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Sirtuins as novel players in the pathogenesis of diabetes mellitus

World Journal of Diabetes 2014年第6期5卷 894-900页

作者： kultigin turkmen Ali Karagoz Adem Kucuk Division of Nephrology Department of Internal MedicineErzincan University Division of Nephrology Department of Internal MedicineIgdr State Hopital Department of Internal Medicine Konya NE University

Diabetes mellitus(DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD+ dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus.

关键词： Diabetes mellitus Sirtuins Hyperglycemia Hyperlipidemia Resveratrol

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Alveolar echinococcosis localized in the liver, lung and brain

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Chinese Medical Journal 2008年第1期121卷 90-92页

作者： Seyit Mehmet Kayacan Sezai Vatansever Suleyman Temiz Bora Uslu Dilek Kayacan Vakur Akkaya Osman Erk Bülent Saka Aytac Karadag kultigin turkmen Fatih Yakar Kerim Guler Istanbul University Istanbul Medical Faculty Department ofInternal Medicine |stanbul Turkey Republic of Turkey Ministry of Health Umraniy.e Education andResearch Hospital Department of Neurology istanbul Turkey Istanbul University Istanbul Medical Faculty Department ofPulmonary Medicine Istanbul Turkey

Echinococcosis is a parasitic disease caused by the ,larval forms of echinococci. It has two main forms as the unilocular cystic form that is more commonly seen and caused by E. granulosus and the alveolar form that is rarely seen and caused by E. multilocularis. E. multilocularis usually contaminates from foxes and sometimes contaminates from domestic animals as dogs and cats to humans and usually affects the liver. Progression of alveolar echinococcosis is more severe and agressive. It can metastise to the lungs, brain and bones. We present a case of alveolar echinococcosis that was initially thought to be a lymphomatous infiltration but then determined to infect the liver, lung and brain in a patient with a large T-cell lymphoma.

关键词： alveolar echinococcosis lymphoma

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