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Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra kumar Gautam rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra rakesh kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

An overview of chemical enhanced oil recovery and its status in India

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Petroleum Science 2023年第4期20卷 2305-2323页

作者： Ganesh kumar Pothula rakesh kumar Vij Achinta Bera Department of Petroleum Engineering School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagarGujarat382007India

India is currently producing crude oil from matured fields because of insufficient discoveries of new ***,in order to control the energy crisis in India,enhanced oil recovery(EOR)techniques are required to reduce the import of crude from the OPEC(Organization of the Petroleum Exporting Countries).This review mentions chemical EOR techniques(polymers,surfactants,alkali,nanoparticles,and combined alkali-surfactant-polymer flooding)and operations in *** EOR methods are one of the most efficient methods for oil *** efficiency is enhanced by interfacial tension(IFT)reduction using surfactants and alkali,and mobility control of injected water is done by adding a polymer to increase the volumetric sweep *** paper also reviews the current trend of chemical EOR,prospects of chemical EOR in Indian oilfields,the development of chemical EOR in India with their challenges raising with economics,and screening criteria for chemical EOR implementation on the field ***,the review gives a brief idea about chemical EOR implementation in Indian oilfields in future prospects to increase the additional oil recovery from existing depleted fields to reduce the import of crude *** outcome of this review depicts all chemical EOR operations and recovery rates both at the laboratory scale and field scale around the *** additional recovery rates are compared from various chemical EOR methods like conventional chemical flooding methods and conventional chemicals combined with nanoparticles on a laboratory *** development of chemical EOR in the past few decades and the EOR policy given by the government of India has been mentioned in this *** analysis provides an idea about enhanced recovery screening and implementation of chemical EOR methods in existing fields will significantly reduce the energy crisis in India.

关键词： Chemical enhanced oil recovery Surfactant flooding Polymer flooding Indian oilfields Enhanced oil recovery challenges in India Screening criteria

DYNAMICAL BEHAVIOR OF AN INNOVATION DIFFUSION MODEL WITH INTRA-SPECIFIC COMPETITION BETWEEN COMPETING ADOPTERS

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Acta Mathematica Scientia 2022年第1期42卷 364-386页

作者： rakesh kumar Anuj kumar SHARMA Govind Prasad SAHU Department of Applied Sciences Shaheed Bhagat Singh State UniversityFerozepurPunjab 152004India Department of Mathematics L.R.D.A.V.CollegeJagraonLudhianaPunjab 142026India Center for Basic Sciences Pt Ravishankar Shukla UniversityRaipur(Chhattisgarh).India

In this paper,we proposed an innovation diffusion model with three compartments to investigate the diffusion of an innovation(product)in a particular *** model exhibits two equilibria,namely,the adopter-free and an interior *** existence and local stability of the adopter-free and interior equilibria are explored in terms of the effective Basic Influence Number(BIN)R_(A).It is investigated that the adopter free steady-state is stable if R_(A)<*** consideringτ(the adoption experience of the adopters)as the bifurcation parameter,we have been able to obtain the critical value ofτresponsible for the periodic solutions due to Hopf *** direction and stability analysis of bifurcating periodic solutions has been performed by using the arguments of normal form theory and the center manifold *** numerical simulations in the support of analytical results have been presented.

关键词： intra-specific competition basic influence number local stability Hopf-bifurcation normal form theory center manifold theorem

A robust deep structured prediction model for petroleum reservoir characterization using pressure transient test data

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Petroleum Research 2022年第2期7卷 204-219页

作者： rakesh kumar Pandey Anil kumar Ajay Mandal Department of Petroleum and Energy Studies School of Engineering and TechnologyDIT UniversityDehradun248009India Data Science Research Group School of ComputingDIT UniversityDehradun248009India Department of Petroleum Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad826004India

A robust deep learning model consisting of long short-term memory and fully connected neural net-works has been proposed to automatically interpret homogeneous petroleum reservoirs having infinite,no flow,and constant pressure outer boundary *** pressure change data recorded during the well test operation along with its derivative is input into the model to perform the classification for identifying the reservoir model and,further,regression to estimate output *** noise was added to analytical models while generating the synthetic training *** hyperparameters were regulated to perform model optimization,resulting in a batch size of 64,Adam optimization algorithm,learning rate of 0.01,and 80:10:10 data split ratio as the best choices of *** perfor-mance accuracy also increased with an increase in the number of samples during *** classification and regression metrics have been used to evaluate the performance of the *** paper also demonstrates the prediction performance of the optimized model using simulated and actual oil well pressure drawdown test *** proposed model achieved minimum and maximum relative errors of 0.0019 and 0.0308,respectively,in estimating output for the simulated test cases and relative error of 0.0319 for the real test case.

关键词： Well test Reservoir characterization Automatic interpretation Prediction model Hyperparameter tuning Performance indicator

Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects

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生物质资源与工程(英文) 2023年第2期8卷 108-124页

作者： Akansha Shrivastava Mamta Pal rakesh kumar Sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology

Sexual dysfunctions and their treatment in liver diseases

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World Journal of Hepatology 2022年第8期14卷 1530-1540页

作者： rakesh kumar Jagdish Department of Hepatology Gastroenterology and Liver Transplant MedicineFortis Hospital NoidaNoida 201301UPIndia

Sexual dysfunction(SD)is a prevalent but very commonly ignored aspect in the treatment of liver diseases and *** etiology of SD is multifactorial and therefore treatment strategies are complex,especially in *** inhibitors are useful and effective in erectile dysfunction in males but in females,no single drug is available for SD,therefore multimodal treatment is required depending upon the *** foremost and fundamental requirement in both genders is to be stress-free and have adequate control of liver *** quality of life is helpful in improving SD and vice versa is also ***,patients suffering from liver diseases should come forward and ask for treatment for SD,and physicians should actively enquire about SD while history taking and evaluating these *** results in deterioration of quality of life,and both are modifiable and treatable aspects of liver diseases,which are never addressed actively,due to social taboos and fears of SD treatment in the presence of liver *** diagnosis of SD does not require costly investigations,as the diagnosis can be established based on validated questionnaires available for both genders,therefore detailed targeted history taking using questionnaires is *** are emerging in this area but is still at an early *** studies should be dedicated to SD in liver diseases.

关键词： Sexual dysfunction Erectile dysfunction Female sexual function index International index of erectile function Phosphodiesterase inhibitors Hepatic venous pressure gradient

Design and Simulation of Ring Network-on-Chip for Different Configured Nodes

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Computers, Materials & Continua 2022年第5期71卷 4085-4100页

作者： Arpit Jain rakesh kumar Dwivedi Hammam Alshazly Adesh kumar Sami Bourouis Manjit Kaur Faculty of Engineering&Computer Sciences Teerthanker Mahaveer UniversityMoradabadUttar Pradesh244001India Faculty of Computers and Information South Valley UniversityQena83523Egypt Department of Electrical and Electronics Engineering School of EngineeringUniversity of Petroleum and Energy StudiesDehradun248007India Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia School of Engineering and Applied Sciences Bennett UniversityGreater Noida201310India

The network-on-chip(NoC)technology is frequently referred to as a front-end solution to a back-end *** physical substructure that transfers data on the chip and ensures the quality of service begins to collapse when the size of semiconductor transistor dimensions shrinks and growing numbers of intellectual property(IP)blocks working together are integrated into a *** system on chip(SoC)architecture of today is so complex that not utilizing the crossbar and traditional hierarchical bus *** connectivity reduces the amount of hardware required for routing and functions,allowing SoCs with NoC interconnect fabrics to operate at higher ***(Octagons)is a direct NoC that is specifically used to solve the scalability problem by expanding each node in the shape of an *** paper discusses the ring NoC design concept and its simulation in Xilinx ISE 14.7,as well as the communication of functional *** the field-programmable gate array(FPGA)synthesis,the performance of NoC is evaluated in terms of hardware and timing *** design allows 64 to 256 node communication in a single chip with‘N’bit data transfer in the ring *** performance of the NoC is evaluated with variable nodes from 2 to 256 in Digilent manufactured Virtex-5 FPGA hardware.

关键词： Ring NoC FPGA synthesis nodes communication SoC design integrated synthesis environment

D^(2)PAM:Epileptic seizures prediction using adversarial deep dual patch attention mechanism

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 755-769页

作者： Arfat Ahmad Khan rakesh kumar Madendran Usharani Thirunavukkarasu Muhammad Faheem Department of Computer Science College of ComputingKhon Kaen UniversityKhon KaenThailand Department of Computer Science and Engineering Rajalakshmi Engineering CollegeChennaiIndia Department of Biomedical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(Deemed to be University)ChennaiIndia School of Technology and Innovations University of VaasaVaasaFinland

Epilepsy is considered as a serious brain disorder in which patients frequently experience *** seizures are defined as the unexpected electrical changes in brain neural activity,which leads to *** researches made an intense effort for predicting the epileptic seizures using brain signal ***,they faced difficulty in obtaining the patients'characteristics because the model's distribution turned to fake predictions,affecting the model's *** addition,the existing prediction models have severe issues,such as overfitting and false positive *** overcome these existing issues,we propose a deep learning approach known as Deep dual‐patch attention mechanism(D^(2)PAM)for classifying the pre‐ictal signals of people with Epilepsy based on the brain *** neural network is integrated with D^(2)PAM,and it lowers the effect of differences between patients to predict *** multi‐network design enhances the trained model's generalisability and stability ***,the proposed model for processing the brain signal is designed to transform the signals into data blocks,which is appropriate for pre‐ictal *** earlier warning of epilepsy with the proposed model obtains the auxiliary *** data of real patients for the experiments provides the improved accuracy by D2PAM approximation compared to the existing *** be more distinctive,the authors have analysed the performance of their work with five patients,and the accuracy comes out to be 95%,97%,99%,99%,and 99%***,the numerical results unveil that the proposed work outperforms the existing models.

关键词： artificial intelligence techniques classification learning(artificial intelligence)