检索结果-南通市图书馆

Overexpression of Twist1 in vascular endothelial cells promotes pathological retinal angiogenesis in mice

Zoological Research 2022年第1期43卷 64-74页

作者： Lin Zhang Shan-Shan Zhang Kai-Fang Wang Yi-Hui Li Hui-Juan Xu kuan-xiang sun Shi Ma Hong-Mei Leng Si-Zhu Chen Wen-Jing Jia Xian-Jun Zhu Jie Li Department of Ophthalmology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan 610072China Qinghai Key Laboratory of Qinghai-Tibetan Plateau Biological Resources Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningQinghai 810008China University of Chinese Academy of Science Beijing 100049China

Retinal angiogenesis is a critical process for normal retinal ***,uncontrolled angiogenesis can lead to pathological neovascularization(NV),which is closely related to most irreversible blindness-causing retinal *** the molecular basis behind pathological NV is important for the treatment of related ***-related protein 1(TWIST1)is a well-known transcription factor and principal inducer of epithelial-mesenchymal transition(EMT)in many human *** previous study showed that Twist1 expression is elevated in pathological retinal *** date,however,the role of TWIST1 in retinal pathological angiogenesis remains to be *** study the role of TWIST1 in pathological retinal NV and identify specific molecular targets for antagonizing pathological NV,we generated an inducible vascular endothelial cell(EC)-specific Twist1 transgenic mouse model(Tg-Twist1iEC+).Whole-mount retinas from Tg-Twist1iEC+mice showed retarded vascular progression and increased vascular density in the front end of the growing retinal vasculature,as well as aneurysm-like pathological retinal ***,overexpression of Twist1 in the ECs promoted cell proliferation but disturbed cell polarity,thus leading to uncontrolled retinal ***1 promoted pathological NV by activating the Wnt/β-catenin signaling pathway and inducing the expression of NV formation-related genes,thereby acting as a‘valve’in the regulation of pathological *** study identified the critical role of TWIST1 in retinal pathological NV,thus providing a potential therapeutic target for pathological NV.

关键词： Pathological angiogenesis TWIST1 Molecular markers Mouse model Retinal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deletion of phosphatidylserine flippase β-subunit Tmem30a in satellite cells leads to delayed skeletal muscle regeneration

引用

Zoological Research 2021年第5期42卷 650-659页

作者： kuan-xiang sun Xiao-Yan Jiang Xiao Li Yu-Jing Su Ju-Lin Wang Lin Zhang Ye-Ming Yang Xian-Jun Zhu Health Management Center Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072 China Department of Ophthalmology First People's Hospital of ShangqiuShangqiuHenan 476000China Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China

Phosphatidylserine(PS)is distributed asymmetrically in the plasma membrane of eukaryotic *** flippase(P4-ATPase)transports PS from the outer leaflet of the lipid bilayer to the inner leaflet of the membrane to maintain PS ***βsubunitTMEM30 Ais indispensable for transport and proper function of *** studies have shown that the ATP11 A and TMEM30 A complex is the molecular switch for myotube ***,the role of Tmem30 a in skeletal muscle regeneration remains *** the current study,Tmem30 a was highly expressed in the tibialis anterior(TA)muscles of dystrophin-null(mdx)mice and BaCl2-induced muscle injury model *** generated a satellite cell(SC)-specific Tmem30 a conditional knockout(cKO)mouse model to investigate the role of Tmem30 a in skeletal muscle *** regenerative ability of cKO mice was evaluated by analyzing the number and diameter of regenerated SCs after the TA muscles were injured by *** to the control mice,the cKO mice showed decreased Pax7+and MYH3+SCs,indicating diminished SC proliferation,and decreased expression of muscular regulatory factors(MYOD and MYOG),suggesting impaired myoblast proliferation in skeletal muscle *** together,these results demonstrate the essential role of Tmem30 a in skeletal muscle regeneration.

关键词： Tmem30a Skeletalmuscle regeneration Knockout mouse model Atp11a Satellite cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chronic infectious unilateral giant thyroid cyst related to diabetes mellitus:A case report

引用

World Journal of Clinical Cases 2024年第8期12卷 1497-1503页

作者： Jiang-Bo Liu Shi-Lei Zhang Wen-Long Jiang Hai-kuan sun Hao-Chen Yang Department of Thyroid and Breast Surgery The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471000Henan ProvinceChina Clinical Medicine School The First Clinical CollegeChongqing Medical UniversityChongqing 400016China

BACKGROUND Patients rarely develop complicated infections in thyroid ***,we describe a patient with chronic infected unilateral giant thyroid cyst related to diabetes mellitus(DM).CASE SUMMARY A 66-year-old male was admitted due to an evident neck lump for 5 d after approximately 40 years of gradually progressive neck mass and 7 years of *** ultrasound and computed tomography scan showed a giant lump in the left thyroid gland *** was diagnosed with a large thyroid nodule complicated by tracheal dislocation and had surgical *** exploration revealed evident inflammatory edema and exudation between the left anterior neck muscles,the nodule and glandular ***,inflammatory lesions did not affect major neck ***,a left partial thyroidectomy was *** observation showed that the cystic thyroid mass consisted of extensive cystic wall calcification and was rich in massive rough sand-like calculi content and purulent *** pathology confirmed benign thyroid cyst with chronic *** The progression of this chronic infectious unilateral giant thyroid cyst may have been related to DM,and identifying blood vessels involvement can prevent serious complications during operation.

关键词： Thyroid nodule Infection Diabetes mellitus Surgery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence

引用

Science China(Life Sciences) 2024年第3期67卷 460-474页

作者： Daoyuan Huang Qian Zhao kuan Yang Jinghui Lei Ying Jing Hongyu Li Chen Zhang Shuai Ma Shuhui sun Yusheng Cai Guibin Wang Jing Qu Weiqi Zhang Si Wang Guang-Hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining ***,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and *** this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome *** all family members,we found that CUL2 deficiency rendered hMSCs the most susceptible to *** investigate CUL2-specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2-deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2 deletion markedly accelerates hMSC ***,we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2(a known negative regulator of proliferation)through the substrate receptor protein APPBP2,which in turn downregulates one of the canonical aging marker-P21^(waf1/cip1),and thereby delays *** work provides important insights into how CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding Bridging Sites and Accelerating Quantum Efficiency for Photocatalytic CO_(2) Reduction

引用

Nano-Micro Letters 2024年第1期16卷 68-84页

作者： Kangwang Wang Zhuofeng Hu Peifeng Yu Alina M.Balu kuan Li Longfu Li Lingyong Zeng Chao Zhang Rafael Luque Kai Yan Huixia Luo School of Materials Science and Engineering State Key Laboratory of Optoelectronic Materials and TechnologiesGuangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesKey Lab of Polymer Composite and Functional MaterialsSun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275People’s Republic of China School of Environmental Science and Engineering Sun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275People’s Republic of China Departamento de Química Orgánica Universidad de CórdobaCampus Universitario de RabanalesEdificio Marie Curie(C3)14014 CórdobaSpain Center for Refining and Advanced Chemicals King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia Universidad ECOTEC Km 13.5 SamborondónEC092302 SamborondónEcuador

We report a novel double-shelled nanoboxes photocatalyst architecture with tailored interfaces that accelerate quantum efficiency for photocatalytic CO_(2) reduction reaction(CO_(2)RR)via Mo–S bridging bonds sites in S_(v)–In_(2)S_(3)@2H–MoTe_(2).The X-ray absorption near-edge structure shows that the formation of S_(v)–In_(2)S_(3)@2H–MoTe_(2) adjusts the coordination environment via interface engineering and forms Mo–S polarized sites at the *** interfacial dynamics and catalytic behavior are clearly revealed by ultrafast femtosecond transient absorption,time-resolved,and in situ diffuse reflectance–Infrared Fourier transform spectroscopy.A tunable electronic structure through steric interaction of Mo–S bridging bonds induces a 1.7-fold enhancement in S_(v)–In_(2)S_(3)@2H–MoTe_(2)(5)photogenerated carrier concentration relative to pristine S_(v)–In_(2)S_(3).Benefiting from lower carrier transport activation energy,an internal quantum efficiency of 94.01%at 380 nm was used for photocatalytic CO_(2)*** study proposes a new strategy to design photocatalyst through bridging sites to adjust the selectivity of photocatalytic CO_(2)RR.

关键词： Quantum efficiency Electronic structure Steric interaction Bridging sites CO_(2)reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictive value of tumor-infiltrating lymphocytes for neoadjuvant therapy response in triple-negative breast cancer: A systematic review and meta-analysis

引用

World Journal of Clinical Oncology 2024年第7期15卷 920-935页

作者： Hai-kuan sun Wen-Long Jiang Shi-Lei Zhang Peng-Cheng Xu Li-Min Wei Jiang-Bo Liu Department of Thyroid and Breast Surgery The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471000Henan ProvinceChina

BACKGROUND The association between tumor-infiltrating lymphocyte(TIL)levels and the res-ponse to neoadjuvant therapy(NAT)in patients with triple-negative breast cancer(TNBC)remains *** To investigate the predictive potential of TIL levels for the response to NAT in TNBC *** A systematic search of the National Center for Biotechnology Information PubMed database was performed to collect relevant published literature prior to August 31,*** correlation between TIL levels and the NAT pathologic com-plete response(pCR)in TNBC patients was assessed using a systematic review and *** analysis,sensitivity analysis,and publication bias analysis were also *** A total of 32 studies were included in this *** overall meta-ana-lysis results indicated that the pCR rate after NAT treatment in TNBC patients in the high TIL subgroup was significantly greater than that in patients in the low TIL subgroup(48.0%vs 27.7%)(risk ratio 2.01;95%confidence interval 1.77-2.29;P<0.001,I2=56%).Subgroup analysis revealed that the between-study hetero-geneity originated from differences in study design,TIL level cutoffs,and study *** bias could have existed in the included *** meta-analysis based on different NAT protocols revealed that all TNBC patients with high levels of TILs had a greater rate of pCR after NAT treatment in all protocols(all P≤0.01),and there was no significant between-protocol difference in the statistics among the different NAT protocols(P=0.29).Additionally,sensitivity analysis demonstrated that the overall results of the meta-analysis remained consistent when the included studies were individually *** TILs can serve as a predictor of the response to NAT treatment in TNBC *** patients with high levels of TILs exhibit a greater NAT pCR rate than those with low levels of TILs,and this predictive capability is con-sistent across different NAT regimens.

关键词： Breast cancer Tumor-infiltrating lymphocyte Neoadjuvant therapy Treatment response Systematic review Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于实测数据的推进轴系轴承动载荷反演识别方法

引用

船舶力学 2024年第4期28卷 594-605页

作者：周凌波胡志宽段勇孙玉东魏强中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082 深海技术科学太湖实验室江苏无锡214082 中国舰船研究设计中心武汉430064

本文针对船舶推进轴系轴承动载荷准确识别的难题开展研究,提出一种基于频响函数求逆并采用全实测数据的频域反演识别方法及相应的数据处理和评价方法;然后,针对推进轴系振动试验台架,开展三种类型外激励作用下的径向轴承动载荷反演试验... 详细信息

本文针对船舶推进轴系轴承动载荷准确识别的难题开展研究,提出一种基于频响函数求逆并采用全实测数据的频域反演识别方法及相应的数据处理和评价方法;然后,针对推进轴系振动试验台架,开展三种类型外激励作用下的径向轴承动载荷反演试验进行验证。试验结果表明:不平衡、随机振动、脉冲激励下轴承动载荷的反演识别结果与直接测量结果在10 Hz~1 kHz频带内的幅频和相频曲线趋势一致,吻合度高;10 Hz~1 kHz频带内,不平衡激励下的轴承动载荷反演误差为0.21~3.5 dB,随机振动激励下为2.03~2.53 dB,脉冲激励下为2.16~4.64 dB,验证了反演识别方法的可行性和准确性。

关键词：推进轴系轴承动载荷反演识别

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于嵌入式AI设备的光伏电池片缺陷智能检测系统

引用

电子设计工程 2024年第4期32卷 129-134页

作者：孙晨邓宽盐城工学院机械工程学院江苏盐城224051 金陵科技学院电子信息工程学院江苏南京211169

针对光伏电池片易受材料、生产工艺等因素影响,产生诸多缺陷且检测难度高等问题,设计了一套以嵌入式AI设备Jetson Xavier NX为控制单元的智能检测分拣系统。该系统利用电致发光成像技术采集图像,选用以ResNet50为主干的Faster RCNN网络... 详细信息

针对光伏电池片易受材料、生产工艺等因素影响,产生诸多缺陷且检测难度高等问题,设计了一套以嵌入式AI设备Jetson Xavier NX为控制单元的智能检测分拣系统。该系统利用电致发光成像技术采集图像,选用以ResNet50为主干的Faster RCNN网络结构作为目标检测算法,并融入特征金字塔网络(FPN)提高网络对多尺度缺陷的特征表达能力。并采用六轴机械臂将各类残片分拣至指定区域。经实验测试,检测的平均精度为92.4%,能够满足实际生产需求。

关键词：缺陷检测 Jetson Xavier NX 电致发光 Faster RCNN FPN

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

风攻角对流线型主梁涡振特性影响的试验研究

引用

工程力学 2024年第S1期41卷 222-227页

作者：王滨璇孙一飞胡波韩原刘庆宽石家庄铁道大学土木工程学院河北石家庄050043 石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室河北石家庄050043 河北省风工程和能源利用工程技术创新中心河北石家庄050043 石家庄铁道大学工程力学系河北石家庄050043

涡激振动是主梁在低风速下常发生的一种振动,可能造成主梁疲劳破坏或影响行车舒适性。为了研究风攻角对流线型箱梁涡激振动特性的影响和作用机理,采用节段模型同步测压、测振的方法,分析了风攻角对涡激振动响应、平均和脉动风压、局部... 详细信息

涡激振动是主梁在低风速下常发生的一种振动,可能造成主梁疲劳破坏或影响行车舒适性。为了研究风攻角对流线型箱梁涡激振动特性的影响和作用机理,采用节段模型同步测压、测振的方法,分析了风攻角对涡激振动响应、平均和脉动风压、局部气动力对涡振的贡献系数的影响。结果表明:涡振振幅随风攻角的增大呈增大趋势;不同风攻角的上表面平均压力系数不同,在-5°风攻角时最大,在+5°风攻角时最小;当风攻角为正时,主梁上表面下游区域和下表面迎风侧斜腹板前端脉动压力系数波动较大,风攻角在一定程度上影响主梁表面脉动压力系数的空间分布,这可能是涡振响应不同的原因之一;风攻角对局部气动力贡献系数有一定的影响,当风攻角为正时,主梁表面气动力对涡激力有增强作用。

关键词：涡激振动风攻角风洞试验气动力特性流线型箱梁

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

带有纵向肋条斜拉索风荷载特性研究

引用

工程力学 2024年第S1期41卷 253-257,291页

作者：褚泽楷常幸孙一飞韩鹏刘庆宽石家庄铁道大学土木工程学院石家庄050043 石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室石家庄050043 河北省风工程和风能利用工程技术创新中心石家庄050043

相关研究表明纵向肋条对斜拉索风雨振有良好的抑制效果,但对斜拉索风荷载特性的影响尚未明确。在斜拉索表面布置了宽度和高度均为5 mm的2根长方体肋条,通过风洞测压实验,研究其在不同雷诺数下环向和展向平均风压分布的影响规律。结果表... 详细信息

相关研究表明纵向肋条对斜拉索风雨振有良好的抑制效果,但对斜拉索风荷载特性的影响尚未明确。在斜拉索表面布置了宽度和高度均为5 mm的2根长方体肋条,通过风洞测压实验,研究其在不同雷诺数下环向和展向平均风压分布的影响规律。结果表明:肋条使斜拉索展向风荷载在分离点产生了较强的三维性,风荷载沿展向无明显变化规律;双分离泡区内,肋条对于斜拉索的环向风荷载分布规律影响较小;肋条改变分离点的位置,加快了层流到湍流的转捩,使得临界区提前;在低雷诺数区,肋条会加强斜拉索表面流场的三维性,随着雷诺数的升高,斜拉索表面流场的三维性先增强后减弱,到达双分离泡区后,斜拉索流场的三维性趋于稳定。

关键词：风洞实验临界区风压分布三维特性纵向肋条

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：