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CCS Chemistry 2024年第10期6卷 2607-2618页

作者： Yong Liu Chaopeng Li Rui Zhang Zibo Liu Zhaobin Han Zheng Wang kuiling ding State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210 Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240

A synergistic Pd/Zn dual chiral catalyst system has been developed for the stereodivergent transformation of Morita–Baylis–Hillman(MBH)carbonates and unprotectedα-hydroxyketones to afford the corresponding allylation products(>50 examples).These products bearing vicinal stereocenters were obtained in high yields with excellent regio-/diastereo-/*** cyclization in an acidic medium,the allylation products could transform to the corresponding acyl-functionalizedβ,γ-disubstitutedα-methylene-γ-butyrolactones(AMGBLs).All four stereoisomers of AMGBL were readily accessed using the same starting materials with full control of the stereochemistry of the contiguous stereogenic centers,simply by switching the chiral ligand combination for the Pd/Zn system.A nucleophilic site-divergent reactivity was observed for the allylation of primary and secondaryα-hydroxyketones,suggesting that distinct enolate intermediates might have prevailed in these reactions.

关键词： asymmetric catalysis Pd/Zn dual catalyst 2-(alkoxycarbonyl)allylation stereodivergent sitedivergent

以基础筑基础以拔尖育拔尖——上海交通大学培养中小学科学类教师的思考与实践

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中国高教研究 2024年第6期 1-5页

作者：丁奎岭中国科学院上海交通大学上海交通大学教育学院上海200240

改革开放以来,我国中小学科学教育体系建设取得了长足发展,但在新形势下仍存在高层次科学类教师数量不够、职业素养水平有待提升、培养体系有待完善等现实挑战。为主动适应中小学科学类教师队伍建设需求,教育部提出实施“国优计划”。... 详细信息

改革开放以来,我国中小学科学教育体系建设取得了长足发展,但在新形势下仍存在高层次科学类教师数量不够、职业素养水平有待提升、培养体系有待完善等现实挑战。为主动适应中小学科学类教师队伍建设需求,教育部提出实施“国优计划”。该计划以优化教育结构,特别是强化科学教育为导向,发挥高水平综合性大学雄厚的科研实力和跨学科资源优势,培养情怀深厚、能力卓越、具备科学与工程素养的高质量科学类教师。上海交通大学始终关注科学教育,率先成立教育学院,不断探索科学类教师培养新模式,为我国科学类教师的创新性培养提供了实践经验。

关键词：高水平综合性大学科学教育科学类教师国优计划

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过渡金属催化芳香碳环的选择性不对称氢化

有机化学 2024年第7期44卷 2063-2076页

作者：陈倩韩召斌丁奎岭上海理工大学材料与化学学院中国科学院上海有机化学研究所金属有机化学国家重点实验室上海交通大学化学化工学院上海交通大学变革性分子前沿科学中心

(杂)芳烃中碳环的不对称氢化是制备饱和以及部分饱和手性六元碳环化合物最直接高效的方法之一.尽管(杂)芳烃的不对称氢化在反应活性、选择性等方面存在着很大的挑战,但近年来该领域还是取得了一些突破.系统地综述了过去几十年过渡金属... 详细信息

(杂)芳烃中碳环的不对称氢化是制备饱和以及部分饱和手性六元碳环化合物最直接高效的方法之一.尽管(杂)芳烃的不对称氢化在反应活性、选择性等方面存在着很大的挑战,但近年来该领域还是取得了一些突破.系统地综述了过去几十年过渡金属催化的芳烃中碳环不对称氢化的研究进展,并讨论了该领域存在的问题及可能的发展方向.

关键词：过渡金属 (杂)芳烃不对称氢化去芳构化

Dedicated to Professor Chengye Yuan and Professor Li-Xin Dai on the Occasion of Their 90th Birthdays

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Chinese Journal of Chemistry 2014年第8期32卷 659-660页

作者： kuiling ding Shanghai Institute of Oranic Chemistry Chinese Academy of Sciences

Professor Chengye Yuan and Professor Li-Xin Dai,Members of Chinese Academy of Sciences,are eminent organic chemists in *** have made significant contributions in the field of organic chemistry in the last 6 decades in ***,they were both born in 1924 and have worked at Shanghai Institute of Organic Chemistry(SIOC)as colleagues for about 60 *** would like to take this wonderful occasion to organize this special issue of Chinese Journal of Chemistry to celebrate their 90th birthdays.

关键词： Dai wonderful birthday

Making Spiroketal-based Diphosphine （SKP） Ligands via a Catalytic Asymmetric Approach

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Chinese Journal of Chemistry 2018年第10期36卷 899-903页

作者： Xiaoming Wang kuiling ding State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences (CAS) 345 Lingling Road Shanghai 200032 China

The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all-carbon spiro backbones, the development of catalytic asymmetric synthesis of chiral spiro structures via short steps is highly valuable. Herein we present our studies on the catalytic asymmetric synthesis of aromatic spiroketals and the corresponding diphos- phine （SKP） ligands.

关键词： chiral ligand spiro compounds spiroketal asymmetric catalysis hydrogenation

Enantioselective Ring Opening of meso-Epoxides with Aro- matic Amines Catalyzed by Dinuclear Magnesium Complexes

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Chinese Journal of Chemistry 2013年第1期31卷 67-71页

作者： Hongli Bao Zheng Wang Tianpa You kuiling ding State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Department of Chemistry University of Science and Technology of China Hefei Anhui 230026 China

The dinuclear magnesium complexes generated in situ from the reaction of chiral multidentate semi-azacrown ether ligands with n-BuzMg were found to be efficient catalysts for enantioselective ring-opening of meso-epox- ides with aniline derivatives, affording the corresponding chiral β-amino alcohols in good yields with up to 90% ee.

关键词： meso-epoxides ring-opening asymmetric catalysis dinuclear complex magnesium

Synthesis of chiral 1,3-bis(1-(diarylphosphoryl)ethyl)-benzenes via Ir-catalyzed double asymmetric hydrogenation of bis(diarylvinylphosphine oxides)

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Science China Chemistry 2014年第8期57卷 1073-1078页

作者： LIU Xu HAN ZhaoBin WANG Zheng ding kuiling State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

A class of chiral 1,3-bis(diarylphosphinoethyl)benzenes, which are key intermediates for the synthesis of PCP-type chiral pincer ligands, were prepared in high diastereomeric ratios and excellent ee values via double asymmetric hydrogenation of the corresponding bis(diarylvinylphosphine oxide) substrates using a SpinPhox/Ir(I) complex as the catalyst. The hydrogenation product 5a was readily transformed into the corresponding borane-protected chiral PCP-type pincer ligand 7a with high enantiomeric excess, exemplifying a viable synthetic route to optically active chiral PCP pincer ligands.

关键词： bis(diarylvinylphosphine oxide) iridium asymmetric hydrogenation PCP-type chiral pincer ligands

Recent advances in catalytic asymmetric hydrogenation:Renaissance of the monodentate phosphorus ligands

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Chinese Science Bulletin 2004年第19期49卷 2003-2016页

作者： GUO Hongchao ding kuiling DAI Lixin State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The history for the development of chiral phos- phorus ligands in catalytic asymmetric hydrogenation is briefly highlighted. This review focuses on the recent ad- vances in the synthesis of the monodentate phosphorus ligands and their applications in catalytic asymmetric hydrogenation. The examples highlighted in this article clearly demonstrated the importance and advantages of monodentate phosphorus ligands, which had been ignored for 30 a and experienced arenaissance at the very beginning of this millennium, particularly in the area of asymmetric hydrogenation.

关键词： chiral phosphorus ligands monodentate ligands asym-metric catalysis hydrogenation

Synthesis of novel chiral bisoxazoline ligands with a spiro[4,4]-1,6-nonadiene skeleton

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Chinese Science Bulletin 2010年第25期55卷 2840-2846页

作者： HAN ZhaoBin WANG Zheng ZHANG XuMu ding kuiling State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Department of Chemistry and Chemical Biology Center of Molecular Catalysis Rutgers The State University of New Jersey New Jersey 08854-8066 USA

A new type of chiral bisoxazoline ligands 1 based on spiro[4,4]-1,6-nonadiene backbone was easily prepared in six steps from racemic spiro[4,4]-nonane-1,6-dione,with the Pd-catalyzed coupling of the enol triflates with CO and amino alcohols as the key steps for the construction of the oxazoline moiety. The structure of the ligand (R,S,S)-1b was unambiguously established by X-ray crystallographic analysis. The chiral Cu(II) complex generated in situ from the combination of spiro bisoxazoline ligand (S,S,S)-1c and Cu(OTf)2 was effective in the catalysis of asymmetric chlorination of the β-ketoester,methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate,affording the corresponding chlorinated derivative in 99% yield with 17% ee.

关键词：双恶唑啉配体手性铜(Ⅱ)配合物 X射线晶体分析螺合成骨架

Preface to Special Issue on Catalysis in Organic Synthesis

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催化学报 2015年第1期36卷 2-2页

作者： kuiling ding Yonggui Zhou Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Dalian Institute of Chemical Physics Chinese Academy of Sciences

Organic synthesis plays a central role in chemistry. The cre-ation of compounds with new properties and functions both distinguishes synthetic chemistry from other sciences and also emphasizes chemistry’s central place in science. In principle, the possibilities for atomic and molecular manipulation are unlimited, which provides a firm molecular basis for biosci-ence, materials science and medical science. Man-made chemi-cals have entered many research fields where they play im-portant roles. Synthesis is changing all aspects of human socie-ty and improving the quality of our life. Catalysts are

关键词：有机合成合成化学催化医学科学通货膨胀中心位置分子操纵分子基础