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Reciprocal regulation of neutrophils and B cells elicits autoantibody-associated protumorigenic effects in human hepatocellular carcinoma

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Reciprocal regulation of neutrophils and B cells elicits aut...

Meta-path reasoning of knowledge graph for commonsense question answering

第十二届全国免疫学学术大会

作者： Liu Rui-Xian kuang dong-ming Institute of Gastroenterology and the Sixth Affiliated Hospital Sun Yat-sen University School of Life Sciences Sun Yat-sen University

Despite recent advances in identifying autoantibody-mediated carcinogenesis in animal models,direct evidence supporting the important role of autoantibodies in the immunopathogenesis of human cancers is still *** recently found that neutrophils are accumulated in hepatocellular carcinoma(HCC),and their levels positively correlated with poor survival of *** we detected high titers of proteinase 3(PR3)-specific anti-neutrophil cytoplasmic autoantibodies(ANCA) in plasma from patients with advanced stage HCCs,and that increased titers of anti-PR3 autoantibodies also correlated with poor clinical outcome of ***,B cells,plasma cells all predominantly accumulated in the peritumoral stroma of HCC *** neutrophils isolated from HCC tumors,but not paired blood,significantly and effectively secreted PR3 proteins;accordingly,only B cells/plasma cells derived from HCC tumors markedly produced anti-PR3 *** kinetic experiments revealed addition of conditioned medium from HCC tumor neutrophils to the ex vivo induction system of plasma cells led to sequential B cell activation,somatic hypermutation,and antiPR3 autoantibody ***,we also demonstrated that,in the presence of anti-PR3 autoantibodies,the neutrophils are more potent to produce protumorigenic factors oncostatin M and matrix ***,the secretion of PR3 by tumor neutrophils may represent a novel mechanism that links the autoimmunity to disease progression in the tumor milieu.

关键词： B cells Hepatocellular carcinoma PR3 Anti-neutrophil cytoplasmic autoantibodies

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Frontiers of Computer Science 2024年第1期18卷 49-59页

作者： Miao ZHANG Tingting HE ming dong National Engineering Research Center for E-Learning Central China Normal UniversityWuhan 430079China Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning Central China Normal UniversityWuhan 430079China National Language Resources Monitoring&Research Center for Network Media Central China Normal UniversityWuhan 430079China School of Computer Central China Normal UniversityWuhan 430079China

Commonsense question answering(CQA)requires understanding and reasoning over QA context and related commonsense knowledge,such as a structured Knowledge Graph(KG).Existing studies combine language models and graph neural networks to model ***,traditional knowledge graph are mostly concept-based,ignoring direct path evidence necessary for accurate *** this paper,we propose MRGNN(Meta-path Reasoning Graph Neural Network),a novel model that comprehensively captures sequential semantic information from concepts and *** MRGNN,meta-paths are introduced as direct inference evidence and an original graph neural network is adopted to aggregate features from both concepts and paths *** conduct sufficient experiments on the CommonsenceQA and OpenBookQA datasets,showing the effectiveness of ***,we conduct further ablation experiments and explain the reasoning behavior through the case study.

关键词： question answering knowledge graph graph neural network meta-path reasoning

Ferrite features in simulated transition zone of EH36 shipbuilding steel submerged arc welded by CaF_(2)-SiO_(2)-MnO fluxes

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Journal of Iron and Steel Research International 2024年第4期31卷 790-796页

作者： ming Zhong dong Hu Da-ming Guo Somnath Basu Cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076MaharashtraIndia

Ferrite features in the simulated transition zone welded with CaF_(2)-SiO_(2)-MnO fluxes containing various MnO contents have been *** laser scanning microscopy has been applied to simulate the thermal cycling of the transition zone and the phase transformations during cooling have been in-situ *** has been found that the appearance temperature for ferrite side plate decreases with increasing Mn content in the weld metals caused by MnO content ***,growth rates for both ferrite side plate and acicular ferrite are significantly enhanced with a higher Mn content of weld ***,from the statistical fractions of salient microstructures,for all samples,the acicular ferrite,grain boundary ferrite,and polygonal ferrite take over more than 90%.It has also been demonstrated that with the increase in Mn content,the ferrite side plate fraction increases slightly from 5%to 10%and the acicular ferrite fraction shows a tendency of first increasing and then decreasing,which experiences the maximum with the flux containing 30 wt.%*** phenomenon is believed to be controlled by the O and Mn contents in weld metals synergistically.

关键词： Submerged arc welding Transition zone Phase transformation Microstructure

Brain Cognition Mechanism-Inspired Hierarchical Navigation Method for Mobile Robots

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Journal of Bionic Engineering 2024年第2期21卷 852-865页

作者： Qiang Zou Chengdong Wu ming Cong dong Liu Faculty of Robot Science and Engineering Northeastern UniversityShenyang110819China School of Mechanical Engineering Dalian University of TechnologyDalian116024China

Autonomous navigation is a fundamental problem in *** methods generally build point cloud map or dense feature map in perceptual space;due to lack of cognition and memory formation mechanism,traditional methods exist poor robustness and low cognitive *** a new navigation technology that draws inspiration from mammal’s navigation,bionic navigation method can map perceptual information into cognitive space,and have strong autonomy and environment *** improve the robot’s autonomous navigation ability,this paper proposes a cognitive map-based hierarchical navigation ***,the mammals’navigation-related grid cells and head direction cells are modeled to provide the robots with location *** then a global path planning strategy based on cognitive map is proposed,which can anticipate one preferred global path to the target with high efficiency and short ***,a hierarchical motion controlling method is proposed,with which the target navigation can be divided into several sub-target navigation,and the mobile robot can reach to these sub-targets with high confidence ***,some experiments are implemented,the results show that the proposed path planning method can avoid passing through obstacles and obtain one preferred global path to the target with high efficiency,and the time cost does not increase extremely with the increase of experience nodes *** motion controlling results show that the mobile robot can arrive at the target successfully only depending on its self-motion information,which is an effective attempt and reflects strong bionic properties.

关键词： Bionic navigation Spatial localization cells Global path planning Hierarchical motion controlling

Receptivity of Mack modes to localized unsteady blowing and suction in a chemical non-equilibrium hypersonic boundary layer

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Acta Mechanica Sinica 2024年第7期40卷 1-18页

作者： Qingjiang Yuan Runjie Song ming dong State Key laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China

This paper studies the local receptivity of the Mack-mode instability to localized unsteady blowing and suction(UBS)in a chem-ical non-equilibrium(CNE)hypersonic boundary *** five-species CNE model is employed,and the receptivity efficiency is formulated by use of the residual *** with the results for the calorically perfect gas(CPG)model,we find that the real-gas effect enhances the receptivity efficiency remarkably in the majority of the second-mode frequency band,and the enhancement is mainly attributed to the modification of the base flow due to the CNE effect,which is akin to the cold-wall effect in hypersonic boundary *** with the destabilizing role of the CNE effect on the Mack second mode,it is concluded that the CNE effect would lead to a greater linearly accumulated perturbation amplitude,implying premature of transition to turbulence in a high-enthalpy hypersonic boundary layer subject to localized perturbations.

关键词： Chemical non-equilibrium flow Boundary-layer instability Hypersonic Receptivity Transition to turbulence

Arbuscular mycorrhizal fungi inoculation and exogenous indole-3-acetic acid application induce antioxidant defense response to alleviate cadmium toxicity in Broussonetia papyrifera

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Pedosphere 2024年第2期34卷 447-459页

作者： Xue LI Jingwei LIANG Hongjian WEI Yuxuan kuang Hui CHEN ming TANG Wentao HU State Key Laboratory of Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern AgricultureGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmCollege of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China

Cadmium(Cd)contamination in soil poses a huge threat to plants even at low concentrations;Broussonetia papyrifera has great potential in remediation of soil heavy metal ***,whether exogenous indole-3-acetic acid(IAA)application and arbuscular mycorrhizal fungi(AMF)have synergistic effects on Cd tolerance of *** remains *** investigate the effects of AMF inoculation and IAA application on the tolerance of *** to Cd stress,two experiments were conducted:the first to investigate the effect of AMF(Rhizophagus irregularis)inoculation on the tolerance of *** to Cd stress and the second to investigate the combined effects of AMF inoculation and IAA application on the tolerance of *** to Cd *** including endogenous hormone concentration,antioxidant defense response,malondialdehyde(MDA)content,and gene expression related to antioxidant enzyme system and hormone were *** results indicated that AMF alleviated Cd toxicity of *** by reducing MDA content and improving antioxidant enzyme activities and Cd absorption ***,the combination of AMF inoculation and IAA application had a synergetic effect on the tolerance of *** to Cd stress through upregulating BpAUX1 and BpAUX2,which might contribute to root growth and root xylem synthesis,and by upregulating BpSOD2 and BpPOD34 to enhance the antioxidant enzyme *** work provides a new insight into the application of IAA in the remediation of soil Cd pollution by mycorrhizal plants.

关键词： enzyme activity geneexpression heavy metal phytoremediation remediation Rhizophagus irregularis soil cadmium pollution stress tolerance

Swelling of Spherical Polyelectrolyte Gels

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Chinese Journal of Polymer Science 2024年第9期42卷 1386-1392,I0009页

作者： ming-Yu Duan Jia-dong Chen Yi-ming Liu Zhao-Feng Peng Guang Chen Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Polyelectrolyte(PE)gels,distinguished by their unique stimuli-responsive swelling behavior,serve as the basis of broad applications,such as artificial muscles and drug *** this work,we present a theoretical model to analyze the electrostatics and its contribution to the swelling behavior of PE gels in salt *** minimizing the free energy of PE gels,we obtain two distinct scaling regimes for the swelling ratio at equilibrium with respect to the salt *** compare our predictions for the swelling ratio with experimental measurements,which show excellent *** addition,we employ a finite element method to assess the applicability range of our theoretical model and *** anticipate that our model will also provide valuable insights into drug adsorption and release,deformation of red blood cells,4D printing and soft robotics,where the underlying mechanism of swelling remains enigmatic.

关键词： Gels Polyelectrolytes Swelling Stimuli-responsive Electrostatic interaction Cell model

Considering individual game behavior and time delay in the multi-channel rumor propagation model

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Communications in Theoretical Physics 2024年第7期76卷 9-29页

作者： Yafang dong Liang'an Huo Xiaoxiao Xie ming Li Business School University of Shanghai for Science and TechnologyShanghai 200093China School of Intelligent Emergency Management University of Shanghai for Science and TechnologyShanghai 200093China

The rapid development of the Internet has accelerated the spread of rumors,posing challenges to social cohesion and *** address this,a multi-channel rumor propagation model incorporating individual game behavior and time delay is *** depicts individuals strategically choosing propagation channels in the rumor spread process,capturing real-world intricacies more ***,the model allowing spreaders to choose between text and video information base *** adoption hinges on benefits versus costs,with payoffs dictating strategy and the propagation process determining an individual's *** theoretical analysis of the model,the propagation threshold and equilibrium points are *** the stability of the model is further demonstrated based on Routh-Hurwitz judgment and Descartes'Rule of *** simulations are conducted to verify the correctness of the theoretical results and the sensitivity of the model to key *** outcomes reveal that increasing the propagation cost of spreaders can significantly curb the spread of *** contrast to the classical ISR model,rumors spread faster and more widely in the improved multi-channel rumor propagation model in this paper,which is a feature more aligned with real-world ***,the validity and predictive ability of the model are verified by using real rumor propagation data sets,indicating that the improved multi-channel rumor propagation model has good practical application and predictive value.

关键词： multi-channel rumor propagation time delay game behavior

Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma

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Dendritic cell-elicited B-cell activation fosters immune pri...