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The Pattern of Contrast Dye through the Thoracic Paravertebral Catheter Does Not Predict Analgesic Efficacy after Breast Cancer Surgery: A Prospective Cohort Study

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Open Journal of Anesthesiology 2018年第12期8卷 285-294页

作者： Yuko Yamada kumiko Tanabe Noritaka Yoshimura Shinobu Yamaguchi Kiyoshi Nagase Hiroki Iida Department of Anesthesiology and Pain Medicine Gifu University Graduate School of Medicine Gifu Japan

Purpose: We examined whether or not the spreading pattern of contrast dye through the catheter into the thoracic paravertebral space (TPVS) was associated with acute post-operative pain relief after breast cancer surgery. Methods: Sixty patients were recruited. After surgery, patients received thoracic paravertebral block (TPVB). The catheter was inserted within the TPVS, and radiographic contrast dye was injected through the catheter. Based on the main spreading patterns of the dye, the patients were divided into a cloud-like (spreading to the posterior compartment of the TPVS) or a longitudinal spread group (spreading to the anterior compartment of the TPVS). The primary endpoint of the study was pain intensity by numeric rating scale (NRS) and additional analgesic requirements within 12 h after surgery. Results: In 22 patients, the spread of contrast dye was not noted in the PVS. Of the 38 eligible patients, 9 patients were assigned to the cloud-like spread group, 28 patients to the longitudinal spread group and 1 patient was excluded. There were no significant differences in the NRS between the two groups both at rest and on moving. No significant differences were found in the frequency of requiring additional analgesics. Conclusions: There is no marked difference in the analgesic efficacy after breast cancer surgery based on the spread of the contrast dye to the posterior or anterior compartment of the TPVS. We should not insert the needle deeply within the TPVS, as the risk of the migration of catheters into the pleural space can be quite high.

关键词： Breast Cancer Postoperative Pain Thoracic Paravertebral Block

Unresectable esophageal cancer treated with multiple chemotherapies in combination with chemoradiotherapy:A case report

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World Journal of Clinical Cases 2021年第12期9卷 2801-2810页

作者： Masahiro Yura Kazuo Koyanagi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Yoshifumi Tamai Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Radiology Hiratsuka City HospitalKanagawa 2540065Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Definitive chemoradiotherapy(dCRT)using cisplatin plus 5fluorouracil(CF)with radiation is considered the standard treatment for unresectable locally advanced T4 esophageal squamous cell carcinoma(ESCC).Recently,induction chemotherapy has received attention as an effective treatment *** SUMMARY We report a successful case of a 59-year-old female with unresectable locally advanced T4 ESCC treated by two additional courses of chemotherapy with CF after induction chemotherapy with docetaxel,cisplatin and fluorouracil(DCF)followed by *** esophagogastroduodenoscopy(EGD)detected a type 2 advanced lesion located on the middle part of the esophagus,with *** tomography detected the primary tumor with suspected invasion of the left bronchus and 90°of direct contact with the aorta,and upper mediastinal lymph node *** findings from biopsy revealed squamous cell *** initially performed induction chemotherapy using three courses of DCF,but the lesion was still evaluated unresectable after DCF ***,we subsequently performed dCRT treatment(CF and radiation).After dCRT,prominent reduction of the primary tumor was recognized but a residual tumor with ulceration was detected by *** the patient had some surgical risk,we performed two additional courses of CF and achieved a clinically complete *** 14 mo from last administration of CF chemotherapy,recurrence has not been detected by computed tomography and EGD,and biopsy from the scar formation has revealed no cancer *** We report successful case with tumor remnants even after DCF and subsequent dCRT,for whom a complete response was finally achieved with two additional courses of CF *** CF chemotherapy could be one radical treatment option for residual ESCC after treatment with induction DCF followed by dCRT to avoid salvage surgery,especially for high-risk patients.

关键词： Unresectable esophageal cancer Induction docetaxel,cisplatin and fluorouracil Chemoradiotherapy Complete response Additional chemotherapy Case report

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疯狂的“育婴包”

品位 2008年第7期 68-69页

作者： kumiko

顶级的奢华大多是祖父辈就开始流传的神话。因为只有经历沧桑洗礼而鲜活的故事，才具有难以撼动的说服务。唯有一针一线，一钉一柳，传承百年的纯手工精湛工艺，才能制造真正的精品。

关键词：背包时尚潮流设计方案 Birkin包

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蛇形诱惑

品位 2008年第10期 66-67页

作者： kumiko

她纤细的腰充满力量，她诱人的嘴藏着不知名的毒，她安静不喧哗，却并不代表她没有意见，当她受到轻视的时候，她会让对手知道谁才是真正的控制者——这也许就是为什么女人会为珠宝上的蛇而倾倒，为什么爱上Boucheron的原因，因为女人... 详细信息

她纤细的腰充满力量，她诱人的嘴藏着不知名的毒，她安静不喧哗，却并不代表她没有意见，当她受到轻视的时候，她会让对手知道谁才是真正的控制者——这也许就是为什么女人会为珠宝上的蛇而倾倒，为什么爱上Boucheron的原因，因为女人自己就是危险又美丽的动物。

关键词：诱惑蛇女人

Relationships between Tongue and Lip Movement and Physical Fitness among Independent Community-Dwelling Elderly in Japan

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Advances in Aging Research 2020年第2期9卷 32-44页

作者： Junko Ouchi Yuko Hayashi Michiko Matsubara Kaoru Fukura kumiko Miyata Michiyo Yamamoto Department of Nursing Faculty of Health Sciences Hokkaido University of Science Sapporo Japan

Aim: The present study aims to examine the association between tongue and lip movement and physical fitness with a sample of independent community-dwelling elderly. Methods: A total of 119 older adults living in a city of Japan participated in this study. Tongue and lip movement was evaluated with oral diadochokinesis (ODK) rate for the syllable “pa”, “ta”, and “ka” measured by counting syllable repetitions within one second. Physical fitness was objectively evaluated with the Timed-Up and Go Test (TUG) and the 30-Second Chair Stand Test (CS-30). Subjective physical fitness was also assessed with a Physical Component Summary score (PCS) of the 36-item Short-Form Health Survey (SF-36). Partial correlation coefficients between ODK rates and physical fitness measures were obtained after adjusting the effects of age and the number of present teeth. Results: There were significant differences in ODK rates for the syllable “ta” and “ka” between the participants aged 65 - 74 and 75 or older. Significant differences in all the physical fitness measures were also observed in the two age groups. Partial correlation analysis with age and number of present teeth as covariates yielded significant correlations of ODK rates to TUG and PCS, but not with CS-30. Conclusion: Older adults whose functional mobility declined tended to maintain the movement of tongue and lips. Moreover, those who perceived declining physical fitness also tended to show a decline of tongue and lip movement. Thus, the present study added some knowledge on the relationships between general physical fitness and tongue and lip movement. It also made several suggestions for future interventions based on the findings.

关键词： Tongue and Lip Movement Oral Diadochokinesis Physical Fitness El-derly

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CHANEL 2.55最经典的“装饰品”

品位 2008年第8期 66-67页

作者： kumiko

菱格纹、金属链，这两大元素已丝毫不能表现出它的时髦之处，但如果你想回避名牌白痴的头衔，想用奢侈品慰藉饱受工作摧残的心灵，想体验二下众星捧月般被闺密包围的感觉，你别无选择，Chanel 2.55。只有它，才能唤起最原始的奢侈体验。

关键词：首饰产品介绍 CHANEL2.55 奢侈品

Metastatic sarcomatoid renal cell carcinoma to the mandible treated with Sorafenib

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Open Journal of Stomatology 2012年第3期2卷 222-227页

作者： Kazuhiro Murakami Kazuhiko Yamamoto kumiko Aoki Ikuyo Fukumoto Tsutomu Sugiura Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Kashihara Japan

A case of metastatic sarcomatoid renal cell carcinoma to the mandible treated with Sorafenib is reported. A 76-year-old man consulted us for hyposthesia of the right lower lip. Panorama X-ray film showed a ra-diolucent lesion in the right mandibular body. A diagnosis of metastatic tumor to the mandible from the left kidney was made after evaluation by computed tomography and positron emission tomography, which also revealed multiple bone metastases. After radiotherapy for mandibular and thoracic lesions, nephrectomy was performed. Histological diagnosis was sarcomatoid renal cell carcinoma. Interferon therapy was performed but was not effective;therefore, a molecular targeted drug, Sorafenib, was administered. Sorafenib effectively inhibited the growth of oral and other metastatic lesions for 10 months. Quality of life was relatively well maintained with tolerable adverse effects. The patient survived for as long as 2 years after appearance of the first symptom.

关键词： Sarcomatoid Renal Cell Carcinoma Oral Metastatic Lesion Molecular Targeted Therapy Sorafenib

Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head:A case report

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World Journal of Gastroenterology 2021年第6期27卷 534-544页

作者： Masahiro Yura Kiminori Takano Kiyohiko Adachi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Yoichiro Ikoma Hiroto Fujisaki Akira Hirata kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Kazuo Koyanagi Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Surgical Pathology Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259193KanagawaJapan

BACKGROUND Pancreaticoduodenectomy(PD)for advanced gastric cancer is rarely performed because of the high morbidity and mortality rates and low survival ***,neoadjuvant chemotherapy for advanced gastric cancer has improved,and chemotherapy combined with trastuzumab may have a preoperative tumorreducing effect,especially for human epidermal growth factor receptor 2(HER2)-positive *** SUMMARY We report a case of successful radical resection with PD after neoadjuvant S-1 plus oxaliplatin(SOX)and trastuzumab in a patient(66-year-old male)with advanced gastric cancer invading the pancreatic *** esophagogastroduodenoscopy detected a type 3 advanced lesion located on the lower part of the stomach obstructing the pyloric *** tomography detected lymph node metastasis and tumor invasion to the pancreatic head without distant *** findings revealed adenocarcinoma and HER2 positivity(immunohistochemical score of 3+).We performed staging laparoscopy and confirmed no liver metastasis,no dissemination,negative lavage cytological findings,and immobility of the distal side of the stomach due to invasion to the *** gastrojejunostomy was performed at that *** course of SOX and three courses of SOX plus trastuzumab were *** computed tomography showed partial response;therefore,PD was performed after neoadjuvant chemotherapy,and pathological radical resection was *** We suggest that radical resection with PD after neoadjuvant chemotherapy plus trastuzumab is an option for locally advanced HER2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.

关键词： Pancreaticoduodenectomy Gastric cancer Neoadjuvant chemotherapy Trastuzumab Human epidermal growth factor receptor 2 Case report

Summer sea ice characteristics of the Chukchi Sea

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Chinese Journal of Polar Science 2001年第2期12卷 109-118页

作者：康建成孙波孙俊英孟广琳 kumiko Goto-Azuma Polar Research Institute of China Cold and Arid Regions Environmental and Engineering Research Institute CAS Institute of Marine Environmental Protection SOA National Institute of Polar Research

During August 1999, we investigated sea ice characteristics; its distribution, surface feature, thickness, ice floe movement, and the temperature field around inter-borders of air/ice/seawater in the Chukchi Sea. Thirteen ice cores were drilled at 11 floe stations in the area of 72°24′ 77°18′N, 153°34′ 163°28′W and the ice core structure was observed. From field observation, three melting processes of ice were observed; surface layer melting, surface and bottom layers melting, and all of ice melting. The observation of temperature fields around sea ice floes showed that the bottom melting under the ice floes were important process. As ice floes and open water areas were alternately distributed in summer Arctic Ocean; the water under ice was colder than the open water by 0.4 2.8℃. The sun radiation heated seawater in open sea areas so that the warmer water went to the bottom when the ice floes move to those areas. This causes ice melting to start at the bottom of the ice floes. This process can balance effectively the temperature fluctuating in the sea in summer. From the crystalline structure of sea ice observed from the cores, it was concluded that the ice was composed of ice crystals and brine-ice films. During the sea ice melting, the brine-ice films between ice crystals melted firstly; then the ice crystals were encircled by brine films; the sea ice became the mixture of ice and liquid brine. At the end of melting, the ice crystals would be separated each other, the bond between ice crystals weakens and this leads to the collapse of the ice sheet.

关键词： Arctic Ocean sea ice climate.