检索结果-南通市图书馆

Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy

引用

Asian Journal of Andrology 2016年第1期18卷 54-59页

作者： Eu chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung Department of Urology Chonnam National University Medical School Gwangju Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju Republic of Korea Department of Radiology Chonnam National University Medical School Gwangju Republic of Korea Department of Hemato-oncology Chonnam National University Medical School Gwangju Republic of Korea Department of Neurosurgery Chonnam National University Medical Schoo Gwangju Republic of Korea

Several studies have revealed that the preoperative serum testosterone and percent tumor volume （PTV） predict extra-prostatic extension （EPE） and biochemical recurrence （BCR） after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy （LRP）. We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen （PSA）〉0.2 ng ml^-1. The threshold for serum total testosterone was 3.0 ng ml^-1, Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone （〈3.0 ng ml^-1） was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone （〈3.0 ng ml^-1, adjusted OR, 8.52; 95% CI, 5.04-14.4, P = 0.001） predicted EPE and PTV （adjusted OR, 1.02; 95% CI, 1.01-1.05, P = 0.046） predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.

关键词： biochemical recurrence extra-prostatic extension prostate neoplasms prostatectomy testosterone tumor burden

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

引用

Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD ***,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis

引用

Hepatobiliary Surgery and Nutrition 2021年第3期10卷 301-307页

作者： Kevin K.W.Chu Albert C.Y.chan Ka Wing Ma Wong Hoi She Wing Chiu Dai Kenneth S.H.Chok Tan To Cheung Chung Mau Lo Department of Surgery The University of Hong KongHong KongChina

Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(HCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting ***:Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were *** logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was ***:Totally 152 patients were ***-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected ***-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of US$91,000,$150,000 and$10,600 *** the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at US$1,***:Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP≥400 ng/mL or bilobar *** routine use in preoperative workup for all HCC patients is not *** disease with AFPng/mL can achieve good negative predictive value for PET-detected *** patients with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative HCC workup.

关键词： Cost-effectiveness study dual-tracer positron emission tomography-computed tomography(dual-tracer PET-CT) hepatocellular carcinoma(HCC) metastatic screening preoperative investigation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

对复平面上Julia集的控制与同步

引用

纺织高校基础科学学报 2014年第3期27卷 342-346页

作者：张权义周敏郑红婵西北工业大学理学院陕西西安710129

探讨了复平面上Julia集的控制与同步.首先,采用联合控制法来控制不动点的稳定性,得到控制后的Julia集随着控制参数的选择逐渐收缩.其次,采用梯度控制法对2个不同Julia集进行同步控制,得到其中一个Julia集随着控制参数的增大逐渐耦合到... 详细信息

探讨了复平面上Julia集的控制与同步.首先,采用联合控制法来控制不动点的稳定性,得到控制后的Julia集随着控制参数的选择逐渐收缩.其次,采用梯度控制法对2个不同Julia集进行同步控制,得到其中一个Julia集随着控制参数的增大逐渐耦合到另一个Julia集,从而实现2个不同Julia集的同步.通过Matlab作图显示了控制方法的有效性.

关键词： Julia集联合控制方法同步控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

QuEChERS方法及其在食品农药多残留分析中的应用

引用

中国食品添加剂 2009年第2期20卷 144-148页

作者：袁雪婵昆明理工大学生命科学与技术学院昆明650224

农药残留分析是分析化学中最复杂的领域,其原因主要是需分离和测定的残留农药量往往是在ng、pg甚至在fg级。一次成功的分析需要有许多操作条件的正确结合和选择,尤其是萃取和净化方法的成功应用,传统样品前处理技术存在许多不足,如单个... 详细信息

农药残留分析是分析化学中最复杂的领域,其原因主要是需分离和测定的残留农药量往往是在ng、pg甚至在fg级。一次成功的分析需要有许多操作条件的正确结合和选择,尤其是萃取和净化方法的成功应用,传统样品前处理技术存在许多不足,如单个样品提取、净化时间较长,有毒溶剂消耗量大,给操作者及环境带来危害,现代样品制备技术正向着经济、节约、减少环境污染、微型化和自动化的方向发展。2003年,由美国农业部农业研究服务中心的Anastassiades M,Lehotay SJ[1]等开发了一种快速、简便、价格低廉的预处理方法来实现高质量的农药多残留物分析方法—QuEChERS法。QuEChERS是一种快速(Quick)、简便(Easy)、廉价(Cheap)、有效(Effective)、耐用(Rugged)、安全(Safe),用于检测食品中农药残留的前处理方法,该法采用含1%醋酸的乙腈提取,加入硫酸镁和氯化钠混合物促使其分层,上清液加入PSA和无水硫酸镁净化分离,最后加入分析保护剂进行GC/MS分析。QuEChERS法的平均样品添加回收率高于85%,干扰目标物检测的杂质少,溶剂用量小,操作简便、快速等特点,将是世界各国小型实验室常规检测农药多残留物的首选预处理方法。

关键词： QuEChERS 农药残留样品前处理研究进展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

原煤可磨性对气流床粉煤气化混配煤煤粉均匀程度的影响

引用

燃料化学学报 2016年第3期44卷 287-294页

作者：刘霞潘婵婵陆海峰梁钦锋郭晓镭龚欣华东理工大学煤气化及能源化工教育部重点实验室上海200237

以气流床粉煤气化工业装置不同时期的两组进料煤粉为研究对象,在实验室按粒径对两组煤粉进行了筛分分组,对分组后子煤粉进行了煤质、煤灰特性及反应活性分析,研究了原煤可磨性差异对混配磨制后煤粉均匀程度的影响。结果表明,原煤可磨性... 详细信息

以气流床粉煤气化工业装置不同时期的两组进料煤粉为研究对象,在实验室按粒径对两组煤粉进行了筛分分组,对分组后子煤粉进行了煤质、煤灰特性及反应活性分析,研究了原煤可磨性差异对混配磨制后煤粉均匀程度的影响。结果表明,原煤可磨性对混煤煤粉的颗粒粒径分布及其均匀性均具有影响。混配磨制煤粉的粒径主要取决于原煤中可磨性指数较小的原煤,此原煤可磨性指数越小,煤粉颗粒粒径越大;可磨性相近的原煤混配制得的煤粉混合较均匀,可磨性差异较大的原煤混配煤粉混合不均,煤粉发生偏析,使得大颗粒煤粉中含有过多的难磨煤,导致煤粉的反应性能变差。

关键词：原煤可磨性粉煤气化混配煤煤粉均匀程度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

动态增强MRI、扩散加权MRI以及18F-FDGPET/CT对口咽与下咽鳞状细胞癌病人化疗后生存率的预测

引用

国际医学放射学杂志 2017年第1期 107-108页

作者： S.H.ng C.T.Liao C.Y.Lin S.C.chan Y.C.Lin T.C.Yen 柴超 Department of Medical Imaging and Radiological Sciences Chang Gung Memorial Hospital Chang Gung University

摘要目的前瞻性评估治疗前动态增强MRI、扩散加权MRI与;F-FDG PET/CT对口咽与下咽鳞状细胞癌病人化疗后生存率的预测。方法组织学证实的患有口咽与下咽鳞状

关键词：扩散加权口咽 MRI 动态增强病人化疗鳞状细胞癌生存率 CT

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国南方鼻咽鳞状细胞癌与EB病毒感染的关系(英文)

引用

癌症 1999年第1期18卷 9-15,19页

作者：宗水生张锦霞陈国雄容振威吴文翰 Middeldorp J.M. Department of Pathology Sun Yat sen University of Medical Sciences Guangzhou China Department of Microbiology University of Hong Kong Hong Kong China Department of Pathology Free University Hospital The Netherlands

目的：探讨中国南方鼻咽癌高发区鼻咽鳞状细胞癌或称角化性鳞状细胞癌（Keratinizingsquamouscellcarcinoma，KSCC）是否也如非角化性癌那样与EB病毒感染有密切的关系。方法：应用PCRSouthernblotting、原位分子杂交和免疫组化法检测38... 详细信息

目的：探讨中国南方鼻咽癌高发区鼻咽鳞状细胞癌或称角化性鳞状细胞癌（Keratinizingsquamouscellcarcinoma，KSCC）是否也如非角化性癌那样与EB病毒感染有密切的关系。方法：应用PCRSouthernblotting、原位分子杂交和免疫组化法检测38例鼻咽鳞状细胞癌组织中EB病毒DNA及其产物EBNA－1，EBNA－2，EBERs，LMP-1，ZEBRA，EA－D，VCA和MA的表达。结果：（1）37例鳞状细胞癌组织中有EBERs阳性癌细胞出现，阳性率达97．4％（37／38）；（2）在37例鳞状细胞癌中的大部分未分化和低分化癌细胞表达EBNA－1和EBERS，21例（56．8％，21／37）组织内有LMP－1表达；（3）其中23例（62．2％，23／37）组织中只有少数癌细胞表达ZEBRA或／和EA－D；（4）22例（59．5％，22／37）组织中分化较好的或角化性癌细胞表达VCA或／和MA。结论：（1）中国南方地区鼻咽鳞状细胞癌与非角化性癌一样与EB病毒的感染有着较恒定而非偶然的关系；（2）鳞状细胞癌组织中大多数未分化和低分化癌细胞均以11型潜伏状态感染EB病毒，主要表达EBNA－1、EBERS和LMP－1，其中一小部分癌细胞也表达溶解期流产型蛋白ZEBRA和EA－D；（3）EB病毒在大部分分化好的和角化性癌细胞中则能够完成其复制周期并表达溶解晚期蛋白VCA或／和MA。

关键词：鼻咽肿瘤鳞状细胞癌 E-B病毒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

急性白血病患者1056例资料分析

引用

白血病．淋巴瘤 2009年第8期18卷 471-472页

作者：庞丽萍徐海婵许蕾钟凤鸾张倩柳金张红宇北京大学深圳医院血液科深圳518036

目的初步研究深圳市急性白血病（AL）发病及可能致白血病危险因素特点。方法回顾分析了2002年至2007年收治的1056例AL患者的资料。结果男性患者较女性患者多见（男：女=1．78：1），急性髓系白血病（AML）患者较急性淋巴细胞性白血病（... 详细信息

目的初步研究深圳市急性白血病（AL）发病及可能致白血病危险因素特点。方法回顾分析了2002年至2007年收治的1056例AL患者的资料。结果男性患者较女性患者多见（男：女=1．78：1），急性髓系白血病（AML）患者较急性淋巴细胞性白血病（ALL）患者多见（AML：ALL=1．8751），AML以青壮年为主（65％），ALL老年少见（1．33％）；AL病例数呈逐年增高趋势；治疗相关性白血病比例明显低于国外文献报道，且主要原因是肿瘤放、化疗和银屑病口服乙双吗啉所致。结论进一步肯定了有关我国急性白血病发病情况的一些特征，同时也提出了一些新的特点，这些新的变化有待于下一次全国性白血病流行病学调查来加以证实。

关键词：白血病,急性病因学危险因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of growth and differentiation factor 6 on the tenogenic differentiation of bone marrow-derived mesenchymal stem cells

引用

Chinese Medical Journal 2013年第8期126卷 1509-1516页

作者： CHAI Wei NI Ming RUI Yun-feng ZHAng Kai-yi ZHAng Qiang XU Liang-liang chan Kai-ming LI Gang WAng Yan Department of O1 thopaedics the General Hospital of ChinesePeople's Liberation Army Beijing 100853 China Department of Orthopaedics Zhongda Hospital School ofMedicine Southeast University Nanjing Jiangsu 210009 China Department of Cardiology the General Hospital of ChinesePeople's Liberation Army Beijing 100853 China Department of Orthopaedics and Traumatology the ClaineseUniversity of Hong Kong Hong Kong SAR China Program of Stem Cell and Regeneration School of BiomedicalScience the Chinese University of Hong Kong Hong Kong SARChina

Background Recent studies showed that bone marrow-derived mesenchymal stem ceils （BMSCs） had risk of ectopic bone formation. In this study, we aimed to investigate the effect of growth and differentiation factor 6 （GDF-6） on the tenogenic differentiation of BMSCs in vitro, and then combined with small intestine submucous （SIS） to promote tendon regeneration in vivo. Methods The BMSCs were isolated from the green fluorescent protein （GFP） rats, and were characterized by multi-differentiation assays following our previous study protocol. BMSCs cultured with different concentrations of GDF-6, without growth factors served as control. After 2 weeks, mRNA expression and protein expression of tendon specific markers were examined by qRT-PCR and Western blotting to define an optimal concentration of GDF-6. Mann-Whitney U-test was used to compare the difference in relative mRNA expression among all groups; P 〈0.05 was regarded as statistically significant. The GDF-6 treated BMSCs combined with SIS were implanted in nude mice and SD rat acute patellar tendon injury model, the BMSCs combined with SIS served as control. After 12 and 4 weeks in nude mice and tendon injury model, the samples were collected for histology. Results After the BMSCs were treated with different concentration of GDF-6 for 2 weeks, the fold changes of the specific markers （Tenomodulin and Scleraxis） mRNA expression were significantly higher in GDF-6 （20 ng/ml） group （P 〈_0.05）, which was also confirmed by Western blotting result. The BMSCs became parallel in orientation after GDF-6 （20 ng/ml） treatment, but the BMSCs in control group were randomly oriented. The GDF-6 （20 ng/ml） treated BMSCs were combined with SIS, and were implanted in nude mice for 12 weeks, the histology showed neo-tendon formation. In the SD rat patellar tendon window injury model, the histology also indicated the GDF-6 （20 ng/ml） treated BMSCs combined with SIS could promote tendon regeneration. Conclusions GDF-6 has tenogenic effe

关键词： tenogenic differentiation, bone marrow-derived mesenchymal stem cells, growth and differentiation factors 6 tendon regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：