同时,将市民活动纳入妇女选举运动领域。1937年日本发动全面侵华战争,妇女选举运动转向为战时体制服务、支持侵略战争,市川也成为战争帮凶。经过战后民主化改革,日本女性获得了平等的参政权,但政治风气却趋于保守。回顾历史,可以说战前、战时妇女选举运动累积的经验,形成了近现代日本政治的暗流。市川在领导妇女选举运动的过程中,一边推动女性参与政治,一边与自民党主导的利益诱导型金权政治相抗衡。其倡导的"政治即是生活"政治理念与实践,也成为导致战后日本两次政权更迭的重要背景。

关键词：市川房枝妇女选举运动日本政治女性参政权

西昆仑山冰芯记录指示的塔克拉玛干沙漠南缘对流层中上部近百年大气尘埃变化趋势

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冰川冻土 2006年第6期28卷 873-878页

作者：李永能杨阳韩建康谢自楚中尾正义东久美子湖南师范大学资源与环境研究所湖南长沙410081 青海师范大学资源与环境学院青海西宁810008 综合地球环境学研究所国立极地研究所

钻自西昆仑山崇测冰帽海拔6 530 m的18.7 m冰芯提供了近百年间的尘埃沉积记录.冰芯记录覆盖的90 a间尘埃表现出持续下降的总趋势,大体可以分为3个阶段,即1930年之前,1930-1960年和1960年之后,尘埃浓度的降低是量级上的.几个突出的尘埃... 详细信息

钻自西昆仑山崇测冰帽海拔6 530 m的18.7 m冰芯提供了近百年间的尘埃沉积记录.冰芯记录覆盖的90 a间尘埃表现出持续下降的总趋势,大体可以分为3个阶段,即1930年之前,1930-1960年和1960年之后,尘埃浓度的降低是量级上的.几个突出的尘埃阶段出现在1900年代早期、1910年代、1920年代后期和1940年代早期,它们分别以约2.5×106、2.7×106、2.5×106和1.5×106粒.mL-1的高浓度为特征,而1970年代则表现出相对较低的浓度(5×105粒.mL-1).就年份来看,突出的高尘埃浓度出现于1906,1915,1919和1943年.根据微粒的粒径资料分析,局地输入的尘埃分量约占总值的17%,剔除后可以得到中、大尺度范围的大气尘埃沉积通量.根据后60 a资料建立的通量平均值为913μ***-2.a-1,大气尘埃随时间的每10 a下降速率为-124μ***-2,它可反映塔克拉玛干沙漠南缘对流层中上部的大气尘埃通量半个多世纪以来的变化趋势.

关键词：冰芯记录尘埃沉积对流层中上部大气尘埃通量持续下降