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Neuroprotection and its molecular mechanism following spinal cord injury

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Neural Regeneration Research 2012年第26期7卷 2051-2062页

作者： Nai-kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery & GoodmanCampbell Brain and Spine Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis IN 46202 USA

Acute spinal cord injury initiates a complex cascade of molecular events termed ＇secondary injury＇, which leads to progressive degeneration ranging from early neuronal apoptosis at the lesion site to delayed degeneration of intact white matter tracts, and, ultimately, expansion of the initial injury. These secondary injury processes include, but are not limited to, inflammation, free radical-induced cell death glutamate excitotoxicity, phospholipase A2 activation, and induction of extrinsic and intrinsic apoptotic pathways, which are important targets in developing neuroprotective strategies for treatment of spinal cord injury. Recently, a number of studies have shown promising results on neuroprotection and recovery of function in rodent models of spinal cord injury using treatments that target secondary injury processes including inflammation, phospholipase A2 activation, and manipulation of the PTEN-AktJmTOR signaling pathway. The present review outlines our ongoing research on the molecular mechanisms of neuroprotection in experimental spinal cord injury and briefly summarizes our earlier findings on the therapeutic potential of pharmacological treatments in spinal cord injury.

关键词： spinal cord injury neuroprotection inflammation oxidation apoptosis glucocorticoid receptor phospolipase A2 microRNAs signaling pathway

Effects of Soil Properties on Phosphorus Subsurface Migration in Sandy Soils

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Pedosphere 2008年第5期18卷 599-610页

作者： ZHANG ming-kui College of Natural Resource and Environmental Sciences Zhejiang University Huajiachi Campus Hangzhou 310029（China）.

The soil factors influencing the potential migration of dissolved and particulate phosphorus(P) from structurally-weak sandy subsoils were evaluated by means of soil column leaching experiments. Soil colloids were extracted from two types of soils to make the colloid-bound forms of P solution. Eight sandy soils with diverse properties were collected for packing soil columns. The effects of influent solutions varying in concentrations of colloids,P,and electrolyte,on the transport of P and quality of leachates were characterized. P migration in the soils was soil property-dependent. High soil electrical conductivity values retarded the mobility of colloids and transportability of colloid-associated P(particulate P) . Soil electrical conductivity was negatively correlated with colloids and reactive particulate P(RPP) concentrations in the leachates,whereas,the total reactive P(TRP) and dissolved reactive P(DRP) concentrations in the leachates were mainly controlled by the P adsorption capacity and the P levels in the subsoil. The reactive particulate P in the leachates was positively correlated with the colloidal concentration. Increased colloidal concentration in the influent could significantly increase the colloidal concentration in the leachates. Elevated P concentration in the influent had little effect on P recovery in the leachates,but it resulted in significant increases in the absolute P concentration in the leachates.

关键词：沙土磷地下迁移土壤性能

滇西南西盟—澜沧地区土壤稀土地球化学异常的发现及找矿意义

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物探与化探 2024年第3期48卷 660-667页

作者：谢岿锐宋旭锋周坤周余国佘中明唐鉴云南省地质调查院云南昆明650214 自然资源部三江成矿作用及资源勘查利用重点实验室云南昆明650061 云南省核工业地质调查院云南昆明650106 云南大学地球科学学院云南昆明650091 云南省地质勘查基金管理中心云南昆明650224

滇西南西盟—澜沧地区属西南“三江”造山带南段,通过1∶5万土壤地球化学测量工作,发现研究区稀土地球化学异常24个,并主要集中分布在昌宁—孟连深大断裂带上及其附近的石炭系平掌组基性火山岩、石炭—二叠系鱼塘寨组碳酸盐沉积岩地层... 详细信息

滇西南西盟—澜沧地区属西南“三江”造山带南段,通过1∶5万土壤地球化学测量工作,发现研究区稀土地球化学异常24个,并主要集中分布在昌宁—孟连深大断裂带上及其附近的石炭系平掌组基性火山岩、石炭—二叠系鱼塘寨组碳酸盐沉积岩地层中。通过对评序靠前的AP00稀土地球化学异常进一步进行1∶1万土壤地球化学测量、1∶1万专项地质测量和少量的轻型山地探矿工程等工作的详细解剖,首次在沉积型碳酸盐岩地层中发现了新型的风化壳型稀土矿,初步估算稀土资源量已达中型规模,取得了较好的找矿突破,拓宽了找矿思路,值得业界借鉴。通过区域地质地球化学背景和AP00稀土异常区资料的综合分析,认为AP00风化壳型稀土矿的形成是经历了4次不同地质作用逐渐富集成矿的过程,是多因复成型稀土矿。根据AP00稀土矿的浸出率较低,重稀土Y元素构造(岩浆)叠加成矿作用明显,推断在深部可能存在以钇为主的重稀土原生矿,预示着寻找重稀土矿具有较大潜力。

关键词：稀土地球化学异常风化壳型稀土矿找矿意义土壤西盟—澜沧

Modular divergent creation of dual-cocatalysts integrated semiconducting sulfide nanotriads for enhanced photocatalytic hydrogen evolution

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Nano Research 2023年第5期16卷 7967-7973页

作者： Chao Gu Yu-Qing Liu Guo-Qiang Liu Hou-ming Xu Yi Li Xiao-Long Zhang Liang Wu Lei Shi Shi-kui Han Min-Rui Gao Shu-Hong Yu Department of Chemistry Institute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleInstitute of EnergyHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Heteronanostructures(HNs)with precise components and interfaces are important for many applications,such as designing efficient and robust solar-to-fuel catalysts via integrating specific semiconductors with favorable band ***,rationally endowing such features with rigorous framework control remains a synthetic ***,we report a modular divergent creation of dual-cocatalysts integrated semiconducting sulfide nanotriads(NTds),comprising both isolated Pd_(x)S oxidation(ox)and MoS_(2) reduction(red)domains within each single CdS counterpart,which exhibit superior photocatalytic activity and stability for hydrogen evolution reaction(HER).The stepwise constructed Pd_(x)S_((ox))−CdS−MoS_(2(red)) NTds possess dualinterfaces facilitating continuous charge separation and segregated active sites accelerating redox reactions,respectively,achieving the HER rate up to 9 mmol·h^(−1)·g^(−1),which is about 60 times higher than that of bare CdS,and show no evidence of deactivation after long-term *** design principle and transformation protocol provide predictable retrosynthetic pathways to HNs with increased degree of complexity and more elaborate functionalities that are otherwise inaccessible.

关键词： heteronanostructures colloidal synthesis semiconducting sulfides photocatalytic hydrogen evolution reaction

Stability evaluation for steep bank slope with microseismic monitoring in Three Gorges Reservoir area

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Journal of Mountain Science 2022年第6期19卷 1588-1601页

作者： XIE Qing-ming LONG kui LI Zi-mu CHEN Li-chuan LIU Hong XU Hong HE Fei LIANG Dan XIANG Xue-kun MA Qiang Chongqing College of Electronic Engineering Chongqing 401331China Technology Innovation Center of Geohazards Automatic Monitoring Ministry of Natural ResourcesChongqing Institute of Geology and Mineral ResourcesChongqing 401120China College of Computer and Information Science College of Software Southwest UniversityChongqing 400715China Chongqing Rail Transit Design and Research Institute Chongqing 401122China

Rock slide is one of the common geohazard in the Three Gorges Reservoir area, and it affects the shipping of the Yangtze River and the safety of people living on the banks. In order to investigate the internal fracturing mechanism of rock mass, distributed microseismic monitoring network was arranged with 15 three component geophones(3C geophones), deployed at borehole and out of the sliding mass in the unstable Dulong slope. Stein Unbiased Risk Estimation(SURE) method was used to noise suppression for the microseismic record, and decomposition parameters of the Continuous Wavelet Transform(CWT) were determined with maximum energy of correlation coefficient(MECC) method. The signal-to-noise ratio was tripled after the process, and source parameters are obtained with full waveform inversion. The rupture volume model was counted by the irregular grid statistics with the events’ density. It shows that the rock slide is of a small scale and composed of a single block. Moreover, the relationship among microseismicity, displacement and rainfall were discussed in the paper. The deformation rate was dramatically changed in the period of intensive events. There is a good consistency especially in the rainfall period. Although there is a time delay, continuous rainfall is more likely to cause the increase of microseismic events. The results show that the Dulong slope is a shallow rock slide in the state of creep deformation, and the rupture mechanism of the rock mass is left-lateral normal fault with shear failure. The research provides more key information for the early warning and prevention of rock slides and helps to reduce the risk of geohazards.

关键词： Stability evaluation Microseismic monitoring Rock slide Rainfall Displacement

Establishment and study of a polarized X-ray radiation facility

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Nuclear Science and Techniques 2023年第8期34卷 54-63页

作者： Xing Zhou Xiao-Yu Qie Si-ming Guo Yong-Bo Huang Zi-Yao Shu Shi-kui Huang Li-Peng Fan Kai-Yue Guo Tao Yu Jin-Jie Wu School of Physical Science and Technology Guangxi UniversityNanning 530004China National Institute of Metrology Beijing 100029China

With the advancement in X-ray astronomical detection technology,various celestial polarization detection projects have been *** meet the calibration requirements of polarimeters on the ground,a polarized X-ray radiation facility was designed for this *** design was based on the principle that X-rays incident at 45°on a crystal produce polarized X-rays,and a second crystal was used to measure the polarization of the X-rays produced by the facility after *** effects of different diaphragm sizes on the degree of polarization were compared,and the facility produced X-rays with polarization degrees of up to 99.55±0.96%using LiF200 and LiF220 *** result revealed that the polarization of incident X-rays is one of the factors affecting the diffraction efficiency of *** replacement of different crystals can satisfy the calibration requirements of polarized X-ray detectors with more energy points in the energy range(4-10)*** the future,the facility should be placed in a vacuum environment to meet the calibration requirements at lower energies.

关键词： Polarized X-rays Polarimetry Calibration Bragg diffraction

Formation of novel TRIP-ductilized bulk metallic glass composites by manipulating nucleation kinetics via minor alloying

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Rare Metals 2023年第7期42卷 2182-2188页

作者： Xi-Lai Jiang Wen-Li Song ming Yang Yuan-Bo Zhou Yan Huang Zhi-Chao Lu Yi-Bo Zhang Jie Dong Liang Wang Bo Peng Chun-ming Hu Jin-kui Zhao Sheng-Zhong Kou Dong Ma School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing100049China Spallation Neutron Source Science Center Dongguan523803China Neutron Science Platform Songshan Lake Materials LaboratoryDongguan523808China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China Institute of Physics Chinese Academy of Sciences(CAS)Beijing100190China

A series of conical bulk metallic glass composites(BMGCs)with compositions of Zr_(47)Cu_(47-x)Al_(5)Ag_(1)Ga_(x)(x=0,1,2,4;at%)were synthesized using the minor alloying method to investigate the effect of Ga addition ... 详细信息

关键词： alloying properties glass

Wave-electric field coupling imaging diagnostic method for filled subgrade

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Journal of Mountain Science 2017年第2期14卷 382-389页

作者： WANG kui ZHAO ming-jie SUN Xiao Key Laboratory of Hydraulic and Waterway Engineering of the Ministry of Education Chongqing Jiaotong UniversityChongqing 400074China School of Hydraulic and Ecology Engineering Nanchang Institute of TechnologyNanchang 330099China

Thick earth-rock filled embankment of large earthwork volume often occurs during the construction of expressways in mountainous and hilly areas. The compaction quality of earth-rock filled subgrade will directly affect the settlement deformation and stability of the embankment after filled. Therefore, effective evaluation on the compaction quality of the earth-rock filled subgrade is an unsolved critical technical issue to control the construction quality of highway engineering. Based on the wave propagation and electrical resistivity characteristics of the earth and rock fillings, a theoretical model of the compaction quality detection by wave-electric field coupling imaging diagnostic method was established. Then, two filled subgrade models containing cavities and heterogeneous bodies respectively were make separately, and by the wave velocity testing and electrical resistivity testing, the wave-electric field coupling imaging diagnostic method was applied to these two model. The result shows that it is feasible to use the wave testing technique and the electrical resistivity testing technique for a diagnostic test of the subgrade compaction quality. Based on the abnormal areas reflected by the wave velocity imaging and electrical resistivity imaging results, we are able to analyze the scope and site of distress but not able to quantitatively evaluate the subgrade compaction quality. We can accurately qualitatively analyze the subgrade compaction quality based on the wave-electric field coupling calculation model of fill subgrade quality proposed by this paper.

关键词：电阻率成像诊断方法电场耦合填方高速公路建设压实质量填石路基基波

梯度温泉水浸浴疗法对高原官兵睡眠质量的改善作用

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中国疗养医学 2024年第6期33卷 37-41页

作者：王军安俊党园园陈雪赵龙魁李金桥姜明敏战略支援部队兴城特勤疗养中心辽宁兴城125105

目的探讨梯度温泉水浸浴疗法对高原官兵睡眠质量的改善作用。方法选取2022年6月至2023年12月来战略支援部队兴城特勤疗养中心疗养的睡眠质量较差的高海拔高原官兵68例,应用随机数字表根据治疗方式不同分为对照组和实验组,每组各34例,... 详细信息

目的探讨梯度温泉水浸浴疗法对高原官兵睡眠质量的改善作用。方法选取2022年6月至2023年12月来战略支援部队兴城特勤疗养中心疗养的睡眠质量较差的高海拔高原官兵68例,应用随机数字表根据治疗方式不同分为对照组和实验组,每组各34例,对照组采取常规温泉浴疗法,实验组采取梯度温泉水浸浴疗法,治疗4周,治疗前后分别使用匹兹堡睡眠质量指数量表(PSQI)及床垫式睡眠监测仪对两组的睡眠状况进行评分及监测,对梯度温泉水浸浴疗法的治疗效果进行评价。结果经过4周治疗,实验组和对照组的PSQI总分分别由(8.83±2.23)分和(8.70±2.09)分降为(5.67±2.55)分和(8.00±2.12)分,实验组治疗前后PSQI总分比较,差异有高度统计学意义(P<0.001),治疗后两组PSQI总分比较,差异有统计学意义(P=0.010);实验组和对照组的夜间总睡眠时间分别由(7.03±1.99)h和(6.77±1.78)h增加到(8.93±0.97)h和(7.07±1.11)h,夜间总睡眠时间在实验组治疗前后(P=0.002)和两组治疗后差异有统计学意义(P=0.029);实验组和对照组的入睡后清醒时间分别由(61.50±33.27)min和(63.50±47.38)min降低为(25.50±22.68)min和(55.17±25.24)min,入睡后清醒时间在实验组治疗前后(P<0.001)和两组治疗后差异有统计学意义(P=0.031);经过治疗,两组的睡眠结构均趋向于正常,实验组与对照组睡眠各期所占比例相比,差异均有统计学意义(P<0.05)。结论梯度温泉水浸浴疗法在改善高原官兵睡眠质量、延长夜间总睡眠时间、缩短入睡后清醒时间以及使异常的睡眠结构趋于正常化方面具有显著作用。

关键词：温泉浴梯度温泉水疗法高原官兵睡眠质量