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Connective tissue growth factor expression hints at aggressive nature of colorectal cancer

World Journal of Gastroenterology 2022年第5期28卷 547-569页

作者： Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid kulsum akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan Mohsin Kazi Muhammad D Hussain Mudassar Syed Department of Clinical Biochemistry Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of General Surgery Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of Pathology Sher-I-Kashmir Institute of Medical SciencesSrinagar 190011Jammu and KashmirIndia Department of Pharmaceutics College of PharmacyKing Saud UniversityPO Box 2457Riyadh 11451Saudi Arabia Department of Pharmaceutical and Biomedical Sciences California Health Sciences UniversityCaliforniaCA 93612United States

BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including *** To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological *** Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version *** CTGF expression levels in tumor specimens were significantly higher than their paired normal *** higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural *** per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC *** analysis indicated that CTGF overexpression was associated with poorer overall and disease-free *** Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC *** findings support prior observations and thus CTGF may be a possible prognostic marker in CRC.

关键词： Connective tissue growth factor Quantitative real time polymerase chain reaction Immunohistochemistry Western blotting Colorectal cancer

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Flood Maps and Bank Shifting of Dharla River in Bangladesh

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Journal of Geoscience and Environment Protection 2017年第9期5卷 109-122页

作者： Indira Bose Umme kulsum Navera Department of Water Resources Engineering Bangladesh University of Engineering and Technology Dhaka Bangladesh

Bangladesh is prone to severe flooding as being located at the confluence of three mighty rivers named the Ganges, Brahmaputra, and Meghna. As a consequence, river flooding and erosion are common natural disasters that severely affect the landscape, lives and economy of the country. Dharla River, one of the trans-boundary rivers originated in the Himalayas, along with Brahmaputra River has a great influence on the recurring floods and erosion in north-western Bangladesh. Almost in every year, excessive erosion and embankment damages caused by Dharla render a thousand of people homeless with massive loss of crops and poultries. As per the environmentalists, this is a matter of huge concern as development of accurate flood maps and erosion prediction for Dharla River has been very challenging. In this study, the flood map and Dharla River bank shifting study have been developed by using HEC-RAS 4.1.0 hydrodynamic model and Landsat satellite images. In addition, the HEC-GeoRAS was used to establish the river reach for HEC-RAS. The calibration and validation have been performed using the observed and simulated water levels for the years of 2013 and 2014 respectively. The HEC-RAS flood water level output was used in HEC-GeoRAS for raster interpolation followed by overlain onto the land surface elevation of the study area. Then, the difference between water level interpolation and land elevation surfaces has been considered as a depth of inundation which is performed in Arc-Map 10.2. Flood maps have been generated for the years 2010, 2013, and 2014 for highest water level of each year. The erosion prone areas have been indicated by analyzing bank shifting of Dharla River for the years 1987, 1997, 2007, and 2017 by digitizing the satellite images in Arc-GIS 10.2. From the observation it has been found that the course of the Dharla River has been shifted vastly since 1987 to 2017 due to erosion.

关键词： Hydrodynamic Modeling GIS Flood Flood Maps Bank Shifting Erosion

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CAR T Cell Immunotherapy That Revolutionary Breakthrough in Human Oncology Treatment: A Review

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Pharmacology & Pharmacy 2022年第11期13卷 483-515页

作者： Shammi Binte Bashar Zannat Akhter Bidhan Chandro Saha Md. Mushfiqul Islam Himaloy Umme kulsum Md. Rashedur Rahman Department of Pharmacy Primeasia University Banani Dhaka Bangladesh Department of Pharmacy Jahangirnagar University Savar Dhaka Bangladesh

The discovery of CAR T cell immunotherapy, also known as chimeric antigen receptor (CAR) T cell immunotherapy, has added a new dimension to the world of cancer treatment. This is a gene-based treatment in which T cells from the patient’s body are taken and genetically engineered in the lab to grow receptors. T cells containing this receptor are then injected into the patient’s body to bind to the antigen on the surface area of the cancer cell and kill the cancer cell. Structurally, the co-stimulatory domain added to CAR T cells has now reached the 5th GEN of chimeric antigen receptor T cells. Chimeric antigen T cell immunotherapy is the first FDA-approved treatment for hematological malignancies that is both safe and effective. However, due to some challenges such as a lack of safety control, an immunosuppressive tumor microenvironment, ineffective T cell trafficking, and so on, CAR-T immunotherapy treatment for solid malignancy is still in the clinical phase. In the result and discussion, we have presented a survey of CAR T cell therapy with a combination of pharmacological drugs. The things we mentioned are that CAR T cell immunotherapy is innovative, suitable, elegant, and also controls synergistic anti-cancer effects. A better understanding of combinatory CAR T cell therapies provides fundamental information for improvement of those therapies, in addition to the article highlighting future opportunities, commercial advancements, and various applications of CAR T cell therapy in different cancer cells. In the entire review article, we have highlighted the neck and crop of CAR T cell therapy, from which it is easy to understand the therapy and the need for this therapy in cancer prevention and its progress.

关键词： Cancer Immunotherapy Chimeric Antigen Receptor Co-Stimulatory Domain Cell Trafficking Hematological Malignancy

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苯巴比妥和卡马西平应用于儿童期癫痫的副作用:随机对照研究

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英国医学杂志中文版 2007年第5期10卷 272-275页

作者： Selina H Banu Moshrat Jahan Umme kulsum Koli Saadia Ferdousi Naila Z Khan Brian Neville 魏研萍 clinical neurophysiologist and paediatric neurologist primary care physician trained in childhood epilepsy child psychologist professor of child development and neurology Prince of Wales's professor of childhood epilepsy

目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2～15岁全身性强直-阵挛发作(51例)或局限性继发全身... 详细信息

目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2～15岁全身性强直-阵挛发作(51例)或局限性继发全身性发作(57例)的患儿。主要结局评估指标癫痫控制和行为学副作用。结果 91例患儿随访12个月。6例需改用其他抗癫痫药物。比较了85例患儿的药物副作用。药物治疗和随访1年,在随访中的后1/4时间,71例患儿未再癫痫发作。随机分组后,苯巴比妥组32例102天、卡马西平组39例74天未再癫痫发作。10例患儿行为学问题增多,其中4例不能接受(苯巴比妥组1例,卡马西平组3例)。但独立 t 检验显示,两组试验药物间没有显著性差异。结论在资源缺乏的国家,苯巴比妥不引起癫痫儿童过多的行为学副作用。临床试验注册号 NCT00381537[***]。

关键词：药物副作用随机对照研究儿童期癫痫苯巴比妥卡马西平强直一阵挛发作抗癫痫药物全身性发作

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