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a. a.proa.h of the interna. friction-dependent tempera.ure cha.ges for conventiona. a.d pure biogenic lubrica.ing grea.es

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Friction 2024年第4期12卷 780-795页

作者： Leif a.ME Erik kuhn MiguelÁngel DELGa.O Depa.tment of Mecha.ica. Engineering a.d Production Ma.a.ement Hamburg University of Applied SciencesHamburg 20099Germany Depa.tment of Chemica. Engineering Research in Product Technology and Chemical Processes(Pro2TecS)University of HuelvaHuelva 21071Spain

This work investiga.ed the tempera.ure cha.ges inside the bulk of lubrica.ing grea.es under controlled high-shea. stress conditions(250-500 s-1).For this purpose,a.newly developed tempera.ure-mea.uring cell ca.led Ca.idus wa. successfully *** tempera.ure cha.ges(ΔT)ha.e been rela.ed to the grea.es'components(thickener,ba.e oil-type,a.d composition)a.d the structura. degra.a.ion of the lubrica.ing ***,a.theoretica. a.proa.h wa. proposed for ca.cula.ing the interna. tempera.ure cha.ge of lubrica.ing grea.es during shea. *** grea.es showed a. interna. tempera.ure profile cha.a.terised by a.sudden rise inΔT within the first 4 h from sta.ting the test a.d subsequentΔT deca. until it rea.hes the stea.y sta.e ***,it wa. found tha. grea.es C1 a.d C5,formula.ed with lithium a.d ca.cium soa.,respectively,with different soa. content(16.1 wt%a.d 9.7 wt%,respectively),but the sa.e ba.e ca.tor oil,showed the highest va.ue of the ma.imumΔT,c.a.3.2 K,a.d the most dra.tic drop ofΔ*** grea.es showed both the highest specific densities a.d hea. *** a.dition,they showed the lowest ra.io of expended energies(Rtee),which mea.s more structura. degra.a.ion in the stressed *** the contra.y,the grea.e C3,with 13 wt%of Li-soa. but the lowest ba.e oil's viscosity,showed the lowest ma.imumΔT a.d the tempera.ure profile wa. cha.a.terised by a.modera.e va.ia.ion ofΔT a.ong the *** biogenic grea.e B3 developed a.low-tempera.ure cha.ge in the group of pure bio-genic grea.es close to grea.e C3.

关键词： shea.-induced structura. degra.a.ion rheology tempera.ure mea.urements lubrica.ing grea.es density lubrica.ing grea.es specific hea. ca.a.ities

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Dista.t cousins come to a.P1’s rescue

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Science China.Life Sciences) 2024年第1期67卷 219-220页

作者： a.dre kuhn Dolf Weijers La.ora.ory of Biochemistry Wageningen UniversityStippeneng 46708WE Wageningenthe Netherlands

There a.e few pla.t processes tha. a.e not in one wa. or a.other influenced by the a.xin signa.ing *** ma.y roles a.xin pla.s in pla.ts ha.e inspired a.ra.ge of investiga.ions towa.ds understa.ding its mecha.isms of *** recent yea.s a.d deca.es,genetic a.a.ysis in the flowering pla.t a.a.idopsis ha. been immensely successful in bringing a.nuclea. response mecha.ism to light(reviewed in Weijers a.d Wa.ner,2016).This system,the nuclea. a.xin pa.hwa.(Na.),a.ts by regula.ing gene expression,a.d when its components a.e muta.ed,growth a.d development is strongly disturbed(Weijers a.d Wa.ner,2016).

关键词： bringing disturbed a.a.idopsis

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The dua. role of stria.a. interneurons:circuit modula.ion a.d trophic support for the ba.a. ga.glia

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Neura. Regenera.ion Resea.ch 2024年第6期19卷 1277-1283页

作者： Elliot Wegma. Ma.lena.Wosiski-kuhn Yu Luo Depa.tment of Molecula. a.d Cellula. Biosciences University of CincinnatiCincinnatiOHUSA Depa.tment of Emergency Medicine a. the School of Medicine University of CincinnatiCincinnatiOHUSA Neuroscience Gra.ua.e Progra. University of CincinnatiCincinnatiOHUSA

Stria.a. interneurons pla. a.key role in modula.ing stria.a.-dependent beha.iors,including motor a.tivity a.d rewa.d a.d emotiona. *** not only provide modula.ion to the ba.a. ga.glia.circuitry under homeosta.is but a.e a.so involved in cha.ges to pla.ticity a.d a.a.ta.ion during disea.e conditions such a. Pa.kinson's or Huntington's *** review a.ms to summa.ize recent findings rega.ding the role of stria.a. cholinergic a.d Ga.a.rgic interneurons in providing circuit modula.ion to the ba.a. ga.glia.in both homeosta.ic a.d disea.e *** a.dition to direct circuit modula.ion,stria.a. interneurons ha.e a.so been shown to provide trophic support to ma.nta.n neuron popula.ions in *** discuss this interesting a.d novel role of stria.a. interneurons,with a.focus on the ma.ntena.ce of a.ult dopa.inergic neurons from interneuronderived sonic-hedgehog.

关键词： cholinergic dopa.ine Ga.a.rgic interneuron levodopa.induced dyskinesia pa.va.bumin sonic hedgehog stria.um trophic fa.tor

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局部麻醉下修补阴道前后壁膨出的可行性、疗效及其功能结局

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 19-20页

作者： kuhn a. Gelma. W. O'Sulliva. S. Monga.a. 朱磊 Urogynkologie Frauenklinik Bern Effingerstr. 102 CH-3010 Bern Switzerland

Introduction: Urogenita. prola.se is a.very common condition in women with a.preva.ence of 30%. If conserva.ive thera.y fa.ls or is not desired by the pa.ient, prola.se repa.r is usua.ly performed under genera. or regiona. a.a.sthetic. The a.m of the study wa. to eva.ua.e fea.ibility, effica.y a.d functiona. outcome a.ter fa.cia. prola.se repa.rs under loca. a.a.sthetic (La.. Pa.ients a.d methods: Between November 1999 a.d December 2000, 130 consecutive pa.ients presenting with a.terior or posterior prola.se or both were invited to ha.e their procedure performed under *** pa.ients with a.symptoma.ic minimum sta.e II prola.se were included. Prior to surgery a.l women completed a.sta.da.dized questionna.re exa.ining the specific a.d non-specific symptoms of prola.se a.d their situa.ion wa. cla.sified using the ICS Pelvic Orga. Prola.se (POP-Q) system. Follow up wa. 30 months. Objective success wa. defined a. a.sta.e 1 or less a.d no symptoms of bulge, subjective success wa. defined a. la.k of specific or non-specific symptoms of prola.se. Results: There were 128 pa.ients who a.reed to ha.e their opera.ions performed under La. 68 in the a.terior group, 52 in the posterior group a.d 8 with a.combined a.terior a.d posterior repa.r. Objective cure ra.e wa. 88%for posterior repa.r, 87%for a.terior repa.r a.d 63%for combined repa.r. Success ra.es were no different in prima.y from recurrent ca.es. There were no intra.pera.ive complica.ions a.d opera.ing time wa. 21 min (a.terior repa.r) or 23 min (posterior repa.r). There wa. no de novo postopera.ive urina.y or stool incontinence a.d a.l pa.ients but two would ha.e the opera.ion performed a.a.n under the sa.e circumsta.ces. The two rema.ning refused due to emba.ra.sment but for no other rea.on. Conclusion: Loca. a.a.sthetic prola.se repa.r is fea.ible a.d effective in middle term results. It is well a.cepted by the pa.ients who benefit from less side effects a.d short hospita. sta..

关键词：阴道前后壁膨出局部麻醉阴道膨出盆腔器官脱垂妇女常见病泌尿生殖器官手术时间区域麻醉非特

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Mecha.ism-driven stra.egies for prevention of rheuma.oid a.thritis

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Rheuma.ology & a.toimmunity 2022年第3期2卷 109-119页

作者： V.Micha.l Holers Kristine a.kuhn M.Kristen Demoruelle Jill M.Norris Ga.y S.Firestein Eddie a.Ja.es Willia. H.Robinson Ja.e H.Buckner Kevin D.Dea.e Division of Rheuma.ology University of Colorado School of MedicineAuroraColoradoUSA Depa.tment of Epidemiology Colorado School of Public HealthAuroraColoradoUSA Division of Rheuma.ology Allergy and ImmunologyUniversity of California San DiegoLa JollaCaliforniaUSA Bena.oya.Resea.ch Institute SeattleWashingtonUSA Division of Immunology a.d Rheuma.ology Stanford UniversityStanfordCaliforniaUSA Depa.tment of Medicine Division of RheumatologyVA Palo Alto Health Care SystemPalo AltoCaliforniaUSA

In seropositive rheuma.oid a.thritis(Ra.,the onset of clinica.ly a.pa.ent infla.ma.ory a.thritis(Ia.is typica.ly preceded by a.prolonged period of a.toimmunity ma.ifest by the presence of circula.ing a.toa.tibodies tha. ca. include a.tibodies to citrullina.ed protein a.tigens(a.Pa.a.d rheuma.oid *** period before clinica. Ia.ca. be designa.ed preclinica. Ra.in those individua.s who ha.e progressed to a.clinica. dia.nosis of Ra.a.d a.“a.‐risk”sta.us in those who ha.e not developed Ia.but exhibit predictive bioma.kers of future clinica. *** the goa. of developing Ra.prevention stra.egies,studies ha.e cha.a.terized immune phenotypes of preclinica. Ra.a.-risk *** these studies,a.model ha. emerged wherein mucosa. infla.ma.ion a.d dysbiosis ma. lea. first to loca. a.toa.tibody production,which should norma.ly be tra.sient,but instea. is followed by a.systemic sprea. of the a.toimmunity a. ma.ifested by serum a.toa.tibody eleva.ions,ultima.ely driving the development of clinica.ly identified joint *** model ca. be envisioned a. the progression of disea.e development through seria.“checkpoints”tha. in principle should constra.n or resolve a.toimmunity;however,instea.,the checkpoints“fa.l”a.d clinica. Ra.*** we review the immune processes tha. a.e likely to be present a. ea.h step a.d the potentia. thera.eutic stra.egies tha. could be envisioned to dela.,diminish,ha.t,or even reverse the progression to clinica. ***,these prevention stra.egies could utilize existing thera.ies a.proved for clinica. Ra.thera.ies a.proved for other disea.es tha. ta.get releva.t pa.hwa.s in the preclinica./a.-risk sta.e,or a.proa.hes tha. ta.get novel pa.hwa.s.

关键词： a.toimmune disea.e infla.ma.ion mucosa prevention rheuma.oid a.thritis

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Va.ia.ility in na.osca.e CMOS technology

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Science China.Informa.ion Sciences) 2011年第5期54卷 936-945页

作者： kuhn Kelin Portla.d Technology Development Intel Corporation Hillsboro OR 97124 USA

Moore’s La. technology sca.ing ha. improved VLSI performa.ce by five orders of ma.nitude in the la.t four deca.es. a. a.va.ced technologies continue the pursuit of Moore’s La., a.va.iety of cha.lenges will need to be overcome. One of these cha.lenges is ma.a.ement of process va.ia.ion. This pa.er discusses the importa.ce of process va.ia.ion in modern CMOS tra.sistor technology, reviews front-end va.ia.ion sources, presents device a.d circuit va.ia.ion mea.urement techniques (including circuit a.d SRa. da.a.from the 32 nm node), a.d compa.es recent intrinsic tra.sistor va.ia.ion performa.ce from the litera.ure.

关键词： CMOS va.ia.ion SRa. Vccmin

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HIV感染患者并发神经梅毒和二期梅毒

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 10-10页

作者： Ma.ini a. Pra.ge B. kuhn a. U.R. Hengge 牛新武 Ha.tklin. der Heinrich- Heine-Univ. Moorenstra.e 5 40225 Dü sseldorf GermanyDr.

a.37-yea.-old pa.ient presented with a.genera.ized ma.ulopa.ula. ra.h, wh ite ora. pla.ues, a.d blurred vision of the left eye. La.ora.ory tests revea.ed the dia.nosis of syphilis II a.d neurosyphilis in the context o... 详细信息

关键词：二期梅毒神经梅毒 HIV感染患者斑丘疹口腔白斑左眼视力泛发性

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Ra.id ma.ufa.ture of Ni-ba.ed supera.loy components by three-dimensiona. printing

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中国有色金属学会会刊：英文版 2006年第A03期16卷 1901-1905页

作者：刘建新 H.a.kuhn ProMeta. Division The Ex One Company8075 Pennsylvania AvenueIrwinPA 15642USA

The cha.lenge to ra.id ma.ufa.turing high performa.ce meta. components is how to consolida.e the uncompressed powder preforms to full or nea. full density without sha.e distortion. a.new a.proa.h developed by ProMeta. wa. proposed, in which a.bimoda. powder, typica.ly a.coa.se prea.loyed powder blended with a.fine meta. powder wa. used to build green preforms by three-dimensiona. printing a.d then sintered a. a.tempera.ure a.ove the solidus tempera.ure of the coa.se prea.loyed powder a.d below the melting tempera.ure of the fine powder pa.ticles or the solidus tempera.ure if the fine powder is a.prea.loyed powder a. well. This a.proa.h wa. successfully a.plied to sinter Ni-ba.ed supera.loy 718 preforms, which were built through three dimensiona. printing into nea. full density.

关键词：高温合金镍三维结构金相

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仅有皮肤表现的Rosa.-Dorfma.病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 8-8页

作者： Plettenberg H. a.tik S. kuhn a. R.Kruse 牛新武 Ha.tklin. der Heinrich -Heine-Univ. Moorenstra.e 5 40225 Dü sseldorf GermanyDr.

Sinus histiocytosis with ma.sive lympha.enopa.hy or Rosa.- Dorfma. disea.e i s a.non-La.gerha.s cell histiocytosis of unknown etiolosy. The most cha.a.teri stic fea.ure is lympha.enopa.hy, especia.ly tha. of cervica. lymph nodes. In a.p roxima.ely 40% of pa.ients there a.e extra.oda. ma.ifesta.ions of the disea.e. Skin is the most commonly a.fected orga. (27% ). We report a.79- yea.-old f ema.e pa.ient with purely cuta.eous ma.ifesta.ions. This form of the disea.e is a.very ra.e differentia. dia.nosis in derma.ology.

关键词：淋巴结外组织细胞增多症朗汉斯巨细胞淋巴结病鉴别诊断表现型

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Sediment genera.ion a.d soil mound denuda.ion in a.ea. of high-density tree throw a.ong a.river va.ley in the Jura.Mounta.ns, Switzerla.d

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Journa. of Mounta.n Science 2021年第2期18卷 377-391页

作者： Philip GREENWOOD Ja. Ba.ER Nikola.s J kuhn Physica. Geogra.hy&Environmenta. Cha.ge Resea.ch Group Department of Environmental SciencesUniversity of BaselKlingelbergstrasse 27Basel-4056Switzerland

a.prelimina.y field-ba.ed investiga.ion wa. underta.en in a.sma.l(<10 km^(2))river va.ley loca.ed in the mounta.nous Jura.region of northwest *** a.ms of the work were to a.sess sediment genera.ion a.d a.nua. sediment... 详细信息

a.prelimina.y field-ba.ed investiga.ion wa. underta.en in a.sma.l(a.ley loca.ed in the mounta.nous Jura.region of northwest *** a.ms of the work were to a.sess sediment genera.ion a.d a.nua. sediment tra.sport ra.es by tree throw on forested hillslopes,a.d to document surfa.e hydrology cha.a.teristics on four fresh soil mounds a.socia.ed with recent tree throws over a.24-da. monitoring *** the soil mounds,a.era.e sediment recovery ra.ged from 7.7-28.2 g(dry weight),equiva.ent to a.suspended sediment concentra.ion of 145.2-327.8 g L^(-1),a.d runoff coefficients ra.ged from 1.0%-4.2%.Ba.ed on a.soil bulk density va.ue of 1,044 kg m^(-3),upslope runoff genera.ion a.ea. were denuded by a. a.era.e 0.14 mm by the end of the 24-da. monitoring period,representing a. erosion ra.e equiva.ent to 2.1 mm yr^(-1).a.ca.50 cm high soil mound could therefore fea.ibly persist for a.ound 200-250 *** tree throw work,the dimensions of 215 individua. tree throws were mea.ured a.d their loca.ions ma.ped in 12 sepa.a.e loca.ions a.ong the river va.ley representing a.cumula.ive a.ea.equiva.ent to 5.3 ha.***,43 per ha..Tree throws genera.ed a.tota. of 20.1 m^(3) of fine-sediment(a.eter),or the equiva.ent of 3.8×10^(-4) m^(3) m^(-2).The process of tree throw wa. origina.ly a.tributed to two extreme wea.her events tha. occurred in west a.d centra. Europe in la.e December *** the 18-yea. period since both storms,this represents a. a.nua. sediment tra.sport ra.e of 2.7×10^(-5) m^(3) m^(-1) yr^(-1).Exploring the rela.ionship with wind on fa.l direction,65.5%of tree throws(143)genera.ly fell in a.downslope direction irrespective of hillslope a.pect on which they were *** infers tha. individua. storms ma. not ha.e been responsible for the ma.ority of tree throws,but instea.,could be a.socia.ed with root *** the high density of tree throws a.d their rela.ive ma.urity(a.era.e a.e 41 yea.s),we hypothesise tha. once tr

关键词： Tree throw Hillslope processes Sediment genera.ion mecha.ism Sediment tra.sport ra.e Soil mound Iba.h river va.ley

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