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Diagnostic performance of narrow-band imaging international colorectal endoscopic and Japanese narrow-band imaging expert team classification systems for colorectal cancer and precancerous lesions

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 58-68页

作者： Yun Wang Wen-Kun Li Ya-Dan Wang kui-liang liu Jing Wu Department of Gastroenterology Peking University Ninth School of Clinical MedicineBeijing 100038China Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing 100050China

BACKGROUND In recent years,two new narrow-band imaging(NBI)classifications have been proposed:The NBI international colorectal endoscopic(NICE)classification and Japanese NBI expert team(JNET)*** validation studies of the two new NBI classifications were conducted in classification setting units by experienced endoscopists,and the application of use in different centers among endoscopists with different endoscopy skills remains *** To evaluate clinical application and possible problems of NICE and JNET classification for the differential diagnosis of colorectal cancer and precancerous *** Six endoscopists with varying levels of experience participated in this ***-seven consecutive patients with a total of 125 lesions were photographed during non-magnifying conventional white-light colonoscopy,non-magnifying NBI,and magnifying *** three groups of endoscopic pictures of each lesion were evaluated by the six endoscopists in randomized order using the NICE and JENT classifications *** we calculated the six endoscopists’sensitivity,specificity,accuracy,positive predictive value,and negative predictive value for each category of the two *** The sensitivity,specificity,and accuracy of JNET classification type 1 and 3 were similar to NICE classification type 1 and 3 in both the highly experienced endoscopist(HEE)and less-experienced endoscopist(LEE)*** specificity of JNET classification type 1 and 3 and NICE classification type 3 in both the HEE and LEE groups was>95%,and the overall interobserver agreement was good in both *** sensitivity of NICE classification type 3 lesions for diagnosis of SM-d carcinoma in the HEE group was significantly superior to that in the LEE group(91.7%vs 83.3%;P=0.042).The sensitivity of JNET classification type 2B lesions for the diagnosis of high-grade dysplasia or superficial submucosal invasive carcinoma in the HEE and LEE groups was 53.8%and 51.3

关键词： Narrow-band imaging international colorectal endoscopic Japanese narrowband imaging expert team Colorectal neoplasms Precancerous lesions Colorectal endoscopy Narrow-band imaging

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Diagnostic value of novel retroflexion colonoscopy in the right colon: A randomized controlled trial

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1336-1345页

作者： Wen-Kun Li Yun Wang Ya-Dan Wang kui-liang liu Chun-Mei Guo Hui Su Hong liu Jing Wu Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China National Clinical Research Center for Digestive Diseases Beijing 100050China Department of Gastroenterology Peking University Ninth School of Clinical MedicineBeijing 100038China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing 100050China

BACKGROUND Colonoscopy is the accepted gold standard for the detection of colorectal cancer. However, colonoscopy is less effective in preventing colon cancer in the right side compared with the left *** To investigate the feasibility of a novel type of retroflexion colonoscope, EC-3490 Ti colonoscope, for detection of proximal colon *** In this prospective trial, we recruited patients who underwent colonoscopy for screening or surveillance. When the endoscopists could not grasp the whole observation of the right-side colon mucosa in the forward view(FV), insertion and withdrawal were repeatedly performed in the FV group with the EC38-i10 F colonoscope while retroflexion was performed in the retroflexed view(RV) group with the EC-3490 Ti colonoscope. Adenoma detection rate, the total number of adenomas per positive participant, the success rate of retroflexion, and endoscope withdrawal time were recorded and *** The total adenoma detection rate(39.3% vs 37.7%, P = 0.646) did not show any significant difference between the two groups. However, the polyp detection rate(59.6% vs 51.0%, P = 0.002), adenoma detection rate in the right colon(21.6% vs 14.4%, P = 0.012), and the total number of adenomas per positive participant(2.1 vs 1.7, P = 0.011) reached statistical significance. Retroflexion was achieved in 91.7% of our cohort. Compared with the FV group, the withdrawal time was significantly prolonged in the RV group(586.1 ± 124.4 s vs 508.8 ± 129.6 s, P < 0.001). In contrast, the proportion of additional ancillary pressure decreased(27.4% vs 45.7%, P < 0.001), and the visual analog scale pain scores did not increase(2.7 ± 1.4 vs 2.8 ± 1.4, P = 0.377).CONCLUSION Retroflexion in the proximal colon could be performed successfully and safely with the EC-3490 Ti colonoscope. This maneuver could detect more adenomas effectively.

关键词： Colorectal adenoma Retroflexion Right colon Adenoma detection rate Cancer

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Malignant glomus tumor of the intestinal ileum with multiorgan metastases:A case report and review of literature

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World Journal of Gastroenterology 2020年第7期26卷 770-776页

作者： Jian-Hong Chen Lin Lin kui-liang liu Hui Su Ling-Ling Wang Peng-Peng Ding Quan Zhou Hong liu Jing Wu Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Pathology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseasesBeijing 100050China

BACKGROUND Glomus tumors(GTs)are rare mesenchymal neoplastic lesions derived from cells of the glomus *** rarely occurs in the visceral organs,where there may be few or no glomus bodies,and the majority of GTs are benign,rarely demonstrating aggressive or malignant behavior and histological *** SUMMARY We report a patient with malignant GTs of the intestinal ileum with multiorgan metastases who was admitted due to moderate *** endoscopy revealed a bleeding mass in the intestinal ileum,and the patient underwent segmental ileal resection through laparoscopic *** histopathological and immunohistochemical diagnoses were consistent with malignant *** follow-up showed that the GT had metastasized to multiple organs such as the colon,brain,and possibly the *** This case was characterized by the highest degree of malignancy and by multiorgan metastases,and it was the first case of intestinal GT uncovered by capsule endoscopy.

关键词： Malignant glomus tumor Intestine Metastases Capsule endoscopy Diagnosis Case report

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Endoscopic classification and pathological features of primary intestinal lymphangiectasia

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World Journal of Gastroenterology 2022年第22期28卷 2482-2493页

作者： Ming-Ming Meng kui-liang liu Xin-Ying Xue Kun Hao Jian Dong Chun-Kai Yu Hong liu Cang-Hai Wang Hui Su Wu Lin Guo-Jun Jiang Nan Wei Ren-Gui Wang Wen-Bin Shen Jing Wu Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Respiratory and Critical Care Medicine Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Lymphatic Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Departments of Pathology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND The appearance of the intestinal mucosa during endoscopy varies among patients with primary intestinal lymphangiectasia(PIL).AIM To classify the endoscopic features of the intestinal mucosa in PIL under endoscopy,combine the patients’imaging and pathological characteristics of the patients,and explain their *** We retrospectively analyzed the endoscopic images of 123 patients with PIL who were treated at the hospital between January 1,2007 and December 31,*** compared and analyzed all endoscopic images,classified them into four types according to the endoscopic features of the intestinal mucosa,and analyzed the post-lymphographic computed tomography(PLCT)and pathological characteristics of each *** According to the endoscopic features of PIL in 123 patients observed during endoscopy,they were classified into four types:nodular-type,granular-type,vesicular-type,and *** showed diffuse thickening of the small intestinal wall,and no contrast agent was seen in the small intestinal wall and mesentery in the patients with nodular and granular *** agent was scattered in the small intestinal wall and mesentery in the patients with vesicular and edematous *** of the small intestinal mucosal pathology revealed that nodular-type and granulartype lymphangiectasia involved the small intestine mucosa in four layers,whereas ectasia of the vesicular-and edematous-type lymphatic vessels largely involved the lamina propria mucosae,submucosae,and muscular *** Endoscopic classification,combined with the patients’clinical manifestations and pathological examination results,is significant and very useful to clinicians when scoping patients with suspected PIL.

关键词： Primary intestinal lymphangiectasia Endoscopic features Post-lymphangiographic computed tomography Pathology

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-kui liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang liu Shuang Li liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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慢性腹泻起病的多发性骨髓瘤1例

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世界华人消化杂志 2016年第32期24卷 4415-4418页

作者：张梦巧刘揆亮王亚丹宿慧吴静刘红首都医科大学附属北京世纪坛医院消化内科北京市100038

多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞恶性增殖性疾病.MM起病时表现多样,临床症状体征不典型.本文报道一例患者,以不明原因慢性腹泻起病,各种化验多无特异性提示,在排除了多种因素后,因骨髓穿刺及活检提示浆细胞增生,可见浆... 详细信息

多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞恶性增殖性疾病.MM起病时表现多样,临床症状体征不典型.本文报道一例患者,以不明原因慢性腹泻起病,各种化验多无特异性提示,在排除了多种因素后,因骨髓穿刺及活检提示浆细胞增生,可见浆细胞及浆母细胞,血清M蛋白阳性而确诊MM.临床医师应提高对此类病例的认识,及时完善相关检查,避免漏诊、误诊.

关键词：慢性腹泻多发性骨髓瘤淀粉样变性

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Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian liang Li Xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-kui Wang Di Zhang Jin-Feng Wang Wan-Lin Lu Jing-Yuan Wang Shi-Feng liang Ran liu Jing-Xin Jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo liang Chao Wang Yunhong Zhang Hong liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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