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Design of Differential Multi-Point Feeding Dual-Polarized SISL Antenna Based on CM Analysis

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Chinese Journal of Electronics 2024年第5期33卷 1245-1252页

作者： Bin TANG Kaixue MA Eric newton MORO Yu LUO Tianjin Key Laboratory of Imaging and Sensing Microelectronics Technology School of MicroelectronicsTianjin University

Dual-polarized antennas are required in the current mobile communication to increase the channel capacity and reducing multi-path effects. Utilizing characteristic mode(CM) analysis, this paper presents a five-patch substrate integrated suspended line(SISL) antenna with suppressed unwanted higher-order modes, and achieves an enhanced bandwidth by using differential multi-point feeding(MPF) systems. Compared to single-point feeding systems, the proposed dual-polarized SISL antenna with the MPF system demonstrates a bandwidth 1.87 times wider. The novel SISL feeding system incorporates two pairs of differentially-fed branch line feed structures. A prototype of the proposed differential-fed antenna is fabricated and measured, showing good agreement between simulated and measured results. The dual-polarization SISL antenna can achieve realized gain from 8.1 dBi to 10.8 dBi within a working frequency from 3.17 GHz to 3.61 GHz(12.98%). Moreover, utilizing low-cost substrates, the proposed SISL antenna has the potential for 5G applications.

关键词： Dual polarized Characteristic mode analysis Feeding system Broadband 5G Substrate integrated suspended line antenna Bandwidth enhanced Suppressed higher-order modes Characteristic mode analysis Feeding system Broadband 5G Substrate integrated suspended line antenna Bandwidth enhanced Suppressed higher-order modes MICROSTRIP PATCH ANTENNA LEAKY-WAVE ANTENNA LOW-PROFILE BANDWIDTH ENHANCEMENT ORDER MODES RADIATION REDUCTION OPERATION TM10

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Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo Kim Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

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中年直立性低血压和晕倒的风险

中华高血压杂志 2017年第10期25卷 998-998页

作者： Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME kucharska-newton a Selvin E 陈云叶鹏

每年有1／3老年人晕倒。直立性低血压（orthostatic hypotension，OH）被认为是晕倒的重要危险因素之一，但先前对此研究的结论并不一致。

关键词：直立性低血压晕倒风险中年危险因素老年人

心血管病与功能状态15年间变化模式:社区动脉粥样硬化风险研究的发现

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中华高血压杂志 2017年第6期25卷 580-580页

作者：刘莉叶鹏 kucharska-newton a Griswold M Yao ZH Foraker R Rose K Rosamond W Wagenknecht L Koton S Pompeii L Windham BG

心血管病是过早丧失机体功能的主要原因,但很少有前瞻性研究检查心血管病患者的功能状态。该研究的目的是检查在社区动脉粥样硬化风险（atherosclerosis risk in communities,ARIC）研究队列中,非致死性心肌梗死、脑卒中和心力衰竭患者... 详细信息

心血管病是过早丧失机体功能的主要原因,但很少有前瞻性研究检查心血管病患者的功能状态。该研究的目的是检查在社区动脉粥样硬化风险（atherosclerosis risk in communities,ARIC）研究队列中,非致死性心肌梗死、脑卒中和心力衰竭患者住院前后功能状态的变化模式。

关键词：心血管病患者动脉粥样硬化状态风险社区致死性心肌梗死间变心力衰竭患者

Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第6期13卷 764-779页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Pedro Lopez Chris Bishop Anna Maria Markarian Valentina Natalucci Jin-Soo Kim Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Pleural Medicine Unit Institute for Respiratory HealthPerthWA 6009Australia Medical School Faculty of Health&Medical SciencesUniversity of Western AustraliaPerthWA 6009Australia Grupo de Pesquisa em Exercicio para Populacoes Clinicas(GPCLIN) Universidade de Caxias do SulCaxias do SulRio Grande do Sul 95070-560Brazil London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK Department of Pathophysiology and Transplantation University of MilanMilan 20133Italy School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully *** muscle secretes myokines,which mediate muscleorgan *** regulate satellite-cell proliferation and migration,inflammatory cascade,insulin secretion,angiogenesis,fatty oxidation,and cancer *** date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be *** is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical ***:A systematic search was undertaken in PubMed,MEDLINE,CINAHL,Embase,SPORTDiscus,andWeb of Science in April *** studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of ***:Sixty-two studies were included(n=1193).Overall,exercise appeared to induce small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically *** aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across *** levels returned to baseline levels within 180 min to 24 h ***,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be ***:Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic *** research is required to investigate the effects of different exercise modes at multiple time points on myok

关键词： Myokine Resistance exercise Aerobic exercise Cytokine Systemic circulation

Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew M.Baschnagel Zijian Ni Sean R.Brennan Hypatia K.newton Darya Buehler Christina Kendziorski Randall J.Kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

血小板糖蛋白Ⅱb/Ⅲa基因多态性与动脉粥样硬化斑块形态的相关性研究:社区动脉粥样硬化风险研究

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中国医学前沿杂志(电子版) 2011年第4期3卷 43-43页

作者： kucharska-newton aM Monda KL Campbell S 杜先锋

目的:血小板的活化与聚集在心血管疾病的发病机制中起到非常重要的作用。作者曾通过社区动脉粥样硬化风险(ARIC)颈动脉MRI研究的数据对血小板糖蛋白Ⅲa(Leu33Pro)单核苷酸多态性(SNP)与颈动脉斑块形态以及血小板标记物表达之间的相关性... 详细信息

目的:血小板的活化与聚集在心血管疾病的发病机制中起到非常重要的作用。作者曾通过社区动脉粥样硬化风险(ARIC)颈动脉MRI研究的数据对血小板糖蛋白Ⅲa(Leu33Pro)单核苷酸多态性(SNP)与颈动脉斑块形态以及血小板标记物表达之间的相关性进行研究。

关键词：血小板 Pro 动脉粥样硬化动脉硬化基因多态性遗传多态性糖蛋白粘蛋白相关性

Surgical Treatment of Nephroblastoma in a 4-Year Male Child: A Case Report and Literature Review

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Case Reports in Clinical Medicine 2024年第2期13卷 43-51页

作者： Alexander Kofi Egote Samuel Kolonziah Blay Constance Amuzuah Egote Cardinal Kofi newton Albert Afriyie Akowuah Emmanuel Nana Bosoma Urology Unit Sunyani Teaching Hospital Sunyani Ghana

Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.

关键词： Nephroblastoma Wilms Tumour Nephrectomy Screening

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

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Science China(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin Zhuang Min-Sheng Peng Ya-Jun Guo Wei-Zhu Qian newton OOtecko Wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-Shi Chen Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration